- Home
- Publications
- Publication Search
- Publication Details
Title
TMEM16A in Cystic Fibrosis: Activating or Inhibiting?
Authors
Keywords
-
Journal
Frontiers in Pharmacology
Volume 10, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2019-01-29
DOI
10.3389/fphar.2019.00003
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Tezacaftor/Ivacaftor in Subjects with Cystic Fibrosis and F508del/F508del-CFTR or F508del/G551D-CFTR
- (2018) Scott H. Donaldson et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Compartmentalized crosstalk of CFTR and TMEM16A (ANO1) through EPAC1 and ADCY1
- (2018) Joana Lérias et al. CELLULAR SIGNALLING
- Inflammatory mediators mediate airway smooth muscle contraction through a G protein-coupled receptor–transmembrane protein 16A–voltage-dependent Ca 2+ channel axis and contribute to bronchial hyperresponsiveness in asthma
- (2018) Pei Wang et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Correcting the F508del-CFTR variant by modulating eukaryotic translation initiation factor 3–mediated translation initiation
- (2018) Darren M. Hutt et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction
- (2018) Eleanor M. Dunican et al. JOURNAL OF CLINICAL INVESTIGATION
- CrossTalk opposing view: mucosal acidification does not drive early progressive lung disease in cystic fibrosis
- (2018) Stephen M. Stick et al. JOURNAL OF PHYSIOLOGY-LONDON
- Lipophilicity of the Cystic Fibrosis Drug, Ivacaftor (VX-770), and Its Destabilizing Effect on the Major CF-causing Mutation: F508del
- (2018) Stephanie Chin et al. MOLECULAR PHARMACOLOGY
- A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte
- (2018) Lindsey W. Plasschaert et al. NATURE
- A revised airway epithelial hierarchy includes CFTR-expressing ionocytes
- (2018) Daniel T. Montoro et al. NATURE
- A novel triple combination of pharmacological chaperones improves F508del-CFTR correction
- (2018) Graeme W. Carlile et al. Scientific Reports
- Synthesis and biological evaluation of novel Ani9 derivatives as potent and selective ANO1 inhibitors
- (2018) Yohan Seo et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- TMEM16A is indispensable for basal mucus secretion in airways and intestine
- (2018) Roberta Benedetto et al. FASEB JOURNAL
- Matrine is a novel inhibitor of the TMEM16A chloride channel with antilung adenocarcinoma effects
- (2018) Shuai Guo et al. JOURNAL OF CELLULAR PHYSIOLOGY
- The Natural Compound Cinnamaldehyde is a Novel Activator of Calcium-Activated Chloride Channel
- (2018) Yayue Huang et al. JOURNAL OF MEMBRANE BIOLOGY
- VX-445–Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles
- (2018) Dominic Keating et al. NEW ENGLAND JOURNAL OF MEDICINE
- VX-659–Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles
- (2018) Jane C. Davies et al. NEW ENGLAND JOURNAL OF MEDICINE
- Roles of mucus adhesion and cohesion in cough clearance
- (2018) Brian Button et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Differential effects of anoctamins on intracellular calcium signals
- (2017) Inês Cabrita et al. FASEB JOURNAL
- Bicarbonate in cystic fibrosis
- (2017) Karl Kunzelmann et al. Journal of Cystic Fibrosis
- Clustering of Ca 2+ transients in interstitial cells of Cajal defines slow wave duration
- (2017) Bernard T. Drumm et al. JOURNAL OF GENERAL PHYSIOLOGY
- Substituted 2-Acylaminocycloalkylthiophene-3-carboxylic Acid Arylamides as Inhibitors of the Calcium-Activated Chloride Channel Transmembrane Protein 16A (TMEM16A)
- (2017) Eric C. Truong et al. JOURNAL OF MEDICINAL CHEMISTRY
- Identification of Resveratrol, an Herbal Compound, as an Activator of the Calcium-Activated Chloride Channel, TMEM16A
- (2017) Ran Chai et al. JOURNAL OF MEMBRANE BIOLOGY
- Rice Bran Extract Inhibits TMEM16A-Involved Activity in the Neonatal Rat Cochlea
- (2017) Kushal Sharma et al. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
- Regulation of TMEM16A/ANO1 and TMEM16F/ANO6 ion currents and phospholipid scrambling by Ca2+ and plasma membrane lipid
- (2017) Rainer Schreiber et al. JOURNAL OF PHYSIOLOGY-LONDON
- Cell-specific mechanisms of TMEM16A Ca2+-activated chloride channel in cancer
- (2017) Hui Wang et al. Molecular Cancer
- Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM
- (2017) Cristina Paulino et al. NATURE
- Tezacaftor–Ivacaftor in Residual-Function Heterozygotes with Cystic Fibrosis
- (2017) Steven M. Rowe et al. NEW ENGLAND JOURNAL OF MEDICINE
- Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del
- (2017) Jennifer L. Taylor-Cousar et al. NEW ENGLAND JOURNAL OF MEDICINE
- Effects of new-generation TMEM16A inhibitors on calcium-activated chloride currents in rabbit urethral interstitial cells of Cajal
- (2017) Stephen Fedigan et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Ginsenoside Rb1, a novel activator of the TMEM16A chloride channel, augments the contraction of guinea pig ileum
- (2017) Shuai Guo et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Airway surface liquid pH is not acidic in children with cystic fibrosis
- (2017) André Schultz et al. Nature Communications
- Correction of CFTR function in nasal epithelial cells from cystic fibrosis patients predicts improvement of respiratory function by CFTR modulators
- (2017) Iwona M. Pranke et al. Scientific Reports
- Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A
- (2017) Cristina Paulino et al. eLife
- Epithelial Chloride Transport by CFTR Requires TMEM16A
- (2017) Roberta Benedetto et al. Scientific Reports
- Mechanism of allosteric activation of TMEM16A/ANO1 channels by a commonly used chloride channel blocker
- (2016) Chau M Ta et al. BRITISH JOURNAL OF PHARMACOLOGY
- Cl− channels in apoptosis
- (2016) Podchanart Wanitchakool et al. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
- Pharmacological analysis of epithelial chloride secretion mechanisms in adult murine airways
- (2016) Ambra Gianotti et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Cystic fibrosis gene modifierSLC26A9modulates airway response to CFTR-directed therapeutics
- (2016) Lisa J. Strug et al. HUMAN MOLECULAR GENETICS
- Relationship between TMEM16A/anoctamin 1 and LRRC8A
- (2016) Roberta Benedetto et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Shikonin Inhibits Intestinal Calcium-Activated Chloride Channels and Prevents Rotaviral Diarrhea
- (2016) Yu Jiang et al. Frontiers in Pharmacology
- Progress in therapies for cystic fibrosis
- (2016) Kris De Boeck et al. Lancet Respiratory Medicine
- Ani9, A Novel Potent Small-Molecule ANO1 Inhibitor with Negligible Effect on ANO2
- (2016) Yohan Seo et al. PLoS One
- Precision Medicine: At What Price?
- (2015) Thomas Ferkol et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Antagonists of the TMEM16A Calcium-activated Chloride Channel Modulate Airway Smooth Muscle Tone and Intracellular Calcium
- (2015) Jennifer Danielsson et al. ANESTHESIOLOGY
- 9-Phenanthrol inhibits recombinant and arterial myocyte TMEM16A channels
- (2015) Sarah K Burris et al. BRITISH JOURNAL OF PHARMACOLOGY
- TMEM16A mediates the hypersecretion of mucus induced by Interleukin-13
- (2015) Jiachen Lin et al. EXPERIMENTAL CELL RESEARCH
- Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking
- (2015) Graeme W. Carlile et al. Journal of Cystic Fibrosis
- Variants in Solute Carrier SLC26A9 Modify Prenatal Exocrine Pancreatic Damage in Cystic Fibrosis
- (2015) Melissa R. Miller et al. JOURNAL OF PEDIATRICS
- Ion channel and lipid scramblase activity associated with expression of TMEM16F/ANO6 isoforms
- (2015) Paolo Scudieri et al. JOURNAL OF PHYSIOLOGY-LONDON
- Anoctamin-1 Cl− Channels in Nociception: Activation by an N-Aroylaminothiazole and Capsaicin and Inhibition by T16A[inh]-A01
- (2015) Farah Deba et al. Molecular Pain
- Origins of Cystic Fibrosis Lung Disease
- (2015) David A. Stoltz et al. NEW ENGLAND JOURNAL OF MEDICINE
- Lumacaftor–Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del CFTR
- (2015) Claire E. Wainwright et al. NEW ENGLAND JOURNAL OF MEDICINE
- Cellular volume regulation by anoctamin 6: Ca2+, phospholipase A2 and osmosensing
- (2015) Lalida Sirianant et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Modulating Ca2+ signals: a common theme for TMEM16, Ist2, and TMC
- (2015) Karl Kunzelmann et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Inhibition of ANO1/TMEM16A Chloride Channel by Idebenone and Its Cytotoxicity to Cancer Cell Lines
- (2015) Yohan Seo et al. PLoS One
- A fluid secretion pathway unmasked by acinar-specificTmem16Agene ablation in the adult mouse salivary gland
- (2015) Marcelo A. Catalán et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Anoctamin 6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages
- (2015) Jiraporn Ousingsawat et al. Nature Communications
- Upregulation of TMEM16A Protein in Bronchial Epithelial Cells by Bacterial Pyocyanin
- (2015) Emanuela Caci et al. PLoS One
- Identification of the Novel TMEM16A Inhibitor Dehydroandrographolide and Its Anticancer Activity on SW620 Cells
- (2015) Yujie Sui et al. PLoS One
- Functional interaction of the cystic fibrosis transmembrane conductance regulator with members of the SLC26 family of anion transporters (SLC26A8 and SLC26A9): Physiological and pathophysiological relevance
- (2014) Elma El Khouri et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Disruption of vascular Ca2+-activated chloride currents lowers blood pressure
- (2014) Christoph Heinze et al. JOURNAL OF CLINICAL INVESTIGATION
- The relative frequency of CFTR mutation classes in European patients with cystic fibrosis
- (2014) K. De Boeck et al. Journal of Cystic Fibrosis
- Ano1, a Ca2+-activated Cl−channel, coordinates contractility in mouse intestine by Ca2+transient coordination between interstitial cells of Cajal
- (2014) Raman Deep Singh et al. JOURNAL OF PHYSIOLOGY-LONDON
- The calcium-activated chloride channel Anoctamin 1 contributes to the regulation of renal function
- (2014) Diana Faria et al. KIDNEY INTERNATIONAL
- Anoctamin 1 Contributes to Inflammatory and Nerve-Injury Induced Hypersensitivity
- (2014) Byeongjun Lee et al. Molecular Pain
- Anoctamins support calcium-dependent chloride secretion by facilitating calcium signaling in adult mouse intestine
- (2014) Rainer Schreiber et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Role of anoctamins in cancer and apoptosis
- (2014) P. Wanitchakool et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Structure and Function of TMEM16 Proteins (Anoctamins)
- (2014) Nicoletta Pedemonte et al. PHYSIOLOGICAL REVIEWS
- Impaired mucus detachment disrupts mucociliary transport in a piglet model of cystic fibrosis
- (2014) M. J. Hoegger et al. SCIENCE
- Some gating potentiators, including VX-770, diminish F508-CFTR functional expression
- (2014) G. Veit et al. Science Translational Medicine
- Potentiator ivacaftor abrogates pharmacological correction of F508 CFTR in cystic fibrosis
- (2014) D. M. Cholon et al. Science Translational Medicine
- TMEM16F is a component of a Ca2+-activated Cl− channel but not a volume-sensitive outwardly rectifying Cl− channel
- (2013) Takahiro Shimizu et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Functional expression of the TMEM16 family of calcium-activated chloride channels in airway smooth muscle
- (2013) George Gallos et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Anoctamin 1 dysregulation alters bronchial epithelial repair in cystic fibrosis
- (2013) Manon Ruffin et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- TMEM16F (Anoctamin 6), an anion channel of delayed Ca2+activation
- (2013) Søren Grubb et al. JOURNAL OF GENERAL PHYSIOLOGY
- Pitfalls of Drug Development: Lessons Learned from Trials of Denufosol in Cystic Fibrosis
- (2013) Richard B. Moss JOURNAL OF PEDIATRICS
- The secret life of CFTR as a calcium-activated chloride channel
- (2013) Arnaud Billet et al. JOURNAL OF PHYSIOLOGY-LONDON
- Molecular functions of anoctamin 6 (TMEM16F): a chloride channel, cation channel, or phospholipid scramblase?
- (2013) Karl Kunzelmann et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- The Transmembrane Protein 16A Ca2+-activated Cl−Channel in Airway Smooth Muscle Contributes to Airway Hyperresponsiveness
- (2012) Cheng-Hai Zhang et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Control of TMEM16A by INO-4995 and other inositolphosphates
- (2012) Yuemin Tian et al. BRITISH JOURNAL OF PHARMACOLOGY
- TMEM16F Forms a Ca2+-Activated Cation Channel Required for Lipid Scrambling in Platelets during Blood Coagulation
- (2012) Huanghe Yang et al. CELL
- Airway epithelial cells—Functional links between CFTR and anoctamin dependent Cl− secretion
- (2012) Karl Kunzelmann et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Anoctamins are a family of Ca2+-activated Cl- channels
- (2012) Y. Tian et al. JOURNAL OF CELL SCIENCE
- SLC26A9-mediated chloride secretion prevents mucus obstruction in airway inflammation
- (2012) Pinelopi Anagnostopoulou et al. JOURNAL OF CLINICAL INVESTIGATION
- Long term effects of denufosol tetrasodium in patients with cystic fibrosis
- (2012) Felix Ratjen et al. Journal of Cystic Fibrosis
- Association of TMEM16A chloride channel overexpression with airway goblet cell metaplasia
- (2012) Paolo Scudieri et al. JOURNAL OF PHYSIOLOGY-LONDON
- Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung
- (2012) Alejandro A. Pezzulo et al. NATURE
- Multiple apical plasma membrane constituents are associated with susceptibility to meconium ileus in individuals with cystic fibrosis
- (2012) Lei Sun et al. NATURE GENETICS
- The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons
- (2012) Hawon Cho et al. NATURE NEUROSCIENCE
- Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction
- (2012) F. Huang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Niflumic Acid Inhibits Goblet Cell Degranulation in a Guinea Pig Asthma Model
- (2012) Mitsuko Kondo et al. ALLERGOLOGY INTERNATIONAL
- F508del-CFTR increases intracellular Ca2+ signaling that causes enhanced calcium-dependent Cl− conductance in cystic fibrosis
- (2011) Joana Raquel Martins et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- CFTR and TMEM16A are Separate but Functionally Related Cl- Channels
- (2011) Jiraporn Ousingsawat et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Anoctamins and gastrointestinal smooth muscle excitability
- (2011) Kenton M. Sanders et al. EXPERIMENTAL PHYSIOLOGY
- Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction
- (2011) Wan Namkung et al. FASEB JOURNAL
- Differential contribution of SLC26A9 to Cl−conductance in polarized and non-polarized epithelial cells
- (2011) Jiraporn Ousingsawat et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Mouse models of cystic fibrosis: Phenotypic analysis and research applications
- (2011) Martina Wilke et al. Journal of Cystic Fibrosis
- Sequential targeting of CFTR by BAC vectors generates a novel pig model of cystic fibrosis
- (2011) N. Klymiuk et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Anoctamins
- (2011) Karl Kunzelmann et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Increased Oxidative Stress Induces Apoptosis in Human Cystic Fibrosis Cells
- (2011) Mathilde Rottner et al. PLoS One
- Human cystic fibrosis airway epithelia have reduced Cl- conductance but not increased Na+ conductance
- (2011) O. A. Itani et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809
- (2011) F. Van Goor et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Loss of Anion Transport without Increased Sodium Absorption Characterizes Newborn Porcine Cystic Fibrosis Airway Epithelia
- (2010) Jeng-Haur Chen et al. CELL
- Therapeutic use of coenzyme Q10and coenzyme Q10-related compounds and formulations
- (2010) Jose M Villalba et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Inhibition of Ca2+-activated Cl− channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea
- (2010) Wan Namkung et al. FASEB JOURNAL
- Disruption of the K+Channel β-Subunit KCNE3 Reveals an Important Role in Intestinal and Tracheal Cl−Transport
- (2010) Patricia Preston et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Expression and Function of Epithelial Anoctamins
- (2010) Rainer Schreiber et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TMEM16A Inhibitors Reveal TMEM16A as a Minor Component of Calcium-activated Chloride Channel Conductance in Airway and Intestinal Epithelial Cells
- (2010) Wan Namkung et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- CFTR-Adenylyl Cyclase I Association Responsible for UTP Activation of CFTR in Well-Differentiated Primary Human Bronchial Cell Cultures
- (2010) Wan Namkung et al. MOLECULAR BIOLOGY OF THE CELL
- Calcium-dependent phospholipid scrambling by TMEM16F
- (2010) Jun Suzuki et al. NATURE
- Effect of VX-770 in Persons with Cystic Fibrosis and the G551D-CFTRMutation
- (2010) Frank J. Accurso et al. NEW ENGLAND JOURNAL OF MEDICINE
- Airway Mucus Function and Dysfunction
- (2010) John V. Fahy et al. NEW ENGLAND JOURNAL OF MEDICINE
- Cystic Fibrosis Pigs Develop Lung Disease and Exhibit Defective Bacterial Eradication at Birth
- (2010) D. A. Stoltz et al. Science Translational Medicine
- Slc26a9 Is Inhibited by the R-region of the Cystic Fibrosis Transmembrane Conductance Regulator via the STAS Domain
- (2009) Min-Hwang Chang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Loss of TMEM16A Causes a Defect in Epithelial Ca2+-dependent Chloride Transport
- (2009) Jiraporn Ousingsawat et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- SLC26A9 is a constitutively active, CFTR-regulated anion conductance in human bronchial epithelia
- (2009) Carol A. Bertrand et al. JOURNAL OF GENERAL PHYSIOLOGY
- Crofelemer, an Antisecretory Antidiarrheal Proanthocyanidin Oligomer Extracted from Croton lechleri, Targets Two Distinct Intestinal Chloride Channels
- (2009) L. Tradtrantip et al. MOLECULAR PHARMACOLOGY
- Chloride channels as drug targets
- (2009) Alan S. Verkman et al. NATURE REVIEWS DRUG DISCOVERY
- Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770
- (2009) F. Van Goor et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Studies on expression and function of the TMEM16A calcium-activated chloride channel
- (2009) Fen Huang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mechanism of direct bicarbonate transport by the CFTR anion channel
- (2008) Lin Tang et al. Journal of Cystic Fibrosis
- TMEM16A confers receptor-activated calcium-dependent chloride conductance
- (2008) Young Duk Yang et al. NATURE
- The development of allergic inflammation
- (2008) Stephen J. Galli et al. NATURE
- CFTR is activated through stimulation of purinergic P2Y2 receptors
- (2008) Diana Faria et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity
- (2008) A. Caputo et al. SCIENCE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now