Cellular volume regulation by anoctamin 6: Ca2+, phospholipase A2 and osmosensing

Anoctamin 6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages

(2015) Jiraporn Ousingsawat et al.   Nature Communications

Identification of a lipid scrambling domain in ANO6/TMEM16F

(2015) Kuai Yu et al.   eLife

SWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel

(2014) Zhaozhu Qiu et al.   CELL

X-ray structure of a calcium-activated TMEM16 lipid scramblase

(2014) Janine D. Brunner et al.   NATURE

Anoctamins support calcium-dependent chloride secretion by facilitating calcium signaling in adult mouse intestine

(2014) Rainer Schreiber et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Anoctamin 6 differs from VRAC and VSOAC but is involved in apoptosis and supports volume regulation in the presence of Ca2+

(2014) C. A. Juul et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Structure and Function of TMEM16 Proteins (Anoctamins)

(2014) Nicoletta Pedemonte et al.   PHYSIOLOGICAL REVIEWS

Identification of LRRC8 Heteromers as an Essential Component of the Volume-Regulated Anion Channel VRAC

(2014) F. K. Voss et al.   SCIENCE

TMEM16F is a component of a Ca2+-activated Cl− channel but not a volume-sensitive outwardly rectifying Cl− channel

(2013) Takahiro Shimizu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

TMEM16F (Anoctamin 6), an anion channel of delayed Ca2+activation

(2013) Søren Grubb et al.   JOURNAL OF GENERAL PHYSIOLOGY

Calcium-activated and apoptotic phospholipid scrambling induced by Ano6 can occur independently of Ano6 ion currents

(2013) A Kmit et al.   Cell Death & Disease

Ca2+-dependent phospholipid scrambling by a reconstituted TMEM16 ion channel

(2013) Mattia Malvezzi et al.   Nature Communications

TMEM16F Forms a Ca2+-Activated Cation Channel Required for Lipid Scrambling in Platelets during Blood Coagulation

(2012) Huanghe Yang et al.   CELL

Expression and Functional Significance of the Ca2+-Activated Cl-Channel ANO6 in Dendritic Cells

(2012) Kalina Szteyn et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Inactivation of anoctamin-6/Tmem16f, a regulator of phosphatidylserine scrambling in osteoblasts, leads to decreased mineral deposition in skeletal tissues

(2012) Harald WA Ehlen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Anoctamins are a family of Ca2+-activated Cl- channels

(2012) Y. Tian et al.   JOURNAL OF CELL SCIENCE

Influence of WNK3 on intracellular chloride concentration and volume regulation in HEK293 cells

(2012) Silvia Cruz-Rangel et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Regulation of bradykinin-induced activation of volume-sensitive outwardly rectifying anion channels by Ca2+nanodomains in mouse astrocytes

(2011) Tenpei Akita et al.   JOURNAL OF PHYSIOLOGY-LONDON

Anoctamins

(2011) Karl Kunzelmann et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Anoctamin 6 is an essential component of the outwardly rectifying chloride channel

(2011) J. R. Martins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological Modulation of Diacylglycerol-Sensitive TRPC3/6/7 Channels

(2010) Christian Harteneck et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

TMEM16A Inhibitors Reveal TMEM16A as a Minor Component of Calcium-activated Chloride Channel Conductance in Airway and Intestinal Epithelial Cells

(2010) Wan Namkung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium-dependent phospholipid scrambling by TMEM16F

(2010) Jun Suzuki et al.   NATURE

Curvature Generation and Pressure Profile Modulation in Membrane by Lysolipids: Insights from Coarse-Grained Simulations

(2009) Jejoong Yoo et al.   BIOPHYSICAL JOURNAL

TMEM16 Proteins Produce Volume-regulated Chloride Currents That Are Reduced in Mice Lacking TMEM16A

(2009) Joana Almaça et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of TMEM16A Causes a Defect in Epithelial Ca2+-dependent Chloride Transport

(2009) Jiraporn Ousingsawat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physiology of Cell Volume Regulation in Vertebrates

(2009) Else K. Hoffmann et al.   PHYSIOLOGICAL REVIEWS