Mechanism of allosteric activation of TMEM16A/ANO1 channels by a commonly used chloride channel blocker

Multiple effects of anthracene-9-carboxylic acid on the TMEM16B/anoctamin2 calcium-activated chloride channel

(2015) O. Lijo Cherian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

New selective inhibitors of calcium-activated chloride channels - T16Ainh-A01, CaCCinh-A01 and MONNA - what do they inhibit?

(2015) D M B Boedtkjer et al.   BRITISH JOURNAL OF PHARMACOLOGY

Study of permeation and blocker binding in TMEM16A calcium-activated chloride channels

(2015) JP Reyes et al.   Channels

Overexpression of ANO1/TMEM16A, an arterial Ca2+-activated Cl− channel, contributes to spontaneous hypertension

(2015) Bingxiang Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

TMEM16 Proteins: Unknown Structure and Confusing Functions

(2015) Alessandra Picollo et al.   JOURNAL OF MOLECULAR BIOLOGY

Pharmacological characterization of TMEM16A currents

(2014) Eamonn Bradley et al.   Channels

Disruption of vascular Ca2+-activated chloride currents lowers blood pressure

(2014) Christoph Heinze et al.   JOURNAL OF CLINICAL INVESTIGATION

X-ray structure of a calcium-activated TMEM16 lipid scramblase

(2014) Janine D. Brunner et al.   NATURE

Structure and Function of TMEM16 Proteins (Anoctamins)

(2014) Nicoletta Pedemonte et al.   PHYSIOLOGICAL REVIEWS

The Concise Guide to PHARMACOLOGY 2013/14: Ion Channels

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Coronary spasm and acute myocardial infarction due to a mutation (V734I) in the nucleotide binding domain 1 of ABCC9

(2013) Keith J. Smith et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Putative pore-loops of TMEM16/anoctamin channels affect channel density in cell membranes

(2013) Aiste Adomaviciene et al.   JOURNAL OF PHYSIOLOGY-LONDON

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

(2013) Adam J. Pawson et al.   NUCLEIC ACIDS RESEARCH

Flufenamic acid as an ion channel modulator

(2013) Romain Guinamard et al.   PHARMACOLOGY & THERAPEUTICS

TMEM16A Induces MAPK and Contributes Directly to Tumorigenesis and Cancer Progression

(2012) U. Duvvuri et al.   CANCER RESEARCH

Airway epithelial cells—Functional links between CFTR and anoctamin dependent Cl− secretion

(2012) Karl Kunzelmann et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Insights into the effects of diclofenac and other non-steroidal anti-inflammatory agents on ion channels

(2012) Asfree Gwanyanya et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Chronic hypoxia-induced upregulation of Ca2+-activated Cl−channel in pulmonary arterial myocytes: a mechanism contributing to enhanced vasoreactivity

(2012) Hui Sun et al.   JOURNAL OF PHYSIOLOGY-LONDON

Proinflammatory cytokine secretion is suppressed by TMEM16A or CFTR channel activity in human cystic fibrosis bronchial epithelia

(2012) Guido Veit et al.   MOLECULAR BIOLOGY OF THE CELL

Fractionation of a Herbal Antidiarrheal Medicine Reveals Eugenol as an Inhibitor of Ca2+-Activated Cl− Channel TMEM16A

(2012) Zhen Yao et al.   PLoS One

Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction

(2012) F. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physiological roles and diseases of tmem16/anoctamin proteins: are they all chloride channels?

(2011) Charity Duran et al.   ACTA PHARMACOLOGICA SINICA

TMEM16A channels generate Ca2+-activated Cl− currents in cerebral artery smooth muscle cells

(2011) Candice Thomas-Gatewood et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Insights into the mechanisms underlying CFTR channel activity, the molecular basis for cystic fibrosis and strategies for therapy

(2011) Patrick Kim Chiaw et al.   Essays in Biochemistry

Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction

(2011) Wan Namkung et al.   FASEB JOURNAL

Anoctamins

(2011) Karl Kunzelmann et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Voltage- and calcium-dependent gating of TMEM16A/Ano1 chloride channels are physically coupled by the first intracellular loop

(2011) Q. Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression profile and protein translation of TMEM16A in murine smooth muscle

(2010) Alison J. Davis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Inhibition of Ca2+-activated Cl− channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea

(2010) Wan Namkung et al.   FASEB JOURNAL

TMEM16A Inhibitors Reveal TMEM16A as a Minor Component of Calcium-activated Chloride Channel Conductance in Airway and Intestinal Epithelial Cells

(2010) Wan Namkung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TMEM16A/Anoctamin 1 protein mediates calcium-activated chloride currents in pulmonary arterial smooth muscle cells

(2010) Boris Manoury et al.   JOURNAL OF PHYSIOLOGY-LONDON

Molecular components of signal amplification in olfactory sensory cilia

(2010) T. Hengl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Pharmacology of Kidney and Inner Ear CLC-K Chloride Channels

(2010) Antonella Gradogna et al.   Frontiers in Pharmacology

Regulation of Proliferation and Membrane Potential by Chloride Currents in Rat Pulmonary Artery Smooth Muscle Cells

(2009) Wenbin Liang et al.   HYPERTENSION

Transmembrane Protein 16A (TMEM16A) Is a Ca2+-regulated Cl–Secretory Channel in Mouse Airways

(2009) Jason R. Rock et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of TMEM16A Causes a Defect in Epithelial Ca2+-dependent Chloride Transport

(2009) Jiraporn Ousingsawat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TMEM16B, A Novel Protein with Calcium-Dependent Chloride Channel Activity, Associates with a Presynaptic Protein Complex in Photoreceptor Terminals

(2009) H. Stohr et al.   JOURNAL OF NEUROSCIENCE

ANO2 is the cilial calcium-activated chloride channel that may mediate olfactory amplification

(2009) Aaron B. Stephan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression Cloning of TMEM16A as a Calcium-Activated Chloride Channel Subunit

(2008) Björn Christian Schroeder et al.   CELL

TMEM16A confers receptor-activated calcium-dependent chloride conductance

(2008) Young Duk Yang et al.   NATURE

TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity

(2008) A. Caputo et al.   SCIENCE