Ani9, A Novel Potent Small-Molecule ANO1 Inhibitor with Negligible Effect on ANO2

New selective inhibitors of calcium-activated chloride channels - T16Ainh-A01, CaCCinh-A01 and MONNA - what do they inhibit?

(2015) D M B Boedtkjer et al.   BRITISH JOURNAL OF PHARMACOLOGY

Overexpression of ANO1/TMEM16A, an arterial Ca2+-activated Cl− channel, contributes to spontaneous hypertension

(2015) Bingxiang Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

TMEM16 Proteins: Unknown Structure and Confusing Functions

(2015) Alessandra Picollo et al.   JOURNAL OF MOLECULAR BIOLOGY

Inhibition of ANO1/TMEM16A Chloride Channel by Idebenone and Its Cytotoxicity to Cancer Cell Lines

(2015) Yohan Seo et al.   PLoS One

Pain-enhancing mechanism through interaction between TRPV1 and anoctamin 1 in sensory neurons

(2015) Yasunori Takayama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anoctamin 1 (TMEM16A) is essential for testosterone-induced prostate hyperplasia

(2015) Joo Young Cha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer

(2015) Anke Bill et al.   Oncotarget

To "Grow" or "Go": TMEM16A Expression as a Switch between Tumor Growth and Metastasis in SCCHN

(2014) D. J. Shiwarski et al.   CLINICAL CANCER RESEARCH

Small Molecule-facilitated Degradation of ANO1 Protein

(2014) Anke Bill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ANO1 (TMEM16A) in pancreatic ductal adenocarcinoma (PDAC)

(2014) D. R. P. Sauter et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Activation of ATP secretion via volume-regulated anion channels by sphingosine-1-phosphate in RAW macrophages

(2014) Philipp Burow et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Purinergic regulation of CFTR and Ca2+-activated Cl− channels and K+ channels in human pancreatic duct epithelium

(2013) Jing Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Functional expression of the TMEM16 family of calcium-activated chloride channels in airway smooth muscle

(2013) George Gallos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Consistent and Differential Genetic Aberrations between Esophageal Dysplasia and Squamous Cell Carcinoma Detected By Array Comparative Genomic Hybridization

(2013) Z.-Z. Shi et al.   CLINICAL CANCER RESEARCH

Overexpressed proprotein convertase 1/3 induces an epithelial-mesenchymal transition in airway epithelium

(2013) Sang-Nam Lee et al.   EUROPEAN RESPIRATORY JOURNAL

Chloride channel inhibition by a red wine extract and a synthetic small molecule prevents rotaviral secretory diarrhoea in neonatal mice

(2013) Eun-A Ko et al.   GUT

Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling

(2013) Adrian Britschgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension

(2012) Abigail S. Forrest et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Inhibition of cell proliferation by a selective inhibitor of the Ca2+-activated Cl− channel, Ano1

(2012) Amelia Mazzone et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Potent vasorelaxant activity of the TMEM16A inhibitor T16Ainh-A01

(2012) Alison J Davis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of Ca2+-activated Cl− channel ANO1/TMEM16A expression suppresses tumor growth and invasiveness in human prostate carcinoma

(2012) Wen Liu et al.   CANCER LETTERS

TMEM16A Induces MAPK and Contributes Directly to Tumorigenesis and Cancer Progression

(2012) U. Duvvuri et al.   CANCER RESEARCH

Ca2+-activated Cl- channels at a glance

(2012) J. Berg et al.   JOURNAL OF CELL SCIENCE

The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons

(2012) Hawon Cho et al.   NATURE NEUROSCIENCE

Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction

(2012) F. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels

(2011) Paolo Scudieri et al.   EXPERIMENTAL PHYSIOLOGY

Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction

(2011) Wan Namkung et al.   FASEB JOURNAL

Rotavirus toxin NSP4 induces diarrhea by activation of TMEM16A and inhibition of Na+ absorption

(2011) Jiraporn Ousingsawat et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Inhibition of Ca2+-activated Cl− channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea

(2010) Wan Namkung et al.   FASEB JOURNAL

TMEM16A Inhibitors Reveal TMEM16A as a Minor Component of Calcium-activated Chloride Channel Conductance in Airway and Intestinal Epithelial Cells

(2010) Wan Namkung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TMEM16B induces chloride currents activated by calcium in mammalian cells

(2009) Simone Pifferi et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

ANO2 is the cilial calcium-activated chloride channel that may mediate olfactory amplification

(2009) Aaron B. Stephan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TMEM16A confers receptor-activated calcium-dependent chloride conductance

(2008) Young Duk Yang et al.   NATURE

TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity

(2008) A. Caputo et al.   SCIENCE