Anoctamins support calcium-dependent chloride secretion by facilitating calcium signaling in adult mouse intestine

The calcium-activated chloride channel Anoctamin 1 contributes to the regulation of renal function

(2014) Diana Faria et al.   KIDNEY INTERNATIONAL

Anoctamin 6 differs from VRAC and VSOAC but is involved in apoptosis and supports volume regulation in the presence of Ca2+

(2014) C. A. Juul et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

TMEM16F is a component of a Ca2+-activated Cl− channel but not a volume-sensitive outwardly rectifying Cl− channel

(2013) Takahiro Shimizu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Exome sequencing reveals a novelANO10mutation in a Japanese patient with autosomal recessive spinocerebellar ataxia

(2013) H. Maruyama et al.   CLINICAL GENETICS

CFTR: a hub for kinases and crosstalk of cAMP and Ca2+

(2013) Karl Kunzelmann et al.   FEBS Journal

Chloride channel inhibition by a red wine extract and a synthetic small molecule prevents rotaviral secretory diarrhoea in neonatal mice

(2013) Eun-A Ko et al.   GUT

TMEM16F (Anoctamin 6), an anion channel of delayed Ca2+activation

(2013) Søren Grubb et al.   JOURNAL OF GENERAL PHYSIOLOGY

The secret life of CFTR as a calcium-activated chloride channel

(2013) Arnaud Billet et al.   JOURNAL OF PHYSIOLOGY-LONDON

A functional CFTR assay using primary cystic fibrosis intestinal organoids

(2013) Johanna F Dekkers et al.   NATURE MEDICINE

Molecular functions of anoctamin 6 (TMEM16F): a chloride channel, cation channel, or phospholipid scramblase?

(2013) Karl Kunzelmann et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Calcium-activated and apoptotic phospholipid scrambling induced by Ano6 can occur independently of Ano6 ion currents

(2013) A Kmit et al.   Cell Death & Disease

Ca2+-dependent phospholipid scrambling by a reconstituted TMEM16 ion channel

(2013) Mattia Malvezzi et al.   Nature Communications

Physiology of Epithelial Chloride and Fluid Secretion

(2013) R. A. Frizzell et al.   Cold Spring Harbor Perspectives in Medicine

TMEM16F Forms a Ca2+-Activated Cation Channel Required for Lipid Scrambling in Platelets during Blood Coagulation

(2012) Huanghe Yang et al.   CELL

Recent Advances in the Genetics of Cerebellar Ataxias

(2012) Anna Sailer et al.   Current Neurology and Neuroscience Reports

Airway epithelial cells—Functional links between CFTR and anoctamin dependent Cl− secretion

(2012) Karl Kunzelmann et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Inactivation of anoctamin-6/Tmem16f, a regulator of phosphatidylserine scrambling in osteoblasts, leads to decreased mineral deposition in skeletal tissues

(2012) Harald WA Ehlen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Anoctamins are a family of Ca2+-activated Cl- channels

(2012) Y. Tian et al.   JOURNAL OF CELL SCIENCE

Functional coupling of TRPC2 cation channels and the calcium-activated anion channels in rat thyroid cells: Implications for iodide homeostasis

(2012) Tero M. Viitanen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Yeast Ist2 Recruits the Endoplasmic Reticulum to the Plasma Membrane and Creates a Ribosome-Free Membrane Microcompartment

(2012) Wendelin Wolf et al.   PLoS One

CFTR and TMEM16A are Separate but Functionally Related Cl- Channels

(2011) Jiraporn Ousingsawat et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

ANO10 c.1150_1151del is a founder mutation causing autosomal recessive cerebellar ataxia in Roma/Gypsies

(2011) Teodora Chamova et al.   JOURNAL OF NEUROLOGY

Ca2+-activated Cl− currents are dispensable for olfaction

(2011) Gwendolyn M Billig et al.   NATURE NEUROSCIENCE

Rotavirus toxin NSP4 induces diarrhea by activation of TMEM16A and inhibition of Na+ absorption

(2011) Jiraporn Ousingsawat et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Anoctamins

(2011) Karl Kunzelmann et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Anoctamin 6 is an essential component of the outwardly rectifying chloride channel

(2011) J. R. Martins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted Next-Generation Sequencing of a 12.5 Mb Homozygous Region Reveals ANO10 Mutations in Patients with Autosomal-Recessive Cerebellar Ataxia

(2010) Sascha Vermeer et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Evidence for intestinal chloride secretion

(2010) Michael Murek et al.   EXPERIMENTAL PHYSIOLOGY

Activation of the basolateral membrane Cl−conductance essential for electrogenic K+secretion suppresses electrogenic Cl−secretion

(2010) Quanhua He et al.   EXPERIMENTAL PHYSIOLOGY

Expression and Function of Epithelial Anoctamins

(2010) Rainer Schreiber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CFTR-Adenylyl Cyclase I Association Responsible for UTP Activation of CFTR in Well-Differentiated Primary Human Bronchial Cell Cultures

(2010) Wan Namkung et al.   MOLECULAR BIOLOGY OF THE CELL

The presence of bestrophin-1 modulates the Ca2+ recruitment from Ca2+ stores in the ER

(2010) Rudgar Neussert et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Impaired  IIb 3 Integrin Activation and Shear-Dependent Thrombus Formation in Mice Lacking Phospholipase D1

(2010) M. Elvers et al.   Science Signaling

Bestrophin and TMEM16—Ca2+ activated Cl− channels with different functions

(2009) Karl Kunzelmann et al.   CELL CALCIUM

TMEM16 Proteins Produce Volume-regulated Chloride Currents That Are Reduced in Mice Lacking TMEM16A

(2009) Joana Almaça et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of TMEM16A Causes a Defect in Epithelial Ca2+-dependent Chloride Transport

(2009) Jiraporn Ousingsawat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TMEM16B, A Novel Protein with Calcium-Dependent Chloride Channel Activity, Associates with a Presynaptic Protein Complex in Photoreceptor Terminals

(2009) H. Stohr et al.   JOURNAL OF NEUROSCIENCE

ER-localized bestrophin 1 activates Ca2+-dependent ion channels TMEM16A and SK4 possibly by acting as a counterion channel

(2009) René Barro-Soria et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

TMEM16B induces chloride currents activated by calcium in mammalian cells

(2009) Simone Pifferi et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Expression Cloning of TMEM16A as a Calcium-Activated Chloride Channel Subunit

(2008) Björn Christian Schroeder et al.   CELL

Ca 2+ -Induced Cl− Efflux at Rat Distal Colonic Epithelium

(2008) B. Hennig et al.   JOURNAL OF MEMBRANE BIOLOGY

TMEM16A confers receptor-activated calcium-dependent chloride conductance

(2008) Young Duk Yang et al.   NATURE

CFTR is activated through stimulation of purinergic P2Y2 receptors

(2008) Diana Faria et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity

(2008) A. Caputo et al.   SCIENCE