Review
Oncology
Hideo Fukuhara, Shinkuro Yamamoto, Takashi Karashima, Keiji Inoue
Summary: Photodynamic technology utilizes light-sensitive and fluorescent substances to accurately diagnose various malignancies by accumulating specifically in tumor cells. This technology enables precise diagnosis and complete resection during surgery, making it a potential treatment option for cancer.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mehran Aksel, Omer Kesmez, Adem Yavas, Mehmet Dincer Bilgin
Summary: This study aimed to investigate the antitumor efficiency of titanium dioxide mediated photodynamic, sonodynamic, and sonophotodynamic therapies on the PC3 prostate cancer cell line. The results suggest that titanium dioxide-mediated sonophotodynamic therapy may offer a promising approach for prostate cancer therapy and play a key role in the apoptotic mechanism of these treatments.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
DanRong Hu, Meng Pan, Yun Yang, Ao Sun, Yu Chen, LiPing Yuan, KangKang Huang, Ying Qu, ChengQi He, Quan Wei, ZhiYong Qian
Summary: A novel polysaccharide-based nanoprodrug was developed for synergistic sonodynamic therapy and phototherapy against localized prostate cancer, showing superior anticancer efficacy under combined sono/photoirradiation.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Medicine, General & Internal
Michal Osuchowski, David Aebisher, Dorota Bartusik-Aebisher, Magdalena Krupka-Olek, Klaudia Dynarowicz, Maria Przygoda, Aleksandra Kawczyk-Krupka
Summary: This study investigated the photodynamic action in excised prostate tissue in vitro as a model for photodynamic therapy. It was found that photodynamic action resulted in morphological changes in prostate cancer tissues, which were attributed to the generation of cytotoxic singlet oxygen. This research provides important insights for future in vitro investigations and in vivo clinical trials.
Review
Oncology
Qin Xue, Jingliang Zhang, Jianhua Jiao, Weijun Qin, Xiaojian Yang
Summary: Over the past two decades, there has been a trend towards early diagnosis of prostate cancer due to increased awareness and PSA screening. However, surgery is not recommended at this stage, leading to negative psychological effects on patients and a higher chance of cancer progression. Focal therapy, specifically photodynamic treatment (PDT), has shown promise as a minimally invasive and safe alternative option for localized prostate cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lucie Paulus, Manuel Gallardo-Villagran, Claire Carrion, Catherine Ouk, Frederique Martin, Bruno Therrien, David Yannick Leger, Bertrand Liagre
Summary: Prostate cancer is a major health issue and the second most common cancer in men. Photodynamic therapy (PDT) is a non-invasive method that uses photosensitizers and light to induce cell death with minimal side effects. However, some photosensitizers used in PDT have low solubility in biological media, requiring functionalization or vectorization for effective internalization. This study used arene-ruthenium cages to deliver photosensitizers to prostate cancer cells. The results showed that most of the compounds induced cytotoxic effects on prostate cancer cells, with confirmed internalization in the cytoplasm. The presence of metals in the photosensitizers decreased the effectiveness of PDT, and in some cases, completely eliminated its effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biology
Michal Osuchowski, Filip Osuchowski, Wojciech Latos, Aleksandra Kawczyk-Krupka
Summary: Photodynamic Therapy (PDT) is a cancer treatment that uses light, a photosensitizer, and oxygen to destroy tumors. Upconversion nanoparticles (UCNPs) have shown great potential in the diagnosis and treatment of prostate cancer.
Review
Oncology
Antonio Machado Alencar Jr, Guru Sonpavde
Summary: Advances in the treatment of rare tumors like penile cancer have been hindered by a lack of understanding of the molecular biology and genomic alterations involved. Localized penile cancers can be effectively treated with surgery, but advanced and metastatic tumors require systemic treatment. Chemotherapy is the current standard, but its efficacy is limited and it has high toxicity. Recent discoveries of genomic alterations in penile cancer have led to trials of new systemic treatments, particularly immunotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Review
Surgery
Arnas Rakauskas, Giancarlo Marra, Isabel Heidegger, Veeru Kasivisvanathan, Alexander Kretschmer, Fabio Zattoni, Felix Preisser, Derya Tilki, Igor Tsaur, Roderick van den Bergh, Claudia Kesch, Francesco Ceci, Christian Fankhauser, Giorgio Gandaglia, Massimo Valerio
Summary: Focal therapy is a modern approach that selectively treats specific parts of the prostate, aiming to retain oncological benefits while minimizing side effects. It has shown to significantly reduce adverse events and preserve genito-urinary function compared to whole gland treatments.
FRONTIERS IN SURGERY
(2021)
Article
Biochemistry & Molecular Biology
Joseph Cacaccio, Farukh A. Durrani, Ishaan Kumar, Mykhaylo Dukh, Susan Camacho, Zahra Fayazi, Adam Sumlin, Eric Kauffman, Khurshid Guru, Ravindra K. Pandey
Summary: Current treatment for prostate cancer varies depending on the cancer's stage, recurrence, and genetic factors. Photodynamic therapy (PDT) using a photosensitizer has shown limitations, but using a near infrared compound as a photosensitizer and sonosensitizer in combination with ultrasound has been found to enhance the destruction of tumor cells. Targeting galectin-1 and galectin-3, known for their overexpression in prostate cancer, can increase the tumor specificity of the therapeutic agent(s).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Xiangjie Luo, Xiaoqin Chi, Yaying Lin, Zhaoxuan Yang, Hongyu Lin, Jinhao Gao
Summary: The photosensitizer-conjugated camptothecin-based prodrug effectively targets cancer cell mitochondria, triggers ROS-responsive release of CPT, and induces mitochondrial damage, achieving high therapeutic efficacy for solid tumors.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Xiuyan Wan, Tong Wu, Liqun Song, Wei Pan, Na Li, Bo Tang
Summary: A novel porphyrin-containing covalent organic framework (COF) was synthesized for decorating selenium nanoparticles (Se NPs) via in situ reduction. Selenium nanoparticle-mediated therapy (SeT) was combined with photodynamic therapy (PDT) to enhance anticancer effects and address the limitations of PDT.
CHEMICAL COMMUNICATIONS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yvonne H. W. Derks, Sanne A. M. van Lith, Helene I. Amatdjais-Groenen, Lieke W. M. Wouters, Annemarie Kip, Gerben M. Franssen, Peter Laverman, Dennis W. P. M. Lowik, Sandra Heskamp, Mark Rijpkema
Summary: In this study, new high-affinity dual-labeled PSMA-targeting ligands with optimized backbone compositions were developed for multimodal imaging and targeted photodynamic therapy. The results showed that these new ligands had high affinity, strong tumor targeting properties, and could specifically visualize PSMA-positive tumors in mice using both radionuclide and fluorescence imaging.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Review
Chemistry, Multidisciplinary
Jun Zhou, Chen Cao, Xinlu Zhang, Xu Zhang, Jiansen Li, Hongzhang Deng, Sheng Wang
Summary: Phototherapies have made significant progress in cancer treatment, but face challenges. Gas therapy, which improves the level of specific gas at the tumor site, shows potential to overcome these challenges. Nanomedicine-based gas-assisted phototherapy has emerged as a promising strategy to enhance treatment efficacy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Weiwei Wu, Yan Yang, Zhuoying Liang, Xiling Song, Yadong Huang, Lin Qiu, Xiaozhong Qiu, Siming Yu, Wei Xue
Summary: This study demonstrated the effective strategy of utilizing near-infrared laser-induced simultaneous release of NO and alkyl radicals to inhibit tumor growth, achieved through the elaborately fabricated biocompatible free radical nanogenerator. Under NIR II laser irradiation, the nanogenerator can precisely control the release profiles of NO and alkyl radicals, displaying synergistic anticancer effects on breast tumors.
Article
Clinical Neurology
Nacim Betrouni, Renaud Lopes, Luc Defebvre, Albert F. G. Leentjens, Kathy Dujardin
MOVEMENT DISORDERS
(2020)
Article
Clinical Neurology
Nacim Betrouni, Moussaoui Yasmina, Stephanie Bombois, Maud Petrault, Thibaut Dondaine, Cedrick Lachaud, Charlotte Laloux, Anne-Marie Mendyk, Hilde Henon, Regis Bordet
TRANSLATIONAL STROKE RESEARCH
(2020)
Article
Clinical Neurology
Laure Lacan, Nacim Betrouni, Marie-Dominique Lamblin, Laurence Chaton, Arnaud Delval, Jean-Louis Bourriez, Laurent Storme, Philippe Derambure, Sylvie NguyenThe Tich
Summary: This study identified six quantitative EEG parameters as early markers for classifying neonatal hypoxic-ischemic encephalopathy (HIE) severity, with amplitude and discontinuity parameters being the best predictors of clinical outcome. Combining these parameters in a multiparametric algorithm could potentially improve classification performance. The lack of relationship between pH and lactate levels and HIE severity highlights the central role of early neonatal EEG.
NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Henri Azais, Anne-Sophie Vignion-Dewalle, Marine Carrier, Jeremy Augustin, Elisabeth Da Maia, Alix Penel, Jeremie Belghiti, Marianne Nikpayam, Clementine Gonthier, Laurine Ziane, Serge Mordon, Pierre Collinet, Geoffroy Canlorbe, Catherine Uzan
Summary: The study found that there is a 98.14% probability of residual microscopic peritoneal metastases (mPM) after complete macroscopic cytoreductive surgery (CRS) for EOC patients. Microscopic PM could be a relevant therapeutic target in the treatment of EOC.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Chemistry, Medicinal
Bauyrzhan Myrzakhmetov, Philippe Arnoux, Serge Mordon, Samir Acherar, Irina Tsoy, Celine Frochot
Summary: This study investigated the influence of solvent polarity, viscosity, concentration, temperature, and pH medium on the photophysical properties of different photosensitizers, providing important insights for research in photodynamic therapy.
Article
Oncology
Andreas G. Wibmer, Michael W. Kattan, Francesco Alessandrino, Alexander D. J. Baur, Lars Boesen, Felipe Boschini Franco, David Bonekamp, Riccardo Campa, Hannes Cash, Violeta Catala, Sebastien Crouzet, Sounil Dinnoo, James Eastham, Fiona M. Fennessy, Kamyar Ghabili, Markus Hohenfellner, Angelique W. Levi, Xinge Ji, Vibeke Logager, Daniel J. Margolis, Paul C. Moldovan, Valeria Panebianco, Tobias Penzkofer, Philippe Puech, Jan Philipp Radtke, Olivier Rouviere, Heinz-Peter Schlemmer, Preston C. Sprenkle, Clare M. Tempany, Joan C. Vilanova, Jeffrey Weinreb, Hedvig Hricak, Amita Shukla-Dave
Summary: In this study, a nomogram combining MRI findings with other patient data was developed to accurately diagnose extraprostatic tumor growth in patients with newly diagnosed prostate cancer. The nomogram showed significantly greater accuracy compared to clinical benchmark models, providing a valuable tool for physicians in predicting extraprostatic extension of prostate cancer.
Article
Oncology
Elise Thecua, Laurine Ziane, Guillaume Paul Grolez, Alexandre Fagart, Abhishek Kumar, Bertrand Leroux, Gregory Baert, Pascal Deleporte, Maximilien Vermandel, Anne-Sophie Vignion-Dewalle, Nadira Delhem, Serge Mordon
Summary: Although photodynamic therapy shows promise in biomedical applications, its complexity poses challenges for widespread acceptance. A novel optical device, CELL-LEF, based on knitted light-emitting fabrics has been developed and tested for in vitro photodynamic therapy. Cell viability studies demonstrate the effectiveness of CELL-LEF for in vitro PDT involving low irradiance over an extended period.
Article
Health Care Sciences & Services
Fabienne Lecomte, Elise Thecua, Laurine Ziane, Pascal Deleporte, Alain Duhamel, Clemence Vamour, Serge Mordon, Thameur Rakza
Summary: This study aims to investigate the feasibility, safety, and parent and healthcare team satisfaction with the BUBOlight device, an innovative alternative to traditional hospital phototherapy, integrating luminous textiles into a sleeping bag. The study will be conducted as an interventional, exploratory, simple group, nonrandomized, single-center trial at Lille Hospital to evaluate neonates receiving phototherapy for jaundice.
JMIR RESEARCH PROTOCOLS
(2021)
Article
Clinical Neurology
Nacim Betrouni, Edouard Alazard, Madli Bayot, Guillaume Carey, Philippe Derambure, Luc Defebvre, Albert Fg Leentjens, Arnaud Delval, Kathy Dujardin
Summary: Through high density electroencephalography (hd-EEG) recordings and comparisons in 108 Parkinson's disease patients, it was found that patients with anxiety symptoms had lower relative power in the alpha1 frequency band in the right prefrontal cortex, and showed different characteristics in functional connectivity compared to those without anxiety.
NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Oncology
Henri-Arthur Leroy, Gregory Baert, Laura Guerin, Nadira Delhem, Serge Mordon, Nicolas Reyns, Anne-Sophie Vignion-Dewalle
Summary: Glioblastomas (GBMs) are aggressive brain tumors with poor prognosis. The standard treatment includes surgery, radiotherapy, and chemotherapy, but survival is limited, particularly for non-surgical patients. Interstitial photodynamic therapy (iPDT) shows promise for improving local control of GBM, with a standardized workflow proposed for clinical application. The procedure involves intraoperative imaging, treatment planning, and robotic assistance for optical fiber implantation.
Review
Oncology
Abhishek Kumar, Olivier Morales, Serge Mordon, Nadira Delhem, Emmanuel Boleslawski
Summary: Hepatocellular Carcinoma (HCC) is a major cause of cancer-related mortality worldwide, with limited treatment options. This review explores the mechanism and benefits of Photodynamic Therapy (PDT) as an anti-cancer therapy, focusing on its application in HCC treatment. The review also discusses the immune response generated by PDT and its potential role in HCC treatment, proposing a combination approach with existing therapies.
Article
Behavioral Sciences
Nacim Betrouni, Quentin Devignes, Madli Bayot, Philippe Derambure, Luc Defebvre, Albert FG. Leentjens, Arnaud Delval, Kathy Dujardin
Summary: This study investigates EEG modifications associated with mild cognitive impairment in Parkinson's disease (PD-MCI) subtypes. The results show that patients with a frontostriatal subtype exhibit spectral and functional EEG alterations, while the posterior cortical subtype does not differ significantly from the normal cognition group. This study provides evidence for the dual syndrome hypothesis and highlights the importance of identifying PD-MCI subtypes.
Article
Clinical Neurology
Nacim Betrouni, Jiyang Jiang, Marco Duering, Marios K. Georgakis, Lena Oestreich, Perminder S. Sachdev, Michael O'Sullivan, Paul Wright, Jessica W. Lo, Regis Bordet
Summary: This study examined the reliability of texture features against imaging settings using data from different centers and found that texture features obtained from routine clinical MR images are robust early predictors of poststroke cognitive impairment and can be combined with other demographic and clinical predictors to build an accurate prediction model.
Article
Clinical Neurology
Madli Bayot, Kathy Dujardin, Morgane Gerard, Aurore Braquet, Celine Tard, Nacim Betrouni, Luc Defebvre, Arnaud Delval
Summary: The study aimed to investigate the impact of attentional load on step initiation in Parkinson's disease with freezing of gait. Results showed that conflict resolution tasks led to similar alterations and brain activity in all groups, suggesting that executive dysfunction is associated with freezing of gait but not the main causal mechanism.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Chemistry, Medicinal
Mathilde Fronville, Muriel Creusot, Serge R. Mordon
Summary: This paper reports the clinical outcomes of using a PpIX-weighted light dose of 4 J/cm² for SDL-PDT treatment of AK lesions on the scalp or face. After six months, the cure rate of patients was 77%, with a median pain score of less than 1 out of 10. Erythema lasted for an average of 3 days, crusts were observed in 28 patients, and discomfort was reported as mild or less in over 97% of patients.
