Platforms for antibiotic discovery

A comprehensive regulatory framework to address the unmet need for new antibacterial treatments

(2013) John H Rex et al.   LANCET INFECTIOUS DISEASES

Artemisinin: Discovery from the Chinese Herbal Garden

(2011) Louis H. Miller et al.   CELL

Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugs

(2011) P. E. Almeida Da Silva et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Strain improvement in actinomycetes in the postgenomic era

(2011) Richard H. Baltz   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Human nutrition, the gut microbiome and the immune system

(2011) Andrew L. Kau et al.   NATURE

Bacterial persistence by RNA endonucleases

(2011) Etienne Maisonneuve et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pyrazinamide Inhibits Trans-Translation in Mycobacterium tuberculosis

(2011) W. Shi et al.   SCIENCE

Persister Cells

(2010) Kim Lewis   Annual Review of Microbiology

Mechanistic Studies of the Inactivation of TEM-1 and P99 by NXL104, a Novel Non- -Lactam  -Lactamase Inhibitor

(2010) T. Stachyra et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Use of Ichip for High-Throughput In Situ Cultivation of "Uncultivable" Microbial Species

(2010) D. Nichols et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Therapeutic effect of (Z)-3-(2,5-dimethoxyphenyl)-2-(4-methoxyphenyl) acrylonitrile (DMMA) against Staphylococcus aureus infection in a murine model

(2010) Ki-Bong Oh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Siderophores from Neighboring Organisms Promote the Growth of Uncultured Bacteria

(2010) Anthony D'Onofrio et al.   CHEMISTRY & BIOLOGY

In Vitro Management of Hospital Pseudomonas aeruginosa Biofilm Using Indigenous T7-Like Lytic Phage

(2010) Sangeeta Ahiwale et al.   CURRENT MICROBIOLOGY

A Phase II trial of 17-allylamino, 17-demethoxygeldanamycin (17-AAG, tanespimycin) in patients with metastatic melanoma

(2010) Simon Pacey et al.   INVESTIGATIONAL NEW DRUGS

Emergence of Pseudomonas aeruginosa Strains Producing High Levels of Persister Cells in Patients with Cystic Fibrosis

(2010) L. R. Mulcahy et al.   JOURNAL OF BACTERIOLOGY

Streptomyces and Saccharopolyspora hosts for heterologous expression of secondary metabolite gene clusters

(2010) Richard H. Baltz   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study

(2010) Karthikeyan K Kumarasamy et al.   LANCET INFECTIOUS DISEASES

Reduced anxiety-like behavior and central neurochemical change in germ-free mice

(2010) K. M. Neufeld et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Treatment with Monoclonal Antibodies againstClostridium difficileToxins

(2010) Israel Lowy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults

(2010) Nadja Larsen et al.   PLoS One

Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism

(2010) M. Komatsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation

(2010) L. Dethlefsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

That Was Then But This Is Now: Malaria Research in the Time of an Eradication Agenda

(2010) S. H. I. Kappe et al.   SCIENCE

Creation of a Bacterial Cell Controlled by a Chemically Synthesized Genome

(2010) D. G. Gibson et al.   SCIENCE

Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters

(2010) Juan Pablo Gomez-Escribano et al.   Microbial Biotechnology

Patients with Long-Term Oral Carriage Harbor High-Persister Mutants of Candida albicans

(2009) M. D. LaFleur et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic-resistantPseudomonas aeruginosa; a preliminary report of efficacy

(2009) A. Wright et al.   CLINICAL OTOLARYNGOLOGY

Global spread of carbapenem-resistant Acinetobacter baumannii

(2009) P. G. Higgins et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The Diarylquinoline TMC207 for Multidrug-Resistant Tuberculosis

(2009) Andreas H. Diacon et al.   NEW ENGLAND JOURNAL OF MEDICINE

The assembled structure of a complete tripartite bacterial multidrug efflux pump

(2009) M. F. Symmons et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanisms of HipA-Mediated Multidrug Tolerance and Its Neutralization by HipB

(2009) M. A. Schumacher et al.   SCIENCE

Antibiotics for Emerging Pathogens

(2009) M. A. Fischbach et al.   SCIENCE

Role of Global Regulators and Nucleotide Metabolism in Antibiotic Tolerance in Escherichia coli

(2008) S. Hansen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

(2008) Helen W. Boucher et al.   CLINICAL INFECTIOUS DISEASES

Are natural products still the best source for antibacterial discovery? The bacterial entry factor

(2008) Lynn L Silver   Expert Opinion on Drug Discovery

Physicochemical Properties of Antibacterial Compounds: Implications for Drug Discovery

(2008) Rosemarie O’Shea et al.   JOURNAL OF MEDICINAL CHEMISTRY

A trap for in situ cultivation of filamentous actinobacteria

(2008) Ekaterina Gavrish et al.   JOURNAL OF MICROBIOLOGICAL METHODS

A core gut microbiome in obese and lean twins

(2008) Peter J. Turnbaugh et al.   NATURE

Nongenetic Individuality in the Host–Phage Interaction

(2008) Sivan Pearl et al.   PLOS BIOLOGY

Metallo-β-lactamase IMP-18 is located in a class 1 integron (In96) in a clinical isolate of Pseudomonas aeruginosa from Mexico

(2007) U. Garza-Ramos et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS