Saxitoxin

Synthesis of Tetrodotoxin, a Classic but Still Fascinating Natural Product

(2013) Toshio Nishikawa et al.   CHEMICAL RECORD

Structure of a Prokaryotic Sodium Channel Pore Reveals Essential Gating Elements and an Outer Ion Binding Site Common to Eukaryotic Channels

(2013) David Shaya et al.   JOURNAL OF MOLECULAR BIOLOGY

Maleimide Conjugates of Saxitoxin as Covalent Inhibitors of Voltage-Gated Sodium Channels

(2013) William H. Parsons et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A 18F-Labeled Saxitoxin Derivative for in Vivo PET-MR Imaging of Voltage-Gated Sodium Channel Expression Following Nerve Injury

(2013) Aileen Hoehne et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Overview on the Marine Neurotoxin, Saxitoxin: Genetics, Molecular Targets, Methods of Detection and Ecological Functions

(2013) Kathleen Cusick et al.   Marine Drugs

Synthesis of saxitoxin derivatives bearing guanidine and urea groups at C13 and evaluation of their inhibitory activity on voltage-gated sodium channels

(2013) Takafumi Akimoto et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Metal-Catalyzed Nitrogen-Atom Transfer Methods for the Oxidation of Aliphatic C–H Bonds

(2012) Jennifer L. Roizen et al.   ACCOUNTS OF CHEMICAL RESEARCH

Fluorescent Saxitoxins for Live Cell Imaging of Single Voltage-Gated Sodium Ion Channels beyond the Optical Diffraction Limit

(2012) Alison E. Ondrus et al.   CHEMISTRY & BIOLOGY

Advances in Targeting Voltage-Gated Sodium Channels with Small Molecules

(2012) Antonio Nardi et al.   ChemMedChem

An AnkyrinG-Binding Motif Is Necessary and Sufficient for Targeting Nav1.6 Sodium Channels to Axon Initial Segments and Nodes of Ranvier

(2012) A. Gasser et al.   JOURNAL OF NEUROSCIENCE

Voltage-gated sodium channels at 60: structure, function and pathophysiology

(2012) William A. Catterall   JOURNAL OF PHYSIOLOGY-LONDON

Isolation and Structural Determination of the First 8-epi-type Tetrodotoxin Analogs from the Newt, Cynops ensicauda popei, and Comparison of Tetrodotoxin Analogs Profiles of This Newt and the Puffer Fish, Fugu poecilonotus

(2012) Yuta Kudo et al.   Marine Drugs

Evolution of Saxitoxin Synthesis in Cyanobacteria and Dinoflagellates

(2012) Jeremiah D. Hackett et al.   MOLECULAR BIOLOGY AND EVOLUTION

China must provide education on HIV

(2012) Jian Zhang et al.   NATURE

The NaV1.7 sodium channel: from molecule to man

(2012) Sulayman D. Dib-Hajj et al.   NATURE REVIEWS NEUROSCIENCE

Prolonged nerve blockade delays the onset of neuropathic pain

(2012) S. A. Shankarappa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Marked difference in saxitoxin and tetrodotoxin affinity for the human nociceptive voltage-gated sodium channel (Nav1.7)

(2012) J. R. Walker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakes

(2012) C. R. Feldman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The molecular mystique of tetrodotoxin

(2012) Edward G. Moczydlowski   TOXICON

Structure of a bacterial voltage-gated sodium channel pore reveals mechanisms of opening and closing

(2012) Emily C. McCusker et al.   Nature Communications

Sodium Channels as Targets for Volatile Anesthetics

(2012) Karl F. Herold et al.   Frontiers in Pharmacology

A Synthetic Route to the Saxitoxin Skeleton: Synthesis of Decarbamoyl α-Saxitoxinol, an Analogue of Saxitoxin Produced by the Cyanobacterium Lyngbya wollei

(2011) Yusuke Sawayama et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Skeletal Analogues of Saxitoxin Derivatives and Evaluation of Their Inhibitory Activity on Sodium Ion Channels NaV1.4 and NaV1.5

(2011) Ryoko Shinohara et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Cardiac Sodium Channel Is Post-Translationally Modified by Arginine Methylation

(2011) Pedro Beltran-Alvarez et al.   JOURNAL OF PROTEOME RESEARCH

A Stereocontrolled Synthesis of (+)-Saxitoxin

(2011) Vasudev R. Bhonde et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The crystal structure of a voltage-gated sodium channel

(2011) Jian Payandeh et al.   NATURE

A Putative Gene Cluster from a Lyngbya wollei Bloom that Encodes Paralytic Shellfish Toxin Biosynthesis

(2011) Troco K. Mihali et al.   PLoS One

Discovery of Nuclear-Encoded Genes for the Neurotoxin Saxitoxin in Dinoflagellates

(2011) Anke Stüken et al.   PLoS One

Na+ Channel ? Subunits: Overachievers of the Ion Channel Family

(2011) William J. Brackenbury et al.   Frontiers in Pharmacology

Regioselective Rhodium(II)-Catalyzed Hydroaminations of Propargylguanidines

(2010) Morgan J. Gainer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Peptide toxins that selectively target insect NaVand CaVchannels

(2010) Glenn F. King et al.   Channels

Interaction between voltage-gated sodium channels and the neurotoxin, tetrodotoxin

(2010) Chong Hyun Lee et al.   Channels

Congenital insensitivity to pain: novel SCN9A missense and in-frame deletion mutations

(2010) James J. Cox et al.   HUMAN MUTATION

Possible Roles of Exceptionally Conserved Residues around the Selectivity Filters of Sodium and Calcium Channels

(2010) Denis B. Tikhonov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and function of splice variants of the cardiac voltage-gated sodium channel Nav1.5

(2010) Annett Schroeter et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Sodium channel gene family: epilepsy mutations, gene interactions and modifier effects

(2010) Miriam H. Meisler et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Chemical and Evolutionary Ecology of Tetrodotoxin (TTX) Toxicity in Terrestrial Vertebrates

(2010) Charles T. Hanifin   Marine Drugs

Neurotoxic Alkaloids: Saxitoxin and Its Analogs

(2010) Maria Wiese et al.   Marine Drugs

The Tetrodotoxin Binding Site Is within the Outer Vestibule of the Sodium Channel

(2010) Harry A. Fozzard et al.   Marine Drugs

New saxitoxin analogues in the marine environment: developments in toxin chemistry, detection and biotransformation during the 2000s

(2010) Paulo Vale   PHYTOCHEMISTRY REVIEWS

Comparison of Neosaxitoxin Versus Bupivacaine via Port Infiltration for Postoperative Analgesia Following Laparoscopic Cholecystectomy

(2010) Alberto J. Rodríguez-Navarro et al.   REGIONAL ANESTHESIA AND PAIN MEDICINE

Novel Modulator of NaV1.1 and NaV1.2 Na+ Channels in Rat Neuronal Cells

(2010) Hua Mao et al.   ACS Medicinal Chemistry Letters

Addition-Hydroamination Reactions of Propargyl Cyanamides: Rapid Access to Highly Substituted 2-Aminoimidazoles

(2009) Robert L. Giles et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Characterisation of the paralytic shellfish toxin biosynthesis gene clusters in Anabaena circinalis AWQC131C and Aphanizomenon sp. NH-5

(2009) Troco K Mihali et al.   BMC BIOCHEMISTRY

De Novo Synthesis of Modified Saxitoxins for Sodium Ion Channel Study

(2009) Brian M. Andresen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Potentiation of Local Anesthetic Activity of Neosaxitoxin with Bupivacaine or Epinephrine: Development of a Long-Acting Pain Blocker

(2009) Alberto J. Rodriguez-Navarro et al.   NEUROTOXICITY RESEARCH

Two novel SCN9A mutations causing insensitivity to pain

(2009) K. B. Nilsen et al.   PAIN

Voltage-Gated Sodium Channels: Therapeutic Targets for Pain

(2009) Sulayman D. Dib-Hajj et al.   PAIN MEDICINE

Cardiac sodium channelopathies

(2009) Ahmad S. Amin et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Synthesis of bifunctional saxitoxin analogues by biotinylation

(2009) Cedric Robillot et al.   TOXICON

Saxitoxins accumulation by freshwater tilapia (Oreochromis niloticus) for human consumption

(2009) Juliana Antunes Galvão et al.   TOXICON

Biosynthetic Intermediate Analysis and Functional Homology Reveal a Saxitoxin Gene Cluster in Cyanobacteria

(2008) R. Kellmann et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Total Synthesis of (−)- and (+)-Decarbamoyloxysaxitoxin and (+)-Saxitoxin

(2008) Osamu Iwamoto et al.   Chemistry-An Asian Journal

Voltage-gated Na Channel Selectivity: The Role of the Conserved Domain III Lysine Residue

(2008) Gregory M. Lipkind et al.   JOURNAL OF GENERAL PHYSIOLOGY

Properties of Wild-Type and Fluorescent Protein-Tagged Mouse Tetrodotoxin-Resistant Sodium Channel (NaV1.8) Heterologously Expressed in Rat Sympathetic Neurons

(2008) Geoffrey G. Schofield et al.   JOURNAL OF NEUROPHYSIOLOGY

Tetrodotoxin for Moderate to Severe Cancer Pain: A Randomized, Double Blind, Parallel Design Multicenter Study

(2008) Neil A. Hagen et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

Toxin-Resistant Sodium Channels: Parallel Adaptive Evolution across a Complete Gene Family

(2008) M. C. Jost et al.   MOLECULAR BIOLOGY AND EVOLUTION

Local infiltration of gonyautoxin is safe and effective in treatment of chronic tension-type headache

(2008) K. Lattes et al.   NEUROLOGICAL RESEARCH

Tetrodotoxin

(2008) Toshio NARAHASHI   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES