Optical Control of Insulin Secretion Using an Incretin Switch

A Roadmap to Success in Photopharmacology

(2015) Johannes Broichhagen et al.   ACCOUNTS OF CHEMICAL RESEARCH

A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function

(2015) J. Broichhagen et al.   CHEMICAL COMMUNICATIONS

Photocontrolled chignolin-derived β-hairpin peptidomimetics

(2015) T. Podewin et al.   CHEMICAL COMMUNICATIONS

Investigating G protein signalling bias at the glucagon-like peptide-1 receptor in yeast

(2014) C Weston et al.   BRITISH JOURNAL OF PHARMACOLOGY

Risk of pancreatitis in patients treated with incretin-based therapies

(2014) Juris J. Meier et al.   DIABETOLOGIA

Photopharmacology: Beyond Proof of Principle

(2014) Willem A. Velema et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pancreatic Safety of Incretin-Based Drugs — FDA and EMA Assessment

(2014) Amy G. Egan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Optical control of insulin release using a photoswitchable sulfonylurea

(2014) Johannes Broichhagen et al.   Nature Communications

Pharmacology, Physiology, and Mechanisms of Incretin Hormone Action

(2013) Jonathan E. Campbell et al.   Cell Metabolism

Metabolic Signaling in Fuel-Induced Insulin Secretion

(2013) Marc Prentki et al.   Cell Metabolism

Lipotoxicity disrupts incretin-regulated human β cell connectivity

(2013) David J. Hodson et al.   JOURNAL OF CLINICAL INVESTIGATION

Minireview: Signal Bias, Allosterism, and Polymorphic Variation at the GLP-1R: Implications for Drug Discovery

(2013) Cassandra Koole et al.   MOLECULAR ENDOCRINOLOGY

Structure of the human glucagon class B G-protein-coupled receptor

(2013) Fai Yiu Siu et al.   NATURE

Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations

(2013) D. Wootten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diabetes Mellitus and the β Cell: The Last Ten Years

(2012) Frances M. Ashcroft et al.   CELL

GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus

(2012) Juris J. Meier   Nature Reviews Endocrinology

Photocontrol of Contracting Muscle Fibers

(2011) Christian Hoppmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Refinement of Glucagon-like Peptide 1 Docking to Its Intact Receptor Using Mid-region Photolabile Probes and Molecular Modeling

(2011) Laurence J. Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type 2 diabetes across generations: from pathophysiology to prevention and management

(2011) Christopher J Nolan et al.   LANCET

Molecular physiology of glucagon-like peptide-1 insulin secretagogue action in pancreatic β cells

(2011) Colin A. Leech et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

A Bridged Azobenzene Derivative as a Reversible, Light-Induced Chirality Switch

(2010) Gebhard Haberhauer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Incretin-Based Therapies for the Treatment of Type 2 Diabetes: Evaluation of the Risks and Benefits

(2010) D. J. Drucker et al.   DIABETES CARE

Allosteric Ligands of the Glucagon-Like Peptide 1 Receptor (GLP-1R) Differentially Modulate Endogenous and Exogenous Peptide Responses in a Pathway-Selective Manner: Implications for Drug Screening

(2010) C. Koole et al.   MOLECULAR PHARMACOLOGY

Light-Directed Protein Binding of a Biologically Relevant β-Sheet

(2009) Christian Hoppmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Crystal Structure of Glucagon-like Peptide-1 in Complex with the Extracellular Domain of the Glucagon-like Peptide-1 Receptor

(2009) Christina Rye Underwood et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Low, but Physiological, Concentration of GLP-1 Stimulates Insulin Secretion Independent of the cAMP-Dependent Protein Kinase Pathway

(2008) Makoto Shigeto et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES