Optochemical Genetics

Tuning Photochromic Ion Channel Blockers

(2011) Alexandre Mourot et al.   ACS Chemical Neuroscience

Sweet and Umami Taste: Natural Products, Their Chemosensory Targets, and Beyond

(2011) Maik Behrens et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorescence Imaging of Azobenzene Photoswitching In Vivo

(2011) Andrew A. Beharry et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Optogenetic photochemical control of designer K+ channels in mammalian neurons

(2011) Doris L. Fortin et al.   JOURNAL OF NEUROPHYSIOLOGY

In vivotwo-photon uncaging of glutamate revealing the structure-function relationships of dendritic spines in the neocortex of adult mice

(2011) Jun Noguchi et al.   JOURNAL OF PHYSIOLOGY-LONDON

LiGluR Restores Visual Responses in Rodent Models of Inherited Blindness

(2011) Natalia Caporale et al.   MOLECULAR THERAPY

The crystal structure of a voltage-gated sodium channel

(2011) Jian Payandeh et al.   NATURE

Structure and function of an irreversible agonist-β2 adrenoceptor complex

(2011) Daniel M. Rosenbaum et al.   NATURE

High-efficiency channelrhodopsins for fast neuronal stimulation at low light levels

(2011) A. Berndt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical and Genetic Engineering of Selective Ion Channel-Ligand Interactions

(2011) C. J. Magnus et al.   SCIENCE

Structure of an Agonist-Bound Human A2A Adenosine Receptor

(2011) F. Xu et al.   SCIENCE

Glutamate Receptor-Like Genes Form Ca2+ Channels in Pollen Tubes and Are Regulated by Pistil D-Serine

(2011) E. Michard et al.   SCIENCE

A modern ionotropic glutamate receptor with a K+ selectivity signature sequence

(2011) H. Janovjak et al.   Nature Communications

A Structural and Mutagenic Blueprint for Molecular Recognition of Strychnine and d-Tubocurarine by Different Cys-Loop Receptors

(2011) Marijke Brams et al.   PLOS BIOLOGY

Light-Induced Control of Protein Translocation by the SecYEG Complex

(2010) Francesco Bonardi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The epithelial sodium channel and the control of sodium balance

(2010) Laurent Schild   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Pharmacology of ionotropic glutamate receptors: A structural perspective

(2010) Philipp Stawski et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Molecular and Cellular Approaches for Diversifying and Extending Optogenetics

(2010) Viviana Gradinaru et al.   CELL

Structural mechanism of C-type inactivation in K+ channels

(2010) Luis G. Cuello et al.   NATURE

Structural basis for the coupling between activation and inactivation gates in K+ channels

(2010) Luis G. Cuello et al.   NATURE

High-performance genetically targetable optical neural silencing by light-driven proton pumps

(2010) Brian Y. Chow et al.   NATURE

From cudgel to scalpel: toward precise neural control with optogenetics

(2010) Simon Peron et al.   NATURE METHODS

Optogenetics

(2010) Karl Deisseroth   NATURE METHODS

A light-gated, potassium-selective glutamate receptor for the optical inhibition of neuronal firing

(2010) Harald Janovjak et al.   NATURE NEUROSCIENCE

Ultrafast optogenetic control

(2010) Lisa A Gunaydin et al.   NATURE NEUROSCIENCE

A Nonproton Ligand Sensor in the Acid-Sensing Ion Channel

(2010) Ye Yu et al.   NEURON

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

(2010) S. F. Traynelis et al.   PHARMACOLOGICAL REVIEWS

Structure of the full-length Shaker potassium channel Kv1.2 by normal-mode-based X-ray crystallographic refinement

(2010) X. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

(2010) E. Y. T. Chien et al.   SCIENCE

Genetic Reactivation of Cone Photoreceptors Restores Visual Responses in Retinitis Pigmentosa

(2010) V. Busskamp et al.   SCIENCE

Optogenetic Control of Cardiac Function

(2010) A. B. Arrenberg et al.   SCIENCE

Photochromic Blockers of Voltage-Gated Potassium Channels

(2009) Matthew���R. Banghart et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Advances in Light Microscopy for Neuroscience

(2009) Brian A. Wilt et al.   Annual Review of Neuroscience

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

New photochemical tools for controlling neuronal activity

(2009) Richard H Kramer et al.   CURRENT OPINION IN NEUROBIOLOGY

Proteins: how RNA polymerases work

(2009) Patrick Cramer et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Pore architecture and ion sites in acid-sensing ion channels and P2X receptors

(2009) Eric B. Gonzales et al.   NATURE

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

(2009) Alexander I. Sobolevsky et al.   NATURE

Crystal structure of the ATP-gated P2X4 ion channel in the closed state

(2009) Toshimitsu Kawate et al.   NATURE

Predicting new molecular targets for known drugs

(2009) Michael J. Keiser et al.   NATURE

Optogenetic dissection of a behavioural module in the vertebrate spinal cord

(2009) Claire Wyart et al.   NATURE

Bi-stable neural state switches

(2009) André Berndt et al.   NATURE NEUROSCIENCE

Voltage-gated potassium channels as therapeutic targets

(2009) Heike Wulff et al.   NATURE REVIEWS DRUG DISCOVERY

Regulators of the cytoplasmic dynein motor

(2009) Julia R. Kardon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nanosculpting reversed wavelength sensitivity into a photoswitchable iGluR

(2009) R. Numano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optical Deconstruction of Parkinsonian Neural Circuitry

(2009) V. Gradinaru et al.   SCIENCE

Azobenzenes—synthesis and carbohydrate applications

(2009) Florian Hamon et al.   TETRAHEDRON

Photocontrol of Neural Activity: Biophysical Mechanisms and Performancein Vivo

(2008) Lucas Sjulson et al.   CHEMICAL REVIEWS

Serotonin Receptors

(2008) David E. Nichols et al.   CHEMICAL REVIEWS

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

(2008) Ricarda J. C. Hilf et al.   NATURE

X-ray structure of a prokaryotic pentameric ligand-gated ion channel

(2008) Ricarda J. C. Hilf et al.   NATURE

Engineering GPCR signaling pathways with RASSLs

(2008) Bruce R Conklin et al.   NATURE METHODS

Microscopy and its focal switch

(2008) Stefan W Hell   NATURE METHODS

Red-shifted optogenetic excitation: a tool for fast neural control derived from Volvox carteri

(2008) Feng Zhang et al.   NATURE NEUROSCIENCE

A structural understanding of the dynamic ribosome machine

(2008) Thomas A. Steitz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Imaging in vivo: watching the brain in action

(2008) Jason N. D. Kerr et al.   NATURE REVIEWS NEUROSCIENCE

 -Helix folding in the presence of structural constraints

(2008) J. A. Ihalainen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optical Switches for Remote and Noninvasive Control of Cell Signaling

(2008) P. Gorostiza et al.   SCIENCE

Heterotrimeric G protein activation by G-protein-coupled receptors

(2007) William M. Oldham et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY