Article
Chemistry, Multidisciplinary
Stefanie D. Pritzl, David B. Konrad, Martina F. Ober, Alexander F. Richter, James A. Frank, Bert Nickel, Dirk Trauner, Theobald Lohmueller
Summary: Photolipids containing azobenzene group in their tails, such as red-azo-PC, have been synthesized to enable photoisomerization with tissue-penetrating red light (>= 630 nm) for versatile applications in biophysics and photopharmaceuticals. The photo-switching effect strongly influences the fluidity and mechanical properties of lipid membranes, leading to shape transitions and vesicle division controlled by specific wavelengths. These results highlight the potential of red-azo-PC as a nanophotonic tool in synthetic biology and biomedical applications.
Article
Endocrinology & Metabolism
Jiannan Xiao, Liliane El Eid, Teresa Buenaventura, Raphael Boutry, Amelie Bonnefond, Ben Jones, Guy A. Rutter, Philippe Froguel, Alejandra Tomas
Summary: This study aimed to determine the kinase activity profiles of human pancreatic beta cells downstream of glucagon-like peptide-1 receptor (GLP-1R) balanced versus biased agonist stimulations. The results showed that acute and sustained GLP-1R agonist exposure had distinct effects on kinase responses, and different biased agonists could modulate distinct kinase interaction networks. These findings have important implications for the selection of appropriate anti-type 2 diabetes therapies.
DIABETES OBESITY & METABOLISM
(2023)
Review
Cell Biology
Eva Tuduri, Sergi Soriano, Lucia Almagro, Eduard Montanya, Paloma Alonso-Magdalena, Angel Nadal, Ivan Quesada
Summary: This review summarizes the age-related alterations, adaptations, and failures of pancreatic β-cells at the molecular, morphological, and functional levels in both mice and humans. The findings suggest that changes in β-cell proliferation, apoptosis, and function with age may impact the development of type 2 diabetes.
AGEING RESEARCH REVIEWS
(2022)
Review
Endocrinology & Metabolism
Ji-Hyun Lee, Ji-Hyeon Lee, Sushil G. Rane
Summary: Pancreatic islet beta cells play a crucial role in diabetes development, with the TGF-β pathway playing an important role in regulating beta cell development, proliferation, and function. This supports the research and therapeutic potential of targeting the TGF-β pathway in diabetes.
Article
Nutrition & Dietetics
Xu Chen, Jinghe Xiao, Juan Pang, Shen Chen, Qing Wang, Wenhua Ling
Summary: The study suggests that pancreatic beta-cell function may be a new predictor for the presence of NAFLD, and insufficient compensatory beta-cell function is associated with NAFLD.
Article
Endocrinology & Metabolism
Harshal A. Deshmukh, Anne Lundager Madsen, Ana Vinuela, Christian Theil Have, Niels Grarup, Andrea Tura, Anubha Mahajan, Alison J. Heggie, Robert W. Koivula, Federico De Masi, Konstantinos K. Tsirigos, Allan Linneberg, Thomas Drivsholm, Oluf Pedersen, Thorkild I. A. Sorensen, Arne Astrup, Anette A. P. Gjesing, Imre Pavo, Andrew R. Wood, Hartmut Ruetten, Angus G. Jones, Anitra D. M. Koopman, Henna Cederberg, Femke Rutters, Martin Ridderstrale, Markku Laakso, Mark McCarthy, Tim M. Frayling, Ele Ferrannini, Paul W. Franks, Ewan R. Pearson, Andrea Mari, Torben Hansen, Mark Walker
Summary: Through a genome-wide meta-analysis, we have identified variations in the GIPR-QPCTL and CDKAL1 loci as key determinants of pancreatic beta-cell glucose sensitivity. These results indicate that genetic variations play a significant role in regulating beta-cell glucose sensitivity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Cell Biology
Algerta Marku, Alessandra Galli, Paola Marciani, Nevia Dule, Carla Perego, Michela Castagna
Summary: Iron is crucial for insulin synthesis and ATP production in pancreatic beta-cells. Proper regulation of iron content is essential to prevent oxidative damage and cell dysfunction. Understanding and controlling iron metabolism in beta-cells could lead to new treatments for diseases such as diabetes.
Article
Genetics & Heredity
Jing Chen, Renhua Li, Sarah Knapp, Guizhi Zhu, Robert L. Whitener, Edward H. Leiter, Clayton E. Mathews
Summary: This study identified genetic linkages that contribute to the susceptibility or resistance of pancreatic beta-cells to AL-induced diabetes. It confirmed previously identified linkages and discovered new ones on chromosomes. The study also observed epistatic interactions between different chromosomes.
FRONTIERS IN GENETICS
(2022)
Review
Biochemistry & Molecular Biology
Kristen E. Rohli, Cierra K. Boyer, Sandra E. Blom, Samuel B. Stephens
Summary: Pancreatic islet beta-cells have the ability to adapt their secretory program to match nutrient availability and peripheral insulin signaling cues. However, as Type 2 diabetes progresses, these adaptive mechanisms fail, leading to a decline in beta-cell function and impaired insulin secretion.
Article
Pharmacology & Pharmacy
A. Coulter-Parkhill, SWM. Dobbin, N. Tanday, VA. Gault, S. McClean, N. Irwin
Summary: Research has shown that a novel peptide, Delta-TRTX-AC1, isolated from the venom of the Mexican Blond tarantula spider, has potential therapeutic benefits for diabetes. It has been found to promote insulin secretion, enhance beta-cell proliferation, and protect against apoptosis. In animal experiments, Delta-TRTX-AC1 was shown to decrease blood glucose levels and suppress appetite. Additionally, it augmented the appetite-suppressing effects of exenatide.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Antonietta Robino, Gianluca Tornese, Davide Tinti, Klemen Dovc, Valeria Castorani, Andrea Conti, Roberto Franceschi, Ivana Rabbone, Riccardo Bonfanti, Tadej Battelino, Eulalia Catamo
Summary: This study investigated the association between HNF1A gene SNPs and type 1 diabetes (T1D) susceptibility. The study found that one of the SNPs was associated with insulin dose-adjusted glycated hemoglobin A1c (IDAA1c) and glycated hemoglobin (HbA1c) values. These findings suggest that HNF1A variants may be a risk factor for beta cell function and glycaemic control in individuals with T1D.
Article
Pharmacology & Pharmacy
Jian Lin, Yan Lan, Daochun Xiang, Rui Ma, Qianjiang Chen, Ke Ding, Jingli Lu
Summary: Pancreatic beta-cell dysfunction is a key factor in the development of diabetes. This study found that IL-33 could promote cell survival and insulin secretion in beta-cells under diabetic conditions. IL-33 achieves this by increasing the expression of its receptor ST2 and the transcription factor PPAR gamma. IL-33 also has anti-inflammatory effects and improves glucose metabolism and mitochondrial function. This research provides important insights into the mechanisms of beta-cell diseases and potential new strategies for diabetes treatment.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Xiaoyang Li, Qiushi Yang, Hang Ye, Shuo Li, Yuzhu Wang, Wanjiang Yu
Summary: The study compared the reliability of different methods for measuring pancreatic fat content and found that measuring half of the pancreas through interlayer data collection can effectively reflect the fat content of the entire pancreas. This method saves time and effort without compromising the results, indicating promising clinical application prospects.
Article
Endocrinology & Metabolism
Mengxue Jiang, Zhijian Kuang, Yaohui He, Yin Cao, Tingyan Yu, Jidong Cheng, Wen Liu, Wei Wang
Summary: This study reveals that SNAPIN plays a crucial role in regulating insulin secretion and beta cell proliferation, with its expression influenced by age and diabetes. The function of SNAPIN is achieved through its impact on cell cycle regulation, suggesting it might be a potential pharmacotherapeutic target for diabetes mellitus.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Kristen Nadeau, Laure El Ghormli, Silva Arslanian, Fida Bacha, Sonia Caprio, Christine C. Chan, Lily Chao, Elvira K. Isganaitis, Maria Rayas, Maggie Siska, Philip Zeitler, TODAY Study Grp
Summary: This study aims to investigate the impact of early attainment of tight glycemic control on long-term β-cell function and glycemic control in youth-onset type 2 diabetes. The research findings suggest that the initial 6 months of glycemic control have an effect on β-cell function and glycemic control over 9 years, and that sex, race/ethnicity, and BMI also influence these relationships.
Article
Endocrinology & Metabolism
Katrina Viloria, Daniela Nasteska, Julia Ast, Annie Hasib, Federica Cuozzo, Silke Heising, Linford J. B. Briant, Martin Hewison, David J. Hodson
Summary: GC-globulin (GC), also known as vitamin D-binding protein, plays a multifunctional role in transporting vitamin 25(OH)D, fatty acids, and scavenging actin. It is highly localized to glucagon-secreting alpha-cells in the pancreatic islets. Loss of GC exacerbates alpha-cell failure during metabolic stress, leading to impaired glucagon secretion and changes in alpha-cell morphology. Restoring GC levels rescues the impairments in glucagon secretion and restores the F-actin cytoskeleton of alpha-cells. Decreased GC levels in alpha-cells of type 2 diabetes donors are associated with changes in alpha-cell mass, morphology, and glucagon expression.
Review
Cell Biology
Roy Anindya, Guy A. Rutter, Gargi Meur
Summary: In this article, the dynamic interaction between pancreatic beta cells, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the host immune system in new-onset type 1 diabetes (T1D) is detailed. It is shown that beta cells express the necessary receptors for SARS-CoV-2 entry and can be infected. However, beta cell expansion and regeneration may effectively compensate for lost beta cells. The appearance of islet autoantibodies following SARS-CoV-2 infection suggests a breakdown of immune tolerance, but many cases also indicate a progression of pre-existing diabetes rather than new-onset T1D.
IMMUNOLOGY AND CELL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Julia Ast, Daniela Nasteska, Nicholas H. F. Fine, Daniel J. Nieves, Zsombor Koszegi, Yann Lanoiselee, Federica Cuozzo, Katrina Viloria, Andrea Bacon, Nguyet T. Luu, Philip N. Newsome, Davide Calebiro, Dylan M. Owen, Johannes Broichhagen, David J. Hodson
Summary: The authors generated mice with an enzyme self-label genome-edited into the endogenous glucagon-like peptide-1 receptor locus, designed fluorescent dyes for specific labeling in complex tissue, and revealed the localization, organization, and dynamics of endogenous GLP1R in cells and tissue. These results not only demonstrate the utility of enzyme self-labels for visualization and interrogation of endogenous proteins, but also provide insights into the biology of class B GPCRs.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Nicola Romano, Chrystel Lafont, Pauline Campos, Anne Guillou, Tatiana Fiordelisio, David J. Hodson, Patrice Mollard, Marie Schaeffer
Summary: Central integration of peripheral appetite-regulating signals is crucial for maintaining energy homeostasis. This study investigated the role of median eminence mural cells in modulating gut hormone effects on feeding behavior. The findings suggest that activation of these vascular cells can alter blood flow velocity, delaying the access of ghrelin to target neurons and thereby modulating food intake in response to peripheral ghrelin.
Article
Chemistry, Analytical
Max Ruwolt, Yi He, Diogo Borges Lima, William Barshop, Johannes Broichhagen, Romain Huguet, Rosa Viner, Fan Liu
Summary: Cross-linking mass spectrometry (XL-MS) is a powerful technique for studying protein structures and interactions. Recent advancements in experimental methods have improved the identification of cross-linked peptides. However, the presence of mono-links still poses challenges due to the time spent on their MS2 acquisition.
ANALYTICAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Guy A. Rutter, Vaibhav Sidarala, Brett A. Kaufman, Scott A. Soleimanpour
Summary: The regulation of glucose-regulated insulin secretion in diabetes is defective. This review focuses on the role of glucose's privileged oxidative metabolism in glucose detection, the regulation of mitochondrial metabolism by Ca2+, and the importance of mitochondrial structure and dynamics in beta cells. Additionally, it highlights the contributions of Professor Randle and his colleagues towards our understanding of insulin secretion regulation.
BIOCHEMICAL JOURNAL
(2023)
Article
Immunology
Laleh Pezhman, Sophie J. Hopkin, Jenefa Begum, Silke Heising, Daniela Nasteska, Mussarat Wahid, G. Ed Rainger, David J. Hodson, Asif J. Iqbal, Myriam Chimen, Helen M. McGettrick
Summary: In this study, we demonstrate the therapeutic potential of the immunopeptide PEPITEM in mitigating the pathological impact of obesity, such as low-grade inflammation and pancreatic dysfunction. Further research is needed to assess its efficacy in reducing obesity-related co-morbidities, particularly in high-risk individuals struggling with weight control through lifestyle modifications. This study highlights the importance of targeting cellular and molecular processes in obesity for effective management and presents PEPITEM as a novel therapeutic option.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Jiannan Xiao, Liliane El Eid, Teresa Buenaventura, Raphael Boutry, Amelie Bonnefond, Ben Jones, Guy A. Rutter, Philippe Froguel, Alejandra Tomas
Summary: This study aimed to determine the kinase activity profiles of human pancreatic beta cells downstream of glucagon-like peptide-1 receptor (GLP-1R) balanced versus biased agonist stimulations. The results showed that acute and sustained GLP-1R agonist exposure had distinct effects on kinase responses, and different biased agonists could modulate distinct kinase interaction networks. These findings have important implications for the selection of appropriate anti-type 2 diabetes therapies.
DIABETES OBESITY & METABOLISM
(2023)
Article
Medicine, Research & Experimental
Pauline Chabosseau, Fiona Yong, Luis F. Delgadillo-Silva, Eun Young Lee, Rana Melhem, Shiying Li, Nidhi Gandhi, Jules Wastin, Livia Lopez Noriega, Isabelle Leclerc, Yusuf Ali, Jing W. Hughes, Robert Sladek, Aida Martinez-Sanchez, Guy A. Rutter
Summary: Spatially-organized increases in Ca2+ within pancreatic beta cells under high glucose stimulation were found to be mediated by leader cells, which possess unique molecular features and localized signaling with delta cells. Single cell RNA sequencing revealed differential gene expression related to cilium biogenesis and transcriptional regulation between leader and follower cells.
Article
Multidisciplinary Sciences
Roderick C. Slieker, Louise A. Donnelly, Elina Akalestou, Livia Lopez-Noriega, Rana Melhem, Aysim Gunes, Frederic Abou Azar, Alexander Efanov, Eleni Georgiadou, Hermine Muniangi-Muhitu, Mahsa Sheikh, Giuseppe N. Giordano, Mikael Akerlund, Emma Ahlqvist, Ashfaq Ali, Karina Banasik, Soren Brunak, Marko Barovic, Gerard A. Bouland, Frederic Burdet, Mickael Canouil, Iulian Dragan, Petra J. M. Elders, Celine Fernandez, Andreas Festa, Hugo Fitipaldi, Phillippe Froguel, Valborg Gudmundsdottir, Vilmundur Gudnason, Mathias J. Gerl, Amber A. van der Heijden, Lori L. Jennings, Michael K. Hansen, Min Kim, Isabelle Leclerc, Christian Klose, Dmitry Kuznetsov, Dina Mansour Aly, Florence Mehl, Diana Marek, Olle Melander, Anne Niknejad, Filip Ottosson, Imre Pavo, Kevin Duffin, Samreen K. Syed, Janice L. Shaw, Over Cabrera, Timothy J. Pullen, Kai Simons, Michele Solimena, Tommi Suvitaival, Asger Wretlind, Peter Rossing, Valeriya Lyssenko, Cristina Legido Quigley, Leif Groop, Bernard Thorens, Paul W. Franks, Gareth E. Lim, Jennifer Estall, Mark Ibberson, Joline W. J. Beulens, Leen M't Hart, Ewan R. Pearson, Guy A. Rutter
Summary: We identified biomarkers for disease progression in type 2 diabetes cohorts, including metabolites, lipids, and proteins. Various substances such as homocitrulline, isoleucine, 2-aminoadipic acid, triacylglycerol species, and sphingomyelin 42:2;2 levels were found to predict faster progression towards insulin requirement. Proteins like GDF15/MIC-1, IL-18Ra, CRELD1, NogoR, FAS, and ENPP7 were associated with faster progression, while others like SMAC/DIABLO, SPOCK1, and HEMK2 predicted slower progression rates. The findings also suggested possible disease mechanisms and potential therapeutic avenues to slow diabetes progression.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Weiwei Xu, M. M. Fahd Qadir, Daniela Nasteska, Paula Mota de Sa, Caroline M. Gorvin, Manuel Blandino-Rosano, Charles R. Evans, Thuong Ho, Evgeniy Potapenko, Rajakrishnan Veluthakal, Fiona B. Ashford, Stavroula Bitsi, Jia Fan, Manika Bhondeley, Kejing Song, Venkata N. Sure, Siva S. V. P. Sakamuri, Lina Schiffer, Wandy Beatty, Rachael Wyatt, Daniel E. Frigo, Xiaowen Liu, Prasad V. Katakam, Wiebke Arlt, Jochen Buck, Lonny R. Levin, Tony Hu, Jay Kolls, Charles F. Burant, Alejandra Tomas, Matthew J. Merrins, Debbie C. Thurmond, Ernesto Bernal-Mizrachi, David J. Hodson, Franck Mauvais-Jarvis
Summary: Male mice without androgen receptor (AR) in pancreatic 0 cells have reduced insulin secretion and develop hyperglycemia. Testosterone activates an extranuclear AR, which enhances glucagon-like peptide-1 (GLP-1) insulin action. This study investigates the mechanisms through which testosterone enhances GLP-1-stimulated insulin secretion in male 0 cells, including the activation of cAMP production and the recruitment of Gas to GLP-1 receptor and AR complexes. Additionally, testosterone promotes insulin secretion in human islets through an actin remodeling cascade. The study provides insights into the genomic and non-genomic actions of AR in regulating insulin exocytosis.
Article
Endocrinology & Metabolism
M. V. Surekha, N. Suneetha, N. Balakrishna, Uday Kumar Putcha, K. Satyanarayana, J. J. Babu Geddam, Pagidoju Sreenu, B. Tulja, Raja Sriswan Mamidi, Guy A. Rutter, Gargi Meur
Summary: This study found that asymptomatic SARS-CoV-2 infection during pregnancy appears to be associated with various abnormal placental histopathologic changes related to placental hypoxia, independent of maternal anemia status. These findings support the independent role of SARS-CoV-2 in causing placental hypoxia in pregnant women.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, Research & Experimental
Alice Adriaenssens, Johannes Broichhagen, Anne de Bray, Julia Ast, Annie Hasib, Ben Jones, Alejandra Tomas, Natalie Figueredo Burgos, Orla Woodward, Jo Lewis, Elisabeth O'Flaherty, Kimberley El, Canqi Cui, Norio Harada, Nobuya Inagaki, Jonathan Campbell, Daniel Brierley, David J. Hodson, Ricardo Samms, Fiona Gribble, Frank Reimann
Summary: The signaling pathways of the central glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) in the brain are not fully understood, and its role in GIP-based therapeutics for weight loss is critical. This study found that Gipr neurons in the hypothalamus and dorsal vagal complex (DVC) play a role in the control of energy balance, but they have different connectivity, transcriptomic profiles, and appetite-controlling mechanisms. The study also showed that GIPR agonists have restricted access to the central nervous system, primarily targeting circumventricular organs. These findings highlight the heterogeneity of the central GIPR signaling axis and suggest the need to consider multiple regulatory pathways in studying the effects of GIP pharmacology on feeding behavior.
Article
Endocrinology & Metabolism
Ann-Kathrin Rueckert, Julia Ast, Annie Hasib, Daniela Nasteska, Katrina Viloria, Johannes Broichhagen, David J. Hodson
Summary: We developed, synthesized and tested light-activated sulfonylureas for optical control of KATP channels and pancreatic beta cell activity. Molecular dynamics simulations inspired us to develop a novel push-pull closed ring azobenzene unit to improve photoswitching characteristics. Three fine-tuned sulfonylureas were synthesized, all of which increased beta cell activity upon blue light illumination. The pyrrolidine-based sulfonylurea showed superior switch OFF performance compared to the first generation.
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
