Cytoplasmic and Mitochondrial NADPH-Coupled Redox Systems in the Regulation of Aging

IDH-1 deficiency induces growth defects and metabolic alterations in GSPD-1-deficient Caenorhabditis elegans

(2019) Hung-Chi Yang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Methylene blue does not bypass Complex III antimycin block in mouse brain mitochondria

(2019) Artem P. Gureev et al.   FEBS LETTERS

Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation

(2019) David Guerrero-Gómez et al.   CELL DEATH AND DIFFERENTIATION

The exceptional longevity of the naked mole-rat may be explained by mitochondrial antioxidant defenses

(2019) Daniel Munro et al.   AGING CELL

Overexpression of CYB5R3 and NQO1, two NAD+ -producing enzymes, mimics aspects of caloric restriction

(2018) Alberto Diaz-Ruiz et al.   AGING CELL

Mammalian Circadian Period, But Not Phase and Amplitude, Is Robust Against Redox and Metabolic Perturbations

(2018) Marrit Putker et al.   ANTIOXIDANTS & REDOX SIGNALING

Mini-Review: Oxidative stress, redox stress or redox success ?

(2018) John M.C. Gutteridge et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

UPRmt regulation and output: a stress response mediated by mitochondrial-nuclear communication

(2018) Andrew Melber et al.   CELL RESEARCH

Metabolic Plasticity Enables Circadian Adaptation to Acute Hypoxia in Zebrafish Cells

(2018) Adolf M. Sandbichler et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Regulation of HSF1 protein stabilization: An updated review

(2018) Chao Huang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Recombinant buckwheat glutaredoxin intake increases lifespan and stress resistance via hsf-1 upregulation in Caenorhabditis elegans

(2018) Fang Li et al.   EXPERIMENTAL GERONTOLOGY

Spatiotemporal compartmentalization of hepatic NADH and NADPH metabolism

(2018) Russell P. Goodman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic deletion of CD38 confers post-ischemic myocardial protection through preserved pyridine nucleotides

(2018) James Boslett et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Phagocyte NADPH oxidase, oxidative stress and lipids: Anti- or pro ageing?

(2018) Laura Baciou et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Expression of the methionine sulfoxide reductase lost during evolution extends Drosophila lifespan in a methionine-dependent manner

(2018) Byung Cheon Lee et al.   Scientific Reports

Do developmental temperatures affect redox level and lifespan in C. elegans through upregulation of peroxiredoxin?

(2018) Dylan Henderson et al.   Redox Biology

Heat-induced longevity in budding yeast requires respiratory metabolism and glutathione recycling

(2018) Marina Musa et al.   Aging-US

Species comparison of liver proteomes reveals links to naked mole-rat longevity and human aging

(2018) Ivonne Heinze et al.   BMC BIOLOGY

External cys/cySS Redox State Modification Controls the Intracellular Redox State and Neurodegeneration via Akt in Aging and Alzheimer's Disease Mouse Model Neurons

(2018) Debolina Ghosh et al.   JOURNAL OF ALZHEIMERS DISEASE

Metabolic oscillations on the circadian time scale inDrosophilacells lacking clock genes

(2018) Guillaume Rey et al.   Molecular Systems Biology

Analysis of redox landscapes and dynamics in living cells and in vivo using genetically encoded fluorescent sensors

(2018) Yejun Zou et al.   Nature Protocols

Reduced Nicotinamide Adenine Dinucleotide Phosphate Inhibits MPTP-Induced Neuroinflammation and Neurotoxicity

(2018) Ying Zhou et al.   NEUROSCIENCE

The Plasma NAD+ Metabolome is Dysregulated in ‘normal’ Ageing

(2018) James Clement et al.   REJUVENATION RESEARCH

Thioredoxin overexpression in both the cytosol and mitochondria accelerates age-related disease and shortens lifespan in male C57BL/6 mice

(2018) Geneva M. Cunningham et al.   GeroScience

Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways

(2018) Ziyun Wu et al.   BMC BIOLOGY

Aging and the clock: Perspective from flies to humans

(2018) Aliza K. De Nobrega et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Disorders in NADPH generation via pentose phosphate pathway influence the reproductive potential of the Saccharomyces cerevisiae yeast due to changes in redox status

(2018) Magdalena Kwolek-Mirek et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Yeast thioredoxin reductase Trr1p controls TORC1-regulated processes

(2018) Cecilia Picazo et al.   Scientific Reports

Altered Expression of Mitochondrial NAD+ Carriers Influences Yeast Chronological Lifespan by Modulating Cytosolic and Mitochondrial Metabolism

(2018) Ivan Orlandi et al.   Frontiers in Genetics

Drosophila methionine sulfoxide reductase A (MSRA) lacks methionine oxidase activity

(2018) Sreya Tarafdar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Uncoupling of oxidative stress resistance and lifespan in long-lived isp-1 mitochondrial mutants in Caenorhabditis elegans

(2017) Dylan J. Dues et al.   FREE RADICAL BIOLOGY AND MEDICINE

Responses to reductive stress in the cardiovascular system

(2017) Diane E. Handy et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ketone bodies mimic the life span extending properties of caloric restriction

(2017) Richard L. Veech et al.   IUBMB LIFE

Uridine monophosphate synthetase enables eukaryoticde novoNAD+biosynthesis from quinolinic acid

(2017) Melanie R. McReynolds et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of a dietary ketone ester on hippocampal glycolytic and tricarboxylic acid cycle intermediates and amino acids in a 3xTgAD mouse model of Alzheimer's disease

(2017) Robert J. Pawlosky et al.   JOURNAL OF NEUROCHEMISTRY

G6pd Deficiency Does Not Affect the Cytosolic Glutathione or Thioredoxin Antioxidant Defense in Mouse Cochlea

(2017) Karessa White et al.   JOURNAL OF NEUROSCIENCE

HDAC inhibitors: A new promising drug class in anti-aging research

(2017) Elena G. Pasyukova et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Combination of NAD+ and NADPH Offers Greater Neuroprotection in Ischemic Stroke Models by Relieving Metabolic Stress

(2017) Qiao Huang et al.   MOLECULAR NEUROBIOLOGY

A genetically encoded tool for manipulation of NADP+/NADPH in living cells

(2017) Valentin Cracan et al.   Nature Chemical Biology

Genetically encoded fluorescent sensors reveal dynamic regulation of NADPH metabolism

(2017) Rongkun Tao et al.   NATURE METHODS

The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD + Cleavage Activity that Promotes Pathological Axonal Degeneration

(2017) Kow Essuman et al.   NEURON

Impaired embryonic development in glucose-6-phosphate dehydrogenase-deficient Caenorhabditis elegans due to abnormal redox homeostasis induced activation of calcium-independent phospholipase and alteration of glycerophospholipid metabolism

(2017) Tzu-Ling Chen et al.   Cell Death & Disease

Transaldolase inhibition impairs mitochondrial respiration and induces a starvation-like longevity response in Caenorhabditis elegans

(2017) Christopher F. Bennett et al.   PLoS Genetics

Non-linear impact of glutathione depletion on C. elegans life span and stress resistance

(2017) Nadine Urban et al.   Redox Biology

Knock out of the NADPH oxidase Nox4 has no impact on life span in mice

(2017) Flavia Rezende et al.   Redox Biology

Nampt Expression Decreases Age-Related Senescence in Rat Bone Marrow Mesenchymal Stem Cells by Targeting Sirt1

(2017) Cao Ma et al.   PLoS One

Anti-Aging Potentials of Methylene Blue for Human Skin Longevity

(2017) Zheng-Mei Xiong et al.   Scientific Reports

Methylene blue inhibits NLRP3, NLRC4, AIM2, and non-canonical inflammasome activation

(2017) Huijeong Ahn et al.   Scientific Reports

Antioxidants reveal an inverted U-shaped dose-response relationship between reactive oxygen species levels and the rate of aging inCaenorhabditis elegans

(2016) David Desjardins et al.   AGING CELL

From yeast to human: exploring the comparative biology of methionine restriction in extending eukaryotic life span

(2016) R. Scott McIsaac et al.   Annals of the New York Academy of Sciences

Methionine Metabolism Alters Oxidative Stress Resistance via the Pentose Phosphate Pathway

(2016) Kate Campbell et al.   ANTIOXIDANTS & REDOX SIGNALING

The role of peroxiredoxin 4 in inflammatory response and aging

(2016) Vladimir I. Klichko et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Redox regulation and pro-oxidant reactions in the physiology of circadian systems

(2016) Isabel Méndez et al.   BIOCHIMIE

The Pentose Phosphate Pathway Regulates the Circadian Clock

(2016) Guillaume Rey et al.   Cell Metabolism

Suppressors of Superoxide-H 2 O 2 Production at Site I Q of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury

(2016) Martin D. Brand et al.   Cell Metabolism

CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism

(2016) Juliana Camacho-Pereira et al.   Cell Metabolism

Glutathione reductase gsr-1 is an essential gene required for Caenorhabditis elegans early embryonic development

(2016) José Antonio Mora-Lorca et al.   FREE RADICAL BIOLOGY AND MEDICINE

Investigating mitochondrial redox state using NADH and NADPH autofluorescence

(2016) Thomas S. Blacker et al.   FREE RADICAL BIOLOGY AND MEDICINE

‘Adipaging’: ageing and obesity share biological hallmarks related to a dysfunctional adipose tissue

(2016) Laura M. Pérez et al.   JOURNAL OF PHYSIOLOGY-LONDON

Atomic structure of the entire mammalian mitochondrial complex I

(2016) Karol Fiedorczuk et al.   NATURE

Circadian rhythms identified inCaenorhabditis elegansby in vivo long-term monitoring of a bioluminescent reporter

(2016) María Eugenia Goya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tryptophan-2,3-dioxygenase (TDO) inhibition ameliorates neurodegeneration by modulation of kynurenine pathway metabolites

(2016) Carlo Breda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restoration of Mitochondrial NAD+Levels Delays Stem Cell Senescence and Facilitates Reprogramming of Aged Somatic Cells

(2016) Myung Jin Son et al.   STEM CELLS

G6PD protects from oxidative damage and improves healthspan in mice

(2016) Sandrina Nóbrega-Pereira et al.   Nature Communications

NADPH: new oxygen for the ROS theory of aging

(2016) Pablo J. Fernandez-Marcos et al.   Oncotarget

The glyoxylate shunt is essential for desiccation tolerance in C. elegans and budding yeast

(2016) Cihan Erkut et al.   eLife

Age-dependent detection of erythrocytes glucose-6-phosphate dehydrogenase and its correlation with oxidative stress

(2016) Pawan Kumar Maurya et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Effects of transgenic methionine sulfoxide reductase A (MsrA) expression on lifespan and age-dependent changes in metabolic function in mice

(2016) Adam B. Salmon et al.   Redox Biology

D-beta-hydroxybutyrate extends lifespan in C. elegans

(2016) Clare Edwards et al.   Aging-US

A peroxiredoxin, PRDX-2, is required for insulin secretion and insulin/IIS-dependent regulation of stress resistance and longevity

(2015) Monika Oláhová et al.   AGING CELL

NOX4 in Mitochondria: Yeast Two-Hybrid-Based Interaction with Complex I Without Relevance for Basal Reactive Oxygen Species?

(2015) Christine Hirschhäuser et al.   ANTIOXIDANTS & REDOX SIGNALING

The paradoxical role of thioredoxin on oxidative stress and aging

(2015) Geneva M. Cunningham et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Nmdmc overexpression extends Drosophila lifespan and reduces levels of mitochondrial reactive oxygen species

(2015) Suyeun Yu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Overexpression of malic enzyme in the larval stage extends Drosophila lifespan

(2015) Gye-Hyeong Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Changes in pH and NADPH Regulate the DNA Binding Activity of Neuronal PAS Domain Protein 2, a Mammalian Circadian Transcription Factor

(2015) Katsuhiro Yoshii et al.   BIOCHEMISTRY

Increased reactive oxygen species production during reductive stress: The roles of mitochondrial glutathione and thioredoxin reductases

(2015) Paavo Korge et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Widespread Proteome Remodeling and Aggregation in Aging C. elegans

(2015) Dirk M. Walther et al.   CELL

Metabolic Cycles in Yeast Share Features Conserved among Circadian Rhythms

(2015) Helen C. Causton et al.   CURRENT BIOLOGY

Mechanism by which caloric restriction improves insulin sensitivity in sedentary obese adults

(2015) Matthew L. Johnson et al.   DIABETES

Calorie restriction and methionine restriction in control of endogenous hydrogen sulfide production by the transsulfuration pathway

(2015) Christopher Hine et al.   EXPERIMENTAL GERONTOLOGY

Metabolome and proteome changes with aging in Caenorhabditis elegans

(2015) Neil Copes et al.   EXPERIMENTAL GERONTOLOGY

The mitochondrial dicarboxylate and 2-oxoglutarate carriers do not transport glutathione

(2015) Lee M. Booty et al.   FEBS LETTERS

Characterization of skn-1/wdr-23 phenotypes in Caenorhabditis elegans; pleiotrophy, aging, glutathione, and interactions with other longevity pathways

(2015) Lanlan Tang et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Suppressors of superoxide production from mitochondrial complex III

(2015) Adam L Orr et al.   Nature Chemical Biology

NAD kinase controls animal NADP biosynthesis and is modulated via evolutionarily divergent calmodulin-dependent mechanisms

(2015) Nick R. Love et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences

(2015) Xiao-Hong Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypothalamic microinflammation: a common basis of metabolic syndrome and aging

(2015) Yizhe Tang et al.   TRENDS IN NEUROSCIENCES

Dietary methionine can sustain cytosolic redox homeostasis in the mouse liver

(2015) Sofi Eriksson et al.   Nature Communications

Fasting, but Not Aging, Dramatically Alters the Redox Status of Cysteine Residues on Proteins in Drosophila melanogaster

(2015) Katja E. Menger et al.   Cell Reports

Relative importance of redox buffers GSH and NAD(P)H in age-related neurodegeneration and Alzheimer disease-like mouse neurons

(2014) Debolina Ghosh et al.   AGING CELL

Effects of chronic mild food restriction on behavior and the hypothalamic malonyl-CoA signaling pathway

(2014) Wataru Iio et al.   ANIMAL SCIENCE JOURNAL

Nox4: A Hydrogen Peroxide-Generating Oxygen Sensor

(2014) Yukio Nisimoto et al.   BIOCHEMISTRY

The imbalanced redox status in senescent endothelial cells is due to dysregulated Thioredoxin-1 and NADPH oxidase 4

(2014) Christine Goy et al.   EXPERIMENTAL GERONTOLOGY

The mitochondrial unfolded protein response and increased longevity: Cause, consequence, or correlation?

(2014) Christopher F. Bennett et al.   EXPERIMENTAL GERONTOLOGY

Protective effects of the thioredoxin and glutaredoxin systems in dopamine-induced cell death

(2014) Lisa Arodin et al.   FREE RADICAL BIOLOGY AND MEDICINE

LC–MS Proteomics Analysis of the Insulin/IGF-1-Deficient Caenorhabditis elegans daf-2(e1370) Mutant Reveals Extensive Restructuring of Intermediary Metabolism

(2014) Geert Depuydt et al.   JOURNAL OF PROTEOME RESEARCH

The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR

(2014) Randall M. Chin et al.   NATURE

Quantitative flux analysis reveals folate-dependent NADPH production

(2014) Jing Fan et al.   NATURE

Methionine Restriction Activates the Retrograde Response and Confers Both Stress Tolerance and Lifespan Extension to Yeast, Mouse and Human Cells

(2014) Jay E. Johnson et al.   PLoS One

Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2

(2014) W. De Haes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis

(2014) S. A. Andrabi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A circadian gene expression atlas in mammals: Implications for biology and medicine

(2014) Ray Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status

(2014) Byung Cheon Lee et al.   Nature Communications

High-Resolution Profiling of Stationary-Phase Survival Reveals Yeast Longevity Factors and Their Genetic Interactions

(2014) Erika Garay et al.   PLoS Genetics

Lifespan Extension by Methionine Restriction Requires Autophagy-Dependent Vacuolar Acidification

(2014) Christoph Ruckenstuhl et al.   PLoS Genetics

Glutathione and mitochondria

(2014) Vicent Ribas et al.   Frontiers in Pharmacology

Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

(2013) David E. Harrison et al.   AGING CELL

Updating the Mitochondrial Free Radical Theory of Aging: An Integrated View, Key Aspects, and Confounding Concepts

(2013) Gustavo Barja   ANTIOXIDANTS & REDOX SIGNALING

Involvement of Redox State in the Aging of Drosophila melanogaster

(2013) William C. Orr et al.   ANTIOXIDANTS & REDOX SIGNALING

SirT1 Regulation of Antioxidant Genes Is Dependent on the Formation of a FoxO3a/PGC-1α Complex

(2013) Yolanda Olmos et al.   ANTIOXIDANTS & REDOX SIGNALING

Cardiolipin and Mitochondrial Function in Health and Disease

(2013) Giuseppe Paradies et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial respiratory chain complex I is inactivated by NADPH oxidase Nox4

(2013) Rafał Kozieł et al.   BIOCHEMICAL JOURNAL

S-Nitrosoglutathione

(2013) Katarzyna A. Broniowska et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Regulation of the human thioredoxin gene promoter and its key substrates: A study of functional and putative regulatory elements

(2013) Hye-Jin Kim Hawkes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

(2013) Ana P. Gomes et al.   CELL

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

(2013) Laurent Mouchiroud et al.   CELL

Direct and Indirect Gene Regulation by a Life-Extending FOXO Protein in C. elegans: Roles for GATA Factors and Lipid Gene Regulators

(2013) Peichuan Zhang et al.   Cell Metabolism

FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells

(2013) Hyeonju Yeo et al.   EMBO JOURNAL

Regulation of longevity and oxidative stress by nutritional interventions: Role of methionine restriction

(2013) Ines Sanchez-Roman et al.   EXPERIMENTAL GERONTOLOGY

The effects of dietary restriction on oxidative stress in rodents

(2013) Michael E. Walsh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Growth Hormone Alters the Glutathione S-Transferase and Mitochondrial Thioredoxin Systems in Long-Living Ames Dwarf Mice

(2013) L. Rojanathammanee et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The Glutathione Reductase GSR-1 Determines Stress Tolerance and Longevity in Caenorhabditis elegans

(2013) Kai Lüersen et al.   PLoS One

Circadian clock-dependent and -independent rhythmic proteomes implement distinct diurnal functions in mouse liver

(2013) D. Mauvoisin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian Clock NAD+ Cycle Drives Mitochondrial Oxidative Metabolism in Mice

(2013) C. B. Peek et al.   SCIENCE

Time line of redox events in aging postmitotic cells

(2013) Nicolas Brandes et al.   eLife

MNADK, a novel liver-enriched mitochondrion-localized NAD kinase

(2013) R. Zhang   Biology Open

Vitamin E supplementation and lifespan in model organisms

(2012) I.M.A. Ernst et al.   AGEING RESEARCH REVIEWS

The Characterization of the Caenorhabditis elegans Mitochondrial Thioredoxin System Uncovers an Unexpected Protective Role of Thioredoxin Reductase 2 in β-Amyloid Peptide Toxicity

(2012) Briseida Cacho-Valadez et al.   ANTIOXIDANTS & REDOX SIGNALING

The Naked Mole-Rat Response to Oxidative Stress: Just Deal with It

(2012) Kaitlyn N. Lewis et al.   ANTIOXIDANTS & REDOX SIGNALING

Stimulation of Histone Deacetylase Activity by Metabolites of Intermediary Metabolism

(2012) Maria Vogelauer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Misexpression screen delineates novel genes controlling Drosophila lifespan

(2012) Donggi Paik et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Two thioredoxin reductases, trxr-1 and trxr-2, have differential physiological roles in Caenorhabditis elegans

(2012) Weixun Li et al.   MOLECULES AND CELLS

Identification and characterization of a human mitochondrial NAD kinase

(2012) Kazuto Ohashi et al.   Nature Communications

Interactions of NADP-Reducing Enzymes Across Varying Environmental Conditions: A Model of Biological Complexity

(2012) Teresa Z. Rzezniczak et al.   G3-Genes Genomes Genetics

Reduced neuronal expression of ribose-5-phosphate isomerase enhances tolerance to oxidative stress, extends lifespan, and attenuates polyglutamine toxicity inDrosophila

(2011) Ching-Tzu Wang et al.   AGING CELL

The thioredoxin TRX-1 regulates adult lifespan extension induced by dietary restriction in Caenorhabditis elegans

(2011) Juan Carlos Fierro-González et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

(2011) P. Gaudet et al.   BRIEFINGS IN BIOINFORMATICS

Antioxidant defense and aging inC. elegans: Is the oxidative damage theory of aging wrong?

(2011) David Gems et al.   CELL CYCLE

Mitochondrial complex I: A central regulator of the aging process

(2011) Rhoda Stefanatos et al.   CELL CYCLE

In Vivo Mapping of Hydrogen Peroxide and Oxidized Glutathione Reveals Chemical and Regional Specificity of Redox Homeostasis

(2011) Simone C. Albrecht et al.   Cell Metabolism

Glutathione-dependent reductive stress triggers mitochondrial oxidation and cytotoxicity

(2011) Huali Zhang et al.   FASEB JOURNAL

The redox stress hypothesis of aging

(2011) Rajindar S. Sohal et al.   FREE RADICAL BIOLOGY AND MEDICINE

Alternative Mitochondrial Electron Transfer as a Novel Strategy for Neuroprotection

(2011) Yi Wen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential cysteine depletion in respiratory chain complexes enables the distinction of longevity from aerobicity

(2011) Mario Schindeldecker et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Increased longevity of some C. elegans mitochondrial mutants explained by activation of an alternative energy-producing pathway

(2011) Marco Gallo et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Life Span Extension and H2O2 Resistance Elicited by Caloric Restriction Require the Peroxiredoxin Tsa1 in Saccharomyces cerevisiae

(2011) Mikael Molin et al.   MOLECULAR CELL

Calorie Restriction: Is AMPK a Key Sensor and Effector?

(2011) Carles Cantó et al.   PHYSIOLOGY

Circadian Rhythms, Aging, and Life Span in Mammals

(2011) Oren Froy   PHYSIOLOGY

Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats

(2011) Nady Braidy et al.   PLoS One

Selenoprotein TRXR-1 and GSR-1 are essential for removal of old cuticle during molting in Caenorhabditis elegans

(2011) J. Stenvall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beneficial Role of Nrf2 in Regulating NADPH Generation and Consumption

(2011) Kai Connie Wu et al.   TOXICOLOGICAL SCIENCES

Identification of evolutionarily conserved genetic regulators of cellular aging

(2010) Gerhard T. Laschober et al.   AGING CELL

Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans

(2010) Wen Yang et al.   AGING CELL

Is Overoxidation of Peroxiredoxin Physiologically Significant?

(2010) Maike Thamsen et al.   ANTIOXIDANTS & REDOX SIGNALING

Constitutive NADPH-Dependent Electron Transferase Activity of the Nox4 Dehydrogenase Domain

(2010) Yukio Nisimoto et al.   BIOCHEMISTRY

Methylene Blue Reduces Aβ Levels and Rescues Early Cognitive Deficit by Increasing Proteasome Activity

(2010) David X. Medina et al.   BRAIN PATHOLOGY

Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction

(2010) Shinichi Someya et al.   CELL

Deletion of the mitochondrial NADH kinase increases mitochondrial DNA stability and life span in the filamentous fungus Podospora anserina

(2010) Riyad El-Khoury et al.   EXPERIMENTAL GERONTOLOGY

Respiratory chain cysteine and methionine usage indicate a causal role for thiyl radicals in aging

(2010) Bernd Moosmann   EXPERIMENTAL GERONTOLOGY

TheDrosophilahomolog of methionine sulfoxide reductase A extends lifespan and increases nuclear localization of FOXO

(2010) Hyewon Chung et al.   FEBS LETTERS

Mitochondrial peroxiredoxins are critical for the maintenance of redox state and the survival of adult Drosophila

(2010) Svetlana N. Radyuk et al.   FREE RADICAL BIOLOGY AND MEDICINE

Respiration-dependent H2O2Removal in Brain Mitochondria via the Thioredoxin/Peroxiredoxin System

(2010) Derek A. Drechsel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ERK-MAPK Pathway Regulates Longevity through SKN-1 and Insulin-like Signaling inCaenorhabditis elegans

(2010) Tetsuya Okuyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial dysfunction in Caenorhabditis elegans causes metabolic restructuring, but this is not linked to longevity

(2010) Steven Zuryn et al.   MECHANISMS OF AGEING AND DEVELOPMENT

A Microarray-Based Genetic Screen for Yeast Chronological Aging Factors

(2010) Mirela Matecic et al.   PLoS Genetics

RNAi Screening Implicates a SKN-1–Dependent Transcriptional Response in Stress Resistance and Longevity Deriving from Translation Inhibition

(2010) Jinling Wang et al.   PLoS Genetics

The energy–redox axis in aging and age-related neurodegeneration☆

(2009) Li-Peng Yap et al.   ADVANCED DRUG DELIVERY REVIEWS

Methionine sulfoxide reductase A expression is regulated by the DAF-16/FOXO pathway inCaenorhabditis elegans

(2009) Alicia N. Minniti et al.   AGING CELL

Peroxiredoxin 5 confers protection against oxidative stress and apoptosis and also promotes longevity inDrosophila

(2009) Svetlana N. Radyuk et al.   BIOCHEMICAL JOURNAL

Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16

(2009) Teppei Hashimoto et al.   BIOGERONTOLOGY

Caenorhabditis elegans lifespan extension caused by treatment with an orally active ROS-generator is dependent on DAF-16 and SIR-2.1

(2009) Tanja Heidler et al.   BIOGERONTOLOGY

Nicotinamidase modulation of NAD+ biosynthesis and nicotinamide levels separately affect reproductive development and cell survival in C. elegans

(2009) T. L. Vrablik et al.   DEVELOPMENT

The Deletion Variant of Nicotinamide Nucleotide Transhydrogenase (Nnt) Does Not Affect Insulin Secretion or Glucose Tolerance

(2009) Nicole Wong et al.   ENDOCRINOLOGY

Quantifying Interactions Within the NADP(H) Enzyme Network in Drosophila melanogaster

(2009) T. J. S. Merritt et al.   GENETICS

Two Sources of Mitochondrial NADPH in the YeastSaccharomyces cerevisiae

(2009) Hikaru Miyagi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

JNK/FOXO-mediated Neuronal Expression of Fly Homologue of Peroxiredoxin II Reduces Oxidative Stress and Extends Life Span

(2009) Kyu-Sun Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial glutathione uptake: characterization in isolated brain mitochondria and astrocytes in culture

(2009) Alison L. Wadey et al.   JOURNAL OF NEUROCHEMISTRY

Overexpression of Mn Superoxide Dismutase Does Not Increase Life Span in Mice

(2009) Y. C. Jang et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

A method for oral administration of hydrophilic substances to Caenorhabditis elegans: Effects of oral supplementation with antioxidants on the nematode lifespan

(2009) Ayumi Shibamura et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Increased age reduces DAF-16 and SKN-1 signaling and the hormetic response of Caenorhabditis elegans to the xenobiotic juglone

(2009) Aaron J. Przybysz et al.   MECHANISMS OF AGEING AND DEVELOPMENT

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Circadian Control of the NAD+ Salvage Pathway by CLOCK-SIRT1

(2009) Y. Nakahata et al.   SCIENCE

Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD+ Biosynthesis

(2009) K. M. Ramsey et al.   SCIENCE

The overexpression of major antioxidant enzymes does not extend the lifespan of mice

(2008) Viviana I. Pérez et al.   AGING CELL

Redox compartmentalization in eukaryotic cells

(2008) Young-Mi Go et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans

(2008) Jennifer M.A. Tullet et al.   CELL

Tissue-specific regulation of SIRT1 by calorie restriction

(2008) D. Chen et al.   GENES & DEVELOPMENT

Quantitative evidence for conserved longevity pathways between divergent eukaryotic species

(2008) E. D. Smith et al.   GENOME RESEARCH

Overexpression of Glucose-6-phosphate Dehydrogenase Extends the Life Span ofDrosophila melanogaster

(2008) Susan K. Legan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Life Span Extension and Neuronal Cell Protection byDrosophilaNicotinamidase

(2008) Vitaly Balan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nicotinamide Riboside and Nicotinic Acid Riboside Salvage in Fungi and Mammals

(2008) Peter Belenky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hope in Alzheimer's fight emerges from unexpected places

(2008) Trisha Gura   NATURE MEDICINE

Real-time imaging of the intracellular glutathione redox potential

(2008) Marcus Gutscher et al.   NATURE METHODS

Shortest-Path Network Analysis Is a Useful Approach toward Identifying Genetic Determinants of Longevity

(2008) J. R. Managbanag et al.   PLoS One

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction

(2008) K. J. Pearson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nonequilibrium thermodynamics of thiol/disulfide redox systems: A perspective on redox systems biology

(2007) Melissa Kemp et al.   FREE RADICAL BIOLOGY AND MEDICINE