Article
Chemistry, Analytical
Yingchun Wu, Caixia Yin, Weijie Zhang, Yongbin Zhang, Fangjun Huo
Summary: This study presents a chemical toolbox, MI-BP-CC, for monitoring viscosity in living cells and fatter liver mice. The toolbox utilizes N,N-diethyl and double bonds as sensitive sites based on the TICT mechanism. The MI-BP-CC probe shows ultra-sensitivity in detecting viscosity and has successfully visualized increased viscosity in pathological models of Parkinson's disease and fatty liver mice.
ANALYTICAL CHEMISTRY
(2022)
Article
Cell Biology
Anjaneyulu Murari, Shauna-Kay Rhooms, Divya Vimal, Kaniz Fatima Binte Hossain, Sanjay Saini, Maximino Villanueva, Michael Schlame, Edward Owusu-Ansah
Summary: The function of phospholipids intertwined with mitochondrial complex I subunits in the membrane domain of CI is unclear. However, disrupted PL transporter STARD7 impairs assembly of OXPHOS system and CI subcomplexes, while restrained knockdown of STARD7 affects incorporation of NDUFS5 and NDUFA1 into the proximal part of CI membrane domain. The knockdown also induces modest cardio-lipin remodeling, indicating alteration in mitochondrial phospholipid composition.
Review
Plant Sciences
Dandan Huang, Guangqin Jing, Lili Zhang, Changbao Chen, Shuhua Zhu
Summary: NO, H2S, and ROS play essential signaling roles in cells through oxidative post-translational modification within suitable ranges of concentration to maintain redox balance and regulate DNA repair pathways, including mtDNA. The interactions among them are intricate, influencing their generation, elimination, and signaling actions. Additionally, NO and H2S may be involved in epigenetic variations in DNA damage repair of plants.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Senzhen Wang, Xiaojuan Xu, Delu Che, Ronghui Fan, Mengke Gao, Yue Cao, Chaochao Ge, Yongli Feng, Jinghua Li, Songqiang Xie, Chaojie Wang, Fujun Dai, Lei Gao, Yuxia Wang
Summary: The study confirmed that mitochondria are the main source of ROS induced by 6c, leading to mitochondrial dysfunction and lysosomal destabilization. Moreover, ROS regulated the expression of 6c-mediated proteins, promoted the formation of autophagosomes, and caused DNA damage, ultimately resulting in cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
James H. Schofield, Zachary T. Schafer
Summary: The relationship between mitophagy and ROS production is complex and not fully understood. This review discusses mtROS generation and their detrimental effects on cellular viability, along with the cellular defense mechanisms against oxidative stress. Furthermore, the prominent mechanisms governing mitophagy induction that bear on oxidative stress are explored.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Chemistry, Multidisciplinary
Hulya Gizem Ozkan, Vanrajsinh Thakor, Hong-Gui Xu, Galyna Bila, Rostyslav Bilyy, Daria Bida, Martin Boettcher, Dimitrios Mougiakakos, Rainer Tietze, Andriy Mokhir
Summary: Elevated levels of reactive oxygen species (ROS) and deficient mitochondria are weak points of cancer cells. Designing highly potent anticancer drugs that target both ROS and mitochondria is a valid therapeutic strategy. However, limiting the drug effects to cancer cells without affecting normal ones remains a challenge. In this study, we developed novel aminoferrocene derivatives that are chemically stable in the presence of ROS, generate mitochondrial ROS in cancer cells but not normal cells, and exhibit anticancer effects in vivo.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Review
Immunology
Miranda D. Chavez, Hubert M. Tse
Summary: Mitochondrial dysfunction and oxidative stress are associated with T cell-mediated autoimmune diseases, and targeting metabolic pathways can inhibit autoreactive T cell activation. Increasing the requirements of Tregs for ROS and oxidative phosphorylation can promote self-tolerance and inhibit the activity of autoreactive T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Hematology
Sonia Poirault-Chassac, Valerie Nivet-Antoine, Amandine Houvert, Alexandre Kauskot, Evelyne Lauret, Rene Lai-Kuen, Isabelle Dusanter-Fourt, Dominique Baruch
Summary: This study demonstrates the functional coupling between ROS and mitochondrial fission in megakaryocytes, which is crucial for the initiation of thrombopoiesis. The findings provide new molecular cues that control the initiation of platelet biogenesis and may help elucidate some unexplained thrombocytopenia.
Article
Biochemistry & Molecular Biology
Hiromu Ito, Hiromi Kurokawa, Hirofumi Matsui
Summary: Mitochondria, essential organelles for energy production in eukaryotes, generate reactive oxygen species during the process which play pivotal roles in cell signaling and iron homeostasis regulation. The regulation of iron transportation, involving proteins like HCP1, DMT1, and mitoferrin, is increasingly understood in relation to mitochondrial reactive oxygen species and diseases.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Karolina Dominiak, Wieslawa Jarmuszkiewicz
Summary: The relationship between mitochondrial production of reactive oxygen species (ROS) and mitochondrial energetics in different rat tissues is dependent on the content of the reduced coenzyme Q pool. Variation in the size of the reduced Q pool in different tissues may reflect diverse levels of ROS production and antioxidant demands. The existence of tissue-specific maximum respiratory chain capacity in ROS production and a proposed new parameter RCRROS highlights the potential control of oxidative phosphorylation through membrane potential.
Article
Obstetrics & Gynecology
Anubhav Srivastava, Pransu Srivastava, Shashank Mathur, Suman Mishra, Sabiya Abbas, Amrit Gupta, Prabhaker Mishra, Meenakshi Tiwari, Lokendra Kumar Sharma
Summary: This study investigated the distribution of mitochondrial DNA (mtDNA) in maternal blood and its association with circulating reactive oxygen species (ROS) levels during normal pregnancy. The results showed a decrease in cellular mtDNA content and an increase in plasma mtDNA content during normal pregnancy. Cellular mtDNA content was significantly lower in the third trimester compared to the first trimester, while plasma mtDNA content did not differ significantly among trimesters. Additionally, higher levels of plasma H2O2 were observed in the third trimester compared to non-pregnant and first trimester. The findings suggest that maternal adaptation during normal pregnancy involves a decrease in cellular mtDNA content and an increase in plasma mtDNA and H2O2 levels.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Biochemistry & Molecular Biology
Fei Chen, Run Su, Shiwei Ni, Yan Liu, Jiexiang Huang, Gege Li, Qun Wang, Xi Zhang, Yufeng Yang
Summary: The study revealed that stem cells can respond differently to various levels of ROS in different conditions, suggesting that antioxidant-based interventions for stem cells and tumors should be carefully formulated according to the specific situations.
Review
Biochemistry & Molecular Biology
Patrizia Bottoni, Giulia Gionta, Roberto Scatena
Summary: Mitochondrial myopathies are a heterogeneous group of diseases caused by genetic mutations in proteins involved in mitochondrial oxidative metabolism. These myopathies show significant differences in their evolution, but some physiological and pathophysiological aspects of mitochondria reveal other potential molecular mechanisms that may play a significant role in their clinical progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Macarena Gonzalez, Tanisha Prashar, Haley Connaughton, Michael Barry, Rebecca Robker, Ryan Rose
Summary: This study investigated the potential of mitochondrial antioxidants to protect sperm quality during cryopreservation. The results showed that the addition of BGP-15 or L-carnitine to the cryopreservation medium improved sperm motility and prevented loss of viability. These antioxidants also reduced DNA oxidative damage, with BGP-15 significantly reducing DNA fragmentation. Overall, this study highlights the importance of mitochondrial antioxidants in improving long-term fertility preservation in males.
Article
Neurosciences
Serene Dhawan, Philip Myers, David M. D. Bailey, Aaron D. Ostrovsky, Jan Felix Evers, Matthias Landgraf
Summary: The study reveals the role of reactive oxygen species (ROS) in regulating the size of neuronal dendritic arbors. It shows that activity-regulated ROS are transmitted between cells through NADPH oxidase and aquaporins, ultimately negatively regulating dendritic arbor size.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Public, Environmental & Occupational Health
Suji Lee, Whanhee Lee, Eunil Lee, Myung Ho Jeong, Seung-Woon Rha, Chong-Jin Kim, Shung Chull Chae, Hyo-Soo Kim, Hyeon-Cheol Gwon, Ho Kim
Summary: This study examined the effect of PM on Asian dust-induced myocardial infarction and found that PM2.5 and PM10 emissions had a significant impact on STEMI patients during Asian dust weather, especially in the < 65-year-old group. Additionally, revision of the Asian dust alarm system is needed to protect vulnerable populations.
Article
Environmental Sciences
You Yeon Choi, Mihyun Yang, Younghyun Lee, Eunil Lee, Young Woo Jin, Ki Moon Seong
Summary: The survey results revealed that respondents generally believed that the national emergency medical plan for radiation accidents was prepared at an above-average level. Inspectors evaluated the emergency medical system for radiation accidents more strictly than licensee workers, especially in terms of radiation medical emergency preparedness and the government's regulatory policy for radiation safety.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Biochemical Research Methods
Eun Jung Koh, So Yeon Yu, Seung Hwan Kim, Seung Jun Kim, Eun-Il Lee, Seung Yong Hwang
Summary: This study assessed the quality of RNA prepared from blood stored at different temperatures and times prior to freezing, as well as the effect of long-term freezing, finding that improper sample handling critically influenced both RNA quality and gene expression patterns.
Article
Neurosciences
Sungdae Kim, Joohyung Kim, Sunyoung Park, Joong-Jean Park, Seungbok Lee
Summary: Loss-of-function mutations in the human OPHN1 gene lead to intellectual disability, and the Drosophila ortholog of OPHN1, Graf, plays a critical role in the development of the mushroom body. The defects in Graf mutants can be rescued by MB-specific expression of Graf and OPHN1, indicating a potential neurodevelopmental role of human OPHN1.
Article
Cell Biology
Yun-Ho Cho, Gye-Hyeong Kim, Joong-Jean Park
Summary: The gene mitochondrial Acon1 (mAcon1) regulates lifespan and age-related memory impairment in fruit flies, improving neural plasticity through autophagy/mitophagy pathways and enhancing learning ability.
Article
Immunology
Eunha Kim, Donggi Paik, Ricardo N. Ramirez, Delaney G. Biggs, Youngjun Park, Ho-Keun Kwon, Gloria B. Choi, Jun R. Huh
Summary: The study reveals that mouse offspring exposed to maternal inflammation during pregnancy are more prone to intestinal inflammation later in life, and interleukin-17A can generate immune-primed phenotypes in offspring by altering the maternal gut microbiota. This provides insights into why children exposed to heightened inflammation in the womb may have an increased risk of developing inflammatory diseases in addition to neurodevelopmental disorders.
Article
Obstetrics & Gynecology
Seongmin Kim, Se Hee Lee, Kyung Jin Min, Sanghoon Lee, Jin Hwa Hong, Jae Yun Song, Jae Kwan Lee, Nak Woo Lee, Eunil Lee
Summary: This study, using next-generation sequencing, demonstrates for the first time that vaginal microbiomes in young women with decreased ovarian function are more sensitive to environmental pollutants, especially volatile organic compounds.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Multidisciplinary Sciences
Donggi Paik, Lina Yao, Yancong Zhang, Sena Bae, Gabriel D. D'Agostino, Minghao Zhang, Eunha Kim, Eric A. Franzosa, Julian Avila-Pacheco, Jordan E. Bisanz, Christopher K. Rakowski, Hera Vlamakis, Ramnik J. Xavier, Peter J. Turnbaugh, Randy S. Longman, Michael R. Krout, Clary B. Clish, Fraydoon Rastinejad, Curtis Huttenhower, Jun R. Huh, A. Sloan Devlin
Summary: This study identifies bile acids produced by gut bacteria that inhibit the differentiation of T(H)17 cells, a key immune cell type involved in inflammatory disorders such as inflammatory bowel disease. The levels of these bile acids are reduced in patients with inflammatory bowel disease and are inversely correlated with the expression of T(H)17-cell-associated genes.
Article
Geriatrics & Gerontology
Ji-Won Shin, Eunil Lee, Seungbong Han, Seung-Ah Choe, Ok Hee Jeon
Summary: This study investigated the association between the secretory phenotypes produced by senescent cells and age-related factors in women, particularly chronological and menopausal age. The results showed that certain proteins were positively associated with chronological age, and other proteins were negatively associated with menopausal age and years since menopause. Furthermore, a specific combination of 13 proteins was found to be associated with age and menopausal state. These findings suggest that SASP factors may serve as potential markers for biological aging associated with ovarian senescence.
REJUVENATION RESEARCH
(2022)
Review
Genetics & Heredity
Greg S. B. Suh, Kweon Yu, Young-Joon Kim, Yangkyun Oh, Joong-Jean Park
Summary: Neurogenetic research using the Drosophila model has significantly advanced in South Korea, leading to important discoveries and implications. The introduction of the Drosophila system in the 1990s elevated neural developmental studies, and the establishment of related resources supported pioneer research in modeling human diseases and understanding genes and neural circuits regulating animal behavior and physiology.
JOURNAL OF NEUROGENETICS
(2023)
Article
Genetics & Heredity
Mari Kim, Gwang-Ic Son, Yun-Ho Cho, Gye-Hyeong Kim, Sung-Eun Yun, Young-Joon Kim, Jongkyeong Chung, Eunil Lee, Joong-Jean Park
Summary: Exposure to dim light at night affects the circadian rhythm and metabolism in Drosophila, leading to decreased levels of branched-chain amino acids and increased expression of enzymes involved in their metabolism. Flies with mutations in the Bcat gene are less vulnerable to starvation stress, and reducing Bcat expression suppresses this vulnerability. Feeding BCAAs to wild-type flies exposed to dim light at night reverses the metabolic vulnerability.
JOURNAL OF NEUROGENETICS
(2023)
Article
Biochemistry & Molecular Biology
Yun Jeong Kim, Eunha Oh, Minhwa Shin, Dae-Hwan Nam, So Young Jeon, Jin Hyuk Yu, Jae Yun Song, Dohsik Minn, Eunil Lee
Summary: The study finds that environmental chemicals, including two phthalate metabolites and mercury, are associated with POI in Korean women. The POI group also has higher consumption of crustaceans and frozen food. Logistic regression analysis suggests that only the metabolite-mono-n-butyl phthalate (MnBP) has a significant difference between the POI and non-POI groups. This indicates that exposure to environmental chemicals may affect the female reproductive system even at low exposure levels.
MOLECULAR & CELLULAR TOXICOLOGY
(2023)
Article
Multidisciplinary Sciences
Yesol Moon, Eunil Lee, Seoeun Lee, Gwang-Ic Son, Hangjin Byeon, Hyang-Ree Shin, Baatar Bolortsetseg
Summary: Recent studies have found that the cortisol awakening response (CAR) is associated with various health risks. This study investigated the factors affecting CAR and found that sleep efficiency and obesity influenced average cortisol levels in the morning (AVE) and the total area under the curve of cortisol levels (AUCg), while factors such as age affected the area under the curve of cortisol levels with respect to increase (AUCi). Furthermore, a marine retreat program was shown to improve CAR levels related to obesity and aging.
Article
Biology
Gwang-ic Son, Eunil Lee, Mari Kim, Seoeun Lee, Yesol Moon, Joonhee Kim
Summary: Human cells are constantly exposed to different stress factors in their physiological environment, and certain mechanical stress has been found to influence cell cycle progression and proliferation. However, the signaling pathways involved in this process are not well understood. In this study, researchers developed a pressure chamber to simulate an elevated barometric pressure environment and investigated its effect on cell proliferation. The results showed that the elevated barometric pressure inhibited cell proliferation by delaying the G2/M phase, which was caused by attenuated cell adhesion and actin cytoskeleton assembly.
ARCHIVES OF BIOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
