‘Adipaging’: ageing and obesity share biological hallmarks related to a dysfunctional adipose tissue

Inflammaging: disturbed interplay between autophagy and inflammasomes

(2016) Antero Salminen et al.   Aging-US

Noninvasive Identification of ATTRwt Cardiac Amyloid: The Re-emergence of Nuclear Cardiology

(2015) Mathew S. Maurer   AMERICAN JOURNAL OF MEDICINE

Molecular insight and pharmacological approaches targeting mitochondrial dynamics in skeletal muscle during obesity

(2015) Huei-Fen Jheng et al.   Annals of the New York Academy of Sciences

Stress as a fundamental theme in cell plasticity

(2015) Ofer Shoshani et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Sirtuin regulation in aging and injury

(2015) Ninu Poulose et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Obesity-Induced Hypertension: Interaction of Neurohumoral and Renal Mechanisms

(2015) J. E. Hall et al.   CIRCULATION RESEARCH

Obesity and fractures in postmenopausal women

(2015) Juliet Compston   CURRENT OPINION IN RHEUMATOLOGY

Adiposity, Obesity, and Arterial AgingNovelty and Significance

(2015) Eric J. Brunner et al.   HYPERTENSION

Pathological Role of Adipose Tissue Dysfunction in Cardio-Metabolic Disorders

(2015) Ippei Shimizu et al.   International Heart Journal

Models and mechanisms for hippocampal dysfunction in obesity and diabetes

(2015) A.M. Stranahan   NEUROSCIENCE

Intentional Weight Loss and All-Cause Mortality: A Meta-Analysis of Randomized Clinical Trials

(2015) Stephen B. Kritchevsky et al.   PLoS One

Exercise Attenuates the Major Hallmarks of Aging

(2015) Nuria Garatachea et al.   REJUVENATION RESEARCH

HIV/AIDS and lipodystrophy: Implications for clinical management in resource-limited settings

(2015) Julia L Finkelstein et al.   Journal of the International AIDS Society

Regional distribution of body fat in relation to DNA methylation within the LPL, ADIPOQ and PPARγ promoters in subcutaneous adipose tissue

(2015) D Drogan et al.   Nutrition & Diabetes

Inflammation triggers specific microRNA profiles in human adipocytes and macrophages and in their supernatants

(2015) Francisco José Ortega et al.   Clinical Epigenetics

The epigenetic signature of subcutaneous fat cells is linked to altered expression of genes implicated in lipid metabolism in obese women

(2015) Peter Arner et al.   Clinical Epigenetics

Relevance of Sympathetic Nervous System Activation in Obesity and Metabolic Syndrome

(2015) Alicia A. Thorp et al.   Journal of Diabetes Research

Vascular stiffness in insulin resistance and obesity

(2015) Guanghong Jia et al.   Frontiers in Physiology

BMI and risk of dementia in two million people over two decades: a retrospective cohort study

(2015) Nawab Qizilbash et al.   Lancet Diabetes & Endocrinology

Age-Associated Weight Gain, Leptin, and SIRT1: A Possible Role for Hypothalamic SIRT1 in the Prevention of Weight Gain and Aging through Modulation of Leptin Sensitivity

(2015) Tsutomu Sasaki   Frontiers in Endocrinology

Unlock the Thermogenic Potential of Adipose Tissue: Pharmacological Modulation and Implications for Treatment of Diabetes and Obesity

(2015) Xiao-Rong Peng et al.   Frontiers in Endocrinology

Control of Adipocyte Differentiation in Different Fat Depots; Implications for Pathophysiology or Therapy

(2015) Xiuquan Ma et al.   Frontiers in Endocrinology

Obesity and weight loss could alter the properties of adipose stem cells?

(2015) Leandra S Baptista   World Journal of Stem Cells

Altered Metabolic and Stemness Capacity of Adipose Tissue-Derived Stem Cells from Obese Mouse and Human

(2015) Laura M. Pérez et al.   PLoS One

Adipose tissue and its role in organ crosstalk

(2014) T. Romacho et al.   Acta Physiologica

Interrelationship among muscle, fat, and bone: Connecting the dots on cellular, hormonal, and whole body levels

(2014) Jasminka Z. Ilich et al.   AGEING RESEARCH REVIEWS

Physical Inactivity and Low Fitness Deserve More Attention to Alter Cancer Risk and Prognosis

(2014) F. Sanchis-Gomar et al.   Cancer Prevention Research

Mitochondrial Biogenesis in Health and Disease. Molecular and Therapeutic Approaches

(2014) Fabian Sanchis-Gomar et al.   CURRENT PHARMACEUTICAL DESIGN

Epigenetic adaptation to regular exercise in humans

(2014) Charlotte Ling et al.   DRUG DISCOVERY TODAY

Metabolically healthy obesity and the risk of cardiovascular disease and type 2 diabetes: the Whitehall II cohort study

(2014) Guy-Marino Hinnouho et al.   EUROPEAN HEART JOURNAL

Obesity and dementia: Adipokines interact with the brain

(2014) Ilse A.C. Arnoldussen et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Physical Fitness can Partly Explain the Metabolically Healthy Obese Phenotype in Women

(2014) F. Poelkens et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Adipose Tissue Immune Response: Novel Triggers and Consequences for Chronic Inflammatory Conditions

(2014) Giorgio Ghigliotti et al.   INFLAMMATION

Increasing Adiposity Is Associated With Higher Adipokine Levels and Lower Bone Mineral Density in Obese Older Adults

(2014) Lina Aguirre et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The impact of ageing on adipose structure, function and vasculature in the B6D2F1 mouse: evidence of significant multisystem dysfunction

(2014) Anthony J. Donato et al.   JOURNAL OF PHYSIOLOGY-LONDON

Metabolically-Healthy Obesity and Coronary Artery Calcification

(2014) Yoosoo Chang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Adipokines: a link between obesity and dementia?

(2014) Amanda J Kiliaan et al.   LANCET NEUROLOGY

Obesity as a risk factor for Alzheimer’s disease: the role of adipocytokines

(2014) Liliana Letra et al.   METABOLIC BRAIN DISEASE

Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source

(2014) You-Ying Chau et al.   NATURE CELL BIOLOGY

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

(2014) Jan Mauer et al.   NATURE IMMUNOLOGY

Stem cell aging: mechanisms, regulators and therapeutic opportunities

(2014) Juhyun Oh et al.   NATURE MEDICINE

Mitochondrial Fission and Fusion in Human Diseases

(2014)   NEW ENGLAND JOURNAL OF MEDICINE

Consequences of obesity and weight loss: a devil's advocate position

(2014) R. E. Brown et al.   Obesity Reviews

Metabolically healthy obesity and risk of incident type 2 diabetes: a meta-analysis of prospective cohort studies

(2014) J. A. Bell et al.   Obesity Reviews

Impact of Aging on the Regenerative Properties of Bone Marrow-, Muscle-, and Adipose-Derived Mesenchymal Stem/Stromal Cells

(2014) Olivia S. Beane et al.   PLoS One

Obesity accelerates epigenetic aging of human liver

(2014) S. Horvath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physical Exercise and Epigenetic Modulation: Elucidating Intricate Mechanisms

(2014) Helios Pareja-Galeano et al.   SPORTS MEDICINE

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

(2014) Diana Jurk et al.   Nature Communications

The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet

(2014) Sarah J. Mitchell et al.   Cell Reports

Osteosarcopenic obesity: the role of bone, muscle, and fat on health

(2014) Michael J. Ormsbee et al.   Journal of Cachexia Sarcopenia and Muscle

Are Metabolically Healthy Overweight and Obesity Benign Conditions?

(2013) Caroline K. Kramer et al.   ANNALS OF INTERNAL MEDICINE

Stem cells isolated from adipose tissue of obese patients show changes in their transcriptomic profile that indicate loss in stemcellness and increased commitment to an adipocyte-like phenotype

(2013) Blanca Oñate et al.   BMC GENOMICS

Intensive Lifestyle Intervention Improves Cardiometabolic and Exercise Parameters in Metabolically Healthy Obese and Metabolically Unhealthy Obese Individuals

(2013) Claudie Dalzill et al.   CANADIAN JOURNAL OF CARDIOLOGY

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging

(2013) Hung-Chun Chang et al.   CELL

Mechanisms and Metabolic Implications of Regional Differences among Fat Depots

(2013) Tamara Tchkonia et al.   Cell Metabolism

Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure

(2013) Marc Liesa et al.   Cell Metabolism

Medicinal Chemistry of the Epigenetic Diet and Caloric Restriction

(2013) S. Martin et al.   CURRENT MEDICINAL CHEMISTRY

The developmental origins of adipose tissue

(2013) Daniel C. Berry et al.   DEVELOPMENT

"Deficiency" of Mitochondria in Muscle Does Not Cause Insulin Resistance

(2013) J. O. Holloszy   DIABETES

Obesity Paradox Does Exist

(2013) V. Hainer et al.   DIABETES CARE

Differences in body composition between metabolically healthy obese and metabolically abnormal obese adults

(2013) S M Camhi et al.   INTERNATIONAL JOURNAL OF OBESITY

Gene expression profiling in subcutaneous, visceral and epigastric adipose tissues of patients with extreme obesity

(2013) G S Gerhard et al.   INTERNATIONAL JOURNAL OF OBESITY

Slow-Twitch Fiber Proportion in Skeletal Muscle Correlates With Insulin Responsiveness

(2013) Charles A. Stuart et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Adipose Inflammation in Obesity: Relationship With Circulating Levels of Inflammatory Markers and Association With Surgery-Induced Weight Loss

(2013) Julie Lasselin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Risk of Myocardial Infarction and Heart Failure Among Metabolically Healthy But Obese Individuals

(2013) Bjørn Mørkedal et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Relationship Between Obesity and Obesity-Related Morbidities Weakens With Aging

(2013) K. L. Canning et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Interplay between adipose tissue and blood vessels in obesity and vascular dysfunction

(2013) Ping Gu et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Causes, consequences, and treatment of osteoporosis in men

(2013) Jameela Banu   Drug Design Development and Therapy

Body Fat Distribution and Insulin Resistance

(2013) Pavankumar Patel et al.   Nutrients

Serum Brain-Derived Neurotrophic Factor and the Risk for Dementia

(2013) Galit Weinstein et al.   JAMA Neurology

Sirtuin-1 is a nutrient-dependent modulator of inflammation

(2013) Maya E. Kotas et al.   Adipocyte

Beyond Fat Grafting

(2012) Carrie A. Stransky et al.   ANNALS OF PLASTIC SURGERY

Adult stem cells: Simply a tool for regenerative medicine or an additional piece in the puzzle of human aging?

(2012) James R. Tollervey et al.   CELL CYCLE

p53-Induced Adipose Tissue Inflammation Is Critically Involved in the Development of Insulin Resistance in Heart Failure

(2012) Ippei Shimizu et al.   Cell Metabolism

High-Fat Diet Triggers Inflammation-Induced Cleavage of SIRT1 in Adipose Tissue To Promote Metabolic Dysfunction

(2012) Angeliki Chalkiadaki et al.   Cell Metabolism

The Intersection Between Aging and Cardiovascular Disease

(2012) Brian J. North et al.   CIRCULATION RESEARCH

Mechanical stimuli and bone health

(2012) Angela M. Cheung et al.   CURRENT OPINION IN RHEUMATOLOGY

The Critical Role of Metabolic Pathways in Aging

(2012) N. Barzilai et al.   DIABETES

Epigenetics

(2012) James R. Tollervey et al.   Epigenetics

The intriguing metabolically healthy but obese phenotype: cardiovascular prognosis and role of fitness

(2012) Francisco B. Ortega et al.   EUROPEAN HEART JOURNAL

The subcutaneous adipose tissue reservoir of functionally active stem cells is reduced in obese patients

(2012) Blanca Oñate et al.   FASEB JOURNAL

Metabolically Healthy Obesity and Risk of All-Cause and Cardiovascular Disease Mortality

(2012) Mark Hamer et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The aged niche disrupts muscle stem cell quiescence

(2012) Joe V. Chakkalakal et al.   NATURE

Inflammation, Adiposity, and Mortality in the Oldest Old

(2012) Inna Lisko et al.   REJUVENATION RESEARCH

Characterization of Human Adipose Tissue-Resident Hematopoietic Cell Populations Reveals a Novel Macrophage Subpopulation with CD34 Expression and Mesenchymal Multipotency

(2012) Hitomi Eto et al.   STEM CELLS AND DEVELOPMENT

Adipose tissue-resident immune cells: key players in immunometabolism

(2012) Henk S. Schipper et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The Developing, Aging Neocortex: How Genetics and Epigenetics Influence Early Developmental Patterning and Age-Related Change

(2012) Kelly Huffman   Frontiers in Genetics

The role of fatty acid metabolism and lipotoxicity in pancreatic β-cell injury: Identification of potential therapeutic targets

(2012) Haopeng Yang et al.   Acta Pharmaceutica Sinica B

“Is obesity linked to aging?”

(2011) Irene P. Tzanetakou et al.   AGEING RESEARCH REVIEWS

Heart Valve Structure and Function in Development and Disease

(2011) Robert B. Hinton et al.   Annual Review of Physiology

Edmonton Obesity Staging System: association with weight history and mortality risk

(2011) Jennifer L. Kuk et al.   Applied Physiology Nutrition and Metabolism

Epigenetic regulation of caloric restriction in aging

(2011) Yuanyuan Li et al.   BMC Medicine

The role of perivascular adipose tissue in vascular smooth muscle cell growth

(2011) Chao-Yu Miao et al.   BRITISH JOURNAL OF PHARMACOLOGY

SirT1 Regulates Adipose Tissue Inflammation

(2011) M. P. Gillum et al.   DIABETES

Immune cells in adipose tissue: Key players in metabolic disorders

(2011) K. Lolmède et al.   DIABETES & METABOLISM

Extending life span by increasing oxidative stress

(2011) Michael Ristow et al.   FREE RADICAL BIOLOGY AND MEDICINE

The redox stress hypothesis of aging

(2011) Rajindar S. Sohal et al.   FREE RADICAL BIOLOGY AND MEDICINE

Obesity paradox in elderly patients with cardiovascular diseases

(2011) Thomas E. Dorner et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Ectopic Lipid Accumulation and Reduced Glucose Tolerance in Elderly Adults Are Accompanied by Altered Skeletal Muscle Mitochondrial Activity

(2011) Darcy L. Johannsen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Impact of Obesity on Cardiovascular Disease

(2011) Kerstyn C. Zalesin et al.   MEDICAL CLINICS OF NORTH AMERICA

Mild Cognitive Impairment

(2011) Ronald C. Petersen   NEW ENGLAND JOURNAL OF MEDICINE

Incident Cardiovascular Disease Events in Metabolically Benign Obese Individuals

(2011) Alexandra D. Ogorodnikova et al.   Obesity

Effects of Weight Loss in Metabolically Healthy Obese Subjects after Laparoscopic Adjustable Gastric Banding and Hypocaloric Diet

(2011) Giorgio Sesti et al.   PLoS One

Human Adipose-Derived Stromal Cells Efficiently Support Hematopoiesis In Vitro and In Vivo: A Key Step for Therapeutic Studies

(2011) Fabienne De Toni et al.   STEM CELLS AND DEVELOPMENT

Macrophages, Meta-Inflammation, and Immuno-Metabolism

(2011) Haim Shapiro et al.   TheScientificWorldJOURNAL

Histone methylation makes its mark on longevity

(2011) Shuo Han et al.   TRENDS IN CELL BIOLOGY

SRT1720 improves survival and healthspan of obese mice

(2011) Robin K. Minor et al.   Scientific Reports

Effects of obesity on bone metabolism

(2011) Jay J Cao   Journal of Orthopaedic Surgery and Research

Tissue-specific dysregulation of DNA methylation in aging

(2010) Reid F. Thompson et al.   AGING CELL

Fat tissue, aging, and cellular senescence

(2010) Tamara Tchkonia et al.   AGING CELL

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

Do obese but metabolically normal women differ in intra-abdominal fat and physical activity levels from those with the expected metabolic abnormalities? A cross-sectional study

(2010) Louise Hayes et al.   BMC PUBLIC HEALTH

Obesity, Inflammation, and Cardiovascular Risk

(2010) P Mathieu et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Adipose tissue recruitment of leukocytes

(2010) Emily K Anderson et al.   CURRENT OPINION IN LIPIDOLOGY

Exercise for bone health: rationale and prescription

(2010) Pascale Schwab et al.   CURRENT OPINION IN RHEUMATOLOGY

Effects of Weight Loss Among Metabolically Healthy Obese Men and Women

(2010) P. M. Janiszewski et al.   DIABETES CARE

Prevalence, Metabolic Features, and Prognosis of Metabolically Healthy Obese Italian Individuals: The Cremona Study

(2010) G. Calori et al.   DIABETES CARE

Effects of a lifestyle intervention in metabolically benign and malign obesity

(2010) K. Kantartzis et al.   DIABETOLOGIA

Brown versus White Adipose Tissue: A Mini-Review

(2010) Christoph H. Saely et al.   GERONTOLOGY

Epigenetics and environment: a complex relationship

(2010) Oscar Aguilera et al.   JOURNAL OF APPLIED PHYSIOLOGY

Aging and Bone

(2010) A.L. Boskey et al.   JOURNAL OF DENTAL RESEARCH

Adiposity hormones and dementia

(2010) Deborah R. Gustafson   JOURNAL OF THE NEUROLOGICAL SCIENCES

Chronic Inflammation in Obesity and the Metabolic Syndrome

(2010) Rosário Monteiro et al.   MEDIATORS OF INFLAMMATION

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vascular basis for brain degeneration: faltering controls and risk factors for dementia

(2010) Raj N Kalaria   NUTRITION REVIEWS

Midlife and Late-Life Obesity and the Risk of Dementia

(2009) Annette L. Fitzpatrick et al.   ARCHIVES OF NEUROLOGY

Are Metabolically Normal but Obese Individuals at Lower Risk for All-Cause Mortality?

(2009) J. L. Kuk et al.   DIABETES CARE

Rapamycin Protects Against High Fat Diet–Induced Obesity in C57BL/6J Mice

(2009) Geng-Ruei Chang et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Influence of Age on the Association Between Various Measures of Obesity and All-Cause Mortality

(2009) Jennifer L. Kuk et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Biological Approaches to Mechanistically Understand the Healthy Life Span Extension Achieved by Calorie Restriction and Modulation of Hormones

(2009) N. Barzilai et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

A paradigm of integrative physiology, the crosstalk between bone and energy metabolisms

(2009) Cyrille B. Confavreux et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Adipose tissue as an endocrine organ

(2009) Sandra Galic et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

A crucial role for adipose tissue p53 in the regulation of insulin resistance

(2009) Tohru Minamino et al.   NATURE MEDICINE

Connecting obesity, aging and diabetes

(2009) Rexford S. Ahima   NATURE MEDICINE

Adiposity indicators and dementia over 32 years in Sweden

(2009) D. R. Gustafson et al.   NEUROLOGY

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

Molecular inflammation: Underpinnings of aging and age-related diseases

(2008) Hae Young Chung et al.   AGEING RESEARCH REVIEWS

Visceral adipose tissue modulates mammalian longevity

(2008) Radhika Muzumdar et al.   AGING CELL

The Obese Without Cardiometabolic Risk Factor Clustering and the Normal Weight With Cardiometabolic Risk Factor Clustering

(2008) Rachel P. Wildman   ARCHIVES OF INTERNAL MEDICINE

Stems Cells and the Pathways to Aging and Cancer

(2008) Derrick J. Rossi et al.   CELL

Conserved Metabolic Regulatory Functions of Sirtuins

(2008) Bjoern Schwer et al.   Cell Metabolism

Metabolically healthy but obese women: effect of an energy-restricted diet

(2008) A. D. Karelis et al.   DIABETOLOGIA

Role of the GH/IGF-1 axis in lifespan and healthspan: Lessons from animal models

(2008) Darlene E. Berryman et al.   GROWTH HORMONE & IGF RESEARCH

Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength

(2008) Xiaodong Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding

(2008) Vered Elgazar-Carmon et al.   JOURNAL OF LIPID RESEARCH

The aging kidney

(2008) Xin J. Zhou et al.   KIDNEY INTERNATIONAL

Metabolically healthy but obese individuals

(2008) Antony D Karelis   LANCET

SIRT1 Exerts Anti-Inflammatory Effects and Improves Insulin Sensitivity in Adipocytes

(2008) T. Yoshizaki et al.   MOLECULAR AND CELLULAR BIOLOGY

BDNF is a novel marker of cognitive function in ageing women: The DR’s EXTRA Study

(2008) Pirjo Komulainen et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Central obesity and increased risk of dementia more than three decades later

(2008) R. A. Whitmer et al.   NEUROLOGY

Vascular aging: insights from studies on cellular senescence, stem cell aging and progeroid syndromes

(2008) Tohru Minamino et al.   Nature clinical practice. Cardiovascular medicine

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

(2007) Colin Selman et al.   FASEB JOURNAL