Immune system and new avenues in Parkinson’s disease research and treatment

Cerebrolysin attenuates hyperalgesia, photophobia, and neuroinflammation in a nitroglycerin-induced migraine model in rats

(2018) Javad Mahmoudi et al.   BRAIN RESEARCH BULLETIN

CRISPR and personalized Treg therapy: new insights into the treatment of rheumatoid arthritis

(2018) Fatemeh Safari et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Immunologic treatment of Parkinson's disease

(2018) Joseph Jankovic   Immunotherapy

Niacin modulates macrophage polarization in Parkinson's disease

(2018) Chandramohan Wakade et al.   JOURNAL OF NEUROIMMUNOLOGY

Neurotrophic factors hold promise for the future of Parkinson’s disease treatment: is there a light at the end of the tunnel?

(2018) Ava Nasrolahi et al.   REVIEWS IN THE NEUROSCIENCES

Autoantibodies Against Amyloid and Glial-Derived Antigens are Increased in Serum and Cerebrospinal Fluid of Lewy Body-Associated Dementias

(2018) Walter Maetzler et al.   JOURNAL OF ALZHEIMERS DISEASE

The role of T cells in the pathogenesis of Parkinson’s disease

(2018) Zhichun Chen et al.   PROGRESS IN NEUROBIOLOGY

Increase in seizure susceptibility in sepsis like condition explained by spiking cytokines and altered adhesion molecules level with impaired blood brain barrier integrity in experimental model of rats treated with lipopolysaccharides

(2017) Rakesh K. Sewal et al.   EPILEPSY RESEARCH

Therapeutic approaches to target alpha-synuclein pathology

(2017) Patrik Brundin et al.   EXPERIMENTAL NEUROLOGY

Alpha-synuclein and iron: two keys unlocking Parkinson’s disease

(2017) Paul Lingor et al.   JOURNAL OF NEURAL TRANSMISSION

Homologous HSV1 and alpha-synuclein peptides stimulate a T cell response in Parkinson's disease

(2017) E. Caggiu et al.   JOURNAL OF NEUROIMMUNOLOGY

MHC class II expression and potential antigen-presenting cells in the retina during experimental autoimmune uveitis

(2017) Deborah A. Lipski et al.   Journal of Neuroinflammation

The role of regulatory T cells in nervous system pathologies

(2017) Samuel S. Duffy et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Reduced Activated T Lymphocytes (CD4+CD25+) and Plasma Levels of Cytokines in Parkinson’s Disease

(2017) Natalia Pessoa Rocha et al.   MOLECULAR NEUROBIOLOGY

Autoimmune antibody decline in Parkinson’s disease and Multiple System Atrophy; a step towards immunotherapeutic strategies

(2017) Tomasz Brudek et al.   Molecular Neurodegeneration

Novel tactics for neuroprotection in Parkinson's disease: Role of antibiotics, polyphenols and neuropeptides

(2017) Dora Reglodi et al.   PROGRESS IN NEUROBIOLOGY

Targets and Mechanisms in Prevention of Parkinson's Disease through Immunomodulatory Treatments

(2017) M. von Euler Chelpin et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Parkinson's disease-associated genetic variation is linked to quantitative expression of inflammatory genes

(2017) Steven Pierce et al.   PLoS One

Effect of adenosine A2A receptor antagonists on motor disorders induced by 6-hydroxydopamine in rat

(2016) Siamak Reyhani-Rad et al.   Acta Cirurgica Brasileira

Parkinson's disease: Autoimmunity and neuroinflammation

(2016) Armando De Virgilio et al.   AUTOIMMUNITY REVIEWS

Effect of the pituitary adenylate cyclase-activating polypeptide on the autophagic activation observed in in vitro and in vivo models of Parkinson's disease

(2016) Asma Lamine-Ajili et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Parkinson’s Disease-Related Proteins PINK1 and Parkin Repress Mitochondrial Antigen Presentation

(2016) Diana Matheoud et al.   CELL

Nurr1-Based Therapies for Parkinson's Disease

(2016) Jie Dong et al.   CNS Neuroscience & Therapeutics

Pituitary adenylate cyclase-activating polypeptide (PACAP) has a neuroprotective function in dopamine-based neurodegeneration in rat and snail parkinsonian models

(2016) Gabor Maasz et al.   Disease Models & Mechanisms

The clinical symptoms of Parkinson's disease

(2016) Sigurlaug Sveinbjornsdottir   JOURNAL OF NEUROCHEMISTRY

Microglia across the lifespan: from origin to function in brain development, plasticity and cognition

(2016) Tuan Leng Tay et al.   JOURNAL OF PHYSIOLOGY-LONDON

Th17 Cells Induce Dopaminergic Neuronal Death via LFA-1/ICAM-1 Interaction in a Mouse Model of Parkinson’s Disease

(2016) Zhan Liu et al.   MOLECULAR NEUROBIOLOGY

Advances in GBA-associated Parkinson's disease – Pathology, presentation and therapies

(2016) Melinda Barkhuizen et al.   NEUROCHEMISTRY INTERNATIONAL

Post-translational modification of α-synuclein in Parkinson׳s disease

(2015) Paul J. Barrett et al.   BRAIN RESEARCH

Microglial M1/M2 polarization and metabolic states

(2015) Ruben Orihuela et al.   BRITISH JOURNAL OF PHARMACOLOGY

Neuroinflammation in Parkinson's disease: role in neurodegeneration and tissue repair

(2015) Sayinthen Vivekanantham et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Docosahexaenoic Acid Alleviates Atopic Dermatitis by Generating Tregs and IL-10/TGF-β-Modified Macrophages via a TGF-β-Dependent Mechanism

(2015) Sang-Chul Han et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Granulocyte-Macrophage Colony Stimulating Factor Exerts Protective and Immunomodulatory Effects in Cortical Trauma

(2015) Matthew L. Kelso et al.   JOURNAL OF NEUROIMMUNOLOGY

Selective VIP Receptor Agonists Facilitate Immune Transformation for Dopaminergic Neuroprotection in MPTP-Intoxicated Mice

(2015) K. E. Olson et al.   JOURNAL OF NEUROSCIENCE

Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy

(2015) Markus Mandler et al.   Molecular Neurodegeneration

FK506 reduces neuroinflammation and dopaminergic neurodegeneration in an α-synuclein-based rat model for Parkinson's disease

(2015) Anke Van der Perren et al.   NEUROBIOLOGY OF AGING

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

M1 and M2 immune activation in Parkinson’s Disease: Foe and ally?

(2015) M.S. Moehle et al.   NEUROSCIENCE

Immunotherapy in Parkinson’s Disease: Micromanaging Alpha-Synuclein Aggregation

(2015) Sonia George et al.   Journal of Parkinsons Disease

Neuroinflammation in Parkinson’s disease and its potential as therapeutic target

(2015) Qinqin Wang et al.   Translational Neurodegeneration

Next-generation active immunization approach for synucleinopathies: implications for Parkinson’s disease clinical trials

(2014) Markus Mandler et al.   ACTA NEUROPATHOLOGICA

PACAP27 prevents Parkinson-like neuronal loss and motor deficits but not microglia activation induced by prostaglandin J2

(2014) Kai-Yvonne Shivers et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

CD200R1 and CD200 expression are regulated by PPAR-γ in activated glial cells

(2014) Guido Dentesano et al.   GLIA

Potent Anti-Inflammatory and Neuroprotective Effects of TGF- 1 Are Mediated through the Inhibition of ERK and p47phox-Ser345 Phosphorylation and Translocation in Microglia

(2014) L. Qian et al.   JOURNAL OF IMMUNOLOGY

Dynamic changes in pro- and anti-inflammatory cytokines in microglia after PPAR-γ agonist neuroprotective treatment in the MPTPp mouse model of progressive Parkinson's disease

(2014) Augusta Pisanu et al.   NEUROBIOLOGY OF DISEASE

Naturally Occurring Alpha-Synuclein Autoantibodies in Parkinson’s Disease: Sources of (Error) Variance in Biomarker Assays

(2014) Sebastian Heinzel et al.   PLoS One

MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration

(2014) Carolina Cebrián et al.   Nature Communications

An impedimetric assay of α-synuclein autoantibodies in early stage Parkinson's disease

(2014) Qiao Xu et al.   RSC Advances

α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration

(2014) Hien T. Tran et al.   Cell Reports

Association of Parkinson Disease with Structural and Regulatory Variants in the HLA Region

(2013) William T. Wissemann et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

The role of inflammation in sporadic and familial Parkinson’s disease

(2013) Michela Deleidi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The hallmarks of Parkinson's disease

(2013) Paul M. A. Antony et al.   FEBS Journal

Therapeutic Efficacy of Suppressing the JAK/STAT Pathway in Multiple Models of Experimental Autoimmune Encephalomyelitis

(2013) Y. Liu et al.   JOURNAL OF IMMUNOLOGY

DJ-1 deficiency triggers microglia sensitivity to dopamine toward a pro-inflammatory phenotype that is attenuated by rasagiline

(2013) Dorit Trudler et al.   JOURNAL OF NEUROCHEMISTRY

GM-CSF induces neuroprotective and anti-inflammatory responses in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine intoxicated mice

(2013) Lisa M. Kosloski et al.   JOURNAL OF NEUROIMMUNOLOGY

MHCII Is Required for  -Synuclein-Induced Activation of Microglia, CD4 T Cell Proliferation, and Dopaminergic Neurodegeneration

(2013) A. S. Harms et al.   JOURNAL OF NEUROSCIENCE

Role and Mechanism of Microglial Activation in Iron-Induced Selective and Progressive Dopaminergic Neurodegeneration

(2013) Wei Zhang et al.   MOLECULAR NEUROBIOLOGY

PACAP promotes neuron survival in early experimental diabetic retinopathy

(2013) Krisztina Szabadfi et al.   NEUROCHEMISTRY INTERNATIONAL

Immune effects of optimized DNA vaccine and protective effects in a MPTP model of Parkinson’s disease

(2013) Zhongmei Chen et al.   NEUROLOGICAL SCIENCES

Microglia, Amyloid and Glucose Metabolism in Parkinson’s Disease with and without Dementia

(2013) Paul Edison et al.   NEUROPSYCHOPHARMACOLOGY

Pre-treatment with silymarin reduces brain myeloperoxidase activity and inflammatory cytokines in 6-OHDA hemi-parkinsonian rats

(2013) Rasool Haddadi et al.   NEUROSCIENCE LETTERS

Neuromelanin of the Human Substantia Nigra: An Update

(2013) Fabio A. Zucca et al.   NEUROTOXICITY RESEARCH

The HLA-DRA variation rs3129882 is not associated with Parkinson's disease in Sweden

(2013) Caroline Ran et al.   PARKINSONISM & RELATED DISORDERS

Immunotherapy for neurodegenerative diseases: Focus on α-synucleinopathies

(2013) Elvira Valera et al.   PHARMACOLOGY & THERAPEUTICS

Triggering of Inflammasome by Aggregated α–Synuclein, an Inflammatory Response in Synucleinopathies

(2013) Gaia Codolo et al.   PLoS One

PINK1 Deficiency Enhances Inflammatory Cytokine Release from Acutely Prepared Brain Slices

(2013) Jun Kim et al.   Experimental Neurobiology

Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synuclein

(2012) Melanie B. Watson et al.   EXPERIMENTAL NEUROLOGY

Pathogenic and physiological autoantibodies in the central nervous system

(2012) Maike Gold et al.   IMMUNOLOGICAL REVIEWS

PACAP is an Endogenous Protective Factor—Insights from PACAP-Deficient Mice

(2012) D. Reglodi et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

LRRK2 Inhibition Attenuates Microglial Inflammatory Responses

(2012) M. S. Moehle et al.   JOURNAL OF NEUROSCIENCE

The link between the GBA gene and parkinsonism

(2012) Ellen Sidransky et al.   LANCET NEUROLOGY

Association between Parkinson's disease and the HLA-DRB1 locus

(2012) Ismaïl Ahmed et al.   MOVEMENT DISORDERS

Correlation between Protective Immunity to a-Synuclein Aggregates, Oxidative Stress and Inflammation

(2012) Marina A. Gruden et al.   NEUROIMMUNOMODULATION

Naturally occurring  -synuclein autoantibody levels are lower in patients with Parkinson disease

(2012) D. Besong-Agbo et al.   NEUROLOGY

α-Synuclein and Anti-α-Synuclein Antibodies in Parkinson’s Disease, Atypical Parkinson Syndromes, REM Sleep Behavior Disorder, and Healthy Controls

(2012) Lynnae M. Smith et al.   PLoS One

An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1

(2012) S. Guareschi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gaucher disease gene GBA functions in immune regulation

(2012) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The robust electrochemical detection of a Parkinson's disease marker in whole blood sera

(2012) Thomas Bryan et al.   Chemical Science

VIP in Neurological Diseases: More Than A Neuropeptide

(2012) Maria Morell et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

IL-21 and IL-21 Receptor Expression in Lymphocytes and Neurons in Multiple Sclerosis Brain

(2011) John S. Tzartos et al.   AMERICAN JOURNAL OF PATHOLOGY

Vasoactive intestinal peptide: a neuropeptide with pleiotropic immune functions

(2011) Mario Delgado et al.   AMINO ACIDS

Neuromelanin is an immune stimulator for dendritic cells in vitro

(2011) Uwe Oberländer et al.   BMC NEUROSCIENCE

Increase expression of α-synuclein in aged human brain associated with neuromelanin accumulation

(2011) Qi Xuan et al.   JOURNAL OF NEURAL TRANSMISSION

Priorities in Parkinson's disease research

(2011) Wassilios G. Meissner et al.   NATURE REVIEWS DRUG DISCOVERY

Rosiglitazone decreases peroxisome proliferator receptor-gamma levels in microglia and inhibits TNF-alpha production: new evidences on neuroprotection in a progressive Parkinson's disease model

(2011) A.R. Carta et al.   NEUROSCIENCE

Increased Mitochondrial Calcium Sensitivity and Abnormal Expression of Innate Immunity Genes Precede Dopaminergic Defects in Pink1-Deficient Mice

(2011) Ravi S. Akundi et al.   PLoS One

α-Synuclein Reactive Antibodies as Diagnostic Biomarkers in Blood Sera of Parkinson's Disease Patients

(2011) Kiran Yanamandra et al.   PLoS One

Evidence for More than One Parkinson's Disease-Associated Variant within the HLA Region

(2011) Erin M. Hill-Burns et al.   PLoS One

Features of Microglia and Neuroinflammation Relevant to Environmental Exposure and Neurotoxicity

(2011) Andrew D. Kraft et al.   International Journal of Environmental Research and Public Health

Compacted DNA Nanoparticle Gene Transfer of GDNF to the Rat Striatum Enhances the Survival of Grafted Fetal Dopamine Neurons

(2010) David M. Yurek et al.   CELL TRANSPLANTATION

Inflammation in neurodegenerative diseases

(2010) Sandra Amor et al.   IMMUNOLOGY

Mitochondrial dysfunction: A potential link between neuroinflammation and neurodegeneration?

(2010) Maarten E. Witte et al.   MITOCHONDRION

Delayed Dominant-Negative TNF Gene Therapy Halts Progressive Loss of Nigral Dopaminergic Neurons in a Rat Model of Parkinson's Disease

(2010) Ashley S Harms et al.   MOLECULAR THERAPY

Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease

(2010) Taye H Hamza et al.   NATURE GENETICS

Parkinson's Disease-Related Protein, α-Synuclein, in Malignant Melanoma

(2010) Yasuhiro Matsuo et al.   PLoS One

A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death

(2009) Kaoru Saijo et al.   CELL

Pituitary Adenylate Cyclase-Activating Polypeptide: Focus on Structure- Activity Relationships of a Neuroprotective Peptide

(2009) S. Bourgault et al.   CURRENT MEDICINAL CHEMISTRY

WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease

(2009) David A. Price et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Anti-melanin antibodies are increased in sera in Parkinson's disease

(2009) K.L. Double et al.   EXPERIMENTAL NEUROLOGY

Regulation of astrocyte inflammatory responses by the Parkinson’s disease-associated gene DJ-1

(2009) Jens Waak et al.   FASEB JOURNAL

Interleukin-10: new perspectives on an old cytokine

(2009) David M. Mosser et al.   IMMUNOLOGICAL REVIEWS

Nitrated  -Synuclein-Induced Alterations in Microglial Immunity Are Regulated by CD4+ T Cell Subsets

(2009) A. D. Reynolds et al.   JOURNAL OF IMMUNOLOGY

Nurr1 Is Required for Maintenance of Maturing and Adult Midbrain Dopamine Neurons

(2009) B. Kadkhodaei et al.   JOURNAL OF NEUROSCIENCE

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

(2009) Etienne C Hirsch et al.   LANCET NEUROLOGY

Chronic expression of low levels of tumor necrosis factor-α in the substantia nigra elicits progressive neurodegeneration, delayed motor symptoms and microglia/macrophage activation

(2009) Ana Laura De Lella Ezcurra et al.   NEUROBIOLOGY OF DISEASE

Nurr1 Expression and Its Modulation in Microglia

(2009) Xiaolan Fan et al.   NEUROIMMUNOMODULATION

Neuromelanin Activates Microglia and Induces Degeneration of Dopaminergic Neurons: Implications for Progression of Parkinson’s Disease

(2009) Wei Zhang et al.   NEUROTOXICITY RESEARCH

[11C]-PK11195 PET: Quantification of neuroinflammation and a monitor of anti-inflammatory treatment in Parkinson's disease?

(2009) A.L. Bartels et al.   PARKINSONISM & RELATED DISORDERS

Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the Discovery

(2009) D. Vaudry et al.   PHARMACOLOGICAL REVIEWS

Human neuromelanin induces neuroinflammation and neurodegeneration in the rat substantia nigra: implications for Parkinson's disease

(2008) Luigi Zecca et al.   ACTA NEUROPATHOLOGICA

Targeted Overexpression of Human α-Synuclein Triggers Microglial Activation and an Adaptive Immune Response in a Mouse Model of Parkinson Disease

(2008) Shaji Theodore et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Parkin Deficiency Increases Vulnerability to Inflammation-Related Nigral Degeneration

(2008) T. C. Frank-Cannon et al.   JOURNAL OF NEUROSCIENCE

Intranigral Lentiviral Delivery of Dominant-negative TNF Attenuates Neurodegeneration and Behavioral Deficits in Hemiparkinsonian rats

(2008) Melissa K McCoy et al.   MOLECULAR THERAPY

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS

Nitrated α–Synuclein Immunity Accelerates Degeneration of Nigral Dopaminergic Neurons

(2008) Eric J. Benner et al.   PLoS One

DJ-1 Modulates α-Synuclein Aggregation State in a Cellular Model of Oxidative Stress: Relevance for Parkinson's Disease and Involvement of HSP70

(2008) Sara Batelli et al.   PLoS One

Synuclein activates microglia in a model of Parkinson's disease

(2007) Xiaomin Su et al.   NEUROBIOLOGY OF AGING