Targets and Mechanisms in Prevention of Parkinson's Disease through Immunomodulatory Treatments

Isobavachalcone Attenuates MPTP-Induced Parkinson's Disease in Mice by Inhibition of Microglial Activation through NF-κB Pathway

(2017) Haoran Jing et al.   PLoS One

Toll-like receptor 2 is increased in neurons in Parkinson’s disease brain and may contribute to alpha-synuclein pathology

(2016) Nicolas Dzamko et al.   ACTA NEUROPATHOLOGICA

IMMUNOMODULATORY FACTOR INDUCED BY GA MEDIATES MACROPHAGE CLEARANCE OF PATHOGENIC AB FORMS AND ENHANCES SYNAPTIC PRESERVATION

(2016) Koronyo-Hamaoui Maya et al.   Alzheimers & Dementia

Effect of glatiramer acetate on short-term memory impairment induced by lipopolysaccharide in male mice

(2016) Fatemeh Mohammadi et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Glatiramer acetate treatment normalized the monocyte activation profile in MS patients to that of healthy controls

(2016) Delgertsetseg Chuluundorj et al.   IMMUNOLOGY AND CELL BIOLOGY

Neuroinflammation: the devil is in the details

(2016) Damon J. DiSabato et al.   JOURNAL OF NEUROCHEMISTRY

Vitamin D Treatment Attenuates Neuroinflammation and Dopaminergic Neurodegeneration in an Animal Model of Parkinson’s Disease, Shifting M1 to M2 Microglia Responses

(2016) Rosa Calvello et al.   Journal of Neuroimmune Pharmacology

Tollip, an early regulator of the acute inflammatory response in the substantia nigra

(2016) Marie Humbert-Claude et al.   Journal of Neuroinflammation

Inhibition of the JAK/STAT Pathway Protects Against α-Synuclein-Induced Neuroinflammation and Dopaminergic Neurodegeneration

(2016) Hongwei Qin et al.   JOURNAL OF NEUROSCIENCE

FTY720 Attenuates 6-OHDA-Associated Dopaminergic Degeneration in Cellular and Mouse Parkinsonian Models

(2016) Manru Ren et al.   NEUROCHEMICAL RESEARCH

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4

(2015) James T. Walsh et al.   JOURNAL OF CLINICAL INVESTIGATION

A Perspective on Roles Played by Innate and Adaptive Immunity in the Pathobiology of Neurodegenerative Disorders

(2015) Howard E. Gendelman et al.   Journal of Neuroimmune Pharmacology

Breaking immune tolerance by targeting Foxp3+ regulatory T cells mitigates Alzheimer’s disease pathology

(2015) Kuti Baruch et al.   Nature Communications

Evaluation of an α synuclein sensitized dendritic cell based vaccine in a transgenic mouse model of Parkinson disease

(2015) Kenneth E Ugen et al.   Human Vaccines & Immunotherapeutics

Neuroinflammation in Parkinson’s disease and its potential as therapeutic target

(2015) Qinqin Wang et al.   Translational Neurodegeneration

Natural Naive CD4 + CD25 + CD127 low Regulatory T Cell (Treg) Development and Function Are Disturbed in Multiple Sclerosis Patients: Recovery of Memory Treg Homeostasis during Disease Progression

(2014) Koen Venken et al.   JOURNAL OF IMMUNOLOGY

Structural Insight into the Function of Myelin Basic Protein as a Ligand for Integrin  M 2

(2014) R. Stapulionis et al.   JOURNAL OF IMMUNOLOGY

Restoration of axon conduction and motor deficits by therapeutic treatment with glatiramer acetate

(2014) Spencer Moore et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Microglial Dynamics and Role in the Healthy and Diseased Brain

(2014) Diego Gomez-Nicola et al.   NEUROSCIENTIST

Vaccination strategies for Parkinson disease

(2014) Marina Romero-Ramos et al.   Human Vaccines & Immunotherapeutics

Neuroimmunological Processes in Parkinson's Disease and their Relation to α-Synuclein: Microglia as the Referee between Neuronal Processes and Peripheral Immunity

(2013) Vanesa Sanchez-Guajardo et al.   ASN Neuro

Gene expression analysis reveals functional pathways of glatiramer acetate activation

(2013) Shlomo Bakshi et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Glatiramer Acetate Protects Against Inflammatory Synaptopathy in Experimental Autoimmune Encephalomyelitis

(2013) Antonietta Gentile et al.   Journal of Neuroimmune Pharmacology

α-Synuclein Vaccination Prevents the Accumulation of Parkinson Disease-Like Pathologic Inclusions in Striatum in Association With Regulatory T Cell Recruitment in a Rat Model

(2013) Vanesa Sanchez-Guajardo et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Bacillus Calmette-Guerin vaccine-mediated neuroprotection is associated with regulatory T-cell induction in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

(2013) Goran Laćan et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Immunogenicity of epitope vaccines targeting different B cell antigenic determinants of human α-synuclein: Feasibility study

(2013) Anahit Ghochikyan et al.   NEUROSCIENCE LETTERS

Immunotherapy for neurodegenerative diseases: Focus on α-synucleinopathies

(2013) Elvira Valera et al.   PHARMACOLOGY & THERAPEUTICS

Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

(2013) Changyoun Kim et al.   Nature Communications

Lipid Peroxidation Product 4-Hydroxy-2-Nonenal Promotes Seeding-Capable Oligomer Formation and Cell-to-Cell Transfer of α-Synuclein

(2012) Eun-Jin Bae et al.   ANTIOXIDANTS & REDOX SIGNALING

Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia

(2012) Lisa Fellner et al.   GLIA

Glatiramer Acetate in Treatment of Multiple Sclerosis: A Toolbox of Random Co-Polymers for Targeting Inflammatory Mechanisms of both the Innate and Adaptive Immune System?

(2012) Babak Jalilian et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

(2012) Kelvin C. Luk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD4+ Regulatory and Effector/Memory T Cell Subsets Profile Motor Dysfunction in Parkinson’s Disease

(2012) Jessica A. Hutter Saunders et al.   Journal of Neuroimmune Pharmacology

Glatiramer Acetate administration does not reduce damage after cerebral ischemia in mice

(2012) Marine Poittevin et al.   JOURNAL OF NEUROIMMUNOLOGY

Antibody-Aided Clearance of Extracellular  -Synuclein Prevents Cell-to-Cell Aggregate Transmission

(2012) E.-J. Bae et al.   JOURNAL OF NEUROSCIENCE

Alpha-synuclein transgenic mice display age-related slowing of gastrointestinal motility associated with transgene expression in the vagal system

(2012) Ali Reza Noorian et al.   NEUROBIOLOGY OF DISEASE

Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms

(2012) Weihua Zhao et al.   NEUROBIOLOGY OF DISEASE

Alpha-Synuclein Cell-to-Cell Transfer and Seeding in Grafted Dopaminergic Neurons In Vivo

(2012) Elodie Angot et al.   PLoS One

Expression of mutant alpha-synuclein modulates microglial phenotype in vitro

(2011) Lalida Rojanathammanee et al.   Journal of Neuroinflammation

Vaccination for Parkinson's disease

(2011) A. Schneeberger et al.   PARKINSONISM & RELATED DISORDERS

Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease

(2011) Eliezer Masliah et al.   PLoS One

Regulatory T Cells Attenuate Th17 Cell-Mediated Nigrostriatal Dopaminergic Neurodegeneration in a Model of Parkinson’s Disease

(2010) Ashley D. Reynolds et al.   JOURNAL OF IMMUNOLOGY

Glatiramer Acetate Modulates TNF-α and IL-10 Secretion in Microglia and Promotes Their Phagocytic Activity

(2010) Refik Pul et al.   Journal of Neuroimmune Pharmacology

Apoptosis of peripheral blood lymphocytes in Parkinson patients

(2010) Màtil Calopa et al.   NEUROBIOLOGY OF DISEASE

Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

(2010) Venu M. Nemani et al.   NEURON

Innate and Adaptive Immunity for the Pathobiology of Parkinson's Disease

(2009) David K. Stone et al.   ANTIOXIDANTS & REDOX SIGNALING

A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death

(2009) Kaoru Saijo et al.   CELL

Induction of CD4+CD25+Foxp3+ regulatory T cell response by glatiramer acetate in type 1 diabetes

(2009) Guoliang Cui et al.   CELL RESEARCH

The glatiramoid class of immunomodulator drugs

(2009) Haim Varkony et al.   EXPERT OPINION ON PHARMACOTHERAPY

Glatiramer acetate improves regulatory T-cell function by expansion of naive CD4+CD25+FOXP3+CD31+ T-cells in patients with multiple sclerosis

(2009) Juergen Haas et al.   JOURNAL OF NEUROIMMUNOLOGY

Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment

(2009) K Ray Chaudhuri et al.   LANCET NEUROLOGY

Molecular mechanisms of α-synuclein neurodegeneration

(2008) Elisa A. Waxman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Toll-like receptors in neurodegeneration

(2008) Eitan Okun et al.   BRAIN RESEARCH REVIEWS

Parkinson's disease: clinical features and diagnosis

(2008) J Jankovic   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Glatiramer acetate positively influences spinal motoneuron survival and synaptic plasticity after ventral root avulsion

(2008) Juliana Milani Scorisa et al.   NEUROSCIENCE LETTERS

α-Synuclein and Polyunsaturated Fatty Acids Promote Clathrin-Mediated Endocytosis and Synaptic Vesicle Recycling

(2008) Tziona Ben Gedalya et al.   TRAFFIC

Synuclein activates microglia in a model of Parkinson's disease

(2007) Xiaomin Su et al.   NEUROBIOLOGY OF AGING