The hallmarks of Parkinson's disease

Light microscopy applications in systems biology: opportunities and challenges

(2013) Paul Michel Aloyse Antony et al.   Cell Communication and Signaling

The genetics of Parkinson's disease: Progress and therapeutic implications

(2013) Andrew B. Singleton et al.   MOVEMENT DISORDERS

The pathology roadmap in Parkinson disease

(2013) D. James Surmeier et al.   Prion

Mitochondrial Biology and Parkinson's Disease

(2013) C. Perier et al.   Cold Spring Harbor Perspectives in Medicine

Genetics of Parkinson's Disease

(2013) C. Klein et al.   Cold Spring Harbor Perspectives in Medicine

Somatic mitochondrial DNA mutations in early parkinson and incidental lewy body disease

(2012) Michael T. Lin et al.   ANNALS OF NEUROLOGY

Induced pluripotent stem cell research: A revolutionary approach to face the challenges in drug screening

(2012) Minjung Song et al.   ARCHIVES OF PHARMACAL RESEARCH

Lysosomal dysfunction in Parkinson disease

(2012) Benjamin Dehay et al.   Autophagy

Hypokinesia without decrement distinguishes progressive supranuclear palsy from Parkinson's disease

(2012) Helen Ling et al.   BRAIN

From α-synuclein to synaptic dysfunctions: New insights into the pathophysiology of Parkinson's disease

(2012) Arianna Bellucci et al.   BRAIN RESEARCH

PLA2G6 Mutations and Other Rare Causes of Neurodegeneration with Brain Iron Accumulation

(2012) Alisdair McNeill   CURRENT DRUG TARGETS

Chelating Agents for Neurodegenerative Diseases

(2012) R. J. Ward et al.   CURRENT MEDICINAL CHEMISTRY

Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences

(2012) Nicole Exner et al.   EMBO JOURNAL

Cell metabolism affects selective vulnerability in PINK1-associated Parkinson's disease

(2012) Zhi Yao et al.   JOURNAL OF CELL SCIENCE

Neuronal vulnerability, pathogenesis, and Parkinson's disease

(2012) David Sulzer et al.   MOVEMENT DISORDERS

Parkinson's disease: Evidence for environmental risk factors

(2012) Karl Kieburtz et al.   MOVEMENT DISORDERS

Identifying prodromal Parkinson's disease: Pre-Motor disorders in Parkinson's disease

(2012) Ronald B. Postuma et al.   MOVEMENT DISORDERS

Living on the edge with too many mouths to feed: Why dopamine neurons die

(2012) J. Paul Bolam et al.   MOVEMENT DISORDERS

Astrocyte-derived GDNF is a potent inhibitor of microglial activation

(2012) Sandra Moreira Rocha et al.   NEUROBIOLOGY OF DISEASE

Iron dysregulation in movement disorders

(2012) Petr Dusek et al.   NEUROBIOLOGY OF DISEASE

Genetics and iron in the systems biology of Parkinson’s disease and some related disorders

(2012) Claudia Funke et al.   NEUROCHEMISTRY INTERNATIONAL

Monogenic Mitochondrial Disorders

(2012) Werner J.H. Koopman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice

(2012) Francisco Pan-Montojo et al.   Scientific Reports

PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy

(2012) Kahori Shiba-Fukushima et al.   Scientific Reports

Solvent exposures and parkinson disease risk in twins

(2011) Samuel M. Goldman et al.   ANNALS OF NEUROLOGY

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

(2011) Jisun Lee et al.   BIOCHEMICAL JOURNAL

Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies

(2011) Joseph R. Mazzulli et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

From Systems Biology to Systems Biomedicine

(2011) Paul MA Antony et al.   CURRENT OPINION IN BIOTECHNOLOGY

Epidemiology and etiology of Parkinson’s disease: a review of the evidence

(2011) Karin Wirdefeldt et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Parkinson disease: Insights in clinical, genetic and pathological features of monogenic disease subtypes

(2011) David Crosiers et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Parkinson’s disease mouse models in translational research

(2011) Paul M. A. Antony et al.   MAMMALIAN GENOME

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

Alpha-synuclein release by neurons activates the inflammatory response in a microglial cell line

(2011) Lydia Alvarez-Erviti et al.   NEUROSCIENCE RESEARCH

Neuroinflammation in Parkinson's disease

(2011) Etienne C. Hirsch et al.   PARKINSONISM & RELATED DISORDERS

Bidirectional Coupling between Astrocytes and Neurons Mediates Learning and Dynamic Coordination in the Brain: A Multiple Modeling Approach

(2011) John J. Wade et al.   PLoS One

Bioenergetic Consequences of PINK1 Mutations in Parkinson Disease

(2011) Andrey Yurevich Abramov et al.   PLoS One

Introduction to Network Analysis in Systems Biology

(2011) A. Ma'ayan   Science Signaling

Ageing, neurodegeneration and Parkinson's disease

(2010) J. V. Hindle   AGE AND AGEING

The Nrf2-Keap1-ARE Signaling Pathway: The Regulation and Dual Function of Nrf2 in Cancer

(2010) Donna D. Zhang   ANTIOXIDANTS & REDOX SIGNALING

Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples

(2010) Douglas B. Kell   ARCHIVES OF TOXICOLOGY

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Neuron-glia metabolic coupling and plasticity

(2010) Pierre J. Magistretti   EXPERIMENTAL PHYSIOLOGY

Regulatory T Cells Attenuate Th17 Cell-Mediated Nigrostriatal Dopaminergic Neurodegeneration in a Model of Parkinson’s Disease

(2010) Ashley D. Reynolds et al.   JOURNAL OF IMMUNOLOGY

Increased iron levels correlate with the selective nigral dopaminergic neuron degeneration in Parkinson’s disease

(2010) Zhanyun Lv et al.   JOURNAL OF NEURAL TRANSMISSION

Metals, oxidative stress and neurodegenerative disorders

(2010) Klaudia Jomova et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

ATP13A2 mutations (PARK9) cause neurodegeneration with brain iron accumulation

(2010) Susanne A. Schneider et al.   MOVEMENT DISORDERS

What are the most important nonmotor symptoms in patients with Parkinson's disease and are we missing them?

(2010) David A. Gallagher et al.   MOVEMENT DISORDERS

A molecular basis for the increased vulnerability of substantia nigra dopamine neurons in aging and Parkinson's disease

(2010) C. Savio Chan et al.   MOVEMENT DISORDERS

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease

(2010) Taye H Hamza et al.   NATURE GENETICS

Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

(2010) Venu M. Nemani et al.   NEURON

Oxidative Stress Induction of DJ-1 Protein in Reactive Astrocytes Scavenges Free Radicals and Reduces Cell Injury

(2010) Takashi Yanagida et al.   Oxidative Medicine and Cellular Longevity

Progression of Parkinson's Disease Pathology Is Reproduced by Intragastric Administration of Rotenone in Mice

(2010) Francisco Pan-Montojo et al.   PLoS One

An energy systems approach to Parkinson's disease

(2010) Peter Wellstead et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Parkinson's Disease

(2009) Christopher H. Hawkes et al.   Annals of the New York Academy of Sciences

Keap1/Nrf2 system regulates neuronal survival as revealed through study of keap1 gene-knockout mice

(2009) Takumi Satoh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phosphorus and proton magnetic resonance spectroscopy demonstrates mitochondrial dysfunction in early and advanced Parkinson's disease

(2009) Elke Hattingen et al.   BRAIN

Regulation of astrocyte inflammatory responses by the Parkinson’s disease-associated gene DJ-1

(2009) Jens Waak et al.   FASEB JOURNAL

Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems

(2009) Viktor I. Korolchuk et al.   FEBS LETTERS

Non-motor symptoms in Parkinson’s disease

(2009) Ariane Park et al.   JOURNAL OF NEUROLOGY

Single Nigrostriatal Dopaminergic Neurons Form Widely Spread and Highly Dense Axonal Arborizations in the Neostriatum

(2009) W. Matsuda et al.   JOURNAL OF NEUROSCIENCE

The control systems structures of energy metabolism

(2009) M. Cloutier et al.   Journal of the Royal Society Interface

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

(2009) Wataru Satake et al.   NATURE GENETICS

Genome-wide association study reveals genetic risk underlying Parkinson's disease

(2009) Javier Simón-Sánchez et al.   NATURE GENETICS

Alterations in lysosomal and proteasomal markers in Parkinson's disease: Relationship to alpha-synuclein inclusions

(2009) Yaping Chu et al.   NEUROBIOLOGY OF DISEASE

Immune Activation in Brain Aging and Neurodegeneration: Too Much or Too Little?

(2009) Kurt M. Lucin et al.   NEURON

Silencing of PINK1 Expression Affects Mitochondrial DNA and Oxidative Phosphorylation in DOPAMINERGIC Cells

(2009) Matthew E. Gegg et al.   PLoS One

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Is Parkinson's disease a prion disorder?

(2009) C. W. Olanow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal regulation of immune responses in the central nervous system

(2009) Li Tian et al.   TRENDS IN IMMUNOLOGY

Tripartite synapses: astrocytes process and control synaptic information

(2009) Gertrudis Perea et al.   TRENDS IN NEUROSCIENCES

Human neuromelanin induces neuroinflammation and neurodegeneration in the rat substantia nigra: implications for Parkinson's disease

(2008) Luigi Zecca et al.   ACTA NEUROPATHOLOGICA

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

(2008) Jia-Yi Li et al.   NATURE MEDICINE

Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

(2008) Jeffrey H Kordower et al.   NATURE MEDICINE

Ubiquitin, the proteasome and protein degradation in neuronal function and dysfunction

(2008) Hwan-Ching Tai et al.   NATURE REVIEWS NEUROSCIENCE

Glial Cells as Players in Parkinsonism: The “Good,” the “Bad,” and the “Mysterious” Glia

(2008) Maria A. Mena et al.   NEUROSCIENTIST

Oxidative insults induce DJ-1 upregulation and redistribution: Implications for neuroprotection

(2008) Nirit Lev et al.   NEUROTOXICOLOGY

Trichloroethylene: Parkinsonism and complex 1 mitochondrial neurotoxicity

(2007) Don M. Gash et al.   ANNALS OF NEUROLOGY