CRISPR and personalized Treg therapy: new insights into the treatment of rheumatoid arthritis

RANKL: A therapeutic target for bone destruction in rheumatoid arthritis

(2017) Sakae Tanaka et al.   Modern Rheumatology

Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

(2017) Justin Eyquem et al.   NATURE

Stabilization of Foxp3 expression by CRISPR-dCas9-based epigenome editing in mouse primary T cells

(2017) Masahiro Okada et al.   Epigenetics & Chromatin

Effector T helper cell populations are elevated in the bone marrow of rheumatoid arthritis patients and correlate with disease severity

(2017) Shufeng Li et al.   Scientific Reports

Janus kinase inhibitors for rheumatoid arthritis

(2016) Kunihiro Yamaoka   CURRENT OPINION IN CHEMICAL BIOLOGY

Regulatory T cell therapy for type 1 diabetes: May the force be with you

(2016) Stephen E. Gitelman et al.   JOURNAL OF AUTOIMMUNITY

Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor

(2016) Katherine G. MacDonald et al.   JOURNAL OF CLINICAL INVESTIGATION

Rheumatoid arthritis: current and future trends

(2016) Kritika Chaudhari et al.   NATURE REVIEWS DRUG DISCOVERY

Mechanisms leading from systemic autoimmunity to joint-specific disease in rheumatoid arthritis

(2016) Anca I. Catrina et al.   Nature Reviews Rheumatology

Repurposing the CRISPR-Cas9 system for targeted DNA methylation

(2016) Aleksandar Vojta et al.   NUCLEIC ACIDS RESEARCH

CRISPR-dCas9 mediated TET1 targeting for selective DNA demethylation at BRCA1 promoter

(2016) Samrat Roy Choudhury et al.   Oncotarget

Dendritic Cell-based Immunotherapy for Rheumatoid Arthritis: from Bench to Bedside

(2016) Md. Selim Ahmed et al.   Immune Network

CRISPR-Cas9 mediated efficient PD-1 disruption on human primary T cells from cancer patients

(2016) Shu Su et al.   Scientific Reports

Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss

(2015) Akilan Krishnamurthy et al.   ANNALS OF THE RHEUMATIC DISEASES

Adoptive Transfer of MAGE-A4 T-cell Receptor Gene-Transduced Lymphocytes in Patients with Recurrent Esophageal Cancer

(2015) S. Kageyama et al.   CLINICAL CANCER RESEARCH

Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Modeling of Filgotinib (GLPG0634), a Selective JAK1 Inhibitor, in Support of Phase IIB Dose Selection

(2015) Florence Namour et al.   CLINICAL PHARMACOKINETICS

Citrullination: A Specific Target for the Autoimmune Response in Rheumatoid Arthritis

(2015) David A. Fox   JOURNAL OF IMMUNOLOGY

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

(2015) Silvana Konermann et al.   NATURE

Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers

(2015) Isaac B Hilton et al.   NATURE BIOTECHNOLOGY

Functional annotation of native enhancers with a Cas9–histone demethylase fusion

(2015) Nicola A Kearns et al.   NATURE METHODS

Expression of citrulline and homocitrulline residues in the lungs of non-smokers and smokers: implications for autoimmunity in rheumatoid arthritis

(2015) Elena B Lugli et al.   ARTHRITIS RESEARCH & THERAPY

The Timing of T Cell Priming and Cycling

(2015) Reinhard Obst   Frontiers in Immunology

Efficacy and safety of olokizumab in patients with rheumatoid arthritis with an inadequate response to TNF inhibitor therapy: outcomes of a randomised Phase IIb study

(2014) Mark C Genovese et al.   ANNALS OF THE RHEUMATIC DISEASES

Sirukumab, a human anti-interleukin-6 monoclonal antibody: a randomised, 2-part (proof-of-concept and dose-finding), phase II study in patients with active rheumatoid arthritis despite methotrexate therapy

(2014) Josef S Smolen et al.   ANNALS OF THE RHEUMATIC DISEASES

Targeting IL-6 for the treatment of rheumatoid arthritis: Phase II investigational drugs

(2014) Luca Semerano et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Moving Receptor Redirected Adoptive Cell Therapy Toward Fine Tuning of Antitumor Responses

(2014) Leonardo Chicaybam et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Regulatory T Cells Inhibit Dendritic Cells by Lymphocyte Activation Gene-3 Engagement of MHC Class II

(2014) Bitao Liang et al.   JOURNAL OF IMMUNOLOGY

One-year Efficacy and Safety Results of Secukinumab in Patients With Rheumatoid Arthritis: Phase II, Dose-finding, Double-blind, Randomized, Placebo-controlled Study

(2014) M. C. Genovese et al.   JOURNAL OF RHEUMATOLOGY

Infliximab treatment reduces the serum levels of interleukin-23 in patients with rheumatoid arthritis

(2014) Yasunori Kageyama et al.   Modern Rheumatology

Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation

(2014) John G Doench et al.   NATURE BIOTECHNOLOGY

TREG-cell therapies for autoimmune rheumatic diseases

(2014) Makoto Miyara et al.   Nature Reviews Rheumatology

Brodalumab, an Anti-IL17RA Monoclonal Antibody, in Psoriatic Arthritis

(2014) Philip J. Mease et al.   NEW ENGLAND JOURNAL OF MEDICINE

Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance

(2014) Roberto A. Maldonado et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type 1 regulatory T cells specific for collagen type II as an efficient cell-based therapy in arthritis

(2014) Hélène Asnagli et al.   ARTHRITIS RESEARCH & THERAPY

A Phase II Randomized Study of Subcutaneous Ixekizumab, an Anti-Interleukin-17 Monoclonal Antibody, in Rheumatoid Arthritis Patients Who Were Naive to Biologic Agents or Had an Inadequate Response to Tumor Necrosis Factor Inhibitors

(2014) Mark C. Genovese et al.   Arthritis & Rheumatology

Periodontitis andPorphyromonas gingivalisin Patients With Rheumatoid Arthritis

(2014) Ted R. Mikuls et al.   Arthritis & Rheumatology

Utilizing Regulatory T Cells Against Rheumatoid Arthritis

(2014) Mohammad Haque et al.   Frontiers in Oncology

HLA shared epitope and ACPA: Just a marker or an active player?

(2013) Federico Pratesi et al.   AUTOIMMUNITY REVIEWS

Can rheumatoid arthritis be prevented?

(2013) Kevin D. Deane   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes

(2013) Luke A. Gilbert et al.   CELL

The Continuum of Cancer Immunosurveillance: Prognostic, Predictive, and Mechanistic Signatures

(2013) Jérôme Galon et al.   IMMUNITY

Pathogen-Specific Treg Cells Expand Early during Mycobacterium tuberculosis Infection but Are Later Eliminated in Response to Interleukin-12

(2013) Shahin Shafiani et al.   IMMUNITY

At the Bedside: CTLA-4- and PD-1-blocking antibodies in cancer immunotherapy

(2013) Margaret K. Callahan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

At the Bench: Preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapy

(2013) Andrew M. Intlekofer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Rheumatoid arthritis: still a chronic disease

(2013) Pierre Miossec   LANCET

RNA-guided gene activation by CRISPR-Cas9–based transcription factors

(2013) Pablo Perez-Pinera et al.   NATURE METHODS

Th17 cells are restrained by Treg cells via the inhibition of interleukin-6 in patients with rheumatoid arthritis responding to anti-tumor necrosis factor antibody therapy

(2012) Jenny L. McGovern et al.   ARTHRITIS AND RHEUMATISM

T-Regulatory Cells: Key Players in Tumor Immune Escape and Angiogenesis

(2012) A. Facciabene et al.   CANCER RESEARCH

The induction of Treg cells by gut-indigenous Clostridium

(2012) Yuji Nagano et al.   CURRENT OPINION IN IMMUNOLOGY

Increased Serum Interleukin 22 in Patients with Rheumatoid Arthritis and Correlation with Disease Activity

(2012) LAURINDO FERREIRA da ROCHA et al.   JOURNAL OF RHEUMATOLOGY

Interaction with activated monocytes enhances cytokine expression and suppressive activity of human CD4+CD45RO+CD25+CD127low regulatory T cells

(2012) Gina J Walter et al.   Journal of Translational Medicine

Tofacitinib or Adalimumab versus Placebo in Rheumatoid Arthritis

(2012) Ronald F. van Vollenhoven et al.   NEW ENGLAND JOURNAL OF MEDICINE

Loss of Sex and Age Driven Differences in the Gut Microbiome Characterize Arthritis-Susceptible *0401 Mice but Not Arthritis-Resistant *0402 Mice

(2012) Andres Gomez et al.   PLoS One

Increased Frequencies of Th22 Cells as well as Th17 Cells in the Peripheral Blood of Patients with Ankylosing Spondylitis and Rheumatoid Arthritis

(2012) Lei Zhang et al.   PLoS One

Regulatory T cells that recognize a ubiquitous stress-inducible self-antigen are long-lived suppressors of autoimmune arthritis

(2012) M. J. C. van Herwijnen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mapping pathogenesis of arthritis through small animal models

(2012) T. L. Vincent et al.   RHEUMATOLOGY

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Progenitor and Terminal Subsets of CD8+ T Cells Cooperate to Contain Chronic Viral Infection

(2012) M. A. Paley et al.   SCIENCE

Molecular Mechanisms of Treg-Mediated T Cell Suppression

(2012) Angelika Schmidt et al.   Frontiers in Immunology

Generation and Large-Scale Expansion of Human Inducible Regulatory T Cells That Suppress Graft-Versus-Host Disease

(2011) K. L. Hippen et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Mavrilimumab, a human monoclonal antibody targeting GM-CSF receptor- , in subjects with rheumatoid arthritis: a randomised, double-blind, placebo-controlled, phase I, first-in-human study

(2011) G. R. Burmester et al.   ANNALS OF THE RHEUMATIC DISEASES

The inflammatory milieu in the rheumatic joint reduces regulatory T-cell function

(2011) Jessica Herrath et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Elevated Th22 Cells Correlated with Th17 Cells in Patients with Rheumatoid Arthritis

(2011) Lei Zhang et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Neuropilin-1 attenuates autoreactivity in experimental autoimmune encephalomyelitis

(2011) Benjamin D. Solomon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

(2011) O. S. Qureshi et al.   SCIENCE

Clinical utility of denosumab for treatment of bone loss in men and women

(2011) Robert Adler et al.   Clinical Interventions in Aging

2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiative

(2010) Daniel Aletaha et al.   ARTHRITIS AND RHEUMATISM

T-cell receptor signals direct the composition and function of the memory CD8+ T-cell pool

(2010) J. E. Smith-Garvin et al.   BLOOD

The environment, geo-epidemiology, and autoimmune disease: Rheumatoid arthritis

(2010) Gabriel J. Tobón et al.   JOURNAL OF AUTOIMMUNITY

Pathogen-specific regulatory T cells delay the arrival of effector T cells in the lung during early tuberculosis

(2010) Shahin Shafiani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Expression of the Autoimmune Susceptibility Gene FcRL3 on Human Regulatory T Cells Is Associated with Dysfunction and High Levels of Programmed Cell Death-1

(2010) L. A. Swainson et al.   JOURNAL OF IMMUNOLOGY

Protein Kinase C-  Mediates Negative Feedback on Regulatory T Cell Function

(2010) A. Zanin-Zhorov et al.   SCIENCE

Curing CNS autoimmune disease with myelin-reactive Foxp3+Treg

(2009) Leigh A. Stephens et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

(2009) Xuyu Zhou et al.   NATURE IMMUNOLOGY

Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells

(2009) Thomas Duhen et al.   NATURE IMMUNOLOGY

G-CSF and GM-CSF as therapeutic targets in rheumatoid arthritis

(2009) Ann L. Cornish et al.   Nature Reviews Rheumatology

Osteoimmunology and the effects of the immune system on bone

(2009) Hiroshi Takayanagi   Nature Reviews Rheumatology

Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis

(2009) Graham P. Wright et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rheumatoid Arthritis Synovium Contains Two Subsets of CD83−DC-LAMP− Dendritic Cells with Distinct Cytokine Profiles

(2008) M. Cristina Lebre et al.   AMERICAN JOURNAL OF PATHOLOGY

Efficacy and safety of certolizumab pegol monotherapy every 4 weeks in patients with rheumatoid arthritis failing previous disease-modifying antirheumatic therapy: the FAST4WARD study

(2008) R Fleischmann et al.   ANNALS OF THE RHEUMATIC DISEASES

Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

(2008) Xuexian O. Yang et al.   IMMUNITY

Critical evaluation of regulatory T cells in autoimmunity: are the most potent regulatory specificities being ignored?

(2008) Arthur A. Vandenbark et al.   IMMUNOLOGY

Pharmacogenetics of etanercept in rheumatoid arthritis

(2008) Maria I Danila et al.   PHARMACOGENOMICS

Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis

(2008) F. Flores-Borja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA