The role of regulatory T cells in nervous system pathologies

Stroke

(2017) Graeme J Hankey   LANCET

Dramatic Shifts in Circulating CD4 but not CD8 T Cell Subsets in Mild Alzheimer's Disease

(2017) Anis Larbi et al.   JOURNAL OF ALZHEIMERS DISEASE

PD1 Negative and PD1 Positive CD4+ T Regulatory Cells in Mild Cognitive Impairment and Alzheimer's Disease

(2017) Marina Saresella et al.   JOURNAL OF ALZHEIMERS DISEASE

Regulatory T cells delay disease progression in Alzheimer-like pathology

(2016) Cira Dansokho et al.   BRAIN

Disease progression in recurrent glioblastoma patients treated with the VEGFR inhibitor axitinib is associated with increased regulatory T cell numbers and T cell exhaustion

(2016) Stephanie Du Four et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Regulatory T and B lymphocytes in a spontaneous autoimmune polyneuropathy

(2016) S. Quan et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

A robust, good manufacturing practice–compliant, clinical-scale procedure to generate regulatory T cells from patients with amyotrophic lateral sclerosis for adoptive cell therapy

(2016) Abdullah Alsuliman et al.   CYTOTHERAPY

α-Synuclein vaccination modulates regulatory T cell activation and microglia in the absence of brain pathology

(2016) Josefine R. Christiansen et al.   Journal of Neuroinflammation

miR-124a and miR-155 enhance differentiation of regulatory T cells in patients with neuropathic pain

(2016) Jens Heyn et al.   Journal of Neuroinflammation

Guillain-Barré syndrome

(2016) Hugh J Willison et al.   LANCET

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Interleukin-1β overproduction is a common cause for neuropathic pain, memory deficit, and depression following peripheral nerve injury in rodents

(2016) Wen-Shan Gui et al.   Molecular Pain

Guillain–Barré syndrome: a century of progress

(2016) John A. Goodfellow et al.   Nature Reviews Neurology

Epidemiology of Multiple Sclerosis: From Risk Factors to Prevention—An Update

(2016) Kassandra Munger et al.   SEMINARS IN NEUROLOGY

Neuroprotective effects of CD4+CD25+Foxp3+ regulatory T cells in a 3xTg-AD Alzheimer’s disease model

(2016) Hyunjung Baek et al.   Oncotarget

Regulatory T cell number in multiple sclerosis patients: A meta-analysis

(2016) Ali Noori-Zadeh et al.   Multiple Sclerosis and Related Disorders

Increased proportion of FoxP3+ regulatory T cells in tumor infiltrating lymphocytes is associated with tumor recurrence and reduced survival in patients with glioblastoma

(2015) Elias J. Sayour et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Role of Regulatory T cell in Clinical Outcome of Traumatic Brain Injury

(2015) Jian-Ning Zhang et al.   CHINESE MEDICAL JOURNAL

Classification, diagnosis, and differential diagnosis of multiple sclerosis

(2015) Ilana Katz Sand   CURRENT OPINION IN NEUROLOGY

Depletion of Foxp3+ regulatory T cells increases severity of mechanical allodynia and significantly alters systemic cytokine levels following peripheral nerve injury

(2015) Justin G. Lees et al.   CYTOKINE

Bee Venom Phospholipase A2, a Novel Foxp3+Regulatory T Cell Inducer, Protects Dopaminergic Neurons by Modulating Neuroinflammatory Responses in a Mouse Model of Parkinson’s Disease

(2015) Eun Sook Chung et al.   JOURNAL OF IMMUNOLOGY

The role of regulatory T cells and microglia in glioblastoma-associated immunosuppression

(2015) Alfred P. See et al.   JOURNAL OF NEURO-ONCOLOGY

Anti-inflammatory T-cell shift in neuropathic pain

(2015) Benjamin Luchting et al.   Journal of Neuroinflammation

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

Clinical correlation of peripheral CD4+-cell sub-sets, their imbalance and Parkinson's disease

(2015) YUHUA CHEN et al.   Molecular Medicine Reports

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Functional Role of Regulatory Lymphocytes in Stroke: Facts and Controversies

(2015) A. Liesz et al.   STROKE

Breaking immune tolerance by targeting Foxp3+ regulatory T cells mitigates Alzheimer’s disease pathology

(2015) Kuti Baruch et al.   Nature Communications

Nociceptive neurons regulate innate and adaptive immunity and neuropathic pain through MyD88 adapter

(2014) Xing-Jun Liu et al.   CELL RESEARCH

Intravenous immunoglobulin exerts reciprocal regulation of Th1/Th17 cells and regulatory T cells in Guillain–Barré syndrome patients

(2014) Mohan S. Maddur et al.   IMMUNOLOGIC RESEARCH

Breaking peripheral immune tolerance to CNS antigens in neurodegenerative diseases: Boosting autoimmunity to fight-off chronic neuroinflammation

(2014) Michal Schwartz et al.   JOURNAL OF AUTOIMMUNITY

Regulatory T Cells in Central Nervous System Injury: A Double-Edged Sword

(2014) James T. Walsh et al.   JOURNAL OF IMMUNOLOGY

CNS Repair Requires Both Effector and Regulatory T Cells with Distinct Temporal and Spatial Profiles

(2014) C. Raposo et al.   JOURNAL OF NEUROSCIENCE

Chronic inflammatory demyelinating polyradiculoneuropathy and variants: where we are and where we should go

(2014) Eduardo Nobile-Orazio   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

Imbalance between IL-17A-Producing Cells and Regulatory T Cells during Ischemic Stroke

(2014) Yuehua Hu et al.   MEDIATORS OF INFLAMMATION

The prevalence of Parkinson's disease: A systematic review and meta-analysis

(2014) Tamara Pringsheim et al.   MOVEMENT DISORDERS

FoxA1 directs the lineage and immunosuppressive properties of a novel regulatory T cell population in EAE and MS

(2014) Yawei Liu et al.   NATURE MEDICINE

Defining the clinical course of multiple sclerosis: The 2013 revisions

(2014) F. D. Lublin et al.   NEUROLOGY

Emotional consequences of neuropathic pain: Insight from preclinical studies

(2014) Ipek Yalcin et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Circulating T-Regulatory Cells in Neuroblastoma: A Pilot Prospective Study

(2014) TVSVGK Tilak et al.   PEDIATRIC HEMATOLOGY AND ONCOLOGY

Foxp3 Expression in Macrophages Associated with RENCA Tumors in Mice

(2014) Christel Devaud et al.   PLoS One

Disrupted TH17/Treg Balance in Patients with Chronic Low Back Pain

(2014) Benjamin Luchting et al.   PLoS One

FoxP3+ Regulatory T Cells Determine Disease Severity in Rodent Models of Inflammatory Neuropathies

(2014) Gerd Meyer zu Hörste et al.   PLoS One

Mitigated Tregs and Augmented Th17 Cells and Cytokines are Associated with Severity of Experimental Autoimmune Neuritis

(2014) X. Wang et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Treg cells mediate recovery from EAE by controlling effector T cell proliferation and motility in the CNS

(2014) Michail Koutrolos et al.   Acta Neuropathologica Communications

The global prevalence of dementia: A systematic review and metaanalysis

(2013) Martin Prince et al.   Alzheimers & Dementia

Much of late life cognitive decline is not due to common neurodegenerative pathologies

(2013) Patricia A. Boyle et al.   ANNALS OF NEUROLOGY

Th1/Th2/Th17/Treg cytokines in Guillain–Barré syndrome and experimental autoimmune neuritis

(2013) Hong-Liang Zhang et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Mitochondrial and cytosolic roles of PINK1 shape induced regulatory T-cell development and function

(2013) Gavin I. Ellis et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

α-Synuclein Vaccination Prevents the Accumulation of Parkinson Disease-Like Pathologic Inclusions in Striatum in Association With Regulatory T Cell Recruitment in a Rat Model

(2013) Vanesa Sanchez-Guajardo et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Boosting Regulatory T Cells Limits Neuroinflammation in Permanent Cortical Stroke

(2013) A. Liesz et al.   JOURNAL OF NEUROSCIENCE

Health-related quality of life in early Parkinson's disease: The impact of nonmotor symptoms

(2013) Gordon W. Duncan et al.   MOVEMENT DISORDERS

Regulatory T cell proliferative potential is impaired in human autoimmune disease

(2013) Fortunata Carbone et al.   NATURE MEDICINE

Guillain-Barré Syndrome and Variants

(2013) Mazen M. Dimachkie et al.   NEUROLOGIC CLINICS

T-cell homeostasis in pediatric multiple sclerosis: Old cells in young patients

(2013) B. Balint et al.   NEUROLOGY

Neuropathic pain in the general population: A systematic review of epidemiological studies

(2013) O. van Hecke et al.   PAIN

Systemic Transplantation of Human Umbilical Cord Derived Mesenchymal Stem Cells-Educated T Regulatory Cells Improved the Impaired Cognition in AβPPswe/PS1dE9 Transgenic Mice

(2013) Hongna Yang et al.   PLoS One

Role of CD25+ CD4+ T cells in acute and persistent coronavirus infection of the central nervous system

(2013) Maria Teresa P. de Aquino et al.   VIROLOGY

Parkinson's Disease and Parkinsonism: Neuropathology

(2013) D. W. Dickson   Cold Spring Harbor Perspectives in Medicine

Regulatory T Cells in Peripheral Blood and Cerebrospinal Fluid of Syphilis Patients with and without Neurological Involvement

(2013) Kang Li et al.   PLoS Neglected Tropical Diseases

Meta-analysis of early nonmotor features and risk factors for Parkinson disease

(2012) Alastair J. Noyce et al.   ANNALS OF NEUROLOGY

Adoptive regulatory T-cell therapy protects against cerebral ischemia

(2012) Peiying Li et al.   ANNALS OF NEUROLOGY

Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature

(2012) C. Kleinschnitz et al.   BLOOD

Neuro-protective effects of bee venom by suppression of neuroinflammatory responses in a mouse model of Parkinson’s disease: Role of regulatory T cells

(2012) Eun Sook Chung et al.   BRAIN BEHAVIOR AND IMMUNITY

Allergen-specific responses of CD19(+)CD5(+)Foxp3(+) regulatory B cells (Bregs) and CD4(+)Foxp3(+) regulatory T cell (Tregs) in immune tolerance of cow milk allergy of late eczematous reactions

(2012) Joonyong Noh et al.   CELLULAR IMMUNOLOGY

Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival

(2012) Jenny S. Henkel et al.   EMBO Molecular Medicine

Regulatory T Cells Accumulate and Proliferate in the Ischemic Hemisphere for up to 30 Days after MCAO

(2012) Tobias Stubbe et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

CD4+ Regulatory and Effector/Memory T Cell Subsets Profile Motor Dysfunction in Parkinson’s Disease

(2012) Jessica A. Hutter Saunders et al.   Journal of Neuroimmune Pharmacology

Altered frequency of T regulatory cells is associated with disability status in relapsing–remitting multiple sclerosis patients

(2012) Lasse Bjerg et al.   JOURNAL OF NEUROIMMUNOLOGY

Prevalence, Characteristics, and Factors Associated With Chronic Pain With and Without Neuropathic Characteristics in São Luís, Brazil

(2012) Érica Brandão de Moraes Vieira et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Rafael Lozano et al.   LANCET

100 years of Lewy pathology

(2012) Michel Goedert et al.   Nature Reviews Neurology

Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms

(2012) Weihua Zhao et al.   NEUROBIOLOGY OF DISEASE

Regulatory T cells attenuate neuropathic pain following peripheral nerve injury and experimental autoimmune neuritis

(2012) Paul J. Austin et al.   PAIN

Foxp3+ Regulatory T Cells Control Persistence of Viral CNS Infection

(2012) Dajana Reuter et al.   PLoS One

Distinctive Effects of T Cell Subsets in Neuronal Injury Induced by Cocultured Splenocytes In Vitro and by In Vivo Stroke in Mice

(2012) Lijuan Gu et al.   STROKE

Alterations of T cell subsets in ALS: a systemic immune activation?

(2011) M. Rentzos et al.   ACTA NEUROLOGICA SCANDINAVICA

Novel role of aquaporin-4 in CD4+ CD25+ T regulatory cell development and severity of Parkinson’s disease

(2011) Ying Chi et al.   AGING CELL

Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis

(2011) David R. Beers et al.   BRAIN

Virus expanded regulatory T cells control disease severity in the Theiler’s virus mouse model of MS

(2011) Maureen H. Richards et al.   JOURNAL OF AUTOIMMUNITY

The impact of non-motor symptoms on health-related quality of life of patients with Parkinson's disease

(2011) Pablo Martinez-Martin et al.   MOVEMENT DISORDERS

Identification of T helper type 1–like, Foxp3+ regulatory T cells in human autoimmune disease

(2011) Margarita Dominguez-Villar et al.   NATURE MEDICINE

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Early recognition of poor prognosis in Guillain-Barre syndrome

(2011) C. Walgaard et al.   NEUROLOGY

Neuroinflammation in Parkinson's disease

(2011) Etienne C. Hirsch et al.   PARKINSONISM & RELATED DISORDERS

T Regulatory Cells Are Markers of Disease Activity in Multiple Sclerosis Patients

(2011) Dacia Dalla Libera et al.   PLoS One

Regulatory T cells in CNS injury: the simple, the complex and the confused

(2011) James T. Walsh et al.   TRENDS IN MOLECULAR MEDICINE

T cells in multiple sclerosis and experimental autoimmune encephalomyelitis

(2010) J. M. Fletcher et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Regulatory B Cells (B10 Cells) and Regulatory T Cells Have Independent Roles in Controlling Experimental Autoimmune Encephalomyelitis Initiation and Late-Phase Immunopathogenesis

(2010) T. Matsushita et al.   JOURNAL OF IMMUNOLOGY

Regulatory T Cells Attenuate Th17 Cell-Mediated Nigrostriatal Dopaminergic Neurodegeneration in a Model of Parkinson’s Disease

(2010) Ashley D. Reynolds et al.   JOURNAL OF IMMUNOLOGY

Molecular Depletion of Descending Serotonin Unmasks Its Novel Facilitatory Role in the Development of Persistent Pain

(2010) F. Wei et al.   JOURNAL OF NEUROSCIENCE

Interleukin-17 Contributes to Neuroinflammation and Neuropathic Pain Following Peripheral Nerve Injury in Mice

(2010) Cristina Fabiola Kim et al.   JOURNAL OF PAIN

Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment

(2010) Ralf Baron et al.   LANCET NEUROLOGY

CD4+FoxP3+ regulatory T-cells in cerebral ischemic stroke

(2010) Xuefang Ren et al.   METABOLIC BRAIN DISEASE

IL-35-mediated induction of a potent regulatory T cell population

(2010) Lauren W Collison et al.   NATURE IMMUNOLOGY

Circulating subsets and CD4+CD25+regulatory T cell function in chronic inflammatory demyelinating polyradiculoneuropathy

(2009) Lara Sanvito et al.   AUTOIMMUNITY

A novel myelin P0–specific T cell receptor transgenic mouse develops a fulminant autoimmune peripheral neuropathy

(2009) Cédric Louvet et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD39+Foxp3+ Regulatory T Cells Suppress Pathogenic Th17 Cells and Are Impaired in Multiple Sclerosis

(2009) J. M. Fletcher et al.   JOURNAL OF IMMUNOLOGY

Immune system alterations in sporadic amyotrophic lateral sclerosis patients suggest an ongoing neuroinflammatory process

(2009) Stefania Mantovani et al.   JOURNAL OF NEUROIMMUNOLOGY

Depletion of CD4+CD25+T cells exacerbates experimental autoimmune encephalomyelitis induced by mouse, but not rat, antigens

(2009) Eitan M. Akirav et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Proteomic Studies of Nitrated Alpha-Synuclein Microglia Regulation by CD4+CD25+ T Cells

(2009) Ashley D. Reynolds et al.   JOURNAL OF PROTEOME RESEARCH

Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke

(2009) Arthur Liesz et al.   NATURE MEDICINE

The Prevalence and Impact of Chronic Pain with Neuropathic Pain Symptoms in the General Population

(2009) Cory Toth et al.   PAIN MEDICINE

CD4+ T cell regulation of CD25 expression controls development of short-lived effector CD8+ T cells in primary and secondary responses

(2009) J. J. Obar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IFN-  receptor signaling mediates spinal microglia activation driving neuropathic pain

(2009) M. Tsuda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Distribution of Foxp3+ T-regulatory cells in experimental autoimmune neuritis rats

(2008) Zhiren Zhang et al.   EXPERIMENTAL NEUROLOGY

Increased levels of activated T-cells and reduced levels of CD4/CD25+ cells in peripheral blood of Guillain-Barré syndrome patients compared to controls

(2008) J. Harness et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Cytokine Mechanisms of Central Sensitization: Distinct and Overlapping Role of Interleukin-1 , Interleukin-6, and Tumor Necrosis Factor-  in Regulating Synaptic and Neuronal Activity in the Superficial Spinal Cord

(2008) Y. Kawasaki et al.   JOURNAL OF NEUROSCIENCE

Impairment of circulating CD4+CD25+regulatory T cells in patients with chronic inflammatory demyelinating polyradiculoneuropathy

(2008) Li-Jun Chi et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

Nitrated α–Synuclein Immunity Accelerates Degeneration of Nigral Dopaminergic Neurons

(2008) Eric J. Benner et al.   PLoS One

Adaptive Immune Neuroprotection in G93A-SOD1 Amyotrophic Lateral Sclerosis Mice

(2008) Rebecca Banerjee et al.   PLoS One

Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation

(2008) Y. Onishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CTLA-4 Control over Foxp3+ Regulatory T Cell Function

(2008) K. Wing et al.   SCIENCE

Compromised CD4+ CD25highregulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell level

(2007) Koen Venken et al.   IMMUNOLOGY