TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci

Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase

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Safety and pharmacokinetics of dicloxacillin in healthy Chinese volunteers following single and multiple oral doses

(2015) Guolan Wu et al.   Drug Design Development and Therapy

Immuno-oncology Combinations: A Review of Clinical Experience and Future Prospects

(2014) S. J. Antonia et al.   CLINICAL CANCER RESEARCH

Murgocil is a Highly Bioactive Staphylococcal-Specific Inhibitor of the Peptidoglycan Glycosyltransferase Enzyme MurG

(2013) Paul A. Mann et al.   ACS Chemical Biology

Discovery of Wall Teichoic Acid Inhibitors as Potential Anti-MRSA β-Lactam Combination Agents

(2013) Hao Wang et al.   CHEMISTRY & BIOLOGY

Investigational Antimicrobial Agents of 2013

(2013) M. J. Pucci et al.   CLINICAL MICROBIOLOGY REVIEWS

Auxiliary factors: a chink in the armor of MRSA resistance to β-lactam antibiotics

(2013) Terry Roemer et al.   CURRENT OPINION IN MICROBIOLOGY

Teichoic acid biosynthesis as an antibiotic target

(2013) Lincoln W Pasquina et al.   CURRENT OPINION IN MICROBIOLOGY

Taking aim at wall teichoic acid synthesis: new biology and new leads for antibiotics

(2013) Edward WC Sewell et al.   JOURNAL OF ANTIBIOTICS

Nafcillin enhances innate immune-mediated killing of methicillin-resistant Staphylococcus aureus

(2013) George Sakoulas et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Systems-level antimicrobial drug and drug synergy discovery

(2013) Terry Roemer et al.   Nature Chemical Biology

Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis

(2013) B. C. Chung et al.   SCIENCE

Inhibition of WTA Synthesis Blocks the Cooperative Action of PBPs and Sensitizes MRSA to β-Lactams

(2012) Maya A. Farha et al.   ACS Chemical Biology

The therapeutic journey of benzimidazoles: A review

(2012) Yogita Bansal et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Wall teichoic acid protects Staphylococcus aureus from inhibition by Congo red and other dyes

(2012) T. Suzuki et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Proton-Binding Capacity of Staphylococcus aureus Wall Teichoic Acid and Its Role in Controlling Autolysin Activity

(2012) Raja Biswas et al.   PLoS One

Methicillin resistance in Staphylococcus aureus requires glycosylated wall teichoic acids

(2012) S. Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restoring Methicillin-Resistant Staphylococcus aureus Susceptibility to  -Lactam Antibiotics

(2012) C. M. Tan et al.   Science Translational Medicine

ABC Transporters Required for Export of Wall Teichoic Acids Do Not Discriminate between Different Main Chain Polymers

(2011) Kathrin Schirner et al.   ACS Chemical Biology

Antagonism of Chemical Genetic Interaction Networks Resensitize MRSA to β-Lactam Antibiotics

(2011) Sang Ho Lee et al.   CHEMISTRY & BIOLOGY

Methicillin-resistant Staphylococcus aureus: the European landscape

(2011) A. P. Johnson   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Synthetic Lethal Compound Combinations Reveal a Fundamental Connection between Wall Teichoic Acid and Peptidoglycan Biosyntheses inStaphylococcus aureus

(2010) Jennifer Campbell et al.   ACS Chemical Biology

Three Decades of  -Lactamase Inhibitors

(2010) S. M. Drawz et al.   CLINICAL MICROBIOLOGY REVIEWS

Role of staphylococcal wall teichoic acid in targeting the major autolysin Atl

(2010) Martin Schlag et al.   MOLECULAR MICROBIOLOGY

The Zwitterionic Cell Wall Teichoic Acid of Staphylococcus aureus Provokes Skin Abscesses in Mice by a Novel CD4+ T-Cell-Dependent Mechanism

(2010) Christopher Weidenmaier et al.   PLoS One

Teichoic acids are temporal and spatial regulators of peptidoglycan cross-linking in Staphylococcus aureus

(2010) M. L. Atilano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of a Small Molecule that Blocks Wall Teichoic Acid Biosynthesis inStaphylococcus aureus

(2009) Jonathan G. Swoboda et al.   ACS Chemical Biology

Molecular Basis and Phenotype of Methicillin Resistance in Staphylococcus aureus and Insights into New  -Lactams That Meet the Challenge

(2009) L. I. Llarrull et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Wall Teichoic Acid Function, Biosynthesis, and Inhibition

(2009) Jonathan G. Swoboda et al.   CHEMBIOCHEM

Probing Teichoic Acid Genetics with Bioactive Molecules Reveals New Interactions among Diverse Processes in Bacterial Cell Wall Biogenesis

(2009) Michael A. D'Elia et al.   CHEMISTRY & BIOLOGY

Chemical Genetic Identification of Peptidoglycan Inhibitors Potentiating Carbapenem Activity against Methicillin-Resistant Staphylococcus aureus

(2009) Joann Huber et al.   CHEMISTRY & BIOLOGY

Wall Teichoic Acid Protects Staphylococcus aureus against Antimicrobial Fatty Acids from Human Skin

(2009) T. Kohler et al.   JOURNAL OF BACTERIOLOGY

The N-Acetylmannosamine Transferase Catalyzes the First Committed Step of Teichoic Acid Assembly in Bacillus subtilis and Staphylococcus aureus

(2009) M. A. D'Elia et al.   JOURNAL OF BACTERIOLOGY

Are essential genes really essential?

(2009) Michael A. D’Elia et al.   TRENDS IN MICROBIOLOGY

Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

(2008) Helen W. Boucher et al.   CLINICAL INFECTIOUS DISEASES

Antimicrobial activity of ceftobiprole, a novel anti–methicillin-resistant Staphylococcus aureus cephalosporin, tested against contemporary pathogens: results from the SENTRY Antimicrobial Surveillance Program (2005–2006)

(2008) Thomas R. Fritsche et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Wall Teichoic Acid Deficiency in Staphylococcus aureus Confers Selective Resistance to Mammalian Group IIA Phospholipase A2 and Human  -Defensin 3

(2008) T. Koprivnjak et al.   INFECTION AND IMMUNITY

Late-Stage Polyribitol Phosphate Wall Teichoic Acid Biosynthesis in Staphylococcus aureus

(2008) T. C. Meredith et al.   JOURNAL OF BACTERIOLOGY

Teichoic acids and related cell-wall glycopolymers in Gram-positive physiology and host interactions

(2008) Christopher Weidenmaier et al.   NATURE REVIEWS MICROBIOLOGY