Modulating immunity as a therapy for bacterial infections

Quorum Sensing Inhibitors Increase the Susceptibility of Bacterial Biofilms to Antibiotics In Vitro and In Vivo

(2011) Gilles Brackman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Viral Infection Augments Nod1/2 Signaling to Potentiate Lethality Associated with Secondary Bacterial Infections

(2011) Yun-Gi Kim et al.   Cell Host & Microbe

Eritoran tetrasodium (E5564) treatment for sepsis: review of preclinical and clinical studies

(2011) Amisha Barochia et al.   Expert Opinion on Drug Metabolism & Toxicology

Peptidoglycan: a critical activator of the mammalian immune system during infection and homeostasis

(2011) Matthew T. Sorbara et al.   IMMUNOLOGICAL REVIEWS

Sensing damage by the NLRP3 inflammasome

(2011) Jaklien C. Leemans et al.   IMMUNOLOGICAL REVIEWS

Immunomodulatory and Protective Roles of Quorum-Sensing Signaling MoleculesN-Acyl Homoserine Lactones during Infection of Mice with Aeromonas hydrophila

(2011) Bijay K. Khajanchi et al.   INFECTION AND IMMUNITY

Pathogen Recognition by the Innate Immune System

(2011) Himanshu Kumar et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Nod-like receptors in intestinal homeostasis, inflammation, and cancer

(2011) Catherine Werts et al.   JOURNAL OF LEUKOCYTE BIOLOGY

High-dose vitamin D3 during intensive-phase antimicrobial treatment of pulmonary tuberculosis: a double-blind randomised controlled trial

(2011) Adrian R Martineau et al.   LANCET

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

Programming the magnitude and persistence of antibody responses with innate immunity

(2011) Sudhir Pai Kasturi et al.   NATURE

Advances in the assessment and control of the effector functions of therapeutic antibodies

(2011) Xu-Rong Jiang et al.   NATURE REVIEWS DRUG DISCOVERY

Shifting the balance: antibiotic effects on host–microbiota mutualism

(2011) Benjamin P. Willing et al.   NATURE REVIEWS MICROBIOLOGY

The Pseudomonas aeruginosa Autoinducer 3O-C12 Homoserine Lactone Provokes Hyperinflammatory Responses from Cystic Fibrosis Airway Epithelial Cells

(2011) Matthew L. Mayer et al.   PLoS One

Nucleotide oligomerization domain-containing proteins instruct T cell helper type 2 immunity through stromal activation

(2011) J. G. Magalhaes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bis-(3′,5′)-cyclic dimeric adenosine monophosphate: Strong Th1/Th2/Th17 promoting mucosal adjuvant

(2011) Thomas Ebensen et al.   VACCINE

Ag85B–ESAT-6 adjuvanted with IC31® promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in volunteers with previous BCG vaccination or tuberculosis infection

(2011) Jaap T. van Dissel et al.   VACCINE

Toll-like receptor pre-stimulation protects mice against lethal infection with highly pathogenic influenza viruses

(2011) Kyoko Shinya et al.   Virology Journal

Immunomodulators as adjuvants for vaccines and antimicrobial therapy

(2010) Erin F. Nicholls et al.   Annals of the New York Academy of Sciences

Perception and Degradation ofN-Acyl Homoserine Lactone Quorum Sensing Signals by Mammalian and Plant Cells

(2010) Max Teplitski et al.   CHEMICAL REVIEWS

Probiotic lactobacilli and VSL#3 induce enterocyte β-defensin 2

(2010) M. Schlee et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis*

(2010) Todd W. Rice et al.   CRITICAL CARE MEDICINE

The controversial relationship between NLRP3, alum, danger signals and the next-generation adjuvants

(2010) Roberto Spreafico et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases

(2010) Jeremy Dupaul-Chicoine et al.   IMMUNITY

Mucosal Administration of Flagellin Protects Mice from Streptococcus pneumoniae Lung Infection

(2010) N. Munoz et al.   INFECTION AND IMMUNITY

TheN-Ethyl-N-Nitrosourea-InducedGoldenticketMouse Mutant Reveals an Essential Function ofStingin theIn VivoInterferon Response toListeria monocytogenesand Cyclic Dinucleotides

(2010) John-Demian Sauer et al.   INFECTION AND IMMUNITY

Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte/macrophage population

(2010) Lis R.V. Antonelli et al.   JOURNAL OF CLINICAL INVESTIGATION

Flagellin Stimulates Protective Lung Mucosal Immunity: Role of Cathelicidin-Related Antimicrobial Peptide

(2010) F.-s. Yu et al.   JOURNAL OF IMMUNOLOGY

Synthetic Cationic Peptide IDR-1002 Provides Protection against Bacterial Infections through Chemokine Induction and Enhanced Leukocyte Recruitment

(2010) Anastasia Nijnik et al.   JOURNAL OF IMMUNOLOGY

Bacterial Flagellin Stimulates Toll‐Like Receptor 5–Dependent Defense against Vancomycin‐ResistantEnterococcusInfection

(2010) Melissa A. Kinnebrew et al.   JOURNAL OF INFECTIOUS DISEASES

Small Molecules That Modulate Quorum Sensing and Control Virulence inPseudomonas aeruginosa

(2010) Margrith E. Mattmann et al.   JOURNAL OF ORGANIC CHEMISTRY

Targeting Toll-like receptors: emerging therapeutics?

(2010) Elizabeth J. Hennessy et al.   NATURE REVIEWS DRUG DISCOVERY

Host interactions of probiotic bacterial surface molecules: comparison with commensals and pathogens

(2010) Sarah Lebeer et al.   NATURE REVIEWS MICROBIOLOGY

c-di-AMP Secreted by Intracellular Listeria monocytogenes Activates a Host Type I Interferon Response

(2010) J. J. Woodward et al.   SCIENCE

Adjuvants for cancer vaccines

(2010) Thomas W. Dubensky et al.   SEMINARS IN IMMUNOLOGY

The potential of 3′,5′-cyclic diguanylic acid (c-di-GMP) as an effective vaccine adjuvant

(2010) Wangxue Chen et al.   VACCINE

Effective, Broad Spectrum Control of Virulent Bacterial Infections Using Cationic DNA Liposome Complexes Combined with Bacterial Antigens

(2010) Robin Ireland et al.   PLoS Pathogens

A novel Toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis

(2009) Ryan Ungaro et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Stimulated Innate Resistance of Lung Epithelium Protects Mice Broadly against Bacteria and Fungi

(2009) Scott E. Evans et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Long-term efficacy of interferon alpha therapy on hepatitis B viral replication in patients with chronic hepatitis B: A meta-analysis

(2009) Yong-Feng Yang et al.   ANTIVIRAL RESEARCH

Phase 2 trial of eritoran tetrasodium (E5564), a Toll-like receptor 4 antagonist, in patients with severe sepsis*

(2009) Mark Tidswell et al.   CRITICAL CARE MEDICINE

Mechanism of action of clinically approved adjuvants

(2009) Bart N Lambrecht et al.   CURRENT OPINION IN IMMUNOLOGY

The path to a successful vaccine adjuvant – ‘The long and winding road’

(2009) Derek T. O’Hagan et al.   DRUG DISCOVERY TODAY

Emerging drugs for the treatment of ulcerative colitis

(2009) Luca Pastorelli et al.   EXPERT OPINION ON EMERGING DRUGS

Role of Nod1 in Mucosal Dendritic Cells during Salmonella Pathogenicity Island 1-Independent Salmonella enterica Serovar Typhimurium Infection

(2009) L. Le Bourhis et al.   INFECTION AND IMMUNITY

The K5 Capsule of Escherichia coli Strain Nissle 1917 Is Important in Mediating Interactions with Intestinal Epithelial Cells and Chemokine Induction

(2009) M. Hafez et al.   INFECTION AND IMMUNITY

Human beta-defensin-3 promotes wound healing in infected diabetic wounds

(2009) Tobias Hirsch et al.   JOURNAL OF GENE MEDICINE

Human Cathelicidin Peptide LL-37 Modulates the Effects of IFN-  on APCs

(2009) A. Nijnik et al.   JOURNAL OF IMMUNOLOGY

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

Unleashing the therapeutic potential of NOD-like receptors

(2009) Kaoru Geddes et al.   NATURE REVIEWS DRUG DISCOVERY

Augmented Lung Inflammation Protects against Influenza A Pneumonia

(2009) Michael J. Tuvim et al.   PLoS One

Potential of immunomodulatory host defense peptides as novel anti-infectives

(2009) Donna M. Easton et al.   TRENDS IN BIOTECHNOLOGY

Enabling a systems biology approach to immunology: focus on innate immunity

(2009) Jennifer L. Gardy et al.   TRENDS IN IMMUNOLOGY

Endotoxin tolerance: new mechanisms, molecules and clinical significance

(2009) Subhra K. Biswas et al.   TRENDS IN IMMUNOLOGY

A novel vaccine adjuvant comprised of a synthetic innate defence regulator peptide and CpG oligonucleotide links innate and adaptive immunity

(2009) Jason Kindrachuk et al.   VACCINE

Stimulation of Lung Innate Immunity Protects against Lethal Pneumococcal Pneumonia in Mice

(2008) Cecilia G. Clement et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Novel anti-infectives: is host defence the answer?

(2008) Pamela Hamill et al.   CURRENT OPINION IN BIOTECHNOLOGY

The Commensal Streptococcus salivarius K12 Downregulates the Innate Immune Responses of Human Epithelial Cells and Promotes Host-Microbe Homeostasis

(2008) C. Cosseau et al.   INFECTION AND IMMUNITY

Human Host Defense Peptide LL-37 Prevents Bacterial Biofilm Formation

(2008) J. Overhage et al.   INFECTION AND IMMUNITY

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(2008) Bart Ferwerda et al.   MOLECULAR MEDICINE

Mucosal delivery of therapeutic and prophylactic molecules using lactic acid bacteria

(2008) Jerry M. Wells et al.   NATURE REVIEWS MICROBIOLOGY

Analogues of muramyl dipeptide (MDP) and tuftsin limit infection and inflammation in murine model of sepsis

(2008) Anna Wardowska et al.   VACCINE

In vitro and In vivo Wound Healing-Promoting Activities of Human Cathelicidin LL-37

(2007) Marta Carretero et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY