Functional annotation of chemical libraries across diverse biological processes

A global genetic interaction network maps a wiring diagram of cellular function

(2016) M. Costanzo et al.   SCIENCE

Systematic Functional Annotation and Visualization of Biological Networks

(2016) Anastasia Baryshnikova   Cell Systems

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities

(2015) Traver Hart et al.   CELL

CYCLoPs: A Comprehensive Database Constructed from Automated Analysis of Protein Abundance and Subcellular Localization Patterns in Saccharomyces cerevisiae

(2015) J. L. Y. Koh et al.   G3-Genes Genomes Genetics

Use of artemisinin and its derivatives to treat HPV-infected/transformed cells and cervical cancer: a review

(2014) Sarah K Goodrich et al.   Future Oncology

Photo-Activated Psoralen Binds the ErbB2 Catalytic Kinase Domain, Blocking ErbB2 Signaling and Triggering Tumor Cell Apoptosis

(2014) Wenle Xia et al.   PLoS One

Mapping the Cellular Response to Small Molecules Using Chemogenomic Fitness Signatures

(2014) A. Y. Lee et al.   SCIENCE

Shifting from the single to the multitarget paradigm in drug discovery

(2013) José L. Medina-Franco et al.   DRUG DISCOVERY TODAY

Evolutionary Survey of Druggable Protein Targets with Respect to Their Subcellular Localizations

(2013) Xiaotong Wang et al.   Genome Biology and Evolution

High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions

(2013) Dominic Hoepfner et al.   MICROBIOLOGICAL RESEARCH

Distinct roles of cell wall biogenesis in yeast morphogenesis as revealed by multivariate analysis of high-dimensional morphometric data

(2013) Hiroki Okada et al.   MOLECULAR BIOLOGY OF THE CELL

Systems-level antimicrobial drug and drug synergy discovery

(2013) Terry Roemer et al.   Nature Chemical Biology

Profile of the GSK Published Protein Kinase Inhibitor Set Across ATP-Dependent and-Independent Luciferases: Implications for Reporter-Gene Assays

(2013) Patricia Dranchak et al.   PLoS One

Construction of a microbial natural product library for chemical biology studies

(2012) Naoki Kato et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Quality-filtering vastly improves diversity estimates from Illumina amplicon sequencing

(2012) Nicholas A Bokulich et al.   NATURE METHODS

Cell death assays for drug discovery

(2011) Oliver Kepp et al.   NATURE REVIEWS DRUG DISCOVERY

Open Babel: An open chemical toolbox

(2011) Noel M O'Boyle et al.   Journal of Cheminformatics

PaDEL-descriptor: An open source software to calculate molecular descriptors and fingerprints

(2010) Chun Wei Yap   JOURNAL OF COMPUTATIONAL CHEMISTRY

The Molecular Mechanism of Action of Artemisinin—The Debate Continues

(2010) Paul M. O’Neill et al.   MOLECULES

Highly-multiplexed barcode sequencing: an efficient method for parallel analysis of pooled samples

(2010) A. M. Smith et al.   NUCLEIC ACIDS RESEARCH

The Genetic Landscape of a Cell

(2010) M. Costanzo et al.   SCIENCE

Pharmacological Promiscuity: Dependence on Compound Properties and Target Specificity in a Set of Recent Roche Compounds

(2009) Jens-Uwe Peters et al.   ChemMedChem

Comprehensive In Vitro Analysis of Voriconazole Inhibition of Eight Cytochrome P450 (CYP) Enzymes: Major Effect on CYPs 2B6, 2C9, 2C19, and 3A

(2008) S. Jeong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pybel: a Python wrapper for the OpenBabel cheminformatics toolkit

(2008) Noel M O'Boyle et al.   Chemistry Central Journal