Hybrid antibiotics – clinical progress and novel designs

Development and evaluation of a highly reliable assay for SUMO-specific protease inhibitors

(2016) Wenjuan Xie et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Understanding the mechanisms and drivers of antimicrobial resistance

(2016) Alison H Holmes et al.   LANCET

Alternatives to antibiotics—a pipeline portfolio review

(2016) Lloyd Czaplewski et al.   LANCET INFECTIOUS DISEASES

Structural hybridization of three aminoglycoside antibiotics yields a potent broad-spectrum bactericide that eludes bacterial resistance enzymes

(2016) Juan Pablo Maianti et al.   MedChemComm

Adjuvants Based on Hybrid Antibiotics Overcome Resistance in Pseudomonas aeruginosa and Enhance Fluoroquinolone Efficacy

(2015) Bala Kishan Gorityala et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multicenter, Double-Blind, Randomized, Phase 2 Study Evaluating the Novel Antibiotic Cadazolid in Patients with Clostridium difficile Infection

(2015) Thomas Louie et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Novel antibacterial active quinolone–fluoroquinolone conjugates and 2D-QSAR studies

(2015) Siva S. Panda et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of ciprofloxacin dimers for evaluation of bacterial permeability in atypical chemical space

(2015) Audrey G. Ross et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Some Anti-Inflammatory Agents Inhibit Esterase Activities of Human Carbonic Anhydrase Isoforms I and II: AnIn VitroStudy

(2015) Zuhal Alım et al.   Chemical Biology & Drug Design

Analysis of effects of MCB3681, the antibacterially active substance of prodrug MCB3837, on human resident microflora as proof of principle

(2015) A. Dalhoff et al.   CLINICAL MICROBIOLOGY AND INFECTION

Search for factors affecting antibacterial activity and toxicity of 1,2,4-triazole-ciprofloxacin hybrids

(2015) Tomasz Plech et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Susceptibility ofClostridium difficileisolates from a Phase 2 clinical trial of cadazolid and vancomycin inC. difficileinfection

(2015) D. N. Gerding et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Clostridium difficile Drug Pipeline: Challenges in Discovery and Development of New Agents

(2015) Angie M. Jarrad et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel lead generation of an anti-tuberculosis agent active against non-replicating mycobacteria: exploring hybridization of pyrazinamide with multiple fragments

(2015) Shankar D. Markad et al.   MEDICINAL CHEMISTRY RESEARCH

Determination of the Primary Molecular Target of 1,2,4-Triazole-Ciprofloxacin Hybrids

(2015) Tomasz Plech et al.   MOLECULES

Design of dual action antibiotics as an approach to search for new promising drugs

(2015) A N Tevyashova et al.   RUSSIAN CHEMICAL REVIEWS

In vitro activity of MCB3681 against Clostridium difficile strains

(2014) Mamun-Ur Rashid et al.   ANAEROBE

Novel 3-arylfuran-2(5H)-one-fluoroquinolone hybrid: Design, synthesis and evaluation as antibacterial agent

(2014) Xu-Dong Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis, and biological evaluation of dihydroartemisinin–fluoroquinolone conjugates as a novel type of potential antitubercular agents

(2014) Fu-Wei Zhou et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Progress in the Discovery of Treatments for C. difficile Infection: A Clinical and Medicinal Chemistry Review

(2014) Lissa Tsutsumi et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

An analysis of FDA-approved drugs for infectious disease: antibacterial agents

(2014) Michael S. Kinch et al.   DRUG DISCOVERY TODAY

Novel hybrids of metronidazole and quinolones: Synthesis, bioactive evaluation, cytotoxicity, preliminary antimicrobial mechanism and effect of metal ions on their transportation by human serum albumin

(2014) Sheng-Feng Cui et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, and evaluation of novel fluoroquinolone–flavonoid hybrids as potent antibiotics against drug-resistant microorganisms

(2014) Zhu-Ping Xiao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Multifunctional compounds: Smart molecules for multifactorial diseases

(2014) Yogita Bansal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Ecological impact of MCB3837 on the normal human microbiota

(2014) Mamun-Ur Rashid et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Lowenstein-Jensen Selective Medium for Reducing Contamination in Mycobacterium tuberculosis Culture

(2014) K. Kassaza et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Discovery of Isoquinolinone Indole Acetic Acids as Antagonists of Chemoattractant Receptor Homologous Molecule Expressed on Th2 Cells (CRTH2) for the Treatment of Allergic Inflammatory Diseases

(2014) Neelu Kaila et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enterobactin-Mediated Delivery of β-Lactam Antibiotics Enhances Antibacterial Activity against Pathogenic Escherichia coli

(2014) Tengfei Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design and synthesis of novel miconazole-based ciprofloxacin hybrids as potential antimicrobial agents

(2014) Xiao-Long Gu et al.   MONATSHEFTE FUR CHEMIE

Siderophore–drug complexes: potential medicinal applications of the ‘Trojan horse’ strategy

(2014) Agnieszka Górska et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Challenges and future prospects of antibiotic therapy: from peptides to phages utilization

(2014) Santi M. Mandal et al.   Frontiers in Pharmacology

Involvement of Fe Uptake Systems and AmpC β-Lactamase in Susceptibility to the Siderophore Monosulfactam BAL30072 in Pseudomonas aeruginosa

(2013) Christian van Delden et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Contribution of β-Lactamases and Porin Proteins OmpK35 and OmpK36 to Carbapenem Resistance in Clinical Isolates of KPC-2-Producing Klebsiella pneumoniae

(2013) Ying Zhang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis and study of antibacterial activities of antibacterial glycopeptide antibiotics conjugated with benzoxaboroles

(2013) SS Printsevskaya et al.   Future Medicinal Chemistry

Cadazolid, a novel antibiotic with potent activity against Clostridium difficile: safety, tolerability and pharmacokinetics in healthy subjects following single and multiple oral doses

(2013) D. Baldoni et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Synthesis and Evaluation of Hetero- and Homodimers of Ribosome-Targeting Antibiotics: Antimicrobial Activity, in Vitro Inhibition of Translation, and Drug Resistance

(2013) Yifat Berkov-Zrihen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Biscatecholate–Monohydroxamate Mixed Ligand Siderophore–Carbacephalosporin Conjugates are Selective Sideromycin Antibiotics that Target Acinetobacter baumannii

(2013) Timothy A. Wencewicz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Platforms for antibiotic discovery

(2013) Kim Lewis   NATURE REVIEWS DRUG DISCOVERY

Combination approaches to combat multidrug-resistant bacteria

(2013) Roberta J. Worthington et al.   TRENDS IN BIOTECHNOLOGY

Potent Targeting of the STAT3 Protein in Brain Cancer Stem Cells: A Promising Route for Treating Glioblastoma

(2013) Sina Haftchenary et al.   ACS Medicinal Chemistry Letters

Population Pharmacokinetics of Palivizumab, a Humanized Anti-Respiratory Syncytial Virus Monoclonal Antibody, in Adults and Children

(2012) Gabriel J. Robbie et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Neomycin–phenolic conjugates: Polycationic amphiphiles with broad-spectrum antibacterial activity, low hemolytic activity and weak serum protein binding

(2012) Brandon Findlay et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis and evaluation of clinafloxacin triazole hybrids as a new type of antibacterial and antifungal agents

(2012) Yan Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Combination Therapy for Treatment of Infections with Gram-Negative Bacteria

(2012) P. D. Tamma et al.   CLINICAL MICROBIOLOGY REVIEWS

Synthesis and in vitro activity of 1,2,4-triazole-ciprofloxacin hybrids against drug-susceptible and drug-resistant bacteria

(2012) Tomasz Plech et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Challenges of Antibacterial Discovery

(2011) L. L. Silver   CLINICAL MICROBIOLOGY REVIEWS

Ionization of Carbon Acids in Liquid Ammonia

(2011) Pengju Ji et al.   ORGANIC LETTERS

Discovery of 4′′-Ether Linked Azithromycin-Quinolone Hybrid Series: Influence of the Central Linker on the Antibacterial Activity

(2011) Dražen Pavlović et al.   ACS Medicinal Chemistry Letters

Berberine-INF55 (5-Nitro-2-Phenylindole) Hybrid Antimicrobials: Effects of Varying the Relative Orientation of the Berberine and INF55 Components

(2010) D. Tomkiewicz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vitro Properties of BAL30072, a Novel Siderophore Sulfactam with Activity against Multiresistant Gram-Negative Bacilli

(2010) M. G. P. Page et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Multiresistant Gram-negative infections: a global perspective

(2010) Jennifer Ho et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Synthesis and antimicrobial activity of thiosemicarbazides, s-triazoles and their Mannich bases bearing 3-chlorophenyl moiety

(2010) Tomasz Plech et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Dual-acting hybrid antibiotics: a promising strategy to combat bacterial resistance

(2010) Varvara Pokrovskaya et al.   Expert Opinion on Drug Discovery

Overview perspective of bacterial resistance

(2010) Guilherme H Furtado et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Has the era of untreatable infections arrived?

(2009) D. M. Livermore   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Drug interactions and the evolution of antibiotic resistance

(2009) Pamela J. Yeh et al.   NATURE REVIEWS MICROBIOLOGY

In Vitro Evaluation of CBR-2092, a Novel Rifamycin-Quinolone Hybrid Antibiotic: Microbiology Profiling Studies with Staphylococci and Streptococci

(2008) G. T. Robertson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vitro Evaluation of CBR-2092, a Novel Rifamycin-Quinolone Hybrid Antibiotic: Studies of the Mode of Action in Staphylococcus aureus

(2008) G. T. Robertson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Drug interactions modulate the potential for evolution of resistance

(2008) J.-B. Michel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA