Targeting TNF and TNF Receptor Pathway in HIV-1 Infection: from Immune Activation to Viral Reservoirs

HIV Latency: Should We Shock or Lock?

(2017) Gilles Darcis et al.   TRENDS IN IMMUNOLOGY

Rates of Serious Infections in HIV-Infected Patients Receiving Tumor Necrosis Factor Inhibitor Therapy for Concomitant Autoimmune Diseases

(2017) Sintawat Wangsiricharoen et al.   ARTHRITIS CARE & RESEARCH

The mTOR Complex Controls HIV Latency

(2016) Emilie Besnard et al.   Cell Host & Microbe

Persistent, Albeit Reduced, Chronic Inflammation in Persons Starting Antiretroviral Therapy in Acute HIV Infection

(2016) Irini Sereti et al.   CLINICAL INFECTIOUS DISEASES

Suboptimal Adherence to Combination Antiretroviral Therapy Is Associated With Higher Levels of Inflammation Despite HIV Suppression

(2016) Jose R. Castillo-Mancilla et al.   CLINICAL INFECTIOUS DISEASES

Extracellular vesicles and infectious diseases: new complexity to an old story

(2016) Jeffrey S. Schorey et al.   JOURNAL OF CLINICAL INVESTIGATION

Recent developments in the effort to cure HIV infection: going beyond N = 1

(2016) Janet D. Siliciano et al.   JOURNAL OF CLINICAL INVESTIGATION

Use of tumor necrosis factor (TNF) inhibitors in patients with HIV/AIDS

(2016) Stephanie M. Gallitano et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

HIV-1 Tat Protein Activates both the MyD88 and TRIF Pathways To Induce Tumor Necrosis Factor Alpha and Interleukin-10 in Human Monocytes

(2016) Rémi Planès et al.   JOURNAL OF VIROLOGY

Tumor-necrosis factor impairs CD4+ T cell–mediated immunological control in chronic viral infection

(2016) Marc Beyer et al.   NATURE IMMUNOLOGY

HIV integration and the establishment of latency in CCL19-treated resting CD4+ T cells require activation of NF-κB

(2016) Suha Saleh et al.   Retrovirology

Tuning of AKT-pathway by Nef and its blockade by protease inhibitors results in limited recovery in latently HIV infected T-cell line

(2016) Amit Kumar et al.   Scientific Reports

TNF and HIV-1 Nef: An Intimate Interplay

(2016) Georges Herbein   EBioMedicine

HIV Nef- and Notch1-dependent Endocytosis of ADAM17 Induces Vesicular TNF Secretion in Chronic HIV Infection

(2016) Christian Ostalecki et al.   EBioMedicine

LEDGIN-mediated Inhibition of Integrase–LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIV

(2016) Lenard S. Vranckx et al.   EBioMedicine

Limited HIV-1 Reactivation in Resting CD4+ T cells from Aviremic Patients under Protease Inhibitors

(2016) Amit Kumar et al.   Scientific Reports

The effect of HAART-induced HIV suppression on circulating markers of inflammation and immune activation

(2015) Nikolas Itaru Wada et al.   AIDS

Exosomes from HIV-1-infected Cells Stimulate Production of Pro-inflammatory Cytokines through Trans-activating Response (TAR) RNA

(2015) Gavin C. Sampey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vpr Enhances Tumor Necrosis Factor Production by HIV-1-Infected T Cells

(2015) Ferdinand Roesch et al.   JOURNAL OF VIROLOGY

HIV reservoirs as obstacles and opportunities for an HIV cure

(2015) Tae-Wook Chun et al.   NATURE IMMUNOLOGY

Eradication of HIV-1 from the Macrophage Reservoir: An Uncertain Goal?

(2015) Wasim Abbas et al.   Viruses-Basel

An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression

(2015) Gilles Darcis et al.   PLoS Pathogens

Monocyte-Activation Phenotypes Are Associated With Biomarkers of Inflammation and Coagulation in Chronic HIV Infection

(2014) Eleanor M. P. Wilson et al.   JOURNAL OF INFECTIOUS DISEASES

Exosomes from Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Cells License Quiescent CD4+ T Lymphocytes To Replicate HIV-1 through a Nef- and ADAM17-Dependent Mechanism

(2014) C. Arenaccio et al.   JOURNAL OF VIROLOGY

New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo

(2014) C Korin Bullen et al.   NATURE MEDICINE

HIV-1 Nef Impairs Key Functional Activities in Human Macrophages through CD36 Downregulation

(2014) Eleonora Olivetta et al.   PLoS One

Cell activation and HIV-1 replication in unstimulated CD4+ T lymphocytes ingesting exosomes from cells expressing defective HIV-1

(2014) Claudia Arenaccio et al.   Retrovirology

Blockade of BFA-mediated apoptosis in macrophages by the HIV-1 Nef protein

(2014) W Abbas et al.   Cell Death & Disease

Regulation of TNF-α with a focus on rheumatoid arthritis

(2013) Eva AV Moelants et al.   IMMUNOLOGY AND CELL BIOLOGY

HIV-1 Nef Interacts with HCV Core, Recruits TRAF2, TRAF5 and TRAF6, and Stimulates HIV-1 Replication in Macrophages

(2013) Kashif A. Khan et al.   Journal of Innate Immunity

Clinical targeting of the TNF and TNFR superfamilies

(2013) Michael Croft et al.   NATURE REVIEWS DRUG DISCOVERY

Clinical Use of HIV Integrase Inhibitors: A Systematic Review and Meta-Analysis

(2013) Peter Messiaen et al.   PLoS One

Histone methyltransferase inhibitors induce HIV-1 recovery in resting CD4+ T cells from HIV-1-infected HAART-treated patients

(2012) Sophie Bouchat et al.   AIDS

Disulfiram reactivates latent HIV-1 expression through depletion of the phosphatase and tensin homolog

(2012) Geneviève Doyon et al.   AIDS

Inhibition of NF-κB activity by HIV-1 Vpr is dependent on Vpr binding protein

(2012) Michael Kogan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journey

(2011) B. B. Aggarwal et al.   BLOOD

Disulfiram Reactivates Latent HIV-1 in a Bcl-2-Transduced Primary CD4+ T Cell Model without Inducing Global T Cell Activation

(2011) S. Xing et al.   JOURNAL OF VIROLOGY

Glial TNFα in the Spinal Cord Regulates Neuropathic Pain Induced by HIV gp120 Application in Rats

(2011) Wenwen Zheng et al.   Molecular Pain

Detection of HIV gp120 in Plasma During Early HIV Infection Is Associated with Increased Proinflammatory and Immunoregulatory Cytokines

(2010) Jenna Rychert et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Lipopolysaccharide (LPS) down-regulates CD4 expression in primary human macrophages through induction of endogenous tumour necrosis factor (TNF) and IL-1β

(2010) G. HERBEIN et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Signaling through the P38 and ERK pathways: a common link between HIV replication and the immune response

(2010) Robert L. Furler et al.   IMMUNOLOGIC RESEARCH

HIV-1 Vpr induces TLR4/MyD88-mediated IL-6 production and reactivates viral production from latency

(2010) Shigeki Hoshino et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Combinatorial Latency Reactivation for HIV-1 Subtypes and Variants

(2010) J. C. Burnett et al.   JOURNAL OF VIROLOGY

Certolizumab Pegol

(2010) Niti Goel et al.   mAbs

Mechanisms of HIV-associated lymphocyte apoptosis: 2010

(2010) N W Cummins et al.   Cell Death & Disease

NF-κB/Rel: agonist and antagonist roles in HIV-1 latency

(2010) Jonathan KL Chan et al.   Current Opinion in HIV and AIDS

The Survival of Memory CD4+ T Cells within the Gut Lamina Propria Requires OX40 and CD30 Signals

(2009) D. R. Withers et al.   JOURNAL OF IMMUNOLOGY

Virion-Associated Vpr of Human Immunodeficiency Virus Type 1 Triggers Activation of Apoptotic Events and Enhances Fas-Induced Apoptosis in Human T Cells

(2009) H. Arokium et al.   JOURNAL OF VIROLOGY

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

(2009) Nicolas Chomont et al.   NATURE MEDICINE

Synergistic Activation of HIV-1 Expression by Deacetylase Inhibitors and Prostratin: Implications for Treatment of Latent Infection

(2009) Sophie Reuse et al.   PLoS One

HIV Nef is Secreted in Exosomes and Triggers Apoptosis in Bystander CD4+ T Cells

(2009) Metka Lenassi et al.   TRAFFIC

HIV-1 Accessory Proteins—Ensuring Viral Survival in a Hostile Environment

(2008) Michael H. Malim et al.   Cell Host & Microbe

Nef and TNFα are Coplayers that Favor HIV-1 Replication in Monocytic Cells and Primary Macrophages

(2008) Georges Herbein et al.   CURRENT HIV RESEARCH

Is HIV infection a TNF receptor signalling-driven disease?

(2008) Georges Herbein et al.   TRENDS IN IMMUNOLOGY

TNF-mediated inflammatory disease

(2007) JR Bradley   JOURNAL OF PATHOLOGY