HIV-1 matrix protein p17 misfolding forms toxic amyloidogenic assemblies that induce neurocognitive disorders

HIV-1-associated neurocognitive disorder: epidemiology, pathogenesis, diagnosis, and treatment

(2017) Christian Eggers et al.   JOURNAL OF NEUROLOGY

Epigenetic mechanisms underlying cognitive impairment and Alzheimer disease hallmarks in 5XFAD mice

(2016) Christian Griñán-Ferré et al.   Aging-US

A lymphomagenic role for HIV beyond immune suppression?

(2016) R. Dolcetti et al.   BLOOD

SIRT1 Overexpression in Mouse Hippocampus Induces Cognitive Enhancement Through Proteostatic and Neurotrophic Mechanisms

(2016) Rubén Corpas et al.   MOLECULAR NEUROBIOLOGY

How Epigallocatechin-3-gallate and Tetracycline Interact with the Josephin Domain of Ataxin-3 and Alter Its Aggregation Mode

(2015) Marcella Bonanomi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Oxidative Stress Is a Central Target for Physical Exercise Neuroprotection Against Pathological Brain Aging

(2015) Yoelvis García-Mesa et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Role of HIV-1 matrix protein p17 variants in lymphoma pathogenesis

(2015) Riccardo Dolcetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toxicity of Protein Oligomers Is Rationalized by a Function Combining Size and Surface Hydrophobicity

(2014) Benedetta Mannini et al.   ACS Chemical Biology

Low levels of HIV-1 RNA detected in the cerebrospinal fluid after up to 10 years of suppressive therapy are associated with local immune activation

(2014) Viktor Dahl et al.   AIDS

HIV-1 Matrix Protein p17 Promotes Lymphangiogenesis and Activates the Endothelin-1/Endothelin B Receptor Axis

(2014) Francesca Caccuri et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A Caenorhabditis elegans-based assay recognizes immunoglobulin light chains causing heart amyloidosis

(2014) L. Diomede et al.   BLOOD

Lenti-GDNF Gene Therapy Protects Against Alzheimer's Disease-Like Neuropathology in 3xTg-AD Mice and MC65 Cells

(2014) Susana Revilla et al.   CNS Neuroscience & Therapeutics

The Peculiar Role of the A2V Mutation in Amyloid-β (Aβ) 1–42 Molecular Assembly

(2014) Massimo Messa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Simian Immunodeficiency Virus and Human Immunodeficiency Virus Type 1 Matrix Proteins Specify Different Capabilities To Modulate B Cell Growth

(2014) F. Caccuri et al.   JOURNAL OF VIROLOGY

Doxycycline in Creutzfeldt-Jakob disease: a phase 2, randomised, double-blind, placebo-controlled trial

(2014) Stéphane Haïk et al.   LANCET NEUROLOGY

Clioquinol promotes the degradation of metal-dependent amyloid-  (A ) oligomers to restore endocytosis and ameliorate A  toxicity

(2014) K. E. S. Matlack et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights from the worm: The C. elegans model for innate immunity

(2014) Maria A. Ermolaeva et al.   SEMINARS IN IMMUNOLOGY

Synthetic HIV-1 matrix protein p17-based AT20-KLH therapeutic immunization in HIV-1-infected patients receiving antiretroviral treatment: A phase I safety and immunogenicity study

(2014) Maria Luisa Iaria et al.   VACCINE

An N-terminal Fragment of the Prion Protein Binds to Amyloid-β Oligomers and Inhibits Their Neurotoxicityin Vivo

(2013) Brian R. Fluharty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A New Face for Old Antibiotics: Tetracyclines in Treatment of Amyloidoses

(2013) Tatiana Stoilova et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular and pathologic insights from latent HIV-1 infection in the human brain

(2013) P. Desplats et al.   NEUROLOGY

HIV-1 matrix protein p17 binds to the IL-8 receptor CXCR1 and shows IL-8-like chemokine activity on monocytes through Rho/ROCK activation

(2012) C. Giagulli et al.   BLOOD

Specific Recognition of Biologically Active Amyloid-β Oligomers by a New Surface Plasmon Resonance-based Immunoassay and anin VivoAssay inCaenorhabditis elegans

(2012) Matteo Stravalaci et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Interaction Studies of HIV-1 Matrix Protein p17 and Heparin

(2012) Antonella Bugatti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Infectious Agents and Neurodegeneration

(2012) Giovanna De Chiara et al.   MOLECULAR NEUROBIOLOGY

C. elegans Expressing Human β2-Microglobulin: A Novel Model for Studying the Relationship between the Molecular Assembly and the Toxic Phenotype

(2012) Luisa Diomede et al.   PLoS One

HIV-1 matrix protein p17 promotes angiogenesis via chemokine receptors CXCR1 and CXCR2

(2012) F. Caccuri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 p17 Matrix Protein Interacts with Heparan Sulfate Side Chain of CD44v3, Syndecan-2, and Syndecan-4 Proteoglycans Expressed on Human Activated CD4+T Cells Affecting Tumor Necrosis Factor α and Interleukin 2 Production

(2011) Maria A. De Francesco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Delineating HIV-Associated Neurocognitive Disorders Using Transgenic Models: The Neuropathogenic Actions of Vpr

(2011) Christopher Power et al.   Journal of Neuroimmune Pharmacology

Opposite Effects of HIV-1 p17 Variants on PTEN Activation and Cell Growth in B Cells

(2011) Cinzia Giagulli et al.   PLoS One

HIV-1 Tat-Induced Microgliosis and Synaptic Damage via Interactions between Peripheral and Central Myeloid Cells

(2011) Shao-Ming Lu et al.   PLoS One

A modified protocol to prepare seed-free starting solutions of amyloid-β (Aβ)1–40 and Aβ1–42 from the corresponding depsipeptides

(2010) Marten Beeg et al.   ANALYTICAL BIOCHEMISTRY

A comparison of the biochemical modifications caused by toxic and non-toxic protein oligomers in cells

(2010) Mariagioia Zampagni et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Tetracycline prevents Aβ oligomer toxicity through an atypical supramolecular interaction

(2010) Cristina Airoldi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

HIV-1 matrix protein p17: A candidate antigen for therapeutic vaccines against AIDS

(2010) Simona Fiorentini et al.   PHARMACOLOGY & THERAPEUTICS

Analysis of Human Immunodeficiency Virus Type 1 Matrix Binding to Membranes and Nucleic Acids

(2009) A. Alfadhli et al.   JOURNAL OF VIROLOGY

Object recognition memory and the rodent hippocampus

(2009) N. J. Broadbent et al.   LEARNING & MEMORY

Synergistic Activation of HIV-1 Expression by Deacetylase Inhibitors and Prostratin: Implications for Treatment of Latent Infection

(2009) Sophie Reuse et al.   PLoS One

HIV-1 matrix protein p17 binds to monocytes and selectively stimulates MCP-1 secretion: role of transcriptional factor AP-1

(2008) Elena Marini et al.   CELLULAR MICROBIOLOGY

HIV-1 gp120 induces cytokine expression, leukocyte adhesion, and transmigration across the blood–brain barrier: modulatory effects of STAT1 signaling

(2008) Bo Yang et al.   MICROVASCULAR RESEARCH

The Efficacy of Tetracyclines in Peripheral and Intracerebral Prion Infection

(2008) Ada De Luigi et al.   PLoS One

HIV-1 matrix protein p17 induces human plasmacytoid dendritic cells to acquire a migratory immature cell phenotype

(2008) S. Fiorentini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic peptide AT20 coupled to KLH elicits antibodies against a conserved conformational epitope from a major functional area of the HIV-1 matrix protein p17

(2008) Simona Fiorentini et al.   VACCINE