HMGB1 and thrombin mediate the blood-brain barrier dysfunction acting as biomarkers of neuroinflammation and progression to neurodegeneration in Alzheimer’s disease
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
HMGB1 and thrombin mediate the blood-brain barrier dysfunction acting as biomarkers of neuroinflammation and progression to neurodegeneration in Alzheimer’s disease
Authors
Keywords
Biomarkers, Blood-brain barrier, Clinical, DAMPS, HMGB1, Neuroinflammation, Neurodegeneration, Permeability, Thrombin
Journal
Journal of Neuroinflammation
Volume 13, Issue 1, Pages -
Publisher
Springer Nature
Online
2016-08-24
DOI
10.1186/s12974-016-0670-z
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Neuroinflammation in Alzheimer's Disease: Mechanisms, Pathologic Consequences, and Potential for Therapeutic Manipulation
- (2017) Kenneth Hensley JOURNAL OF ALZHEIMERS DISEASE
- Anti-high mobility group box 1 antibody exerts neuroprotection in a rat model of Parkinson's disease
- (2016) Tatsuya Sasaki et al. EXPERIMENTAL NEUROLOGY
- The blood–brain barrier endothelium: a target for pro-inflammatory cytokines: Figure 1
- (2015) Keith D. Rochfort et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Amyloid β: one of three danger-associated molecules that are secondary inducers of the proinflammatory cytokines that mediate Alzheimer's disease
- (2015) I A Clark et al. BRITISH JOURNAL OF PHARMACOLOGY
- The dynamic blood-brain barrier
- (2015) James Keaney et al. FEBS Journal
- Immune attack: the role of inflammation in Alzheimer disease
- (2015) Frank L. Heppner et al. NATURE REVIEWS NEUROSCIENCE
- Altered Nrf2 Signaling Mediates Hypoglycemia-Induced Blood–Brain Barrier Endothelial Dysfunction In Vitro
- (2015) Ravi K. Sajja et al. PLoS One
- The neurovascular unit - concept review
- (2014) V. Muoio et al. Acta Physiologica
- Role of high-mobility group box-1 protein in disruption of vascular barriers and regulation of leukocyte–endothelial interactions
- (2014) Mohd Imtiaz Nawaz et al. JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION
- Alzheimer’s disease drug-development pipeline: few candidates, frequent failures
- (2014) Jeffrey L Cummings et al. Alzheimers Research & Therapy
- Amyloid-β and Tau
- (2014) George S. Bloom JAMA Neurology
- Pericyte loss influences Alzheimer-like neurodegeneration in mice
- (2013) Abhay P. Sagare et al. Nature Communications
- Anti-high mobility group box-1 antibody therapy for traumatic brain injury
- (2012) Yu Okuma et al. ANNALS OF NEUROLOGY
- HMGB1 in vascular diseases: Its role in vascular inflammation and atherosclerosis
- (2012) A.W.S. de Souza et al. AUTOIMMUNITY REVIEWS
- Does a Pro-Inflammatory Process Precede Alzheimers Disease and Mild Cognitive Impairment?
- (2012) M. T. Ferretti et al. Current Alzheimer Research
- HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4
- (2012) Milena Schiraldi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Soluble thrombomodulin levels in plasma of multiple sclerosis patients and their implication
- (2012) Barry W. Festoff et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- HMGB1 and leukocyte migration during trauma and sterile inflammation
- (2012) Emilie Venereau et al. MOLECULAR IMMUNOLOGY
- HMGB1 in Development and Diseases of the Central Nervous System
- (2012) Ping Fang et al. MOLECULAR NEUROBIOLOGY
- A breach in the blood–brain barrier
- (2012) Peter Carmeliet et al. NATURE
- Brain and Circulating Levels of Aβ1–40 Differentially Contribute to Vasomotor Dysfunction in the Mouse Brain
- (2012) Laibaik Park et al. STROKE
- The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease
- (2011) Guy M. McKhann et al. Alzheimers & Dementia
- The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease
- (2011) Marilyn S. Albert et al. Alzheimers & Dementia
- High-mobility group box-1 impairs memory in mice through both toll-like receptor 4 and Receptor for Advanced Glycation End Products
- (2011) Andréy Mazarati et al. EXPERIMENTAL NEUROLOGY
- Cerebral microvascular endothelium and the pathogenesis of neurodegenerative diseases
- (2011) Paula Grammas et al. EXPERT REVIEWS IN MOLECULAR MEDICINE
- TLR2 Is a Primary Receptor for Alzheimer's Amyloid Peptide To Trigger Neuroinflammatory Activation
- (2011) S. Liu et al. JOURNAL OF IMMUNOLOGY
- Thrombomodulin and its role in inflammation
- (2011) Edward M. Conway Seminars in Immunopathology
- Anti-high Mobility Group Box-1 Monoclonal Antibody Protects the Blood–Brain Barrier From Ischemia-Induced Disruption in Rats
- (2011) Jiyong Zhang et al. STROKE
- Amyloid-β Contributes to Blood–Brain Barrier Leakage in Transgenic Human Amyloid Precursor Protein Mice and in Humans With Cerebral Amyloid Angiopathy
- (2011) Anika M.S. Hartz et al. STROKE
- Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis
- (2010) Theodore J. Iwashyna et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Potential biomarkers for vascular damage in ALzheimer’s disease: Thrombomodulin and von Willebrand factor
- (2010) B.B. Yavuz et al. Journal of Nutrition Health & Aging
- HMGB1 induces human lung endothelial cell cytoskeletal rearrangement and barrier disruption
- (2010) Rachel K. Wolfson et al. MICROVASCULAR RESEARCH
- Alzheimer disease macrophages shuttle amyloid-beta from neurons to vessels, contributing to amyloid angiopathy
- (2009) Justin Zaghi et al. ACTA NEUROPATHOLOGICA
- Coagulation and innate immune responses: can we view them separately?
- (2009) M. Delvaeye et al. BLOOD
- Plasma thrombomodulin activity, tissue factor activity and high levels of circulating procoagulant phospholipid as prognostic factors for acute myocardial infarction
- (2009) Patrick Van Dreden et al. BLOOD COAGULATION & FIBRINOLYSIS
- Clearance of Amyloid-β Peptide Across the Blood-Brain Barrier: Implication for Therapies in Alzheimers Disease
- (2009) R. Deane et al. CNS & Neurological Disorders-Drug Targets
- Soluble Forms of RAGE in Human Diseases: Clinical and Therapeutical Implications
- (2009) Francesca Santilli et al. CURRENT MEDICINAL CHEMISTRY
- Concepts in microvascular endothelial barrier regulation in health and disease
- (2009) Joe G.N. Garcia MICROVASCULAR RESEARCH
- Does neuroinflammation fan the flame in neurodegenerative diseases?
- (2009) Tamy C Frank-Cannon et al. Molecular Neurodegeneration
- Convergence and amplification of toll-like receptor (TLR) and receptor for advanced glycation end products (RAGE) signaling pathways via high mobility group B1 (HMGB1)
- (2008) Judy R. van Beijnum et al. ANGIOGENESIS
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started