Can Humanized Mice Reflect the Complex Pathobiology of HIV-Associated Neurocognitive Disorders?

Curing HIV: Pharmacologic Approaches to Target HIV-1 Latency

(2011) Shailesh K. Choudhary et al.   Annual Review of Pharmacology and Toxicology

Development of human CD4+FoxP3+ regulatory T cells in human stem cell factor-, granulocyte-macrophage colony-stimulating factor-, and interleukin-3-expressing NOD-SCID IL2R null humanized mice

(2011) E. Billerbeck et al.   BLOOD

Loss of Neuronal Integrity during Progressive HIV-1 Infection of Humanized Mice

(2011) P. K. Dash et al.   JOURNAL OF NEUROSCIENCE

Immune reconstitution of the female reproductive tract of humanized BLT mice and their susceptibility to human immunodeficiency virus infection

(2011) Rikke Olesen et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

One Percent Tenofovir Applied Topically to Humanized BLT Mice and Used According to the CAPRISA 004 Experimental Design Demonstrates Partial Protection from Vaginal HIV Infection, Validating the BLT Model for Evaluation of New Microbicide Candidates

(2011) P. W. Denton et al.   JOURNAL OF VIROLOGY

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

A Topical Microbicide Gel Formulation of CCR5 Antagonist Maraviroc Prevents HIV-1 Vaginal Transmission in Humanized RAG-hu Mice

(2011) C. Preston Neff et al.   PLoS One

Humanized Rag1−/−γc−/− Mice Support Multilineage Hematopoiesis and Are Susceptible to HIV-1 Infection via Systemic and Vaginal Routes

(2011) Ramesh Akkina et al.   PLoS One

Functional CD47/signal regulatory protein alpha (SIRPα) interaction is required for optimal human T- and natural killer- (NK) cell homeostasis in vivo

(2011) Nicolas Legrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenic expression of human signal regulatory protein alpha in Rag2−/−γc−/−mice improves engraftment of human hematopoietic cells in humanized mice

(2011) Till Strowig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The utility of the new generation of humanized mice to study HIV-1 infection: transmission, prevention, pathogenesis, and treatment

(2011) Bradford K Berges et al.   Retrovirology

Improving human hemato-lymphoid-system mice by cytokine knock-in gene replacement

(2011) Tim Willinger et al.   TRENDS IN IMMUNOLOGY

Humanized mouse models to study human diseases

(2011) Michael A Brehm et al.   Current Opinion in Endocrinology Diabetes and Obesity

Highly Active Antiretroviral Therapy Potently Suppresses HIV Infection in Humanized Rag2-/-γc-/- Mice

(2010) Kaori Sango et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Links between Progressive HIV-1 Infection of Humanized Mice and Viral Neuropathogenesis

(2010) Santhi Gorantla et al.   AMERICAN JOURNAL OF PATHOLOGY

Comparison of human cord blood engraftment between immunocompromised mouse strains

(2010) S. P. McDermott et al.   BLOOD

CD8+ Cell Depletion Accelerates HIV-1 Immunopathology in Humanized Mice

(2010) S. Gorantla et al.   JOURNAL OF IMMUNOLOGY

Long-Term Human CD34+ Stem Cell-Engrafted Nonobese Diabetic/SCID/IL-2R null Mice Show Impaired CD8+ T Cell Maintenance and a Functional Arrest of Immature NK Cells

(2010) M. C. Andre et al.   JOURNAL OF IMMUNOLOGY

HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors

(2010) Robert K. Heaton et al.   JOURNAL OF NEUROVIROLOGY

Systemic Administration of Antiretrovirals Prior to Exposure Prevents Rectal and Intravenous HIV-1 Transmission in Humanized BLT Mice

(2010) Paul W. Denton et al.   PLoS One

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Dynamics of memory and naïve CD8+ T lymphocytes in humanized NOD/SCID/IL-2Rγnull mice infected with CCR5-tropic HIV-1

(2010) Kei Sato et al.   VACCINE

Microglia: biology and pathology

(2009) Manuel B. Graeber et al.   ACTA NEUROPATHOLOGICA

Humanized Mice for Modeling Human Infectious Disease: Challenges, Progress, and Outlook

(2009) Nicolas Legrand et al.   Cell Host & Microbe

LT R Signaling Induces Cytokine Expression and Up-Regulates Lymphangiogenic Factors in Lymph Node Anlagen

(2009) M. F. Vondenhoff et al.   JOURNAL OF IMMUNOLOGY

Suppression of Human Immunodeficiency Virus Type 1 (HIV-1) Viremia with Reverse Transcriptase and Integrase Inhibitors, CD4+ T-Cell Recovery, and Viral Rebound upon Interruption of Therapy in a New Model for HIV Treatment in the Humanized Rag2-/- c-/- Mouse

(2009) S. K. Choudhary et al.   JOURNAL OF VIROLOGY

Selective infection of CD4+ effector memory T lymphocytes leads to preferential depletion of memory T lymphocytes in R5 HIV-1-infected humanized NOD/SCID/IL-2Rγnull mice

(2009) Chuanyi Nie et al.   VIROLOGY

Endothelial CD47 interaction with SIRP  is required for human T-cell transendothelial migration under shear flow conditions in vitro

(2008) M. Stefanidakis et al.   BLOOD

Bone-marrow-derived microglia: myth or reality?

(2008) Denis Soulet et al.   CURRENT OPINION IN PHARMACOLOGY