Amyloid and Alzheimer's Disease: Inside and Out

Immunohistochemical Visualization of Amyloid-β Protein Precursor and Amyloid-β in Extra- and Intracellular Compartments in the Human Brain

(2017) Leena Aho et al.   JOURNAL OF ALZHEIMERS DISEASE

Neurodegenerative lysosomal disorders: A continuum from development to late age

(2014) Ralph A. Nixon et al.   Autophagy

A Novel PS1 Gene Mutation in a Large Aboriginal Kindred

(2014) Rachel Butler et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Clifford R. Jack et al.   Alzheimers & Dementia

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

Intraneuronal APP, Not Free A  Peptides in 3xTg-AD Mice: Implications for Tau versus A -Mediated Alzheimer Neurodegeneration

(2011) M. J. Winton et al.   JOURNAL OF NEUROSCIENCE

Presenilin Is Necessary for Efficient Proteolysis through the Autophagy-Lysosome System in a  -Secretase-Independent Manner

(2011) K. M. Neely et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's Disease Brain-Derived Amyloid- -Mediated Inhibition of LTP In Vivo Is Prevented by Immunotargeting Cellular Prion Protein

(2011) A. E. Barry et al.   JOURNAL OF NEUROSCIENCE

Lysosomal Proteolysis Inhibition Selectively Disrupts Axonal Transport of Degradative Organelles and Causes an Alzheimer's-Like Axonal Dystrophy

(2011) S. Lee et al.   JOURNAL OF NEUROSCIENCE

Sphingolipid Storage Affects Autophagic Metabolism of the Amyloid Precursor Protein and Promotes A  Generation

(2011) I. Y. Tamboli et al.   JOURNAL OF NEUROSCIENCE

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

Predicting MCI outcome with clinically available MRI and CSF biomarkers

(2011) D. Heister et al.   NEUROLOGY

Anti-Aβ Therapeutics in Alzheimer's Disease: The Need for a Paradigm Shift

(2011) Todd E. Golde et al.   NEURON

Analysis of microdissected human neurons by a sensitive ELISA reveals a correlation between elevated intracellular concentrations of Aβ42 and Alzheimer’s disease neuropathology

(2010) Masakazu Hashimoto et al.   ACTA NEUROPATHOLOGICA

Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease

(2010) Gunnar K. Gouras et al.   ACTA NEUROPATHOLOGICA

Morphologically distinct types of amyloid plaques point the way to a better understanding of Alzheimer’s disease pathogenesis

(2010) MR D’Andrea et al.   BIOTECHNIC & HISTOCHEMISTRY

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

Prion protein and Aβ-related synaptic toxicity impairment

(2010) Anna Maria Calella et al.   EMBO Molecular Medicine

Investigation of 15 of the top candidate genes for late-onset Alzheimer’s disease

(2010) Olivia Belbin et al.   HUMAN GENETICS

Macroautophagy Is Not Directly Involved in the Metabolism of Amyloid Precursor Protein

(2010) Barry Boland et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Memory Impairment in Transgenic Alzheimer Mice Requires Cellular Prion Protein

(2010) D. A. Gimbel et al.   JOURNAL OF NEUROSCIENCE

11C-PiB PET assessment of change in fibrillar amyloid-β load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study

(2010) Juha O Rinne et al.   LANCET NEUROLOGY

Alzheimer's disease: clinical trials and drug development

(2010) Francesca Mangialasche et al.   LANCET NEUROLOGY

Deleterious Effects of Amyloid β Oligomers Acting as an Extracellular Scaffold for mGluR5

(2010) Marianne Renner et al.   NEURON

The Genetics of Alzheimer Disease: Back to the Future

(2010) Lars Bertram et al.   NEURON

Amyloid β-peptide levels in laser capture microdissected cornu ammonis 1 pyramidal neurons of Alzheimerʼs brain

(2010) Mikio Aoki et al.   NEUROREPORT

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Activation and intrinsic  -secretase activity of presenilin 1

(2010) K. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic amyloid-  oligomers impair long-term memory independently of cellular prion protein

(2010) C. Balducci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid and Direct Transport of Cell Surface APP to the Lysosome defines a novel selective pathway

(2010) Angela Lorenzen et al.   Molecular Brain

2009 Alzheimer's disease facts and figures

(2009)   Alzheimers & Dementia

Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease

(2009) Clifford R. Jack et al.   BRAIN

Targeting Aβ and tau in Alzheimer's disease, an early interim report

(2009) Todd E. Golde et al.   EXPERIMENTAL NEUROLOGY

β-Amyloid Causes Depletion of Synaptic Vesicles Leading to Neurotransmission Failure

(2009) Jorge Parodi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysosomes as “Suicide Bags” in Cell Death: Myth or Reality?

(2009) Boris Turk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The fibroblast growth factor receptor substrate 3 adapter is a developmentally regulated microtubule-associated protein expressed in migrating and differentiated neurons

(2009) Todd Hryciw et al.   JOURNAL OF NEUROCHEMISTRY

Characterizing the Appearance and Growth of Amyloid Plaques in APP/PS1 Mice

(2009) P. Yan et al.   JOURNAL OF NEUROSCIENCE

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

(2009) Clifford R Jack et al.   LANCET NEUROLOGY

S655 phosphorylation enhances APP secretory traffic

(2009) Sandra Isabel Vieira et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Multimodal techniques for diagnosis and prognosis of Alzheimer's disease

(2009) Richard J. Perrin et al.   NATURE

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

Neuropathology of nondemented aging: Presumptive evidence for preclinical Alzheimer disease

(2009) Joseph L. Price et al.   NEUROBIOLOGY OF AGING

Acceleration of cortical thinning in familial Alzheimer's disease

(2009) W.D. Knight et al.   NEUROBIOLOGY OF AGING

JNK regulates APP cleavage and degradation in a model of Alzheimer's disease

(2009) Alessio Colombo et al.   NEUROBIOLOGY OF DISEASE

A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease

(2009) S. Salloway et al.   NEUROLOGY

The Role of Apolipoprotein E in Alzheimer's Disease

(2009) Jungsu Kim et al.   NEURON

Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide

(2009) X. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Novel Sorting Nexin Modulates Endocytic Trafficking and α-Secretase Cleavage of the Amyloid Precursor Protein

(2008) Susanne Schöbel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Amyloid β-Protein Precursor by Phosphorylation and Protein Interactions

(2008) Toshiharu Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Classification of Toxic Amyloid Oligomers

(2008) Charles G. Glabe   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuropathology and Cognitive Impairment in Alzheimer Disease: A Complex but Coherent Relationship

(2008) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE

Four-pool modeling of proton exchange processes in biological systems in the presence of MRI-paramagnetic chemical exchange saturation transfer (PARACEST) agents

(2008) Alex X. Li et al.   MAGNETIC RESONANCE IN MEDICINE

Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease

(2008) Melanie Meyer-Luehmann et al.   NATURE

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses

(2008) Lars Bertram et al.   NATURE REVIEWS NEUROSCIENCE

18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease

(2008) Norman R. Relkin et al.   NEUROBIOLOGY OF AGING

Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo

(2008) John R. Cirrito et al.   NEURON