High-Fat Diet Induces Hepatic Insulin Resistance and Impairment of Synaptic Plasticity

High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice

(2014) Steven E. Arnold et al.   NEUROBIOLOGY OF DISEASE

JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death

(2014) S Win et al.   Cell Death & Disease

Lipoic acid restores age-associated impairment of brain energy metabolism through the modulation of Akt/JNK signaling and PGC1α transcriptional pathway

(2013) Tianyi Jiang et al.   AGING CELL

Metabolic triad in brain aging: mitochondria, insulin/IGF-1 signalling and JNK signalling: Figure 1

(2013) Fei Yin et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Adult-onset deletion of Pten increases islet mass and beta cell proliferation in mice

(2013) Kai-Ting Yang et al.   DIABETOLOGIA

Protein kinase C (PKC) participates in acetaminophen hepatotoxicity through c-jun-N-terminal kinase (JNK)-dependent and -independent signaling pathways

(2013) Behnam Saberi et al.   HEPATOLOGY

A high-fat diet or galanin in the PVN decreases phosphorylation of CREB in the nucleus accumbens

(2013) M.E. Bocarsly et al.   NEUROSCIENCE

Age-Dependent Modulation of Synaptic Plasticity and Insulin Mimetic Effect of Lipoic Acid on a Mouse Model of Alzheimer’s Disease

(2013) Harsh Sancheti et al.   PLoS One

Mitochondrial Energy Metabolism and Redox Signaling in Brain Aging and Neurodegeneration

(2012) Fei Yin et al.   ANTIOXIDANTS & REDOX SIGNALING

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Insulin-like growth factors in the brain and their potential clinical implications

(2012) E. E. Benarroch   NEUROLOGY

Silencing of nicotinamide nucleotide transhydrogenase impairs cellular redox homeostasis and energy metabolism in PC12 cells

(2011) Fei Yin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Insulin resistance and Alzheimer's disease

(2011) Suzanne M. De La Monte   BMB Reports

c-Jun N-terminal Kinase (JNK)-dependent Acute Liver Injury from Acetaminophen or Tumor Necrosis Factor (TNF) Requires Mitochondrial Sab Protein Expression in Mice

(2011) Sanda Win et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activity-Dependent Regulation of Surface Glucose Transporter-3

(2011) J. M. Ferreira et al.   JOURNAL OF NEUROSCIENCE

Four weeks administration of Liraglutide improves memory and learning as well as glycaemic control in mice with high fat dietary-induced obesity and insulin resistance

(2010) D. W. Porter et al.   DIABETES OBESITY & METABOLISM

Inducible Nitric Oxide Distribution in the Fatty Liver of a Mouse with High Fat Diet-Induced Obesity

(2010) Seung-Kwon HA et al.   EXPERIMENTAL ANIMALS

Hippocampal memory processes are modulated by insulin and high-fat-induced insulin resistance

(2010) Ewan C. McNay et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

A high-fat diet impairs neurogenesis: Involvement of lipid peroxidation and brain-derived neurotrophic factor

(2010) Hee Ra Park et al.   NEUROSCIENCE LETTERS

Insulin-stimulated translocation of GLUT4 to the plasma membrane in rat hippocampus is PI3-kinase dependent

(2009) C.A. Grillo et al.   BRAIN RESEARCH

Sex Differences in High-fat Diet-induced Obesity, Metabolic Alterations and Learning, and Synaptic Plasticity Deficits in Mice

(2009) Ling-Ling Hwang et al.   Obesity

Insulin and JNK: optimizing metabolic homeostasis and lifespan

(2009) Jason Karpac et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats

(2008) Alexis M. Stranahan et al.   HIPPOCAMPUS