Long-term treatment with intranasal insulin ameliorates cognitive impairment, tau hyperphosphorylation and microglial activation in a streptozotocin-induced Alzheimer’s rat model

Brain-Wide Insulin Resistance, Tau Phosphorylation Changes, and Hippocampal Neprilysin and Amyloid-  Alterations in a Monkey Model of Type 1 Diabetes

(2016) J. Morales-Corraliza et al.   JOURNAL OF NEUROSCIENCE

Intranasal Insulin Prevents Anesthesia-Induced Spatial Learning and Memory Deficit in Mice

(2016) Yongli Zhang et al.   Scientific Reports

Targeting Insulin Signaling for the Treatment of Alzheimer's Disease

(2015) Yanxing Chen et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Intracerebroventricular Streptozotocin Injections as a Model of Alzheimer’s Disease: in Search of a Relevant Mechanism

(2015) Paweł Grieb   MOLECULAR NEUROBIOLOGY

Tau and neurodegenerative disease: the story so far

(2015) Khalid Iqbal et al.   Nature Reviews Neurology

Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease

(2014) F. G. De Felice et al.   DIABETES

Type 3 diabetes is sporadic Alzheimer׳s disease: Mini-review

(2014) Suzanne M. de la Monte   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Intranasal insulin restores insulin signaling, increases synaptic proteins, and reduces Aβ level and microglia activation in the brains of 3xTg-AD mice

(2014) Yanxing Chen et al.   EXPERIMENTAL NEUROLOGY

Insulin protects against Aβ-induced spatial memory impairment, hippocampal apoptosis and MAPKs signaling disruption

(2014) Rasoul Ghasemi et al.   NEUROPHARMACOLOGY

Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi

(2013) Lai-Ling Du et al.   AGE

Intracerebroventricular Streptozotocin Exacerbates Alzheimer-Like Changes of 3xTg-AD Mice

(2013) Yanxing Chen et al.   MOLECULAR NEUROBIOLOGY

Age-Dependent Neuroplasticity Mechanisms in Alzheimer Tg2576 Mice Following Modulation of Brain Amyloid-β Levels

(2013) Anna M. Lilja et al.   PLoS One

Intranasal Delivery of Plasma and Platelet Growth Factors Using PRGF-Endoret System Enhances Neurogenesis in a Mouse Model of Alzheimer’s Disease

(2013) Eduardo Anitua et al.   PLoS One

Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature

(2013) T. Wyss-Coray et al.   Cold Spring Harbor Perspectives in Medicine

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

A Non-transgenic Mouse Model (icv-STZ Mouse) of Alzheimer’s Disease: Similarities to and Differences from the Transgenic Model (3xTg-AD Mouse)

(2012) Yanxing Chen et al.   MOLECULAR NEUROBIOLOGY

Insulin in the brain: There and back again

(2012) William A. Banks et al.   PHARMACOLOGY & THERAPEUTICS

Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment

(2011) Suzanne Craft   ARCHIVES OF NEUROLOGY

Diabetes mellitus as a modulator of functional impairment and decline in Alzheimer’s disease. The Real.FR cohort

(2011) C. M. Sanz et al.   DIABETIC MEDICINE

Cerebral amyloid angiopathy in streptozotocin rat model of sporadic Alzheimer’s disease: a long-term follow up study

(2011) Melita Salkovic-Petrisic et al.   JOURNAL OF NEURAL TRANSMISSION

Brain Insulin Signaling and Alzheimer's Disease: Current Evidence and Future Directions

(2011) Helgi B. Schiöth et al.   MOLECULAR NEUROBIOLOGY

The role of microglia in amyloid clearance from the AD brain

(2010) C. Y. Daniel Lee et al.   JOURNAL OF NEURAL TRANSMISSION

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dysregulation of Insulin Signaling, Glucose Transporters, O -GlcNAcylation, and Phosphorylation of Tau and Neurofilaments in the Brain

(2009) Yanqiu Deng et al.   AMERICAN JOURNAL OF PATHOLOGY

Awake Intranasal Insulin Delivery Modifies Protein Complexes and Alters Memory, Anxiety, and Olfactory Behaviors

(2009) D. R. Marks et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease: synaptic dysfunction and Aβ

(2009) Ganesh M Shankar et al.   Molecular Neurodegeneration

Microtubule-associated protein tau in development, degeneration and protection of neurons

(2008) Jian-Zhi Wang et al.   PROGRESS IN NEUROBIOLOGY