Mitochondrial dysfunction precedes depression of AMPK/AKT signaling in insulin resistance induced by high glucose in primary cortical neurons

Mitochondrial Hormesis and Diabetic Complications: Figure 1

(2015) Kumar Sharma   DIABETES

Mitochondrial Dysfunction Launches Dexamethasone-Induced Skeletal Muscle Atrophy via AMPK/FOXO3 Signaling

(2015) Jing Liu et al.   MOLECULAR PHARMACEUTICS

AMPK at the Nexus of Energetics and Aging

(2014) Kristopher Burkewitz et al.   Cell Metabolism

Metabolic effects of resveratrol: addressing the controversies

(2014) Jacob L. Bitterman et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Reloading functionally ameliorates disuse-induced muscle atrophy by reversing mitochondrial dysfunction, and similar benefits are gained by administering a combination of mitochondrial nutrients

(2014) Jing Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

(–)-Epigallocatechin-3-gallate attenuated myocardial mitochondrial dysfunction and autophagy in diabetic Goto–Kakizaki rats

(2014) J. Liu et al.   FREE RADICAL RESEARCH

Type 2 diabetes as a redox disease

(2014) James D Watson   LANCET

Mitochondrial allostatic load puts the 'gluc' back in glucocorticoids

(2014) Martin Picard et al.   Nature Reviews Endocrinology

Impaired mitochondrial respiration promotes dendritic branching via the AMPK signaling pathway

(2014) A Gioran et al.   Cell Death & Disease

Neuroprotective effect of osmotin against ethanol-induced apoptotic neurodegeneration in the developing rat brain

(2014) M I Naseer et al.   Cell Death & Disease

Energy Failure

(2013) Divya Pathak et al.   ANNALS OF NEUROLOGY

The Impact of Peripheral Neuropathy and Cognitive Decrements on Gait in Older Adults With Type 2 Diabetes Mellitus

(2013) Tine Roman de Mettelinge et al.   ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION

Rac1 Signaling Is Required for Insulin-Stimulated Glucose Uptake and Is Dysregulated in Insulin-Resistant Murine and Human Skeletal Muscle

(2013) L. Sylow et al.   DIABETES

Impaired adenosine monophosphate-activated protein kinase signalling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and peripheral neuropathy in diabetes

(2012) Subir K. Roy Chowdhury et al.   BRAIN

AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern

(2012) D. Grahame Hardie et al.   CHEMISTRY & BIOLOGY

Altered APP Processing in Insulin-Resistant Conditions Is Mediated by Autophagosome Accumulation via the Inhibition of Mammalian Target of Rapamycin Pathway

(2012) S. M. Son et al.   DIABETES

α-Lipoic acid regulates lipid metabolism through induction of sirtuin 1 (SIRT1) and activation of AMP-activated protein kinase

(2012) W.-L. Chen et al.   DIABETOLOGIA

Fatty liver as a consequence and cause of insulin resistance: Lessons from type 2 diabetic liver

(2012) Toshinari Takamura et al.   ENDOCRINE JOURNAL

DPP4-inhibitor improves neuronal insulin receptor function, brain mitochondrial function and cognitive function in rats with insulin resistance induced by high-fat diet consumption

(2012) Noppamas Pipatpiboon et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Adipokine inflammation and insulin resistance: the role of glucose, lipids and endotoxin

(2012) M K Piya et al.   JOURNAL OF ENDOCRINOLOGY

Enhanced autophagy plays a cardinal role in mitochondrial dysfunction in type 2 diabetic Goto–Kakizaki (GK) rats: ameliorating effects of (−)-epigallocatechin-3-gallate

(2012) Jiong Yan et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Effects of metformin on learning and memory behaviors and brain mitochondrial functions in high fat diet induced insulin resistant rats

(2012) Hiranya Pintana et al.   LIFE SCIENCES

Knockdown of the Fat Mass and Obesity Gene Disrupts Cellular Energy Balance in a Cell-Type Specific Manner

(2012) Ryan T. Pitman et al.   PLoS One

Can Alzheimer Disease Be a Form of Type 3 Diabetes?

(2012) Giulia Accardi et al.   REJUVENATION RESEARCH

Cortical Neurons Develop Insulin Resistance and Blunted Akt Signaling: A Potential Mechanism Contributing to Enhanced Ischemic Injury in Diabetes

(2011) Bhumsoo Kim et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial dysfunction in the liver of type 2 diabetic Goto–Kakizaki rats: improvement by a combination of nutrients

(2011) Jiejie Hao et al.   BRITISH JOURNAL OF NUTRITION

Hyperinsulinemia Induces Insulin Resistance in Dorsal Root Ganglion Neurons

(2011) Bhumsoo Kim et al.   ENDOCRINOLOGY

PPARγ Agonist Improves Neuronal Insulin Receptor Function in Hippocampus and Brain Mitochondria Function in Rats with Insulin Resistance Induced by Long Term High-Fat Diets

(2011) Noppamas Pipatpiboon et al.   ENDOCRINOLOGY

AMP-Activated Protein Kinase Regulates Neuronal Polarization by Interfering with PI 3-Kinase Localization

(2011) S. Amato et al.   SCIENCE

Genetic Targeting Aromatase in Male Amyloid Precursor Protein Transgenic Mice Down-Regulates  -Secretase (BACE1) and Prevents Alzheimer-Like Pathology and Cognitive Impairment

(2010) C. McAllister et al.   JOURNAL OF NEUROSCIENCE

Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and A  deposition in an Alzheimer mouse model with diabetes

(2010) S. Takeda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting mitochondrial biogenesis for preventing and treating insulin resistance in diabetes and obesity: Hope from natural mitochondrial nutrients☆

(2009) Jiankang Liu et al.   ADVANCED DRUG DELIVERY REVIEWS

Expanding roles for AMP-activated protein kinase in neuronal survival and autophagy

(2009) Jeroen Poels et al.   BIOESSAYS

α-Lipoic acid increases energy expenditure by enhancing adenosine monophosphate–activated protein kinase–peroxisome proliferator-activated receptor-γ coactivator-1α signaling in the skeletal muscle of aged mice

(2009) Yi Wang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The Insulin/Akt Signaling Pathway Is Targeted by Intracellular β-Amyloid

(2009) Han-Kyu Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanisms involved in cholesterol-induced neuronal insulin resistance

(2009) Changiz Taghibiglou et al.   NEUROPHARMACOLOGY

Role of Mitochondrial Dysfunction in Insulin Resistance

(2008) Jeong-a Kim et al.   CIRCULATION RESEARCH

NS21: Re-defined and modified supplement B27 for neuronal cultures

(2008) Yucui Chen et al.   JOURNAL OF NEUROSCIENCE METHODS

Physiological glucose is critical for optimized neuronal viability and AMPK responsiveness in vitro

(2007) Amy M. Kleman et al.   JOURNAL OF NEUROSCIENCE METHODS