Increased oxidative stress and apoptosis in the hypothalamus of diabetic male mice in the insulin receptor substrate-2 knockout model

Role of Apoptosis in disease

(2016) B. Favaloro et al.   Aging-US

The role for IGF-1-derived small neuropeptides as a therapeutic target for neurological disorders

(2015) Jian Guan et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Daucosterol protects neurons against oxygen–glucose deprivation/reperfusion-mediated injury by activating IGF1 signaling pathway

(2015) Li-hua Jiang et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Anatomy of a negative feedback loop: the case of IκBα

(2015) Riku Fagerlund et al.   Journal of the Royal Society Interface

IRS2 integrates insulin/IGF1 signalling with metabolism, neurodegeneration and longevity

(2014) M. F. White   DIABETES OBESITY & METABOLISM

Insulin and insulin-like growth factor receptors in the brain: Physiological and pathological aspects

(2014) Haim Werner et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Obesity- and aging-induced excess of central transforming growth factor-β potentiates diabetic development via an RNA stress response

(2014) Jingqi Yan et al.   NATURE MEDICINE

Hypothalamic inflammation: a double-edged sword to nutritional diseases

(2012) Dongsheng Cai et al.   Annals of the New York Academy of Sciences

One Step from Prediabetes to Diabetes: Hypothalamic Inflammation?

(2012) Dongsheng Cai   ENDOCRINOLOGY

The ‘complexities’ of life and death: Death receptor signalling platforms

(2012) Laura S. Dickens et al.   EXPERIMENTAL CELL RESEARCH

IKKβ/NF-κB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes

(2012) Juxue Li et al.   NATURE CELL BIOLOGY

Insulin-like growth factors in the brain and their potential clinical implications

(2012) E. E. Benarroch   NEUROLOGY

The p53 network: cellular and systemic DNA damage responses in aging and cancer

(2012) H. Christian Reinhardt et al.   TRENDS IN GENETICS

Differential Insulin Receptor Substrate-1 (IRS1)-Related Modulation of Neuropeptide Y and Proopiomelanocortin Expression in Nondiabetic and Diabetic IRS2−/−Mice

(2011) Emma Burgos-Ramos et al.   ENDOCRINOLOGY

Study on Establishment of Congenic Strains and Screening of Characteristics in IRS-2 Deficient Mice to Support Translational Research on Type 2 Diabetes

(2011) Haruo HASHIMOTO   EXPERIMENTAL ANIMALS

Signalling by insulin and IGF receptors: supporting acts and new players

(2011) Kenneth Siddle   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Targeting the Anti-Apoptotic Protein c-FLIP for Cancer Therapy

(2011) Ahmad R. Safa et al.   Cancers

Differential sensitivity to adrenergic stimulation underlies the sexual dimorphism in the development of diabetes caused by Irs-2 deficiency

(2010) Maria Jose Garcia-Barrado et al.   BIOCHEMICAL PHARMACOLOGY

TNF-α-induced ROS production triggering apoptosis is directly linked to Romo1 and Bcl-XL

(2010) J J Kim et al.   CELL DEATH AND DIFFERENTIATION

Crosstalk of reactive oxygen species and NF-κB signaling

(2010) Michael J Morgan et al.   CELL RESEARCH

Relationships Between Daily Acute Glucose Fluctuations and Cognitive Performance Among Aged Type 2 Diabetic Patients

(2010) M. R. Rizzo et al.   DIABETES CARE

AMP-activated Protein Kinase (AMPK) Negatively Regulates Nox4-dependent Activation of p53 and Epithelial Cell Apoptosis in Diabetes

(2010) Assaad A. Eid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program

(2010) D. Ren et al.   SCIENCE

Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

(2009) Bayani Uttara et al.   Current Neuropharmacology

Inhibition of PTP1B Restores IRS1-Mediated Hepatic Insulin Signaling in IRS2-Deficient Mice

(2009) A. Gonzalez-Rodriguez et al.   DIABETES

Cellular FLICE-inhibitory protein (c-FLIP) signalling: A key regulator of receptor-mediated apoptosis in physiologic context and in cancer

(2009) Marina Bagnoli et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

TNFα and reactive oxygen species in necrotic cell death

(2008) Michael J Morgan et al.   CELL RESEARCH

SIRT1 Regulates Apoptosis and Nanog Expression in Mouse Embryonic Stem Cells by Controlling p53 Subcellular Localization

(2008) Myung-Kwan Han et al.   Cell Stem Cell

Cellular FLICE-Like Inhibitory Protein (C-FLIP): A Novel Target for Cancer Therapy

(2008) Ahmad Safa et al.   CURRENT CANCER DRUG TARGETS