Radiation-Induced Alterations in the Recurrent Glioblastoma Microenvironment: Therapeutic Implications

Oxidative stress and mitochondrial adaptive shift during pituitary tumoral growth

(2018) Maria Eugenia Sabatino et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of Microenvironment in Glioma Invasion: What We Learned from In Vitro Models

(2018) Ivana Manini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Adenosine A3 Receptor Regulates Differentiation of Glioblastoma Stem-Like Cells to Endothelial Cells under Hypoxia

(2018) René Rocha et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Heparan Sulfate Proteoglycans as Relays of Neuroinflammation

(2018) Paul O’Callaghan et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Ionizing radiation augments glioma tropism of mesenchymal stem cells

(2018) Jonathan G. Thomas et al.   JOURNAL OF NEUROSURGERY

Reactive Astrocytes in Glioblastoma Multiforme

(2018) Xiudong Guan et al.   MOLECULAR NEUROBIOLOGY

An active role for neurons in glioma progression: making sense of Scherer’s structures

(2018) Shawn Gillespie et al.   NEURO-ONCOLOGY

Proinvasive extracellular matrix remodeling in tumor microenvironment in response to radiation

(2018) Ki-Chun Yoo et al.   ONCOGENE

Combining Immunotherapy and Radiotherapy for Cancer Treatment: Current Challenges and Future Directions

(2018) Yifan Wang et al.   Frontiers in Pharmacology

Late Effects of Radiation Prime the Brain Microenvironment for Accelerated Tumor Growth

(2018) Chong Duan et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Microglia/Astrocytes–Glioblastoma Crosstalk: Crucial Molecular Mechanisms and Microenvironmental Factors

(2018) Diana Matias et al.   Frontiers in Cellular Neuroscience

Distinctions Between the Metabolic Changes in Glioblastoma Cells and Glioma Stem-like Cells Following Irradiation

(2017) E.I. Spehalski et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

The Clinical Potential of Senolytic Drugs

(2017) James L. Kirkland et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma

(2017) Humsa S. Venkatesh et al.   NATURE

RBIO-01. EXTRACELLULAR MILIEU IN RECURRENT HUMAN GLIOMAS: A REPERTOIRE FOR NOVEL DRUG DEVELOPMENT

(2017) Kshama Gupta et al.   NEURO-ONCOLOGY

Is the blood–brain barrier really disrupted in all glioblastomas? A critical assessment of existing clinical data

(2017) Jann N Sarkaria et al.   NEURO-ONCOLOGY

Disrupting the CD47-SIRPα anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for malignant pediatric brain tumors

(2017) Sharareh Gholamin et al.   Science Translational Medicine

New clues in the malignant progression of glioblastoma: can thioredoxin system play a role?

(2017) Fatih Erdi et al.   Turkish Neurosurgery

MiR-34a modulates ionizing radiation-induced senescence in lung cancer cells

(2017) Xiaoyuan He et al.   Oncotarget

Ionizing Radiation-Induced Immune and Inflammatory Reactions in the Brain

(2017) Katalin Lumniczky et al.   Frontiers in Immunology

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

CCL2 Produced by the Glioma Microenvironment Is Essential for the Recruitment of Regulatory T Cells and Myeloid-Derived Suppressor Cells

(2016) Alan L. Chang et al.   CANCER RESEARCH

CSF1 Overexpression Promotes High-Grade Glioma Formation without Impacting the Polarization Status of Glioma-Associated Microglia and Macrophages

(2016) I. De et al.   CANCER RESEARCH

Therapeutic options in recurrent glioblastoma—An update

(2016) Katharina Seystahl et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Mitochondrial Dysfunction in Gliomas: Pharmacotherapeutic Potential of Natural Compounds

(2016) Lalita Guntuku et al.   Current Neuropharmacology

Colony-stimulating factor 1 receptor blockade prevents fractionated whole-brain irradiation-induced memory deficits

(2016) Xi Feng et al.   Journal of Neuroinflammation

The role of microglia and macrophages in glioma maintenance and progression

(2016) Dolores Hambardzumyan et al.   NATURE NEUROSCIENCE

Stereotactic modulation of blood-brain barrier permeability to enhance drug delivery

(2016) Geoff Appelboom et al.   NEURO-ONCOLOGY

Radiation-induced brain injury: low-hanging fruit for neuroregeneration

(2016) Terry C. Burns et al.   Neurosurgical Focus

Antagonistic Effects of Endogenous Nitric Oxide in a Glioblastoma Photodynamic Therapy Model

(2016) Jonathan M. Fahey et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Inhibition of radiation-induced glioblastoma invasion by genetic and pharmacological targeting of MDA-9/Syntenin

(2016) Timothy P. Kegelman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of NG2 Proteoglycan in Glioma

(2016) Sridevi Yadavilli et al.   Translational Oncology

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis

(2016) Megan K. Ruhland et al.   Nature Communications

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse

(2016) Marco Demaria et al.   Cancer Discovery

Polarization of macrophages in the tumor microenvironment is influenced by EGFR signaling within colon cancer cells

(2016) Weina Zhang et al.   Oncotarget

Hypoxia promotes glioma-associated macrophage infiltration via periostin and subsequent M2 polarization by upregulating TGF-beta and M-CSFR

(2016) Xiaofan Guo et al.   Oncotarget

Elimination of microglia improves cognitive function following cranial irradiation

(2016) Munjal M. Acharya et al.   Scientific Reports

Role of Redox Status in Development of Glioblastoma

(2016) Aleli Salazar-Ramiro et al.   Frontiers in Immunology

Anti-CD47 Treatment Stimulates Phagocytosis of Glioblastoma by M1 and M2 Polarized Macrophages and Promotes M1 Polarized Macrophages In Vivo

(2016) Michael Zhang et al.   PLoS One

Critical roles of chemokine receptor CCR5 in regulating glioblastoma proliferation and invasion

(2015) Lanfu Zhao et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion

(2015) Humsa S. Venkatesh et al.   CELL

Impact of renin-angiotensin system blockade on clinical outcome in glioblastoma

(2015) E. Januel et al.   EUROPEAN JOURNAL OF NEUROLOGY

Mouse models rarely mimic the transcriptome of human neurodegenerative diseases: A systematic bioinformatics-based critique of preclinical models

(2015) Terry C. Burns et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Signaling and stress: The redox landscape in NOS2 biology

(2015) Douglas D. Thomas et al.   FREE RADICAL BIOLOGY AND MEDICINE

Aging-like changes in the transcriptome of irradiated microglia

(2015) Matthew D. Li et al.   GLIA

Portrait of inflammatory response to ionizing radiation treatment

(2015) Federica Di Maggio et al.   Journal of Inflammation-London

Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study

(2015) Nicholas Butowski et al.   NEURO-ONCOLOGY

Tumor microenvironment tenascin-C promotes glioblastoma invasion and negatively regulates tumor proliferation

(2015) Shuli Xia et al.   NEURO-ONCOLOGY

Colony stimulating factor 1 receptor inhibition delays recurrence of glioblastoma after radiation by altering myeloid cell recruitment and polarization

(2015) Jason H. Stafford et al.   NEURO-ONCOLOGY

ADAM-9 is a novel mediator of tenascin-C-stimulated invasiveness of brain tumor–initiating cells

(2015) Susobhan Sarkar et al.   NEURO-ONCOLOGY

Sublethal dose of irradiation enhances invasion of malignant glioma cells through p53-MMP 2 pathway in U87MG mouse brain tumor model

(2015) Jian Pei et al.   Radiation Oncology

Wnt/β-catenin pathway involvement in ionizing radiation-induced invasion of U87 glioblastoma cells

(2015) Zhen Dong et al.   STRAHLENTHERAPIE UND ONKOLOGIE

Irradiation induces glioblastoma cell senescence and senescence-associated secretory phenotype

(2015) Hee-Young Jeon et al.   TUMOR BIOLOGY

Regulation of cytoskeletal dynamics by redox signaling and oxidative stress: implications for neuronal development and trafficking

(2015) Carlos Wilson et al.   Frontiers in Cellular Neuroscience

Extracellular matrix as target for antitumor therapy

(2015) Andras Jeney et al.   OncoTargets and Therapy

Blood Brain Barrier: A Challenge for Effectual Therapy of Brain Tumors

(2015) Arijit Bhowmik et al.   Biomed Research International

Hypoxia induces macrophage polarization and re-education toward an M2 phenotype in U87 and U251 glioblastoma models

(2015) Marine M Leblond et al.   OncoImmunology

Enhancing the Efficacy of Drug-loaded Nanocarriers against Brain Tumors by Targeted Radiation Therapy

(2015) Brian C. Baumann et al.   Oncotarget

Ionizing radiation induces tumor cell lysyl oxidase secretion

(2014) Colette J Shen et al.   BMC CANCER

Radiation promotes malignant progression of glioma cells through HIF-1alpha stabilization

(2014) Young-Heon Kim et al.   CANCER LETTERS

Heparan sulfate in the regulation of neural differentiation and glioma development

(2014) Anqi Xiong et al.   FEBS Journal

The Effect of Radiation on the Immune Response to Cancers

(2014) Bonggoo Park et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bradykinin enhances invasion of malignant glioma into the brain parenchyma by inducing cells to undergo amoeboid migration

(2014) Stefanie Seifert et al.   JOURNAL OF PHYSIOLOGY-LONDON

In vivo radiation response of proneural glioma characterized by protective p53 transcriptional program and proneural-mesenchymal shift

(2014) J. Halliday et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrated multi-cohort transcriptional meta-analysis of neurodegenerative diseases

(2014) Matthew D Li et al.   Acta Neuropathologica Communications

Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity

(2013) Andrea Casazza et al.   CANCER CELL

Fractionated radiation-induced nitric oxide promotes expansion of glioma stem-like cells

(2013) Rae-Kwon Kim et al.   CANCER SCIENCE

Proteoglycans and their roles in brain cancer

(2013) Anna Wade et al.   FEBS Journal

Mechanisms of Radiation Toxicity in Transformed and Non-Transformed Cells

(2013) Ronald-Allan Panganiban et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Characterization of DNA damage-induced cellular senescence by ionizing radiation in endothelial cells

(2013) Kwang Seok Kim et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Challenges With the Diagnosis and Treatment of Cerebral Radiation Necrosis

(2013) Samuel T. Chao et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Cytokine Patterns in Brain Tumour Progression

(2013) Radu Albulescu et al.   MEDIATORS OF INFLAMMATION

The Pathobiology of Collagens in Glioma

(2013) Leo S. Payne et al.   MOLECULAR CANCER RESEARCH

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

Sustained elevation of Snail promotes glial-mesenchymal transition after irradiation in malignant glioma

(2013) Roshan Mahabir et al.   NEURO-ONCOLOGY

Radiation Therapy-Induced Tumor Invasiveness Is Associated with SDF-1-Regulated Macrophage Mobilization and Vasculogenesis

(2013) Shu-Chi Wang et al.   PLoS One

Tumor-Associated Macrophages in Glioma: Friend or Foe?

(2013) Benjamin C. Kennedy et al.   Journal of Oncology

Infiltration of glioma cells in brain parenchyma stimulated by radiation in the F98/Fischer rat model

(2012) Guillaume Desmarais et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Irradiation Alters MMP-2/TIMP-2 System and Collagen Type IV Degradation in Brain

(2012) Won Hee Lee et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Tumor-Associated Microglia/Macrophages Enhance the Invasion of Glioma Stem-like Cells via TGF- 1 Signaling Pathway

(2012) X.-z. Ye et al.   JOURNAL OF IMMUNOLOGY

Essential role of cooperative NF-κB and Stat3 recruitment to ICAM-1 intronic consensus elements in the regulation of radiation-induced invasion and migration in glioma

(2012) D Kesanakurti et al.   ONCOGENE

Post-radiation increase in VEGF enhances glioma cell motility in vitro

(2012) Whoon Kil et al.   Radiation Oncology

Microenvironment and Radiation Therapy

(2012) Michio Yoshimura et al.   Biomed Research International

Radiation Therapy for the Treatment of Recurrent Glioblastoma: An Overview

(2012) Dante Amelio et al.   Cancers

Irradiation Promotes an M2 Macrophage Phenotype in Tumor Hypoxia

(2012) Chi-Shiun Chiang et al.   Frontiers in Oncology

Targeting SDF-1/CXCR4 to inhibit tumour vasculature for treatment of glioblastomas

(2011) D Tseng et al.   BRITISH JOURNAL OF CANCER

Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury

(2011) Edouard I. Azzam et al.   CANCER LETTERS

The brain tumor microenvironment

(2011) Nikki A. Charles et al.   GLIA

Inflammatory Macrophages Induce Nrf2 Transcription Factor-dependent Proteasome Activity in Colonic NCM460 Cells and Thereby Confer Anti-apoptotic Protection

(2011) Susanne Sebens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Commentary on effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-Year analysis of the EORTC-NCIC trial (Lancet Oncol. 2009;10:459-466)

(2010) Ute Linz   CANCER

CD44 Attenuates Activation of the Hippo Signaling Pathway and Is a Prime Therapeutic Target for Glioblastoma

(2010) Y. Xu et al.   CANCER RESEARCH

Sleeping Beauty–Mediated Somatic Mutagenesis Implicates CSF1 in the Formation of High-Grade Astrocytomas

(2010) Aaron M. Bender et al.   CANCER RESEARCH

Consequences of ionizing radiation-induced damage in human neural stem cells

(2010) Munjal M. Acharya et al.   FREE RADICAL BIOLOGY AND MEDICINE

Aging-related alterations in the extracellular matrix modulate the microenvironment and influence tumor progression

(2010) Cynthia C. Sprenger et al.   INTERNATIONAL JOURNAL OF CANCER

Irradiation induces regionally specific alterations in pro-inflammatory environments in rat brain

(2010) Won Hee Lee et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Proteoglycans in cancer biology, tumour microenvironment and angiogenesis

(2010) Renato V. Iozzo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Reactive oxygen species control senescence-associated matrix metalloproteinase-1 through c-Jun-N-terminal kinase

(2010) Jaya Dasgupta et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice

(2010) Mitomu Kioi et al.   JOURNAL OF CLINICAL INVESTIGATION

The Evolution of Extracellular Matrix

(2010) Suat Özbek et al.   MOLECULAR BIOLOGY OF THE CELL

Redox Regulation in Cancer: A Double-edged Sword with Therapeutic Potential

(2010) Asha Acharya et al.   Oxidative Medicine and Cellular Longevity

Patterns of failure and comparison of different target volume delineations in patients with glioblastoma treated with conformal radiotherapy plus concomitant and adjuvant temozolomide

(2010) Giuseppe Minniti et al.   RADIOTHERAPY AND ONCOLOGY

The Mechanical Rigidity of the Extracellular Matrix Regulates the Structure, Motility, and Proliferation of Glioma Cells

(2009) T. A. Ulrich et al.   CANCER RESEARCH

Modulation of hyaluronan production by CD44 positive glioma cells

(2009) Marzenna Wiranowska et al.   INTERNATIONAL JOURNAL OF CANCER

Reduced Expression of the Hyaluronan and Proteoglycan Link Proteins in Malignant Gliomas

(2009) Hosung Sim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glioma-astrocyte interaction modifies the astrocyte phenotype in a co-culture experimental model

(2009) Gagliano   ONCOLOGY REPORTS

Hypoxia- and Vascular Endothelial Growth Factor-Induced Stromal Cell-Derived Factor-1α/CXCR4 Expression in Glioblastomas

(2008) David Zagzag et al.   AMERICAN JOURNAL OF PATHOLOGY

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

NADPH oxidase mediates radiation-induced oxidative stress in rat brain microvascular endothelial cells

(2008) J. Racquel Collins-Underwood et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Proteoglycan Brevican Binds to Fibronectin after Proteolytic Cleavage and Promotes Glioma Cell Motility

(2008) Bin Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Malignant Gliomas in Adults

(2008) Patrick Y. Wen et al.   NEW ENGLAND JOURNAL OF MEDICINE