Elimination of microglia improves cognitive function following cranial irradiation

Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-β pathology

(2016) Elizabeth E. Spangenberg et al.   BRAIN

Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke

(2016) Gergely Szalay et al.   Nature Communications

Inhibition of colony stimulating factor-1 receptor improves antitumor efficacy of BRAF inhibition

(2015) Stephen Mok et al.   BMC CANCER

Stem Cell Transplantation Reverses Chemotherapy-Induced Cognitive Dysfunction

(2015) M. M. Acharya et al.   CANCER RESEARCH

Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice

(2015) Nabil N. Dagher et al.   Journal of Neuroinflammation

Elimination of Microglia Improves Functional Outcomes Following Extensive Neuronal Loss in the Hippocampus

(2015) R. A. Rice et al.   JOURNAL OF NEUROSCIENCE

Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study

(2015) Nicholas Butowski et al.   NEURO-ONCOLOGY

Colony stimulating factor 1 receptor inhibition delays recurrence of glioblastoma after radiation by altering myeloid cell recruitment and polarization

(2015) Jason H. Stafford et al.   NEURO-ONCOLOGY

Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor

(2015) William D. Tap et al.   NEW ENGLAND JOURNAL OF MEDICINE

Radiation and Inflammation

(2015) Dörthe Schaue et al.   SEMINARS IN RADIATION ONCOLOGY

T H 2-Polarized CD4 + T Cells and Macrophages Limit Efficacy of Radiotherapy

(2015) Stephen L. Shiao et al.   Cancer Immunology Research

Characterizing Newly Repopulated Microglia in the Adult Mouse: Impacts on Animal Behavior, Cell Morphology, and Neuroinflammation

(2015) Monica R. P. Elmore et al.   PLoS One

Persistent changes in neuronal structure and synaptic plasticity caused by proton irradiation

(2014) Vipan K. Parihar et al.   Brain Structure & Function

Sustained Inhibition of Receptor Tyrosine Kinases and Macrophage Depletion by PLX3397 and Rapamycin as a Potential New Approach for the Treatment of MPNSTs

(2014) P. P. Patwardhan et al.   CLINICAL CANCER RESEARCH

Long-term cognitive effects of human stem cell transplantation in the irradiated brain

(2014) Munjal M. Acharya et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

Microglia Dictate the Impact of Saturated Fat Consumption on Hypothalamic Inflammation and Neuronal Function

(2014) Martin Valdearcos et al.   Cell Reports

Defining the Optimal Window for Cranial Transplantation of Human Induced Pluripotent Stem Cell-Derived Cells to Ameliorate Radiation-Induced Cognitive Impairment

(2014) Munjal M. Acharya et al.   Stem Cells Translational Medicine

Inhibition of CSF-1 Receptor Improves the Antitumor Efficacy of Adoptive Cell Transfer Immunotherapy

(2013) S. Mok et al.   CANCER RESEARCH

Molecular Pathways: Radiation-Induced Cognitive Impairment

(2013) D. Greene-Schloesser et al.   CLINICAL CANCER RESEARCH

Cranial irradiation compromises neuronal architecture in the hippocampus

(2013) V. K. Parihar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytokines in Radiobiological Responses: A Review

(2012) Dörthe Schaue et al.   RADIATION RESEARCH

When Is the Hippocampus Involved in Recognition Memory?

(2011) G. R. I. Barker et al.   JOURNAL OF NEUROSCIENCE

Deficiency of the macrophage growth factor CSF-1 disrupts pancreatic neuroendocrine tumor development

(2011) S M Pyonteck et al.   ONCOGENE

Absence of Colony Stimulation Factor-1 Receptor Results in Loss of Microglia, Disrupted Brain Development and Olfactory Deficits

(2011) Bryna Erblich et al.   PLoS One

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Rescue of radiation-induced cognitive impairment through cranial transplantation of human embryonic stem cells

(2009) Munjal M. Acharya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA