Disrupting the CD47-SIRPα anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for malignant pediatric brain tumors

CD47 blockade triggers T cell–mediated destruction of immunogenic tumors

(2015) Xiaojuan Liu et al.   NATURE MEDICINE

Pre-Clinical Development of a Humanized Anti-CD47 Antibody with Anti-Cancer Therapeutic Potential

(2015) Jie Liu et al.   PLoS One

Epigenetics of cancer stem cells: Pathways and therapeutics

(2014) Samriddhi Shukla et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Developing Interventions for Cancer-Related Cognitive Dysfunction in Childhood Cancer Survivors

(2014) S. M. Castellino et al.   JNCI-Journal of the National Cancer Institute

Molecular sub-group-specific immunophenotypic changes are associated with outcome in recurrent posterior fossa ependymoma

(2013) Lindsey M. Hoffman et al.   ACTA NEUROPATHOLOGICA

The Interaction Between Signal Regulatory Protein Alpha (SIRPα) and CD47: Structure, Function, and Therapeutic Target

(2013) A. Neil Barclay et al.   Annual Review of Immunology

BET Bromodomain Inhibition of MYC-Amplified Medulloblastoma

(2013) P. Bandopadhayay et al.   CLINICAL CANCER RESEARCH

Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis

(2013) Vijay Ramaswamy et al.   LANCET ONCOLOGY

Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response

(2013) D. Tseng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineered SIRP  Variants as Immunotherapeutic Adjuvants to Anticancer Antibodies

(2013) K. Weiskopf et al.   SCIENCE

A prognostic gene expression signature in infratentorial ependymoma

(2012) Khalida Wani et al.   ACTA NEUROPATHOLOGICA

Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas

(2012) Marcel Kool et al.   ACTA NEUROPATHOLOGICA

The CD47–SIRPα pathway in cancer immune evasion and potential therapeutic implications

(2012) Mark P Chao et al.   CURRENT OPINION IN IMMUNOLOGY

The Cancer Stem-Cell Hypothesis: Its Emerging Role in Lung Cancer Biology and Its Relevance for Future Therapy

(2012) John D. O’Flaherty et al.   Journal of Thoracic Oncology

Anti-CD47 antibodies promote phagocytosis and inhibit the growth of human myeloma cells

(2012) D Kim et al.   LEUKEMIA

The clinical implications of medulloblastoma subgroups

(2012) Paul A. Northcott et al.   Nature Reviews Neurology

Antibody therapy targeting the CD47 protein is effective in a model of aggressive metastatic leiomyosarcoma

(2012) B. Edris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

(2012) S. B. Willingham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extranodal dissemination of non-Hodgkin lymphoma requires CD47 and is inhibited by anti-CD47 antibody therapy

(2011) M. P. Chao et al.   BLOOD

Multidisciplinary management of childhood brain tumors: a review of outcomes, recent advances, and challenges

(2011) Ian F. Pollack   Journal of Neurosurgery-Pediatrics

Monoclonal antibodies in neuro-oncology

(2011) Lois A. Lampson   mAbs

Childhood brain tumors: epidemiology, current management and future directions

(2011) Ian F. Pollack et al.   Nature Reviews Neurology

Temozolomide in the treatment of children with newly diagnosed diffuse intrinsic pontine gliomas: a report from the Children's Oncology Group

(2011) K. J. Cohen et al.   NEURO-ONCOLOGY

Genome-wide molecular characterization of central nervous system primitive neuroectodermal tumor and pineoblastoma

(2011) S. Miller et al.   NEURO-ONCOLOGY

Histone deacetylase inhibition decreases proliferation and potentiates the effect of ionizing radiation in atypical teratoid/rhabdoid tumor cells

(2011) J. A. Knipstein et al.   NEURO-ONCOLOGY

Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma

(2011) M. Monje et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic Antibody Targeting of CD47 Eliminates Human Acute Lymphoblastic Leukemia

(2010) Mark P. Chao et al.   CANCER RESEARCH

Integrative Genomic Analysis of Medulloblastoma Identifies a Molecular Subgroup That Drives Poor Clinical Outcome

(2010) Yoon-Jae Cho et al.   JOURNAL OF CLINICAL ONCOLOGY

Medulloblastoma Comprises Four Distinct Molecular Variants

(2010) Paul A. Northcott et al.   JOURNAL OF CLINICAL ONCOLOGY

Calreticulin Is the Dominant Pro-Phagocytic Signal on Multiple Human Cancers and Is Counterbalanced by CD47

(2010) M. P. Chao et al.   Science Translational Medicine

Identification of CD15 as a Marker for Tumor-Propagating Cells in a Mouse Model of Medulloblastoma

(2009) Tracy-Ann Read et al.   CANCER CELL

Multipotent CD15+ Cancer Stem Cells in Patched-1-Deficient Mouse Medulloblastoma

(2009) R. J. Ward et al.   CANCER RESEARCH

CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis

(2009) Siddhartha Jaiswal et al.   CELL

CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells

(2009) Ravindra Majeti et al.   CELL

Immune Gene and Cell Enrichment Is Associated with a Good Prognosis in Ependymoma

(2009) A. M. Donson et al.   JOURNAL OF IMMUNOLOGY