Colony-stimulating factor 1 receptor blockade prevents fractionated whole-brain irradiation-induced memory deficits

Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-β pathology

(2016) Elizabeth E. Spangenberg et al.   BRAIN

Brain radiation injury leads to a dose- and time-dependent recruitment of peripheral myeloid cells that depends on CCR2 signaling

(2016) Michael J. Moravan et al.   Journal of Neuroinflammation

Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease

(2016) H. Lian et al.   JOURNAL OF NEUROSCIENCE

Targeting the colony stimulating factor 1 receptor alleviates two forms of Charcot–Marie–Tooth disease in mice

(2015) Dennis Klein et al.   BRAIN

Human Embryonic Stem Cell-Derived Oligodendrocyte Progenitors Remyelinate the Brain and Rescue Behavioral Deficits following Radiation

(2015) Jinghua Piao et al.   Cell Stem Cell

CSF-1/CSF-1R targeting agents in clinical development for cancer therapy

(2015) Carola H Ries et al.   CURRENT OPINION IN PHARMACOLOGY

IgM-Dependent Phagocytosis in Microglia Is Mediated by Complement Receptor 3, Not Fc /  Receptor

(2015) J. R. Weinstein et al.   JOURNAL OF IMMUNOLOGY

Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice

(2015) Nabil N. Dagher et al.   Journal of Neuroinflammation

Colony stimulating factor 1 receptor inhibition delays recurrence of glioblastoma after radiation by altering myeloid cell recruitment and polarization

(2015) Jason H. Stafford et al.   NEURO-ONCOLOGY

Increased KIT Inhibition Enhances Therapeutic Efficacy in Gastrointestinal Stromal Tumor

(2014) T. S. Kim et al.   CLINICAL CANCER RESEARCH

Long-Term In Vivo Imaging of Dendritic Spines in the Hippocampus Reveals Structural Plasticity

(2014) L. Gu et al.   JOURNAL OF NEUROSCIENCE

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

Cranial Irradiation Alters the Brain’s Microenvironment and Permits CCR2+ Macrophage Infiltration

(2014) Josh M. Morganti et al.   PLoS One

Microglia Dictate the Impact of Saturated Fat Consumption on Hypothalamic Inflammation and Neuronal Function

(2014) Martin Valdearcos et al.   Cell Reports

KIT oncogene inhibition drives intratumoral macrophage M2 polarization

(2013) Michael J. Cavnar et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of Microglial Proliferation during Chronic Neurodegeneration

(2013) D. Gomez-Nicola et al.   JOURNAL OF NEUROSCIENCE

Advances in thin tissue Golgi-Cox impregnation: Fast, reliable methods for multi-assay analyses in rodent and non-human primate brain

(2013) Nathan D. Levine et al.   JOURNAL OF NEUROSCIENCE METHODS

Whole Brain Radiation-Induced Vascular Cognitive Impairment: Mechanisms and Implications

(2013) Junie P. Warrington et al.   JOURNAL OF VASCULAR RESEARCH

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

Cranial irradiation compromises neuronal architecture in the hippocampus

(2013) V. K. Parihar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Absence of CCL2 is sufficient to restore hippocampal neurogenesis following cranial irradiation

(2012) Star W. Lee et al.   BRAIN BEHAVIOR AND IMMUNITY

CCR2 Deficiency Prevents Neuronal Dysfunction and Cognitive Impairments Induced by Cranial Irradiation

(2012) K. Belarbi et al.   CANCER RESEARCH

Radiation-induced cognitive impairment-from bench to bedside

(2012) D. Greene-Schloesser et al.   NEURO-ONCOLOGY

Cranial Irradiation Alters Dendritic Spine Density and Morphology in the Hippocampus

(2012) Ayanabha Chakraborti et al.   PLoS One

Regionally Distinct Responses of Microglia and Glial Progenitor Cells to Whole Brain Irradiation in Adult and Aging Rats

(2012) Kun Hua et al.   PLoS One

Chronic Administration of the Angiotensin-Converting Enzyme Inhibitor, Ramipril, Prevents Fractionated Whole-Brain Irradiation-Induced Perirhinal Cortex-Dependent Cognitive Impairment

(2012) Tammy C. Lee et al.   RADIATION RESEARCH

Thy1-hAPPLond/Swe+mouse model of Alzheimer's disease displays broad behavioral deficits in sensorimotor, cognitive and social function

(2012) Mehrdad Faizi et al.   Brain and Behavior

Human Neural Stem Cell Transplantation Ameliorates Radiation-Induced Cognitive Dysfunction

(2011) M. M. Acharya et al.   CANCER RESEARCH

Absence of Colony Stimulation Factor-1 Receptor Results in Loss of Microglia, Disrupted Brain Development and Olfactory Deficits

(2011) Bryna Erblich et al.   PLoS One

New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?

(2010) Wei Deng et al.   NATURE REVIEWS NEUROSCIENCE

Selective Chemokine Receptor Usage by Central Nervous System Myeloid Cells in CCR2-Red Fluorescent Protein Knock-In Mice

(2010) Noah Saederup et al.   PLoS One

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats

(2009) S. Jessberger et al.   LEARNING & MEMORY

The AT1 Receptor Antagonist, L-158,809, Prevents or Ameliorates Fractionated Whole-Brain Irradiation–Induced Cognitive Impairment

(2008) Mike E. Robbins et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS