The Role of Natural Products in Targeting Cardiovascular Diseases via Nrf2 Pathway: Novel Molecular Mechanisms and Therapeutic Approaches

Fucoxanthin Elicits Epigenetic Modifications, Nrf2 Activation and Blocking Transformation in Mouse Skin JB6 P+ Cells

(2018) Yuqing Yang et al.   AAPS Journal

Bardoxolone Methyl Improves Kidney Function in Patients with Chronic Kidney Disease Stage 4 and Type 2 Diabetes: Post-Hoc Analyses from Bardoxolone Methyl Evaluation in Patients with Chronic Kidney Disease and Type 2 Diabetes Study

(2018) Melanie P. Chin et al.   AMERICAN JOURNAL OF NEPHROLOGY

Noncanonical NF-κB signaling in microvessels of atherosclerotic lesions is associated with inflammation, atheromatous plaque morphology and myocardial infarction

(2018) Chrissta X. Maracle et al.   ATHEROSCLEROSIS

Tanshindiol C inhibits oxidized low-density lipoprotein induced macrophage foam cell formation via a peroxiredoxin 1 dependent pathway

(2018) Yuyu Yang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Nuclear factor E2-related factor 2 deficiency impairs atherosclerotic lesion development but promotes features of plaque instability in hypercholesterolaemic mice

(2018) Anna-Kaisa Ruotsalainen et al.   CARDIOVASCULAR RESEARCH

Epigenetic modification of Nrf2 by sulforaphane increases the antioxidative and anti-inflammatory capacity in a cellular model of Alzheimer's disease

(2018) Fangfang Zhao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Candida albicans β-Glucan-Containing Particles Increase HO-1 Expression in Oral Keratinocytes via a Reactive Oxygen Species/p38 Mitogen-Activated Protein Kinase/Nrf2 Pathway

(2018) Yoko Ishida et al.   INFECTION AND IMMUNITY

Astaxanthin Induces the Nrf2/HO-1 Antioxidant Pathway in Human Umbilical Vein Endothelial Cells by Generating Trace Amounts of ROS

(2018) Tingting Niu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The triterpenoid corosolic acid blocks transformation and epigenetically reactivates Nrf2 in TRAMP-C1 prostate cells

(2018) Jie Yang et al.   MOLECULAR CARCINOGENESIS

SP121A PHASE 2/3 STUDY OF THE EFFICACY AND SAFETY OF BARDOXOLONE METHYL IN PATIENTS WITH ALPORT SYNDROME

(2018) Oliver Gross et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Cardioprotective role of azafrin in against myocardial injury in rats via activation of the Nrf2-ARE pathway

(2018) Shuyu Yang et al.   PHYTOMEDICINE

Anti-inflammatory activity of Khayandirobilide A from Khaya senegalensis via NF-κB, AP-1 and p38 MAPK/Nrf2/HO-1 signaling pathways in lipopolysaccharide-stimulated RAW 264.7 and BV-2 cells

(2018) Miao-Miao Zhou et al.   PHYTOMEDICINE

Ligustilide attenuates vascular inflammation and activates Nrf2/HO-1 induction and, NO synthesis in HUVECs

(2018) Eun Sik Choi et al.   PHYTOMEDICINE

Protective effect of dioscin against doxorubicin-induced cardiotoxicity via adjusting microRNA-140-5p-mediated myocardial oxidative stress

(2018) Lisha Zhao et al.   Redox Biology

Bioactive flavonoids in medicinal plants: Structure, activity and biological fate

(2018) Tian-yang Wang et al.   Asian Journal of Pharmaceutical Sciences

Epigallocatechin gallate upregulates NRF2 to prevent diabetic nephropathy via disabling KEAP1

(2017) Weixia Sun et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nutritionally relevant concentrations of resveratrol and hydroxytyrosol mitigate oxidative burst of human granulocytes and monocytes and the production of pro-inflammatory mediators in LPS-stimulated RAW 264.7 macrophages

(2017) Elisabetta Bigagli et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Taxifolin Activates the Nrf2 Anti-Oxidative Stress Pathway in Mouse Skin Epidermal JB6 P+ Cells through Epigenetic Modifications

(2017) Haixue Kuang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fisetin Protects PC12 Cells from Tunicamycin-Mediated Cell Death via Reactive Oxygen Species Scavenging and Modulation of Nrf2-Driven Gene Expression, SIRT1 and MAPK Signaling in PC12 Cells

(2017) Jui-Hung Yen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oxidative Stress in Cardiovascular Diseases: Involvement of Nrf2 Antioxidant Redox Signaling in Macrophage Foam Cells Formation

(2017) Bee Ooi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Marine Natural Product Honaucin A Attenuates Inflammation by Activating the Nrf2-ARE Pathway

(2017) Samantha J. Mascuch et al.   JOURNAL OF NATURAL PRODUCTS

Methyleugenol protects against t -BHP-triggered oxidative injury by induction of Nrf2 dependent on AMPK/GSK3β and ERK activation

(2017) Junfeng Zhou et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Salidroside protects against foam cell formation and apoptosis, possibly via the MAPK and AKT signaling pathways

(2017) Jing Ni et al.   Lipids in Health and Disease

Evaluation of the antioxidant properties of carexanes in AGS cells transfected with the Helicobacter pylori 's protein HspB

(2017) Elisabetta Buommino et al.   MICROBIAL PATHOGENESIS

VPS34 stimulation of p62 phosphorylation for cancer progression

(2017) X Jiang et al.   ONCOGENE

(-)-7(S)-hydroxymatairesinol protects against tumor necrosis factor-α-mediated inflammation response in endothelial cells by blocking the MAPK/NF-κB and activating Nrf2/HO-1

(2017) Di Yang et al.   PHYTOMEDICINE

Aryl hydrocarbon receptor (AHR): “pioneer member” of the basic-helix/loop/helix per - Arnt - sim (bHLH/PAS) family of “sensors” of foreign and endogenous signals

(2017) Daniel W. Nebert   PROGRESS IN LIPID RESEARCH

Betulin exhibits anti-inflammatory activity in LPS-stimulated macrophages and endotoxin-shocked mice through an AMPK/AKT/Nrf2-dependent mechanism

(2017) Xinxin Ci et al.   Cell Death & Disease

Antioxidants for Healthy Skin: The Emerging Role of Aryl Hydrocarbon Receptors and Nuclear Factor-Erythroid 2-Related Factor-2

(2017) Masutaka Furue et al.   Nutrients

MicroRNA-200a activates Nrf2 signaling to protect osteoblasts from dexamethasone

(2017) Sai Zhao et al.   Oncotarget

Protective effect of butin against ischemia/reperfusion-induced myocardial injury in diabetic mice: involvement of the AMPK/GSK-3β/Nrf2 signaling pathway

(2017) Jialin Duan et al.   Scientific Reports

Xanthohumol ameliorates lipopolysaccharide (LPS)-induced acute lung injury via induction of AMPK/GSK3β-Nrf2 signal axis

(2017) Hongming Lv et al.   Redox Biology

Activation of Nrf2 signaling by natural products-can it alleviate diabetes?

(2017) Manuel Matzinger et al.   BIOTECHNOLOGY ADVANCES

Reserpine Inhibit the JB6 P+ Cell Transformation Through Epigenetic Reactivation of Nrf2-Mediated Anti-oxidative Stress Pathway

(2016) Bo Hong et al.   AAPS Journal

TAK1 Regulates the Nrf2 Antioxidant System Through Modulating p62/SQSTM1

(2016) Kazunori Hashimoto et al.   ANTIOXIDANTS & REDOX SIGNALING

Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Endothelial Cells Accelerates Atherosclerosis in MiceHighlights

(2016) Marit Westerterp et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Withaferin A induces heme oxygenase (HO-1) expression in endothelial cells via activation of the Keap1/Nrf2 pathway

(2016) Karen Heyninck et al.   BIOCHEMICAL PHARMACOLOGY

Polyphenol intake from a Mediterranean diet decreases inflammatory biomarkers related to atherosclerosis: a substudy of the PREDIMED trial

(2016) Alexander Medina-Remón et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Dietary polyphenols are inversely associated with metabolic syndrome in Polish adults of the HAPIEE study

(2016) Giuseppe Grosso et al.   EUROPEAN JOURNAL OF NUTRITION

Andrographolide induces Nrf2 and heme oxygenase 1 in astrocytes by activating p38 MAPK and ERK

(2016) Siew Ying Wong et al.   Journal of Neuroinflammation

Baicalein alleviates doxorubicin-induced cardiotoxicity via suppression of myocardial oxidative stress and apoptosis in mice

(2016) Bidya Dhar Sahu et al.   LIFE SCIENCES

AMPK Facilitates Nuclear Accumulation of Nrf2 by Phosphorylating at Serine 550

(2016) Min Sung Joo et al.   MOLECULAR AND CELLULAR BIOLOGY

Natural Products to Counteract the Epidemic of Cardiovascular and Metabolic Disorders

(2016) Birgit Waltenberger et al.   MOLECULES

Curcumin ameliorates nephrosclerosis via suppression of histone acetylation independent of hypertension

(2016) Kumiko Muta et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

MicroRNA-93 Downregulation Ameliorates Cerebral Ischemic Injury Through the Nrf2/HO-1 Defense Pathway

(2016) Peng Wang et al.   NEUROCHEMICAL RESEARCH

Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?

(2016) Tarique Hussain et al.   Oxidative Medicine and Cellular Longevity

The Dual Roles of NRF2 in Cancer

(2016) Silvia Menegon et al.   TRENDS IN MOLECULAR MEDICINE

Paeonol and danshensu combination attenuates apoptosis in myocardial infarcted rats by inhibiting oxidative stress: Roles of Nrf2/HO-1 and PI3K/Akt pathway

(2016) Hua Li et al.   Scientific Reports

DNA Demethylation Upregulated Nrf2 Expression in Alzheimer’s Disease Cellular Model

(2016) Huimin Cao et al.   Frontiers in Aging Neuroscience

Antioxidant Functions of the Aryl Hydrocarbon Receptor

(2016) Cornelia Dietrich   Stem Cells International

The Effect of Protandim® Supplementation on Athletic Performance and Oxidative Blood Markers in Runners

(2016) Seteena L. Ueberschlag et al.   PLoS One

GSK-3β downregulates Nrf2 in cultured cortical neurons and in a rat model of cerebral ischemia-reperfusion

(2016) Xi Chen et al.   Scientific Reports

Oxidative stress, redox regulation and diseases of cellular differentiation

(2015) Zhi-Wei Ye et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Triptolide Attenuates Myocardial Ischemia/Reperfusion Injuries in Rats by Inducing the Activation of Nrf2/HO-1 Defense Pathway

(2015) Haijie Yu et al.   Cardiovascular Toxicology

MiR-141 Activates Nrf2-Dependent Antioxidant Pathway via Down-Regulating the Expression of Keap1 Conferring the Resistance of Hepatocellular Carcinoma Cells to 5-Fluorouracil

(2015) Liang Shi et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Quercetin protects mouse liver against nickel-induced DNA methylation and inflammation associated with the Nrf2/HO-1 and p38/STAT1/NF-κB pathway

(2015) Chan-Min Liu et al.   FOOD AND CHEMICAL TOXICOLOGY

Activated AMPK boosts the Nrf2/HO-1 signaling axis—A role for the unfolded protein response

(2015) Kristin Zimmermann et al.   FREE RADICAL BIOLOGY AND MEDICINE

Epigenetic regulation of Keap1-Nrf2 signaling

(2015) Yue Guo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Structural basis of Keap1 interactions with Nrf2

(2015) Peter Canning et al.   FREE RADICAL BIOLOGY AND MEDICINE

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

(2015) Xiaofang Sun et al.   HEPATOLOGY

Modulation of oxidized-LDL receptor-1 (LOX1) contributes to the antiatherosclerosis effect of oleanolic acid

(2015) Qixiao Jiang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Magnolia Bioactive Constituent 4-O-Methylhonokiol Prevents the Impairment of Cardiac Insulin Signaling and the Cardiac Pathogenesis in High-Fat Diet-Induced Obese Mice

(2015) Zhiguo Zhang et al.   International Journal of Biological Sciences

Xanthohumol, a Polyphenol Chalcone Present in Hops, Activating Nrf2 Enzymes To Confer Protection against Oxidative Damage in PC12 Cells

(2015) Juan Yao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Curcumin protects hearts from FFA-induced injury by activating Nrf2 and inactivating NF-κB both in vitro and in vivo

(2015) Chunlai Zeng et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Punicalagin Induces Nrf2/HO-1 Expression via Upregulation of PI3K/AKT Pathway and Inhibits LPS-Induced Oxidative Stress in RAW264.7 Macrophages

(2015) Xiaolong Xu et al.   MEDIATORS OF INFLAMMATION

Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response

(2015) Ryota Saito et al.   MOLECULAR AND CELLULAR BIOLOGY

Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation

(2015) Yang Bai et al.   Oxidative Medicine and Cellular Longevity

Palmitate-induced endothelial dysfunction is attenuated by cyanidin-3-O-glucoside through modulation of Nrf2/Bach1 and NF-κB pathways

(2015) D. Fratantonio et al.   TOXICOLOGY LETTERS

A Systematic Review of the Efficacy of Bioactive Compounds in Cardiovascular Disease: Phenolic Compounds

(2015) Oscar Rangel-Huerta et al.   Nutrients

NRF2 Signaling Negatively Regulates Phorbol-12-Myristate-13-Acetate (PMA)-Induced Differentiation of Human Monocytic U937 Cells into Pro-Inflammatory Macrophages

(2015) Min-gu Song et al.   PLoS One

Modulation of NRF2 signaling pathway by nuclear receptors: Implications for cancer

(2014) Akhileshwar Namani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Ginger Compound [6]-Shogaol and Its Cysteine-Conjugated Metabolite (M2) Activate Nrf2 in Colon Epithelial Cells in Vitro and in Vivo

(2014) Huadong Chen et al.   CHEMICAL RESEARCH IN TOXICOLOGY

DNA Methylation Map of Human Atherosclerosis

(2014) S. Zaina et al.   Circulation-Cardiovascular Genetics

Therapeutic targeting of GSK3β enhances the Nrf2 antioxidant response and confers hepatic cytoprotection in hepatitis C

(2014) Yongfang Jiang et al.   GUT

Dietary ellagic acid improves oxidant-induced endothelial dysfunction and atherosclerosis: Role of Nrf2 activation

(2014) Yi Ding et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Maslinic acid protects vascular smooth muscle cells from oxidative stress through Akt/Nrf2/HO-1 pathway

(2014) Xiaofei Qin et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Bardoxolone methyl (CDDO-Me) as a therapeutic agent: an update on its pharmacokinetic and pharmacodynamic properties

(2014) Shu-Feng Zhou et al.   Drug Design Development and Therapy

Glutathione and mitochondria

(2014) Vicent Ribas et al.   Frontiers in Pharmacology

 -Linolenic acid attenuates doxorubicin-induced cardiotoxicity in rats through suppression of oxidative stress and apoptosis

(2013) X. Yu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Biological Relevance of Inflammation and Oxidative Stress in the Pathogenesis of Arterial Diseases

(2013) David P. Hajjar et al.   AMERICAN JOURNAL OF PATHOLOGY

Regulation of antioxidant system, lipids and fatty acid β-oxidation contributes to the cardioprotective effect of sodium tanshinone IIA sulphonate in isoproterenol-induced myocardial infarction in rats

(2013) Bo Wei et al.   ATHEROSCLEROSIS

Sulforaphane enhances Nrf2 expression in prostate cancer TRAMP C1 cells through epigenetic regulation

(2013) Chengyue Zhang et al.   BIOCHEMICAL PHARMACOLOGY

The absence of macrophage Nrf2 promotes early atherogenesis

(2013) Anna-Kaisa Ruotsalainen et al.   CARDIOVASCULAR RESEARCH

Epigenetic Reactivation of Nrf2 in Murine Prostate Cancer TRAMP C1 Cells by Natural Phytochemicals Z-Ligustilide and Radix Angelica Sinensis via Promoter CpG Demethylation

(2013) Zheng-Yuan Su et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Macrophages Increases Inflammation and Accelerates Atherosclerosis in Mice

(2013) Marit Westerterp et al.   CIRCULATION RESEARCH

PI3K/Akt Pathway Mediates Nrf2/ARE Activation in Human L02 Hepatocytes Exposed to Low-Concentration HBCDs

(2013) Wen Zou et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Antrodia salmonea inhibits TNF-α-induced angiogenesis and atherogenesis in human endothelial cells through the down-regulation of NF-κB and up-regulation of Nrf2 signaling pathways

(2013) Hsin-Ling Yang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Tanshinone IIA suppresses cholesterol accumulation in human macrophages: role of heme oxygenase-1

(2013) Zhiping Liu et al.   JOURNAL OF LIPID RESEARCH

Pharmaceutically active secondary metabolites of marine actinobacteria

(2013) Panchanathan Manivasagan et al.   MICROBIOLOGICAL RESEARCH

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

(2013) Yoshinobu Ichimura et al.   MOLECULAR CELL

Isothiocyanates protect against oxidized LDL-induced endothelial dysfunction by upregulating Nrf2-dependent antioxidation and suppressing NFκB activation

(2013) Chin-Shiu Huang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Genomic Structure and Variation of Nuclear Factor (Erythroid-Derived 2)-Like 2

(2013) Hye-Youn Cho   Oxidative Medicine and Cellular Longevity

Curcumin Pretreatment Induces Nrf2 and an Antioxidant Response and Prevents Hemin-Induced Toxicity in Primary Cultures of Cerebellar Granule Neurons of Rats

(2013) Susana González-Reyes et al.   Oxidative Medicine and Cellular Longevity

The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores endothelial function impaired by reduced Nrf2 activity in chronic kidney disease

(2013) Mohammad A. Aminzadeh et al.   Redox Biology

Myeloid Deletion of Nuclear Factor Erythroid 2−Related Factor 2 Increases Atherosclerosis and Liver Injury

(2012) Alan R. Collins et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation

(2012) Holly K. Bryan et al.   BIOCHEMICAL PHARMACOLOGY

Chronic depletion of glutathione exacerbates ventricular remodelling and dysfunction in the pressure-overloaded heart

(2012) Yosuke Watanabe et al.   CARDIOVASCULAR RESEARCH

The Aryl Hydrocarbon Receptor Complex and the Control of Gene Expression

(2012) Timothy V. Beischlag et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Nrf2 in bone marrow-derived cells positively contributes to the advanced stage of atherosclerotic plaque formation

(2012) Nobuhiko Harada et al.   FREE RADICAL BIOLOGY AND MEDICINE

The aryl hydrocarbon receptor: a molecular pathway for the environmental control of the immune response

(2012) Francisco J. Quintana   IMMUNOLOGY

Epigallocatechin-3-gallate prevents TNF-α-induced NF-κB activation thereby upregulating ABCA1 via the Nrf2/Keap1 pathway in macrophage foam cells

(2012) Chao-Ke Tang   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Quercetin Ameliorates Cardiovascular, Hepatic, and Metabolic Changes in Diet-Induced Metabolic Syndrome in Rats

(2012) Sunil K. Panchal et al.   JOURNAL OF NUTRITION

The synthetic triterpenoid, RTA 405, increases the glomerular filtration rate and reduces angiotensin II–induced contraction of glomerular mesangial cells

(2012) Yanfeng Ding et al.   KIDNEY INTERNATIONAL

The microcosmos of cancer

(2012) Amaia Lujambio et al.   NATURE

Pharmacodynamics of curcumin as DNA hypomethylation agent in restoring the expression of Nrf2 via promoter CpGs demethylation

(2011) Tin Oo Khor et al.   BIOCHEMICAL PHARMACOLOGY

Modification of Keap1 Cysteine Residues by Sulforaphane

(2011) Chenqi Hu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis

(2011) Stefan Freigang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Histone deacetylase inhibition activates transcription factor Nrf2 and protects against cerebral ischemic damage

(2011) Bing Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Identification of Ketoconazole as an AhR-Nrf2 Activator in Cultured Human Keratinocytes: The Basis of Its Anti-Inflammatory Effect

(2011) Gaku Tsuji et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

NF-E2–Related Factor 2 Promotes Atherosclerosis by Effects on Plasma Lipoproteins and Cholesterol Transport That Overshadow Antioxidant Protection

(2010) Berenice Barajas et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Silencing of either SR-A or CD36 reduces atherosclerosis in hyperlipidaemic mice and reveals reciprocal upregulation of these receptors

(2010) P. I. Makinen et al.   CARDIOVASCULAR RESEARCH

Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway

(2010) Ian M. Copple et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coffee constituents as modulators of Nrf2 nuclear translocation and ARE (EpRE)-dependent gene expression

(2010) Ute Boettler et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Nrf2 Expression Is Regulated by Epigenetic Mechanisms in Prostate Cancer of TRAMP Mice

(2010) Siwang Yu et al.   PLoS One

Protective mechanisms of 3-caffeoyl, 4-dihydrocaffeoyl quinic acid from Salicornia herbacea against tert-butyl hydroperoxide-induced oxidative damage

(2009) Yong Pil Hwang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Endothelial dysfunction and cardiovascular risk factors

(2009) Fernando Grover-Páez et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

LOX-1 augments oxLDL uptake by lysoPC-stimulated murine macrophages but is not required for oxLDL clearance from plasma

(2009) David F. Schaeffer et al.   JOURNAL OF LIPID RESEARCH

Disruption of Nrf2 Enhances Upregulation of Nuclear Factor-κB Activity, Proinflammatory Cytokines, and Intercellular Adhesion Molecule-1 in the Brain after Traumatic Brain Injury

(2009) Wei Jin et al.   MEDIATORS OF INFLAMMATION

KEAP1 E3 Ligase-Mediated Downregulation of NF-κB Signaling by Targeting IKKβ

(2009) Dung-Fang Lee et al.   MOLECULAR CELL

Glutathione Deficiency in Cardiac Patients Is Related to the Functional Status and Structural Cardiac Abnormalities

(2009) Thibaud Damy et al.   PLoS One

Curcumin prevents the oxidation and lipid modification of LDL and its inhibition of prostacyclin generation by endothelial cells in culture

(2009) Mohamedain M. Mahfouz et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Activation of the Nrf2/ARE pathway via S-alkylation of cysteine 151 in the chemopreventive agent-sensor Keap1 protein by falcarindiol, a conjugated diacetylene compound

(2009) Tomokazu Ohnuma et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK

(2008) Guang-Hui Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells

(2008) Patrick L. Apopa et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Disruption of Nrf2, a Key Inducer of Antioxidant Defenses, Attenuates ApoE-Mediated Atherosclerosis in Mice

(2008) Thomas E. Sussan et al.   PLoS One

Carnosic acid, acatechol-typeelectrophilic compound, protects neurons bothin vitroandin vivothrough activation of the Keap1/Nrf2 pathway viaS-alkylation of targeted cysteines on Keap1

(2007) Takumi Satoh et al.   JOURNAL OF NEUROCHEMISTRY