Punicalagin Induces Nrf2/HO-1 Expression via Upregulation of PI3K/AKT Pathway and Inhibits LPS-Induced Oxidative Stress in RAW264.7 Macrophages

HO-1 attenuates hippocampal neurons injury via the activation of BDNF–TrkB–PI3K/Akt signaling pathway in stroke

(2014) Dashi Qi et al.   BRAIN RESEARCH

Reduced scytonemin isolated from Nostoc commune suppresses LPS/IFNγ-induced NO production in murine macrophage RAW264 cells by inducing hemeoxygenase-1 expression via the Nrf2/ARE pathway

(2014) Tomohiro Itoh et al.   FOOD AND CHEMICAL TOXICOLOGY

Suppression of NADPH oxidase- and mitochondrion-derived superoxide by Notoginsenoside R1 protects against cerebral ischemia–reperfusion injury through estrogen receptor-dependent activation of Akt/Nrf2 pathways

(2014) X. Meng et al.   FREE RADICAL RESEARCH

Punicalagin Inhibits Inflammation in LPS-Induced RAW264.7 Macrophages via the Suppression of TLR4-Mediated MAPKs and NF-κB Activation

(2014) Xiaolong Xu et al.   INFLAMMATION

Crocin Suppresses LPS-Stimulated Expression of Inducible Nitric Oxide Synthase by Upregulation of Heme Oxygenase-1 via Calcium/Calmodulin-Dependent Protein Kinase 4

(2014) Ji-Hee Kim et al.   MEDIATORS OF INFLAMMATION

PI3K/Akt-Independent NOS/HO Activation Accounts for the Facilitatory Effect of Nicotine on Acetylcholine Renal Vasodilations: Modulation by Ovarian Hormones

(2014) Eman Y. Gohar et al.   PLoS One

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Pomegranate and its derivatives can improve bone health through decreased inflammation and oxidative stress in an animal model of postmenopausal osteoporosis

(2013) Mélanie Spilmont et al.   EUROPEAN JOURNAL OF NUTRITION

Anti-inflammatory effects of β-hydroxyisovalerylshikonin in BV2 microglia are mediated through suppression of the PI3K/Akt/NF-kB pathway and activation of the Nrf2/HO-1 pathway

(2013) Rajapaksha Gedara Prasad Tharanga Jayasooriya et al.   FOOD AND CHEMICAL TOXICOLOGY

Pomegranate juice exacerbates oxidative stress and nigrostriatal degeneration in Parkinson's disease

(2013) Victor Tapias et al.   NEUROBIOLOGY OF AGING

Pomegranate juice and punicalagin attenuate oxidative stress and apoptosis in human placenta and in human placental trophoblasts

(2012) Baosheng Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Anti-proliferative activity and protection against oxidative DNA damage by punicalagin isolated from pomegranate husk

(2012) Farrukh Aqil et al.   FOOD RESEARCH INTERNATIONAL

Free radical-operated proteotoxic stress in macrophages primed with lipopolysaccharide

(2012) Zili Zhai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Baicalein Protects against 6-OHDA-Induced Neurotoxicity through Activation of Keap1/Nrf2/HO-1 and Involving PKCα and PI3K/AKT Signaling Pathways

(2012) Zaijun Zhang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Pomegranate peel and fruit extracts: A review of potential anti-inflammatory and anti-infective effects

(2012) Tariq Ismail et al.   JOURNAL OF ETHNOPHARMACOLOGY

Kaempferol Inhibits P. intermedia Lipopolysaccharide-Induced Production of Nitric Oxide Through Translational Regulation in Murine Macrophages: Critical Role of Heme Oxygenase-1-Mediated ROS Reduction

(2012) In Soon Choi et al.   JOURNAL OF PERIODONTOLOGY

Enhanced activity of punicalagin delivered via polymeric implants against benzo[a]pyrene-induced DNA adducts

(2012) Farrukh Aqil et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Pomegranate-mediated chemoprevention of experimental hepatocarcinogenesis involves Nrf2-regulated antioxidant mechanisms

(2011) Anupam Bishayee et al.   CARCINOGENESIS

Oral infusion of pomegranate fruit extract inhibits prostate carcinogenesis in the TRAMP model

(2011) V. M. Adhami et al.   CARCINOGENESIS

An IκBα phosphorylation inhibitor induces heme oxygenase-1(HO-1) expression through the activation of reactive oxygen species (ROS)–Nrf2–ARE signaling and ROS–PI3K/Akt signaling in an NF-κB-independent mechanism

(2011) Kyoung-jin Min et al.   CELLULAR SIGNALLING

Extract of Salvia miltiorrhiza (Danshen) induces Nrf2-mediated heme oxygenase-1 expression as a cytoprotective action in RAW 264.7 macrophages

(2011) Seung Eun Lee et al.   JOURNAL OF ETHNOPHARMACOLOGY

Potential roles of PI3K/Akt and Nrf2–Keap1 pathways in regulating hormesis of Z-ligustilide in PC12 cells against oxygen and glucose deprivation

(2011) Hongyi Qi et al.   NEUROPHARMACOLOGY

Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism

(2011) D. Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Nrf2-ARE Pathway

(2010) Jeffrey A. Johnson et al.   Annals of the New York Academy of Sciences

Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential

(2010) Ananta Paine et al.   BIOCHEMICAL PHARMACOLOGY

Celecoxib induces heme oxygenase-1 expression in macrophages and vascular smooth muscle cells via ROS-dependent signaling pathway

(2010) Jang-Shiun Wang et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

KEAP1 E3 Ligase-Mediated Downregulation of NF-κB Signaling by Targeting IKKβ

(2009) Dung-Fang Lee et al.   MOLECULAR CELL

Genetic deficiency of NADPH oxidase does not diminish, but rather enhances, LPS-induced acute inflammatory responses in vivo

(2008) Wei-Jian Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Heme oxygenase-1–derived carbon monoxide enhances the host defense response to microbial sepsis in mice

(2008) Su Wol Chung et al.   JOURNAL OF CLINICAL INVESTIGATION