Prospects on the Use of Schizochytrium sp. to Develop Oral Vaccines

Enhanced production of carotenoids using a Thraustochytrid microalgal strain containing high levels of docosahexaenoic acid-rich oil

(2018) Hansung Park et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Virus-Like Particle Engineering: From Rational Design to Versatile Applications

(2018) Xuanwei Ding et al.   Biotechnology Journal

Docosahexaenoic acid in the treatment of rheumatoid arthritis: A double-blind, placebo-controlled, randomized cross-over study with microalgae vs . sunflower oil

(2018) C. Dawczynski et al.   CLINICAL NUTRITION

The algal chloroplast as a synthetic biology platform for production of therapeutic proteins

(2018) Yuliya M. Dyo et al.   MICROBIOLOGY-SGM

Efficient Expression of an Alzheimer’s Disease Vaccine Candidate in the Microalga Schizochytrium sp. Using the Algevir System

(2018) Benita Ortega-Berlanga et al.   MOLECULAR BIOTECHNOLOGY

Local anesthetic effect of docosahexaenoic acid on the nociceptive jaw-opening reflex in rats

(2018) Kazuki Mitome et al.   NEUROSCIENCE RESEARCH

Intron-containing algal transgenes mediate efficient recombinant gene expression in the green microalga Chlamydomonas reinhardtii

(2018) Thomas Baier et al.   NUCLEIC ACIDS RESEARCH

Comparison of secretory signal peptides for heterologous protein expression in microalgae: Expanding the secretion portfolio for Chlamydomonas reinhardtii

(2018) João Vitor Dutra Molino et al.   PLoS One

A sixteen-week three-armed, randomized, controlled trial investigating clinical and biochemical effects of targeted alterations in dietary linoleic acid and n-3 EPA+DHA in adults with episodic migraine: Study protocol

(2018) John Douglas Mann et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Virus-Like Particle Engineering: From Rational Design to Versatile Applications

(2018) Xuanwei Ding et al.   Biotechnology Journal

Effect of TLR ligands co-encapsulated with multiepitopic antigen in nanoliposomes targeted to human DCs via Fc receptor for cancer vaccines

(2017) Felix Rueda et al.   IMMUNOBIOLOGY

High-yield secretion of recombinant proteins from the microalga Chlamydomonas reinhardtii

(2017) Erick Miguel Ramos-Martinez et al.   PLANT BIOTECHNOLOGY JOURNAL

Docosahexaenoic acid attenuates LPS-stimulated inflammatory response by regulating the PPARγ/NF-κB pathways in primary bovine mammary epithelial cells

(2017) Xuexiu He et al.   RESEARCH IN VETERINARY SCIENCE

An Overview of Novel Adjuvants Designed for Improving Vaccine Efficacy

(2017) Srinivasa Reddy Bonam et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Algevir: An Expression System for Microalgae Based on Viral Vectors

(2017) Bernardo Bañuelos-Hernández   Frontiers in Microbiology

Thraustochytrids as production organisms for docosahexaenoic acid (DHA), squalene, and carotenoids

(2016) Inga Marie Aasen et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Immunoregulatory functions of immune complexes in vaccine and therapy

(2016) Yu‐mei Wen et al.   EMBO Molecular Medicine

N-3 polyunsaturated fatty acids modulate B cell activity in pre-clinical models: Implications for the immune response to infections

(2016) Jarrett Whelan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Immunity, tolerance and autoimmunity in the liver: A comprehensive review

(2016) Derek G. Doherty   JOURNAL OF AUTOIMMUNITY

ω-3 fatty acids as an adjuvant therapy ameliorates methotrexate-induced hepatotoxicity in children and adolescents with acute lymphoblastic leukemia: A randomized placebo-controlled study

(2016) Nancy Samir Elbarbary et al.   NUTRITION

Efficient expression of nuclear transgenes in the green alga Chlamydomonas: synthesis of an HIV antigen and development of a new selectable marker

(2016) Rouhollah Barahimipour et al.   PLANT MOLECULAR BIOLOGY

Novel lipopeptides of ESAT-6 induce strong protective immunity against Mycobacterium tuberculosis : Routes of immunization and TLR agonists critically impact vaccine’s efficacy

(2016) Nancy Gupta et al.   VACCINE

A novel rabies virus lipopeptide provides a better protection by improving the magnitude of DCs activation and T cell responses

(2016) Rui Liu et al.   VIRUS RESEARCH

Stabilization Challenges and Formulation Strategies Associated with Oral Biologic Drug Delivery Systems

(2015) Vu Truong-Le et al.   ADVANCED DRUG DELIVERY REVIEWS

Effect of Dietary Marine Microalgae (Schizochytrium) Powder on Egg Production, Blood Lipid Profiles, Egg Quality, and Fatty Acid Composition of Egg Yolk in Layers

(2015) J. H. Park et al.   ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES

Effects of oral eicosapentaenoic acid versus docosahexaenoic acid on human peripheral blood mononuclear cell gene expression

(2015) Fumiyoshi Tsunoda et al.   ATHEROSCLEROSIS

Enhancement of the Immunostimulatory Activity of a TLR7 Ligand by Conjugation to Polysaccharides

(2015) Hiroyuki Shinchi et al.   BIOCONJUGATE CHEMISTRY

Developments and challenges in biodiesel production from microalgae: A review

(2015) Tanvi Taparia et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Rapid high-yield expression of a candidate influenza vaccine based on the ectodomain of M2 protein linked to flagellin in plants using viral vectors

(2015) Eugenia S. Mardanova et al.   BMC BIOTECHNOLOGY

How squalene GLAdly helps generate antigen-specific T cells via antigen-carrying neutrophils and IL-18

(2015) Justin D. Kedl et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The content of docosahexaenoic acid in the maternal diet differentially affects the immune response in lactating dams and suckled offspring

(2015) Caroline Richard et al.   EUROPEAN JOURNAL OF NUTRITION

Pathogens, Commensal Symbionts, and Pathobionts: Discovery and Functional Effects on the Host

(2015) Mathias Hornef   ILAR JOURNAL

Chuanminshen violaceum polysaccharides improve the immune responses of foot-and-mouth disease vaccine in mice

(2015) Haibo Feng et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Design and preclinical characterization of a novel vaccine adjuvant formulation consisting of a synthetic TLR4 agonist in a thermoreversible squalene emulsion

(2015) Jean Haensler et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Microalgae Lipid Characterization

(2015) Linxing Yao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Microalgae for the prevention of cardiovascular disease and stroke

(2015) Maria Filomena de Jesus Raposo et al.   LIFE SCIENCES

The relationship between dietary fat sources and immune response in poultry and pigs: An updated review

(2015) S. Swiatkiewicz et al.   Livestock Science

Marine Polysaccharides from Algae with Potential Biomedical Applications

(2015) Maria de Jesus Raposo et al.   Marine Drugs

Advax delta inulin adjuvant overcomes immune immaturity in neonatal mice thereby allowing single–dose influenza vaccine protection

(2015) Yoshikazu Honda-Okubo et al.   VACCINE

Safety and effectiveness of MF-59 adjuvanted influenza vaccines in children and adults

(2015) Steven Black   VACCINE

Advances and challenges in mucosal adjuvant technology

(2015) Daniel Newsted et al.   VACCINE

MiRNA-194 Regulates Palmitic Acid-Induced Toll-Like Receptor 4 Inflammatory Responses in THP-1 Cells

(2015) Huiqun Tian et al.   Nutrients

Omega-3 supplementation, milk quality and cow immune-competence

(2015) Andrea Bragaglio et al.   Italian Journal of Agronomy

Recent Advances of Vaccine Adjuvants for Infectious Diseases

(2015) Sujin Lee et al.   Immune Network

Vaccine instability in the cold chain: Mechanisms, analysis and formulation strategies

(2014) Ozan S. Kumru et al.   BIOLOGICALS

Production of recombinant proteins in microalgae at pilot greenhouse scale

(2014) Javier A. Gimpel et al.   BIOTECHNOLOGY AND BIOENGINEERING

Metabolite profiling of Schizochytrium sp. by GC-MS, an oleaginous microbial source of biodiesel

(2014) Roberto Mioso et al.   BRAZILIAN JOURNAL OF MICROBIOLOGY

Immunological aspects of using plant cells as delivery vehicles for oral vaccines

(2014) Sergio Rosales-Mendoza et al.   Expert Review of Vaccines

Transgenic plants: a 5-year update on oral antipathogen vaccine development

(2014) Marisela Hernández et al.   Expert Review of Vaccines

New advances in mucosal vaccination

(2014) Charani Ranasinghe   IMMUNOLOGY LETTERS

Algal Sterols are as Effective as β-Sitosterol in Reducing Plasma Cholesterol Concentration

(2014) Jingnan Chen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Dose–response of supplementing marine algae (Schizochytrium spp.) on production performance, fatty acid profiles, and wool parameters of growing lambs1

(2014) S. J. Meale et al.   JOURNAL OF ANIMAL SCIENCE

Extraction of squalene as value-added product from the residual biomass of Schizochytrium mangrovei PQ6 during biodiesel producing process

(2014) Minh Hien Hoang et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

The Specialized Proresolving Mediator 17-HDHA Enhances the Antibody-Mediated Immune Response against Influenza Virus: A New Class of Adjuvant?

(2014) Sesquile Ramon et al.   JOURNAL OF IMMUNOLOGY

Regulation of Intestinal IgA Responses by Dietary Palmitic Acid and Its Metabolism

(2014) Jun Kunisawa et al.   JOURNAL OF IMMUNOLOGY

Comparison of Thraustochytrids Aurantiochytrium sp., Schizochytrium sp., Thraustochytrium sp., and Ulkenia sp. for Production of Biodiesel, Long-Chain Omega-3 Oils, and Exopolysaccharide

(2014) Kim Jye Lee Chang et al.   MARINE BIOTECHNOLOGY

Reactive Oxygen Species and Autophagy Modulation in Non-Marine Drugs and Marine Drugs

(2014) Ammad Farooqi et al.   Marine Drugs

Palmitoleic acid prevents palmitic acid-induced macrophage activation and consequent p38 MAPK-mediated skeletal muscle insulin resistance

(2014) Nicola A. Talbot et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Photosynthetic biomanufacturing in green algae; production of recombinant proteins for industrial, nutritional, and medical uses

(2014) Beth A. Rasala et al.   PHOTOSYNTHESIS RESEARCH

Algal chloroplast produced camelid VH H antitoxins are capable of neutralizing botulinum neurotoxin

(2014) Daniel J. Barrera et al.   PLANT BIOTECHNOLOGY JOURNAL

The mucosal immune system for vaccine development

(2014) Aayam Lamichhane et al.   VACCINE

Comparison of the safety and immunogenicity of an MF59®-adjuvanted with a non-adjuvanted seasonal influenza vaccine in elderly subjects

(2014) Sharon E. Frey et al.   VACCINE

Algae-based oral recombinant vaccines

(2014) Elizabeth A. Specht et al.   Frontiers in Microbiology

Alga-Produced Cholera Toxin-Pfs25 Fusion Proteins as Oral Vaccines

(2013) James A. Gregory et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Biomass Composition, Lipid Characterization, and Metabolic Profile Analysis of the Fed-Batch Fermentation Process of Two Different Docosahexanoic Acid Producing Schizochytrium sp. Strains

(2013) Liang Qu et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Culturable diversity and biochemical features of thraustochytrids from coastal waters of Southern China

(2013) Ying Liu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Preparation of transgenic Dunaliella salina for immunization against white spot syndrome virus in crayfish

(2013) Shuying Feng et al.   ARCHIVES OF VIROLOGY

Improvement of docosahexaenoic acid production on glycerol by Schizochytrium sp. S31 with constantly high oxygen transfer coefficient

(2013) Guifang Chang et al.   BIORESOURCE TECHNOLOGY

The relationship of oxygen uptake rate and kLa with rheological properties in high cell density cultivation of docosahexaenoic acid by Schizochytrium sp. S31

(2013) Guifang Chang et al.   BIORESOURCE TECHNOLOGY

Introducing new vaccines in developing countries

(2013) Sonali Kochhar et al.   Expert Review of Vaccines

An update on safety and immunogenicity of vaccines containing emulsion-based adjuvants

(2013) Christopher B Fox et al.   Expert Review of Vaccines

A 3-week dietary bioequivalence study in preweaning farm piglets of two sources of docosahexaenoic acid produced from two different organisms

(2013) Irina Fedorova-Dahms et al.   FOOD AND CHEMICAL TOXICOLOGY

Marine microorganisms: An emerging avenue in modern nutraceuticals and functional foods

(2013) Pradeep Dewapriya et al.   FOOD RESEARCH INTERNATIONAL

A planning model for the WHO-EPI vaccine distribution network in developing countries

(2013) Sheng-I Chen et al.   IIE TRANSACTIONS

Dendritic cell activation, phagocytosis and CD69 expression on cognate T cells are suppressed by n-3 long-chain polyunsaturated fatty acids

(2013) Heather Teague et al.   IMMUNOLOGY

Evaluation of suppressive and pro-resolving effects of EPA and DHA in human primary monocytes and T-helper cells

(2013) Anke Jaudszus et al.   JOURNAL OF LIPID RESEARCH

Key roles of adjuvants in modern vaccines

(2013) Steven G Reed et al.   NATURE MEDICINE

Vaccination against Influenza with Recombinant Hemagglutinin Expressed by Schizochytrium sp. Confers Protective Immunity

(2013) Anne-Cécile V. Bayne et al.   PLoS One

The adjuvant effect of MF59 is due to the oil-in-water emulsion formulation, none of the individual components induce a comparable adjuvant effect

(2013) Samuele Calabro et al.   VACCINE

A novel hepatitis B vaccine containing Advax™, a polysaccharide adjuvant derived from delta inulin, induces robust humoral and cellular immunity with minimal reactogenicity in preclinical testing

(2013) Fadi Saade et al.   VACCINE

Polysaccharides from Ganoderma formosanum function as a Th1 adjuvant and stimulate cytotoxic T cell response in vivo

(2013) Chia-Chen Pi et al.   VACCINE

Toxicity and dose determination of quillaja saponin, aluminum hydroxide and squalene in olive flounder (Paralichthys olivaceus)

(2013) Tharabenahalli-Nagaraju Vinay et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Effect of carotenoid β-cryptoxanthin on cellular and humoral immune response in rabbit

(2013) Soroush Ghodratizadeh et al.   VETERINARY RESEARCH COMMUNICATIONS

Cloning and functional analysis of putative malonyl-CoA:acyl-carrier protein transacylase gene from the docosahexaenoic acid-producer Schizochytrium sp. TIO1101

(2013) Rubin Cheng et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Dietaryω-3 Polyunsaturated Fatty Acid DHA: A Potential Adjuvant in the Treatment of Cancer

(2013) Nicolò Merendino et al.   Biomed Research International

Versatile Transformation System That Is Applicable to both Multiple Transgene Expression and Gene Targeting for Thraustochytrids

(2012) Keishi Sakaguchi et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Overexpression of acetyl-CoA synthetase increased the biomass and fatty acid proportion in microalga Schizochytrium

(2012) Jinfei Yan et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Docosahexaenoic acid in the goat kid diet: Effects on immune system and meat quality1

(2012) I. Moreno-Indias et al.   JOURNAL OF ANIMAL SCIENCE

Efficient recombinant protein production and secretion from nuclear transgenes in Chlamydomonas reinhardtii

(2012) Kyle J. Lauersen et al.   JOURNAL OF BIOTECHNOLOGY

DHA-enriched fish oil targets B cell lipid microdomains and enhances ex vivo and in vivo B cell function

(2012) Eric A. Gurzell et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways

(2012) Shurong Huang et al.   JOURNAL OF LIPID RESEARCH

n-3 and n-6 polyunsaturated fatty acids differentially regulate adipose angiotensinogen and other inflammatory adipokines in part via NF-κB-dependent mechanisms

(2012) Nalin Siriwardhana et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Benefits of using algae as natural sources of functional ingredients

(2012) Elena Ibañez et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Omega-3 polyunsaturated fatty acids enrichment alters performance and immune response in infectious bursal disease challenged broilers

(2012) Elham Maroufyan et al.   Lipids in Health and Disease

An Automatic Refolding Apparatus for Preparative-Scale Protein Production

(2012) Yanye Feng et al.   PLoS One

The mechanism of action of MF59 – An innately attractive adjuvant formulation

(2012) D.T. O’Hagan et al.   VACCINE

Gut-associated lymphoid tissues for the development of oral vaccines

(2011) Jun Kunisawa et al.   ADVANCED DRUG DELIVERY REVIEWS

Carbohydrate-based immune adjuvants

(2011) Nikolai Petrovsky et al.   Expert Review of Vaccines

Bioactivities from Marine Algae of the Genus Gracilaria

(2011) Cynthia Layse F. De Almeida et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dietary Fatty Acids Affect the Immune System in Male Mice Sensitized to Ovalbumin or Vaccinated with Influenza

(2011) Astrid Hogenkamp et al.   JOURNAL OF NUTRITION

Agrobacterium tumefaciens mediated transformation of marine microalgae Schizochytrium

(2011) Rubin Cheng et al.   MICROBIOLOGICAL RESEARCH

Algae as Protein Factories: Expression of a Human Antibody and the Respective Antigen in the Diatom Phaeodactylum tricornutum

(2011) Franziska Hempel et al.   PLoS One

An alternative renewable source of squalene for use in emulsion adjuvants

(2011) Luis A. Brito et al.   VACCINE

Astaxanthin stimulates cell-mediated and humoral immune responses in cats

(2011) Jean Soon Park et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Development of a stepwise aeration control strategy for efficient docosahexaenoic acid production by Schizochytrium sp.

(2010) Lu-Jing Ren et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Use of oil bodies and oleosins in recombinant protein production and other biotechnological applications

(2010) S.C. Bhatla et al.   BIOTECHNOLOGY ADVANCES

SLOWER GOING

(2010) LISA M. JARVIS   CHEMICAL & ENGINEERING NEWS

Marine pharmacology in 2007–8: Marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous system, and other miscellaneous mechanisms of action

(2010) Alejandro M.S. Mayer et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Purification, characterization and immunostimulating activity of water-soluble polysaccharide isolated from Capsosiphon fulvescens

(2010) Ye Seul Na et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Omega-3 fatty acids attenuate dendritic cell function via NF-κB independent of PPARγ

(2010) Eve Draper et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Marine Polysaccharides in Pharmaceutical Applications: An Overview

(2010) Paola Laurienzo   Marine Drugs

Th1 and Th2 Chemokines, Vaccine-Induced Immunity, and Allergic Disease in Infants After Maternal ω-3 Fatty Acid Supplementation During Pregnancy and Lactation

(2010) Catrin Furuhjelm et al.   PEDIATRIC RESEARCH

Seed-based expression systems for plant molecular farming

(2010) Joseph Boothe et al.   PLANT BIOTECHNOLOGY JOURNAL

Engineering the Chloroplast Targeted Malarial Vaccine Antigens in Chlamydomonas Starch Granules

(2010) David Dauvillée et al.   PLoS One

Identification of T. gondii epitopes, adjuvants, and host genetic factors that influence protection of mice and humans

(2010) Tze Guan Tan et al.   VACCINE

Establishment of a transgene expression system for the marine microalga Schizochytrium by 18S rDNA-targeted homologous recombination

(2010) Ru-Bin Cheng et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Squalene: A natural triterpene for use in disease management and therapy

(2009) L. Harivardhan Reddy et al.   ADVANCED DRUG DELIVERY REVIEWS

Biodiesel production by microalgal biotechnology

(2009) GuanHua Huang et al.   APPLIED ENERGY

Production of recombinant proteins by microbes and higher organisms

(2009) Arnold L. Demain et al.   BIOTECHNOLOGY ADVANCES

Mucosal vaccines: novel advances in technology and delivery

(2009) Yoshikazu Yuki et al.   Expert Review of Vaccines

Heat-stable oral alga-based vaccine protects mice from Staphylococcus aureus infection

(2009) Imke A.J. Dreesen et al.   JOURNAL OF BIOTECHNOLOGY

Characterization of Both Polyunsaturated Fatty Acid Biosynthetic Pathways in Schizochytrium sp.

(2009) J. Casey Lippmeier et al.   LIPIDS

Comparative effects of DHA and EPA on cell function

(2009) Renata Gorjão et al.   PHARMACOLOGY & THERAPEUTICS

Biochemical characterization of polyunsaturated fatty acid synthesis in Schizochytrium: Release of the products as free fatty acids

(2009) James G. Metz et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Impact of methyl jasmonate on squalene biosynthesis in microalga Schizochytrium mangrovei

(2009) Cai-Jun Yue et al.   PROCESS BIOCHEMISTRY

Chemical structural and chain conformational characterization of some bioactive polysaccharides isolated from natural sources

(2008) Liqun Yang et al.   CARBOHYDRATE POLYMERS

Fatty acid-induced induction of Toll-like receptor-4/nuclear factor-κB pathway in adipocytes links nutritional signalling with innate immunity

(2008) Andreas Schaeffler et al.   IMMUNOLOGY

Efficacies of inactivated vaccines against betanodavirus in grouper larvae (Epinephelus coioides) by bath immunization

(2008) Yu-Hsuan Kai et al.   VACCINE

Sulfated modification can enhance the adjuvant activity of astragalus polysaccharide for ND vaccine

(2007) Xiaoyan Huang et al.   CARBOHYDRATE POLYMERS