Review
Microbiology
Shalini Iyer, Rajesh Yadav, Smriti Agarwal, Shashank Tripathi, Rachit Agarwal
Summary: Researchers have used bioengineering techniques to synthesize vaccines against respiratory viral pathogens. These vaccines enhance immunogenicity by controlling their physicochemical properties and have shown promising results in treating diseases such as COVID-19. The feasibility of using materials such as polymeric particles, liposomes, and virus-like particles for vaccine development has been explored.
CLINICAL MICROBIOLOGY REVIEWS
(2022)
Article
Immunology
Richard I. Walker, A. Louis Bourgeois
Summary: Oral immunization is an effective strategy against mucosal enteric pathogens. Inactivated whole bacterial cells can also induce protective immunity. Developing a safe and simple delivery format with controlled immunogenic amounts of complex antigens is essential. Enhancing the efficacy of whole cell vaccines can be achieved through genetic engineering and the use of mucosal adjuvants. The development of ETVAX, a vaccine candidate against enterotoxigenic Escherichia coli (ETEC), has shown promising results.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Becca A. Flitter, Molly R. Braun, Sean N. Tucker
Summary: Next generation vaccines must be developed, manufactured, and administered quickly to combat emerging infections and prevent future pandemics. The oral Ad5 modular vaccine platform shows promise in preventing infection and reducing transmission of respiratory pathogens through innovative technologies like enteric-coated vaccine tablets.
Review
Nanoscience & Nanotechnology
Kai Zhao, Yinzhuo Xie, Xuezheng Lin, Wei Xu
Summary: Mucosal immunization is an effective way to trigger mucosal immune responses, but most vaccines are currently administered through intramuscular injection, resulting in a lack of mucosal immune response. Biodegradable mucoadhesive nanoparticles show promise as vaccine delivery systems for mucosal administration.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Pharmacology & Pharmacy
Asma Ghaemi, Masoume Vakili-Azghandi, Khalil Abnous, Seyed Mohammad Taghdisi, Mohammad Ramezani, Mona Alibolandi
Summary: Gene therapy has the potential to prevent or treat various genetic or acquired diseases by regulating gene and protein expression. Effective delivery systems are needed to ensure successful gene therapy, and oral delivery approaches show promise in treating diseases such as inflammatory bowel disease and cancer. This review provides an update on the development of oral gene delivery techniques for gene therapy and vaccination purposes.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Immunology
Santosh Bhujbal, Rushikesh Bhujbal, Prabhanjan Giram
Summary: The recent advances in the CRISPR/Cas system for vaccine development and viral vector delivery are reviewed in this article. The strategies for vaccine development, as well as the limitations and future prospects of the CRISPR/Cas system, are also discussed.
EXPERT REVIEW OF VACCINES
(2022)
Article
Immunology
Erandi Velarde de la Cruz, Lingyun Wang, Deepanwita Bose, Sailaja Gangadhara, Robert L. Wilson, Rama R. Amara, Pamela A. Kozlowski, Anna Aldovini
Summary: The study evaluated a SHIV mucosal immunization in Rhesus macaques, showing that SHIVBG505-OPV immunization stimulated more significant systemic cell-mediated responses, but antibody responses were disappointing. There were no significant differences in post-infection viral loads between groups post-challenge, but the vaccinated groups had more significant preservation of Th17 CD4+ T cells in both blood and rectal mucosa.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Susanne Koethe, Patricia Koenig, Kerstin Wernike, Jana Schulz, Ilona Reimann, Martin Beer
Summary: Marker or DIVA vaccines are beneficial for eradicating animal diseases in high prevalence regions. This study developed an efficient BVDV-1 modified double marker vaccine candidate based on the genetic background of Bungowannah virus and showed high level of clinical protection against BVDV-1.
Article
Chemistry, Multidisciplinary
Liangliang Wang, Li Yang, Feng Zhang, Xuejie Liu, Qian Xie, Qingyun Liu, Lifang Yuan, Tianyi Zhao, Sidian Xie, Qiuyi Xu, Wudi Zhou, Lin Mei, Huacheng Yan, Xiaowei Zeng, Yuelong Shu
Summary: Seasonal influenza A viruses continue to pose a public health threat, and current vaccines are not sufficiently effective because of virus mutation. There is an urgent need to develop a broad-protection influenza A vaccine. In this study, DNA nanovaccines containing potential universal hemagglutinin (HA) sequences were developed and delivered via microneedle, inducing better cellular and cross-reactivity and protective immunity compared with intramuscular injection.
CELL REPORTS PHYSICAL SCIENCE
(2023)
Article
Immunology
Carlos Angulo, Veronica Sanchez, Karen Delgado, Elizabeth Monreal-Escalante, Luis Hernandez-Adame, Miriam Angulo, Marlene Tello-Olea, Martha Reyes-Becerril
Summary: Vaccines have been crucial in saving millions of humans and animals from fatal diseases. While subunit vaccines have several advantages, they lack strong immunogenicity. Nanotechnology offers a promising approach to vaccine development, utilizing nanoparticles as carriers and adjuvants, particularly for oral vaccines. This review provides an update on recent developments in oral organic nanovaccines, discussing suitable nanomaterials for oral vaccine design and advancements in fighting the major pathogens causing human and animal diseases over the past five years.
MICROBIAL PATHOGENESIS
(2022)
Article
Medicine, General & Internal
Ann Levin, Laura Boonstoppel, Logan Brenzel, Ulla Griffiths, Raymond Hutubessy, Mark Jit, Vittal Mogasale, Sarah Pallas, Stephen Resch, Christian Suharlim, Karene Hoi Ting Yeung
Summary: This study aims to address the lack of standardization and gaps in definitions and methodological guidance in immunization costing. The development of a consensus statement and recommendations can facilitate interpretation of economic evidence by decision makers.
Review
Virology
Vivek P. Chavda, Rajashri Bezbaruah, Mansi Athalye, Palak K. Parikh, Abu Sufiyan Chhipa, Snehal Patel, Vasso Apostolopoulos
Summary: This paper discusses the potential of replicating viral vectors as vaccine carriers for SARS-CoV-2. Despite being the third member of human coronaviruses, SARS-CoV-2 has a much wider range of transmission compared to previous coronaviruses. Although there is a possibility of zoonotic origin, no animal originated coronavirus similar to the initial edition of SARS-CoV-2 has been identified so far.
Review
Immunology
Muhammad Umer Ashraf, Yeji Kim, Sunil Kumar, Dongyeob Seo, Maryam Ashraf, Yong-Soo Bae
Summary: There are various emerging vaccination strategies for COVID-19, but selecting the most effective one remains a challenge; over 200 vaccines are being tested globally, with more than 50 clinical trials underway; a diverse range of vaccine candidate platforms are being evaluated, including the potential for a new oral mucosal COVID-19 vaccine.
Review
Immunology
Ahmed Elkashif, Marwa Alhashimi, Ekramy E. Sayedahmed, Suryaprakash Sambhara, Suresh K. Mittal
Summary: The development of new vaccine strategies is urgently needed to address the challenges posed by the emergence of new viruses due to global population growth and environmental changes. Adenovirus-based vaccine platforms offer a promising solution to meet the broad immune needs in pandemic situations.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Myriam Lamrayah, Capucine Phelip, Celine Coiffier, Celine Lacroix, Thibaut Willemin, Thomas Trimaille, Bernard Verrier
Summary: This study investigates the potential of micelles composed of polylactide-block-poly(N-acryloxysuccinimide-co-N-vinylpyrrolidone) as a delivery system for vaccines. The micelles were non-toxic and efficiently taken up by immune cells. Coupling of antigenic protein p24 on the micelles improved its antigenicity. In mouse immunization, the micelles showed comparable immune response intensity to gold standards and higher avidity index over time.
Article
Clinical Neurology
S. Garfias, B. Tamaya Dominguez, A. Toledo Rojas, M. Arroyo, U. Rodriguez, C. Boll, A. L. Sosa, E. Sciutto, L. Adalid-Peralta, Y. Martinez Lopez, G. Fragoso, A. Fleury
Summary: This study evaluated the characteristics of peripheral blood lymphocytes in patients with AD and PD, and their association with the diseases and their progression. The findings indicate that the phenotypes of lymphocytes in AD and PD patients change and are associated with the severity of the diseases.
Review
Medicine, Research & Experimental
Graciela Cardenas, Diana Torres-Garcia, Jacquelynne Cervantes-Torres, Sergio Rosales-Mendoza, Agnes Fleury, Gladis Fragoso, Juan Pedro Laclette, Edda Sciutto
Summary: The SARS-CoV-2 outbreak in China in 2019 has become a global pandemic, with a focus on acute respiratory distress syndrome (ARDS) and hyperinflammation in at-risk populations. Glucocorticoids may help improve prognosis by controlling the proinflammatory response, with proper dosage, timing, and delivery being crucial. Administering glucocorticoids intranasally may effectively control inflammation without causing unwanted side effects.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Juan Voutssas-Lara, Jacquelynne Cervantes-Torres, Marisela Hernandez, Raul J. Bobes, Edmundo Lamoyi, Ricardo A. Vazquez-Ramirez, Luis Mendoza, Karen L. Reyes-Barrera, Rogelio Lopez-Martinez, Angel G. Alpuche-Solis, Sergio Rosales-Mendoza, Leonor Huerta, Gladis Fragoso, Edda Sciutto
Summary: This study explores the effects of different adjuvants on the specific antibody response induced by immunizing mice with the human Inactivated Influenza vaccine (IIV). Results show that adjuvants can modify the extent and quality of humoral immunity against the IIV vaccine, impacting the effectiveness of vaccination. Adjuvants elicit a more diverse repertoire of epitope-recognizing antibodies, possibly influencing the neutralization properties and specificity of the antibodies induced.
MOLECULAR IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Graciela Cardenas, Maria Chavez-Canales, Ana Maria Espinosa, Antonio Jordan-Rios, Daniel Anica Malagon, Manlio Fabio Marquez Murillo, Laura Victoria Torres Araujo, Ricardo Leopoldo Barajas Campos, Rosa Maria Wong-Chew, Luis Esteban Ramirez Gonzalez, Karent Ibet Cresencio, Enrique Garcia Velazquez, Mariana Rodriguez de la Cerda, Yoana Leyva, Joselin Hernandez-Ruiz, Maria Luisa Hernandez-Medel, Mireya Leon-Hernandez, Karen Medina Quero, Anahi Sanchez Moncivais, Sergio Hernandez Diaz, Ignacia Rosalia Zeron Martinez, Adriana Martinez-Cuazitl, Ivan Noe Martinez Salazar, Eduardo Beltran Sarmiento, Aldo Figueroa Pena, Patricia Sarai Hernandez, Rafel Ignacio Aguilar Reynoso, Daniela Murillo Reyes, Luis Rodrigo Del Rio Ambriz, Rogelio Antonio Alfaro Bonilla, Jocelyn Cruz, Leonor Huerta, Nora Alma Fierro, Marisela Hernandez, Mayra Perez-Tapia, Gabriela Meneses, Erick Espindola-Arriaga, Gabriela Rosas, Alberto Chinney, Sergio Rosales Mendoza, Juan Alberto Hernandez-Aceves, Jaquelynne Cervantes-Torres, Anai Fuentes Rodriguez, Roxana Olguin Alor, Sandra Ortega Francisco, Evelyn Alvarez Salazar, Hugo Besedovsky, Marta C. Romano, Raul J. Bobes, Helgi Jung, Gloria Soldevila, Juan Lopez-Alvarenga, Gladis Fragoso, Juan Pedro Laclette, Edda Sciutto
Summary: This study aims to compare the effectiveness of intranasal versus intravenous low-dose dexamethasone in moderate and severe COVID-19 patients. The protocol is conducted in five health institutions in Mexico City and will evaluate clinical improvement and reduction in mortality as primary and secondary outcomes respectively.
Article
Multidisciplinary Sciences
Celeste Trejo-Moreno, Enrique Jimenez-Ferrer, Gabriela Castro-Martinez, Marisol Mendez-Martinez, Maria Angelica Santana, Gerardo Arrellin-Rosas, Jose Pedraza-Chaverri, Omar Noel Medina-Campos, Beatriz Hernandez-Tellez, Oscar Ramirez-Pliego, Maribel Herrera-Ruiz, Jacquelynne Cervantes-Torres, Zimri Aziel Alvarado-Ojeda, Alejandro Costet-Mejia, Gladis Fragoso, Gabriela Rosas-Salgado
Summary: This study characterized a murine model of endothelial dysfunction induced by chronic intraperitoneal administration of angiotensin II (AGII) for 10 weeks, which led to increased production of systemic soluble VCAM, ROS, and ICAM-1 expression, as well as inflammation in the kidney, elevated blood pressure levels, vascular remodeling, and damage to various target organs. The proposed model is representative of ED and is easy to implement, safe, rapid, and inexpensive.
SCIENTIFIC REPORTS
(2021)
Article
Veterinary Sciences
Maria Josefina Contreras-Luna, Gladis Fragoso-Gonzalez, Rene Alvaro Segura-Velazquez, Jacquelynne Brenda Cervantes-Torres, Rogelio Alonso-Morales, Luis Alfonso Ramirez-Martinez, Dolores Adriana Ayon-Nunez, Raul Jose Bobes, Jose Ivan Sanchez-Betancourt
Summary: This study evaluated the immunogenicity and antigenic properties of NSP1 and NSP11 recombinant proteins expressed in Escherichia coli cells. The results showed that these proteins were immunogenic in pigs and demonstrated higher specificity in recognizing PRRSV antigens. Both NSP1 and NSP11 proteins elicited neutralizing antibodies against PRRSV.
VETERINARY MEDICINE AND SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Manuel F. Giraldo-Velasquez, Ivan N. Perez-Osorio, Alejandro Espinosa-Ceron, Brandon M. Barcena, Arturo Calderon-Gallegos, Gladis Fragoso, Monica Torres-Ramos, Nayeli Paez-Martinez, Edda Sciutto
Summary: Inhalants, including toluene, can induce neuroinflammation and histological damages, but intranasally administered methylprednisolone treatment can reverse these damages.
Article
Medicine, General & Internal
Dolores Adriana Ayon-Nunez, Jacquelynne Cervantes-Torres, Carlos Cabello-Gutierrez, Sergio Rosales-Mendoza, Diana Rios-Valencia, Leonor Huerta, Raul J. Bobes, Julio Cesar Carrero, Rene Segura-Velazquez, Nora Alma Fierro, Marisela Hernandez, Joaquin Zuniga-Ramos, Gerardo Gamba, Graciela Cardenas, Emmanuel Frias-Jimenez, Luis Alonso Herrera, Gladis Fragoso, Edda Sciutto, Francisco Suarez-Guemes, Juan Pedro Laclette
Summary: COVID-19 pandemic is still ongoing and evolving worldwide, and monitoring population immunity is crucial for decision-making on returning to normality. This article describes the development of an RBD-based ELISA method for detecting specific antibodies, which can provide an indication of protective immunity against SARS-CoV-2.
Review
Biochemistry & Molecular Biology
Ivan Emmanuel Ramos-Martinez, Edgar Ramos-Martinez, Rene Alvaro Segura-Velazquez, Manuel Saavedra-Montanez, Jacquelynne Brenda Cervantes-Torres, Marco Cerbon, Dulce Papy-Garcia, Edgar Zenteno, Jose Ivan Sanchez-Betancourt
Summary: This article introduces the role of glycoconjugates in viral entry and discusses therapeutic strategies focused on inhibiting the interaction between viruses and glycoconjugates. It also emphasizes the importance of jointly evaluating and designing strategies to inhibit the interactions of both heparan sulfates and sialic acids, and expresses the expectation for a deeper understanding of interspecies transmission.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Jacquelynne Cervantes-Torres, Sergio Rosales-Mendoza, Carlos Cabello, Laura Montero, Juan Hernandez-Aceves, Guillermo Granados, Arturo Calderon-Gallegos, Francisco Zuniga-Flores, Mirna Ruiz-Rivera, Julio Cesar Abarca-Magana, Sandra Ortega-Francisco, Roxana Olguin-Alor, Georgina Diaz, Filipo Paczka-Garcia, Rubi Zavala-Gaytan, Ricardo Vazquez-Ramirez, Dolores Adriana Ayon-Nunez, Julio Cesar Carrero, Diana Rios, Mariana Jasso-Ramirez, Rebeca Vazquez-Hernandez, David Venegas, Daniel Garzon, Laura Cobos, Rene Segura-Velazquez, Nelly Villalobos, Gabriela Meneses, Joaquin Zuniga, Gerardo Gamba, Graciela Cardenas, Marisela Hernandez, Michael E. Parkhouse, Marta C. Romano, Luis Alonso Herrera, Raul J. Bobes, Mayra Perez-Tapia, Leonor Huerta, Nora Fierro, Isabel Gracia, Gloria Soldevilla, Gladis Fragoso, Francisco Suarez-Guemes, Juan P. Laclette, Edda Sciutto
Summary: The rapid spread of COVID-19 has led to an unprecedented effort in vaccine development. Various vaccines, including inactivated viruses and novel platforms such as RNA, DNA, proteins, and non-replicating viral vectors, have been developed. The global demand for vaccines and the emergence of new variants call for accessible vaccines that can be adapted to the prevailing variants. This study focuses on the immunogenic properties of a group of theoretically predicted RBD peptides, aiming to develop an effective, safe, and low-cost epitope-focused vaccine.
Article
Pharmacology & Pharmacy
Graciela Cardenas, Raul J. Bobes, Gladis Fragoso, Nicolas I. Perez-Osorio, Marisela Hernandez, Alejandro Espinosa, Agnes Fleury, Jose Flores, Juan Pedro Laclette, Edda Sciutto, Helgi Jung-Cook
Summary: Dexamethasone and methylprednisolone are effective glucocorticoids for controlling inflammation. Intranasal administration bypasses the blood-brain barrier and allows direct access to the central nervous system. This study found that intranasal delivery of DXM and MEP has high bioavailability and is comparable to intravenous administration, suggesting it can be a non-invasive alternative for systemic drug delivery.
Article
Biochemistry & Molecular Biology
Alfredo Cruz-Gregorio, Ana Karina Aranda-Rivera, Omar Emiliano Aparicio-Trejo, Omar Noel Medina-Campos, Edda Sciutto, Gladis Fragoso, Jose Pedraza-Chaverri
Summary: Breast cancer is the second most common cancer in women worldwide. The mortality rate has decreased due to early diagnosis and more effective treatments, but HER2 and TNBC still have poor prognoses. The immunomodulatory peptide GK-1 is being proposed as a new alternative for immunotherapy of these aggressive tumors. GK-1 has shown promising results in reducing tumor growth and lung metastasis in experimental models.
Article
Oncology
Juan A. Hernandez-Aceves, Jacquelynne Cervantes-Torres, Diana Torres-Garcia, Francisco J. Zuniga-Flores, Osiris J. Patino-Chavez, Jorge A. Pena Agudelo, Jose Eduardo Aguayo-Flores, Yonathan Garfias, Laura Montero-Leon, Laura Romero-Romero, Armando Perez-Torres, Gladis Fragoso, Edda Sciutto
Summary: GK-1 has shown anti-tumor and anti-metastatic effects in an experimental model of breast cancer. It can decrease tumor growth, lung and lymph node metastases, and intra-tumor vascular areas. Furthermore, GK-1 prevents T cell exhaustion, enhances cytotoxic activity, and improves the prognosis of triple-negative breast cancer.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Chemistry, Medicinal
Reinier Gesto-Borroto, Gabriela Meneses, Alejandro Espinosa-Ceron, Guillermo Granados, Jacquelynne Cervantes-Torres, Alexandre Cardoso-Taketa, Edda Sciutto, Maria Luisa Villarreal
Summary: This study evaluated the anti-inflammatory activity of methanolic extracts from nine populations of Galphimia species in Mexico. The extracts showed significant inhibition of inflammation processes both in vitro and in vivo. It was found that the presence of galphimines did not mediate the observed anti-inflammatory effects.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2022)
