Reactive Oxygen Species and Autophagy Modulation in Non-Marine Drugs and Marine Drugs

STAT3 down regulates LC3 to inhibit autophagy and pancreatic cancer cell growth

(2015) Jingjing Gong et al.   Oncotarget

DIRAS3 regulates the autophagosome initiation complex in dormant ovarian cancer cells

(2014) Zhen Lu et al.   Autophagy

Autophagy inhibition switches low-dose camptothecin-induced premature senescence to apoptosis in human colorectal cancer cells

(2014) Jian-wei Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Mechanistic insights on petrosaspongiolide M inhibitory effects on immunoproteasome and autophagy

(2014) Maria Chiara Monti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Induction of autophagy contributes to crizotinib resistance in ALK-positive lung cancer

(2014) Cheng Ji et al.   CANCER BIOLOGY & THERAPY

The Four Faces of Autophagy: Implications for Cancer Therapy

(2014) D. A. Gewirtz   CANCER RESEARCH

ARHI (DIRAS3) induces autophagy in ovarian cancer cells by downregulating the epidermal growth factor receptor, inhibiting PI3K and Ras/MAP signaling and activating the FOXo3a-mediated induction of Rab7

(2014) Z Lu et al.   CELL DEATH AND DIFFERENTIATION

Autophagy Inhibition Augments the Anticancer Effects of Epirubicin Treatment in Anthracycline-Sensitive and -Resistant Triple-Negative Breast Cancer

(2014) S. Chittaranjan et al.   CLINICAL CANCER RESEARCH

Extracellular signal-regulated kinase, receptor interacting protein, and reactive oxygen species regulate shikonin-induced autophagy in human hepatocellular carcinoma

(2014) Ke Gong et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Protective effect of polysaccharides from Sargassum horneri against oxidative stress in RAW264.7 cells

(2014) Zheng-Shun Wen et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Induction of ROS-Dependent Mitochondria-Mediated Intrinsic Apoptosis in MDA-MB-231 Cells by Glycoprotein from Codium decorticatum

(2014) Ramar Thangam et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Disruption of autophagy by the histone deacetylase inhibitor MGCD0103 and its therapeutic implication in B-cell chronic lymphocytic leukemia

(2014) V El-Khoury et al.   LEUKEMIA

The Marine Fungal Metabolite, Dicitrinone B, Induces A375 Cell Apoptosis through the ROS-Related Caspase Pathway

(2014) Li Chen et al.   Marine Drugs

Cytotoxic Effects of Fascaplysin against Small Cell Lung Cancer Cell Lines

(2014) Gerhard Hamilton   Marine Drugs

Cracking the Cytotoxicity Code: Apoptotic Induction of 10-Acetylirciformonin B is Mediated through ROS Generation and Mitochondrial Dysfunction

(2014) Huei-Chuan Shih et al.   Marine Drugs

Another Facet to the Anticancer Response to Lamellarin D: Induction of Cellular Senescence through Inhibition of Topoisomerase I and Intracellular Ros Production

(2014) Caroline Ballot et al.   Marine Drugs

Inhibition of Akt Reverses the Acquired Resistance to Sorafenib by Switching Protective Autophagy to Autophagic Cell Death in Hepatocellular Carcinoma

(2014) B. Zhai et al.   MOLECULAR CANCER THERAPEUTICS

Targeting autophagy overcomes Enzalutamide resistance in castration-resistant prostate cancer cells and improves therapeutic response in a xenograft model

(2014) H G Nguyen et al.   ONCOGENE

Phase II and Pharmacodynamic Study of Autophagy Inhibition Using Hydroxychloroquine in Patients With Metastatic Pancreatic Adenocarcinoma

(2014) B. M. Wolpin et al.   ONCOLOGIST

Inhibition of Beclin 1 Expression Enhances Cisplatin-Induced Apoptosis Through a Mitochondrial-Dependent Pathway in Human Ovarian Cancer SKOV3/DDP Cells

(2014) Yang Sun et al.   ONCOLOGY RESEARCH

Astaxanthin Treatment Confers Protection against Oxidative Stress in U937 Cells Stimulated with Lipopolysaccharide Reducing O2− Production

(2014) Sara Franceschelli et al.   PLoS One

ROS-Mediated Autophagy Induced by Dysregulation of Lipid Metabolism Plays a Protective Role in Colorectal Cancer Cells Treated with Gambogic Acid

(2014) Haiyuan Zhang et al.   PLoS One

Proteasome Inhibitors Activate Autophagy Involving Inhibition of PI3K-Akt-mTOR Pathway as an Anti-Oxidation Defense in Human RPE Cells

(2014) Bingrong Tang et al.   PLoS One

Inhibition of cathepsin S induces autophagy and apoptosis in human glioblastoma cell lines through ROS-mediated PI3K/AKT/mTOR/p70S6K and JNK signaling pathways

(2014) Li Zhang et al.   TOXICOLOGY LETTERS

High-mobility group nucleosome-binding domain 5 increases drug resistance in osteosarcoma through upregulating autophagy

(2014) Chaoqun Yang et al.   TUMOR BIOLOGY

Inhibition of autophagy significantly enhances combination therapy with sorafenib and HDAC inhibitors for human hepatoma cells

(2014) Hang Yuan   WORLD JOURNAL OF GASTROENTEROLOGY

Suppression of autophagy by chloroquine sensitizes 5-fluorouracil-mediated cell death in gallbladder carcinoma cells

(2014) Xiao Liang et al.   Cell and Bioscience

AR-A 014418 Used against GSK3beta Downregulates Expression of hnRNPA1 and SF2/ASF Splicing Factors

(2014) Ajay K. Yadav et al.   Journal of Oncology

Essential role of autophagy in fucoxanthin-induced cytotoxicity to human epithelial cervical cancer HeLa cells

(2013) Li-li Hou et al.   ACTA PHARMACOLOGICA SINICA

Marine algal natural products with anti-oxidative, anti-inflammatory, and anti-cancer properties

(2013) Jin-Ching Lee et al.   Cancer Cell International

The mTOR Kinase Inhibitors, CC214-1 and CC214-2, Preferentially Block the Growth of EGFRvIII-Activated Glioblastomas

(2013) B. Gini et al.   CLINICAL CANCER RESEARCH

Molecular Pathways: Reactive Oxygen Species Homeostasis in Cancer Cells and Implications for Cancer Therapy

(2013) V. Nogueira et al.   CLINICAL CANCER RESEARCH

Reduced scytonemin isolated from Nostoc commune induces autophagic cell death in human T-lymphoid cell line Jurkat cells

(2013) Tomohiro Itoh et al.   FOOD AND CHEMICAL TOXICOLOGY

Papuamine causes autophagy following the reduction of cell survival through mitochondrial damage and JNK activation in MCF-7 human breast cancer cells

(2013) SYU-ICHI KANNO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Hirsutanol A, a novel sesquiterpene compound from fungus Chondrostereum sp., induces apoptosis and inhibits tumor growth through mitochondrial-independent ROS production: Hirsutanol A inhibits tumor growth through ROS production

(2013) Fen Yang et al.   Journal of Translational Medicine

The Marine Natural Product Manzamine A Targets Vacuolar ATPases and Inhibits Autophagy in Pancreatic Cancer Cells

(2013) Georgios Kallifatidis et al.   Marine Drugs

ω-3 polyunsaturated fatty acids inhibit the proliferation of the lung adenocarcinoma cell line A549 in vitro

(2013) QING-HUA YAO et al.   Molecular Medicine Reports

Autophagy variation within a cell population determines cell fate through selective degradation of Fap-1

(2013) Jacob M. Gump et al.   NATURE CELL BIOLOGY

Autophagy chews Fap to promote apoptosis

(2013) Sanket Joshi et al.   NATURE CELL BIOLOGY

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Synthesis of Clionamine B, an Autophagy Stimulating Aminosteroid Isolated from the Sponge Cliona celata

(2013) Roberto Forestieri et al.   ORGANIC LETTERS

Coibamide A Induces mTOR-Independent Autophagy and Cell Death in Human Glioblastoma Cells

(2013) Andrew M. Hau et al.   PLoS One

Anti-proliferative effect of methanolic extract of Gracilaria tenuistipitata on oral cancer cells involves apoptosis, DNA damage, and oxidative stress

(2012) Chi-Chen Yeh et al.   BMC Complementary and Alternative Medicine

Reactive oxygen species regulation of autophagy in cancer: Implications for cancer treatment

(2012) Lin Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Stellettin A Induces Endoplasmic Reticulum Stress in Murine B16 Melanoma Cells

(2012) Wing Keung Liu et al.   JOURNAL OF NATURAL PRODUCTS

Hirsutanol A Induces Apoptosis and Autophagy via Reactive Oxygen Species Accumulation in Breast Cancer MCF-7 Cells

(2012) Fen Yang et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Anti-tumour effects of elatol, a marine derivative compound obtained from red algaeLaurencia microcladia

(2012) Andreza Campos et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

SD118-Xanthocillin X (1), a Novel Marine Agent Extracted from Penicillium commune, Induces Autophagy through the Inhibition of the MEK/ERK Pathway

(2012) Ying Zhao et al.   Marine Drugs

In Vivo Induction of Apoptosis by Fucoxanthin, a Marine Carotenoid, Associated with Down-Regulating STAT3/EGFR Signaling in Sarcoma 180 (S180) Xenografts-Bearing Mice

(2012) Jun Wang et al.   Marine Drugs

10-Acetylirciformonin B, A Sponge Furanoterpenoid, Induces DNA Damage and Apoptosis in Leukemia Cells

(2012) Jui-Hsin Su et al.   MOLECULES

Antiproliferation and Induction of Apoptosis in Ca9-22 Oral Cancer Cells by Ethanolic Extract of Gracilaria tenuistipitata

(2012) Chi-Chen Yeh et al.   MOLECULES

Aqueous Extracts of the Edible Gracilaria tenuistipitata are Protective Against H2O2-Induced DNA Damage, Growth Inhibition, and Cell Cycle Arrest

(2012) Jing-Iong Yang et al.   MOLECULES

Papuamine and haliclonadiamine, obtained from an Indonesian spongeHaliclonasp., inhibited cell proliferation of human cancer cell lines

(2012) Hiroyuki Yamazaki et al.   NATURAL PRODUCT RESEARCH

Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency

(2012) Q. McAfee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial ROS generation for regulation of autophagic pathways in cancer

(2011) Zi-yue Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cell death by autophagy: facts and apparent artefacts

(2011) D Denton et al.   CELL DEATH AND DIFFERENTIATION

Cellular Redox Pathways as a Therapeutic Target in the Treatment of Cancer

(2011) Alberto J. Montero et al.   DRUGS

The Role of Autophagy in Cancer: Therapeutic Implications

(2011) Z. J. Yang et al.   MOLECULAR CANCER THERAPEUTICS

Negative regulation of autophagy

(2010) C Liang   CELL DEATH AND DIFFERENTIATION

A novel activity from an old compound: Manzamine A reduces the metastatic potential of AsPC-1 pancreatic cancer cells and sensitizes them to TRAIL-induced apoptosis

(2010) Esther A. Guzmán et al.   INVESTIGATIONAL NEW DRUGS

Effect of Elatol, Isolated from Red Seaweed Laurencia dendroidea, on Leishmania amazonensis

(2010) Adriana Oliveira dos Santos et al.   Marine Drugs

Rhabdastrellic Acid-A Induced Autophagy-Associated Cell Death through Blocking Akt Pathway in Human Cancer Cells

(2010) Dan-Dan Li et al.   PLoS One

Steroid glycosides from marine organisms

(2010) Natalia V. Ivanchina et al.   STEROIDS

Hydroxychloroquine Modulates Metabolic Activity and Proliferation and Induces Autophagic Cell Death of Human Dermal Fibroblasts

(2009) Bettina Ramser et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Hydroxychloroquine Induces Autophagic Cell Death of Human Dermal Fibroblasts: Implications for Treating Fibrotic Skin Diseases

(2009) Aarne Oikarinen   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Bafilomycins Produced in Culture byStreptomycesspp. Isolated from Marine Habitats Are Potent Inhibitors of Autophagy†

(2009) Gavin Carr et al.   JOURNAL OF NATURAL PRODUCTS

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells

(2009) K Zhu et al.   ONCOGENE

Regulation of Autophagy by Reactive Oxygen Species (ROS): Implications for Cancer Progression and Treatment

(2008) Meghan B. Azad et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy-Modulating Aminosteroids Isolated from the SpongeCliona celata

(2008) Robert A. Keyzers et al.   ORGANIC LETTERS

Rhabdastrellic acid-A inhibited PI3K/Akt pathway and induced apoptosis in human leukemia HL-60 cells

(2007) J GUO et al.   CELL BIOLOGY INTERNATIONAL