BIN1 regulates BACE1 intracellular trafficking and amyloid-β production

An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease

(2015) Y. Kizuka et al.   EMBO Molecular Medicine

BIN1 Membrane Curvature Sensing and Generation Show Autoinhibition Regulated by Downstream Ligands and PI(4,5)P2

(2014) Tingting Wu et al.   BIOCHEMISTRY

EHD1 mediates vesicle trafficking required for normal muscle growth and transverse tubule development

(2014) Avery D. Posey et al.   DEVELOPMENTAL BIOLOGY

N-WASP is required for Amphiphysin-2/BIN1-dependent nuclear positioning and triad organization in skeletal muscle and is involved in the pathophysiology of centronuclear myopathy

(2014) S. Falcone et al.   EMBO Molecular Medicine

Amphiphysin 2 (BIN1) in physiology and diseases

(2014) Ivana Prokic et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretase

(2014) Kunihiko Kanatsu et al.   Nature Communications

A Function for EHD Family Proteins in Unidirectional Retrograde Dendritic Transport of BACE1 and Alzheimer’s Disease Aβ Production

(2014) Virginie Buggia-Prévot et al.   Cell Reports

Snapin-Mediated BACE1 Retrograde Transport Is Essential for Its Degradation in Lysosomes and Regulation of APP Processing in Neurons

(2014) Xuan Ye et al.   Cell Reports

Protein trafficking and maturation regulate intramembrane proteolysis

(2013) Yuichi Morohashi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The myotubularin–amphiphysin 2 complex in membrane tubulation and centronuclear myopathies

(2013) Barbara Royer et al.   EMBO REPORTS

Cooperative Recruitment of Dynamin and BIN/Amphiphysin/Rvs (BAR) Domain-containing Proteins Leads to GTP-dependent Membrane Scission

(2013) Michael Meinecke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology

(2013) J Chapuis et al.   MOLECULAR PSYCHIATRY

Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library

(2013) Hiroko Koike-Yusa et al.   NATURE BIOTECHNOLOGY

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Genetic Screens in Human Cells Using the CRISPR-Cas9 System

(2013) Tim Wang et al.   SCIENCE

Bridging integrator 1 (BIN1): form, function, and Alzheimer's disease

(2013) Meng-Shan Tan et al.   TRENDS IN MOLECULAR MEDICINE

The role of APP and BACE1 trafficking in APP processing and amyloid-β generation

(2013) Xiaojie Zhang et al.   Alzheimers Research & Therapy

Inverse Synaptic Tagging of Inactive Synapses via Dynamic Interaction of Arc/Arg3.1 with CaMKIIβ

(2012) Hiroyuki Okuno et al.   CELL

BACE1 Protein Endocytosis and Trafficking Are Differentially Regulated by Ubiquitination at Lysine 501 and the Di-leucine Motif in the Carboxyl Terminus

(2012) Eugene L. Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Depletion of GGA1 and GGA3 Mediates Postinjury Elevation of BACE1

(2012) K. R. Walker et al.   JOURNAL OF NEUROSCIENCE

Activity-Dependent Proteolytic Cleavage of Neuroligin-1

(2012) Kunimichi Suzuki et al.   NEURON

Role of genes linked to sporadic Alzheimer's disease risk in the production of  -amyloid peptides

(2012) J. Bali et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor That Affords Robust CNS Aβ Reduction

(2012) Andrew W. Stamford et al.   ACS Medicinal Chemistry Letters

BACE1 Activity Is Modulated by Cell-Associated Sphingosine-1-Phosphate

(2011) N. Takasugi et al.   JOURNAL OF NEUROSCIENCE

ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1

(2011) R. Sannerud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitin Regulates GGA3-mediated Degradation of BACE1

(2010) Eugene L. Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EHD1 is a synaptic protein that modulates exocytosis through binding to snapin

(2010) Shunhui Wei et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

EHD proteins: key conductors of endocytic transport

(2010) Naava Naslavsky et al.   TRENDS IN CELL BIOLOGY

AMPH-1/Amphiphysin/Bin1 functions with RME-1/Ehd1 in endocytic recycling

(2009) Saumya Pant et al.   NATURE CELL BIOLOGY

Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to GPCR oligomerization

(2008) Damien Maurel et al.   NATURE METHODS