Host and viral determinants of influenza A virus species specificity

H5N1 Influenza A Virus PB1-F2 Relieves HAX-1-Mediated Restriction of Avian Virus Polymerase PA in Human Lung Cells

(2018) B. Mazel-Sanchez et al.   JOURNAL OF VIROLOGY

The evolutionary history of vertebrate RNA viruses

(2018) Mang Shi et al.   NATURE

Influenza Hemagglutinin Protein Stability, Activation, and Pandemic Risk

(2018) Charles J. Russell et al.   TRENDS IN MICROBIOLOGY

Mutations Conferring Increased Sensitivity to Tripartite Motif 22 Restriction Accumulated Progressively in the Nucleoprotein of Seasonal Influenza A (H1N1) Viruses between 1918 and 2009

(2018) Isabel Pagani et al.   mSphere

Differential Splicing of ANP32A in Birds Alters Its Ability to Stimulate RNA Synthesis by Restricted Influenza Polymerase

(2018) Steven F. Baker et al.   Cell Reports

Physiological Exploration of the Long Term Evolutionary Selection against Expression ofN-Glycolylneuraminic Acid in the Brain

(2017) Yuko Naito-Matsui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo evasion of MxA by avian influenza viruses requires human signature in the viral nucleoprotein

(2017) Christoph M. Deeg et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Novel insights into bat influenza A viruses

(2017) Kevin Ciminski et al.   JOURNAL OF GENERAL VIROLOGY

Single-cell studies of IFN-β promoter activation by wild-type and NS1-defective influenza A viruses

(2017) M. J Killip et al.   JOURNAL OF GENERAL VIROLOGY

Loss of CMAH during Human Evolution Primed the Monocyte–Macrophage Lineage toward a More Inflammatory and Phagocytic State

(2017) Jonathan J. Okerblom et al.   JOURNAL OF IMMUNOLOGY

Role of Neuraminidase in Influenza A(H7N9) Virus Receptor Binding

(2017) Donald J. Benton et al.   JOURNAL OF VIROLOGY

pH Optimum of Hemagglutinin-Mediated Membrane Fusion Determines Sensitivity of Influenza A Viruses to the Interferon-Induced Antiviral State and IFITMs

(2017) Thomas Gerlach et al.   JOURNAL OF VIROLOGY

Co-expression of sialic acid receptors compatible with avian and human influenza virus binding in emus ( Dromaius novaehollandiae )

(2017) Naveen Gujjar et al.   VIROLOGY

Functional Insights into ANP32A-Dependent Influenza A Virus Polymerase Host Restriction

(2017) Patricia Domingues et al.   Cell Reports

A CRISPR Activation Screen Identifies a Pan-avian Influenza Virus Inhibitory Host Factor

(2017) Brook E. Heaton et al.   Cell Reports

Deep mutational scanning identifies sites in influenza nucleoprotein that affect viral inhibition by MxA

(2017) Orr Ashenberg et al.   PLoS Pathogens

Selective Bottlenecks Shape Evolutionary Pathways Taken during Mammalian Adaptation of a 1918-like Avian Influenza Virus

(2016) Louise H. Moncla et al.   Cell Host & Microbe

Influenza A virus PB1-F2 protein prolongs viral shedding in chickens lengthening the transmission window

(2016) Joe James et al.   JOURNAL OF GENERAL VIROLOGY

Role of the B Allele of Influenza A Virus Segment 8 in Setting Mammalian Host Range and Pathogenicity

(2016) Matthew L. Turnbull et al.   JOURNAL OF VIROLOGY

Host Protein Moloney Leukemia Virus 10 (MOV10) Acts as a Restriction Factor of Influenza A Virus by Inhibiting the Nuclear Import of the Viral Nucleoprotein

(2016) Junsong Zhang et al.   JOURNAL OF VIROLOGY

Constitutively Expressed IFITM3 Protein in Human Endothelial Cells Poses an Early Infection Block to Human Influenza Viruses

(2016) Xiangjie Sun et al.   JOURNAL OF VIROLOGY

Complexities in Ferret Influenza Virus Pathogenesis and Transmission Models

(2016) Jessica A. Belser et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains

(2016) Eric Thierry et al.   MOLECULAR CELL

Species difference in ANP32A underlies influenza A virus polymerase host restriction

(2016) Jason S. Long et al.   NATURE

Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis

(2016) Aartjan J. W. te Velthuis et al.   NATURE REVIEWS MICROBIOLOGY

Molecular requirements for a pandemic influenza virus: An acid-stable hemagglutinin protein

(2016) Marion Russier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of importin-α isoforms in human nasal mucosa: implication for adaptation of avian influenza A viruses to human host

(2016) Khwansiri Ninpan et al.   Virology Journal

Viral factors in influenza pandemic risk assessment

(2016) Marc Lipsitch et al.   eLife

Influenza Virus Adaptation PB2-627K Modulates Nucleocapsid Inhibition by the Pathogen Sensor RIG-I

(2015) Michaela Weber et al.   Cell Host & Microbe

Adaptive mutation PB2 D701N promotes nuclear import of influenza vRNPs in mammalian cells

(2015) Hanna Sediri et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Identification of Influenza A Virus PB2 Residues Involved in Enhanced Polymerase Activity and Virus Growth in Mammalian Cells at Low Temperatures

(2015) Tsuyoshi Hayashi et al.   JOURNAL OF VIROLOGY

H1N1 Swine Influenza Viruses Differ from Avian Precursors by a Higher pH Optimum of Membrane Fusion

(2015) Jan Baumann et al.   JOURNAL OF VIROLOGY

Fitness Inference from Short-Read Data: Within-Host Evolution of a Reassortant H5N1 Influenza Virus

(2015) Christopher J.R. Illingworth   MOLECULAR BIOLOGY AND EVOLUTION

Cryo-EM Structure of Influenza Virus RNA Polymerase Complex at 4.3 Å Resolution

(2015) Shenghai Chang et al.   MOLECULAR CELL

The soft palate is an important site of adaptation for transmissible influenza viruses

(2015) Seema S. Lakdawala et al.   NATURE

Crystal structure of the RNA-dependent RNA polymerase from influenza C virus

(2015) Narin Hengrung et al.   NATURE

Mx GTPases: dynamin-like antiviral machines of innate immunity

(2015) Otto Haller et al.   TRENDS IN MICROBIOLOGY

Influenza virus polymerase: Functions on host range, inhibition of cellular response to infection and pathogenicity

(2015) Ariel Rodriguez-Frandsen et al.   VIRUS RESEARCH

Mammalian adaptation of influenza A(H7N9) virus is limited by a narrow genetic bottleneck

(2015) Hassan Zaraket et al.   Nature Communications

Animal models for influenza virus transmission studies: a historical perspective

(2015) Nicole M Bouvier   Current Opinion in Virology

pp32 and APRIL are host cell-derived regulators of influenza virus RNA synthesis from cRNA

(2015) Kenji Sugiyama et al.   eLife

Misdelivery at the Nuclear Pore Complex—Stopping a Virus Dead in Its Tracks

(2015) Justin Flatt et al.   Cells

Cracking the ANP32 whips: Important functions, unequal requirement, and hints at disease implications

(2014) Patrick T. Reilly et al.   BIOESSAYS

One-way trip: Influenza virus' adaptation to gallinaceous poultry may limit its pandemic potential

(2014) Jason S. Long et al.   BIOESSAYS

Identification, Characterization, and Natural Selection of Mutations Driving Airborne Transmission of A/H5N1 Virus

(2014) Martin Linster et al.   CELL

Influenza Virus-Host Interactome Screen as a Platform for Antiviral Drug Development

(2014) Tokiko Watanabe et al.   Cell Host & Microbe

Cellular DDX21 RNA Helicase Inhibits Influenza A Virus Replication but Is Counteracted by the Viral NS1 Protein

(2014) Guifang Chen et al.   Cell Host & Microbe

A LC3-Interacting Motif in the Influenza A Virus M2 Protein Is Required to Subvert Autophagy and Maintain Virion Stability

(2014) Rupert Beale et al.   Cell Host & Microbe

The Nuclear Export Protein of H5N1 Influenza A Viruses Recruits Matrix 1 (M1) Protein to the Viral Ribonucleoprotein to Mediate Nuclear Export

(2014) Linda Brunotte et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycomic Characterization of Respiratory Tract Tissues of Ferrets

(2014) Nan Jia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RIG-I from waterfowl and mammals differ in their abilities to induce antiviral responses against influenza A viruses

(2014) Q. Shao et al.   JOURNAL OF GENERAL VIROLOGY

Viral determinants of influenza A virus host range

(2014) A. V. Cauldwell et al.   JOURNAL OF GENERAL VIROLOGY

The Nucleoprotein of Newly Emerged H7N9 Influenza A Virus Harbors a Unique Motif Conferring Resistance to Antiviral Human MxA

(2014) David Riegger et al.   JOURNAL OF VIROLOGY

PB2 Mutations D701N and S714R Promote Adaptation of an Influenza H5N1 Virus to a Mammalian Host

(2014) V. Czudai-Matwich et al.   JOURNAL OF VIROLOGY

Stepwise Priming by Acidic pH and a High K+ Concentration Is Required for Efficient Uncoating of Influenza A Virus Cores after Penetration

(2014) S. Stauffer et al.   JOURNAL OF VIROLOGY

Structure of influenza A polymerase bound to the viral RNA promoter

(2014) Alexander Pflug et al.   NATURE

At the centre: influenza A virus ribonucleoproteins

(2014) Amie J. Eisfeld et al.   NATURE REVIEWS MICROBIOLOGY

Enabling the 'host jump': structural determinants of receptor-binding specificity in influenza A viruses

(2014) Yi Shi et al.   NATURE REVIEWS MICROBIOLOGY

Shotgun glycomics of pig lung identifies natural endogenous receptors for influenza viruses

(2014) L. Byrd-Leotis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Infection of swineex vivotissues with avian viruses including H7N9 and correlation with glycomic analysis

(2013) Renee W. Y. Chan et al.   Influenza and Other Respiratory Viruses

Entry of influenza A virus: host factors and antiviral targets

(2013) T. O. Edinger et al.   JOURNAL OF GENERAL VIROLOGY

TRIM22 Inhibits Influenza A Virus Infection by Targeting the Viral Nucleoprotein for Degradation

(2013) A. Di Pietro et al.   JOURNAL OF VIROLOGY

The Human Interferon-Induced MxA Protein Inhibits Early Stages of Influenza A Virus Infection by Retaining the Incoming Viral Genome in the Cytoplasm

(2013) Han Xiao et al.   JOURNAL OF VIROLOGY

The Effect of the PB2 Mutation 627K on Highly Pathogenic H5N1 Avian Influenza Virus Is Dependent on the Virus Lineage

(2013) J. S. Long et al.   JOURNAL OF VIROLOGY

The Short Stalk Length of Highly Pathogenic Avian Influenza H5N1 Virus Neuraminidase Limits Transmission of Pandemic H1N1 Virus in Ferrets

(2013) D. Blumenkrantz et al.   JOURNAL OF VIROLOGY

Host Restriction of Influenza Virus Polymerase Activity by PB2 627E Is Diminished on Short Viral Templates in a Nucleoprotein-Independent Manner

(2013) D. Paterson et al.   JOURNAL OF VIROLOGY

Adaptive Mutations in the Nuclear Export Protein of Human-Derived H5N1 Strains Facilitate a Polymerase Activity-Enhancing Conformation

(2013) P. Reuther et al.   JOURNAL OF VIROLOGY

Receptor binding by an H7N9 influenza virus from humans

(2013) Xiaoli Xiong et al.   NATURE

Review of Influenza A Virus in Swine Worldwide: A Call for Increased Surveillance and Research

(2013) A. Vincent et al.   Zoonoses and Public Health

Glycomic Analysis of Human Respiratory Tract Tissues and Correlation with Influenza Virus Infection

(2013) Trevenan Walther et al.   PLoS Pathogens

Isolation of a Novel Swine Influenza Virus from Oklahoma in 2011 Which Is Distantly Related to Human Influenza C Viruses

(2013) Ben M. Hause et al.   PLoS Pathogens

Influenza HA Subtypes Demonstrate Divergent Phenotypes for Cleavage Activation and pH of Fusion: Implications for Host Range and Adaptation

(2013) Summer E. Galloway et al.   PLoS Pathogens

Pandemic Influenza A Viruses Escape from Restriction by Human MxA through Adaptive Mutations in the Nucleoprotein

(2013) Benjamin Mänz et al.   PLoS Pathogens

Mechanisms by Which Ambient Humidity May Affect Viruses in Aerosols

(2012) Wan Yang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The nuclear import machinery is a determinant of influenza virus host adaptation

(2012) Patricia Resa-Infante et al.   BIOESSAYS

Unstable Polymerase-Nucleoprotein Interaction Is Not Responsible for Avian Influenza Virus Polymerase Restriction in Human Cells

(2012) A. V. Cauldwell et al.   JOURNAL OF VIROLOGY

A Small-RNA Enhancer of Viral Polymerase Activity

(2012) J. T. Perez et al.   JOURNAL OF VIROLOGY

Cellular Protein HAX1 Interacts with the Influenza A Virus PA Polymerase Subunit and Impedes Its Nuclear Translocation

(2012) W.-B. Hsu et al.   JOURNAL OF VIROLOGY

Investigation of Influenza Virus Polymerase Activity in Pig Cells

(2012) O. Moncorge et al.   JOURNAL OF VIROLOGY

Functional Balance of the Hemagglutinin and Neuraminidase Activities Accompanies the Emergence of the 2009 H1N1 Influenza Pandemic

(2012) R. Xu et al.   JOURNAL OF VIROLOGY

Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets

(2012) Masaki Imai et al.   NATURE

A distinct lineage of influenza A virus from bats

(2012) S. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets

(2012) S. Herfst et al.   SCIENCE

The Potential for Respiratory Droplet-Transmissible A/H5N1 Influenza Virus to Evolve in a Mammalian Host

(2012) C. A. Russell et al.   SCIENCE

Adaptive mutations in NEP compensate for defective H5N1 RNA replication in cultured human cells

(2012) Benjamin Mänz et al.   Nature Communications

Human-like PB2 627K Influenza Virus Polymerase Activity Is Regulated by Importin-α1 and -α7

(2012) Ben Hudjetz et al.   PLoS Pathogens

Adaptive mutation in influenza A virus non-structural gene is linked to host switching and induces a novel protein by alternative splicing

(2012) Mohammed Selman et al.   Emerging Microbes & Infections

A new splice variant of the human guanylate-binding protein 3 mediates anti-influenza activity through inhibition of viral transcription and replication

(2011) Alexandra Nordmann et al.   FASEB JOURNAL

Interaction of the Influenza A Virus Polymerase PB2 C-terminal Region with Importin α Isoforms Provides Insights into Host Adaptation and Polymerase Assembly

(2011) Stephane Boivin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical Impact of the Host Adaptation-associated PB2 E627K Mutation on the Temperature-dependent RNA Synthesis Kinetics of Influenza A Virus Polymerase Complex

(2011) Shilpa Aggarwal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lack of transmission of a human influenza virus with avian receptor specificity between ferrets is not due to decreased virus shedding but rather a lower infectivity in vivo

(2011) K. L. Roberts et al.   JOURNAL OF GENERAL VIROLOGY

Reassortment and Mutation of the Avian Influenza Virus Polymerase PA Subunit Overcome Species Barriers

(2011) A. Mehle et al.   JOURNAL OF VIROLOGY

Length Variations in the NA Stalk of an H7N1 Influenza Virus Have Opposite Effects on Viral Excretion in Chickens and Ducks

(2011) T. W. Hoffmann et al.   JOURNAL OF VIROLOGY

Comprehensive Proteomic Analysis of Influenza Virus Polymerase Complex Reveals a Novel Association with Mitochondrial Proteins and RNA Polymerase Accessory Factors

(2011) B. G. Bradel-Tretheway et al.   JOURNAL OF VIROLOGY

The contribution of animal models to the understanding of the host range and virulence of influenza A viruses

(2011) Christopher D. O’Donnell et al.   MICROBES AND INFECTION

Hemagglutinin-neuraminidase balance confers respiratory-droplet transmissibility of the pandemic H1N1 influenza virus in ferrets

(2011) H.-L. Yen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Host- and Strain-Specific Regulation of Influenza Virus Polymerase Activity by Interacting Cellular Proteins

(2011) E. Bortz et al.   mBio

Differential use of importin-α isoforms governs cell tropism and host adaptation of influenza virus

(2011) Gülsah Gabriel et al.   Nature Communications

Host Determinant Residue Lysine 627 Lies on the Surface of a Discrete, Folded Domain of Influenza Virus Polymerase PB2 Subunit

(2011) Franck Tarendeau et al.   PLoS Pathogens

IFITM3 Inhibits Influenza A Virus Infection by Preventing Cytosolic Entry

(2011) Eric M. Feeley et al.   PLoS Pathogens

Eurasian-Origin Gene Segments Contribute to the Transmissibility, Aerosol Release, and Morphology of the 2009 Pandemic H1N1 Influenza Virus

(2011) Seema S. Lakdawala et al.   PLoS Pathogens

The Influenza Virus Protein PB1-F2 Inhibits the Induction of Type I Interferon at the Level of the MAVS Adaptor Protein

(2011) Zsuzsanna T. Varga et al.   PLoS Pathogens

Comparative distribution of human and avian type sialic acid influenza receptors in the pig

(2010) Rahul K Nelli et al.   BMC Veterinary Research

RIG-I Detects Viral Genomic RNA during Negative-Strand RNA Virus Infection

(2010) Jan Rehwinkel et al.   CELL

Influenza Virus Evolution, Host Adaptation, and Pandemic Formation

(2010) Jeffery K. Taubenberger et al.   Cell Host & Microbe

Glycan Analysis and Influenza A Virus Infection of Primary Swine Respiratory Epithelial Cells

(2010) Allen C. Bateman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inefficient Control of Host Gene Expression by the 2009 Pandemic H1N1 Influenza A Virus NS1 Protein

(2010) B. G. Hale et al.   JOURNAL OF VIROLOGY

PB2 Residue 158 Is a Pathogenic Determinant of Pandemic H1N1 and H5 Influenza A Viruses in Mice

(2010) B. Zhou et al.   JOURNAL OF VIROLOGY

The PB2 Subunit of the Influenza Virus RNA Polymerase Affects Virulence by Interacting with the Mitochondrial Antiviral Signaling Protein and Inhibiting Expression of Beta Interferon

(2010) K. M. Graef et al.   JOURNAL OF VIROLOGY

Evidence for Avian and Human Host Cell Factors That Affect the Activity of Influenza Virus Polymerase

(2010) O. Moncorge et al.   JOURNAL OF VIROLOGY

Receptor Specificity and Transmission of H2N2 Subtype Viruses Isolated from the Pandemic of 1957

(2010) Claudia Pappas et al.   PLoS One

Association of RIG-I with innate immunity of ducks to influenza

(2010) M. R. W. Barber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influenza A virus-generated small RNAs regulate the switch from transcription to replication

(2010) J. T. Perez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Uniquely human evolution of sialic acid genetics and biology

(2010) A. Varki   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of influenza virus sialic acid receptors in minor poultry species

(2010) Brian Kimble et al.   Virology Journal

Biological and Structural Characterization of a Host-Adapting Amino Acid in Influenza Virus

(2010) Shinya Yamada et al.   PLoS Pathogens

Functional significance of the hemadsorption activity of influenza virus neuraminidase and its alteration in pandemic viruses

(2009) Jennifer Uhlendorff et al.   ARCHIVES OF VIROLOGY

NS2/NEP protein regulates transcription and replication of the influenza virus RNA genome

(2009) Nicole C. Robb et al.   JOURNAL OF GENERAL VIROLOGY

Ostrich Involvement in the Selection of H5N1 Influenza Virus Possessing Mammalian-Type Amino Acids in the PB2 Protein

(2009) K. Shinya et al.   JOURNAL OF VIROLOGY

Adaptive strategies of the influenza virus polymerase for replication in humans

(2009) Andrew Mehle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate immune responses to influenza A H5N1: friend or foe?

(2009) Joseph Sriyal Malik Peiris et al.   TRENDS IN IMMUNOLOGY

Detection of expression of influenza virus receptors in tissues of BALB/c mice by histochemistry

(2009) Zhang-Yong Ning et al.   VETERINARY RESEARCH COMMUNICATIONS

An Inhibitory Activity in Human Cells Restricts the Function of an Avian-like Influenza Virus Polymerase

(2008) Andrew Mehle et al.   Cell Host & Microbe

Influenza A Virus Strains Differ in Sensitivity to the Antiviral Action of Mx-GTPase

(2008) J. Dittmann et al.   JOURNAL OF VIROLOGY

Asparagine 631 Variants of the Chicken Mx Protein Do Not Inhibit Influenza Virus Replication in Primary Chicken Embryo Fibroblasts or In Vitro Surrogate Assays

(2008) C. T. O. Benfield et al.   JOURNAL OF VIROLOGY

Avian Influenza A Virus Polymerase Association with Nucleoprotein, but Not Polymerase Assembly, Is Impaired in Human Cells during the Course of Infection

(2008) M.-A. Rameix-Welti et al.   JOURNAL OF VIROLOGY

Glycan topology determines human adaptation of avian H5N1 virus hemagglutinin

(2008) Aarthi Chandrasekaran et al.   NATURE BIOTECHNOLOGY

The Host-Dependent Interaction of α-Importins with Influenza PB2 Polymerase Subunit Is Required for Virus RNA Replication

(2008) Patricia Resa-Infante et al.   PLoS One

Interaction of Polymerase Subunit PB2 and NP with Importin α1 Is a Determinant of Host Range of Influenza A Virus

(2008) Gülsah Gabriel et al.   PLoS Pathogens

Quantitative biochemical rationale for differences in transmissibility of 1918 pandemic influenza A viruses

(2008) A. Srinivasan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA