PB2 Mutations D701N and S714R Promote Adaptation of an Influenza H5N1 Virus to a Mammalian Host

A simple and fast system for cloning influenza A virus gene segments into pHW2000- and pCAGGS-based vectors

(2013) Volker Czudai-Matwich et al.   ARCHIVES OF VIROLOGY

Adaptive mutations in the H5N1 polymerase complex

(2013) Gülsah Gabriel et al.   VIRUS RESEARCH

Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets

(2012) Masaki Imai et al.   NATURE

Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets

(2012) S. Herfst et al.   SCIENCE

Human-like PB2 627K Influenza Virus Polymerase Activity Is Regulated by Importin-α1 and -α7

(2012) Ben Hudjetz et al.   PLoS Pathogens

Interaction of the Influenza A Virus Polymerase PB2 C-terminal Region with Importin α Isoforms Provides Insights into Host Adaptation and Polymerase Assembly

(2011) Stephane Boivin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential use of importin-α isoforms governs cell tropism and host adaptation of influenza virus

(2011) Gülsah Gabriel et al.   Nature Communications

Host Determinant Residue Lysine 627 Lies on the Surface of a Discrete, Folded Domain of Influenza Virus Polymerase PB2 Subunit

(2011) Franck Tarendeau et al.   PLoS Pathogens

Evidence for Avian and Human Host Cell Factors That Affect the Activity of Influenza Virus Polymerase

(2010) O. Moncorge et al.   JOURNAL OF VIROLOGY

Structural Basis of the Influenza A Virus RNA Polymerase PB2 RNA-binding Domain Containing the Pathogenicity-determinant Lysine 627 Residue

(2009) Takashi Kuzuhara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ostrich Involvement in the Selection of H5N1 Influenza Virus Possessing Mammalian-Type Amino Acids in the PB2 Protein

(2009) K. Shinya et al.   JOURNAL OF VIROLOGY

A Single-Amino-Acid Substitution in a Polymerase Protein of an H5N1 Influenza Virus Is Associated with Systemic Infection and Impaired T-Cell Activation in Mice

(2009) J. L. Fornek et al.   JOURNAL OF VIROLOGY

Selection of H5N1 Influenza Virus PB2 during Replication in Humans

(2009) Q. M. Le et al.   JOURNAL OF VIROLOGY

An Inhibitory Activity in Human Cells Restricts the Function of an Avian-like Influenza Virus Polymerase

(2008) Andrew Mehle et al.   Cell Host & Microbe

The Host-Dependent Interaction of α-Importins with Influenza PB2 Polymerase Subunit Is Required for Virus RNA Replication

(2008) Patricia Resa-Infante et al.   PLoS One

Interaction of Polymerase Subunit PB2 and NP with Importin α1 Is a Determinant of Host Range of Influenza A Virus

(2008) Gülsah Gabriel et al.   PLoS Pathogens

The development and genetic diversity of H5N1 influenza virus in China, 1996–2006

(2008) L. Duan et al.   VIROLOGY

Phylogenetic analyses of highly pathogenic avian influenza virus isolates from Germany in 2006 and 2007 suggest at least three separate introductions of H5N1 virus

(2007) E. Starick et al.   VETERINARY MICROBIOLOGY