Deep mutational scanning identifies sites in influenza nucleoprotein that affect viral inhibition by MxA

A Balance between Inhibitor Binding and Substrate Processing Confers Influenza Drug Resistance

(2016) Li Jiang et al.   JOURNAL OF MOLECULAR BIOLOGY

Accurate Measurement of the Effects of All Amino-Acid Mutations on Influenza Hemagglutinin

(2016) Michael Doud et al.   Viruses-Basel

Influenza A viruses escape from MxA restriction at the expense of efficient nuclear vRNP import

(2016) Veronika Götz et al.   Scientific Reports

Software for the analysis and visualization of deep mutational scanning data

(2015) Jesse D Bloom   BMC BIOINFORMATICS

Oligomerization and GTP-binding Requirements of MxA for Viral Target Recognition and Antiviral Activity against Influenza A Virus

(2015) Patricia E. Nigg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Positive Selection in CD8+T-Cell Epitopes of Influenza Virus Nucleoprotein Revealed by a Comparative Analysis of Human and Swine Viral Lineages

(2015) Heather M. Machkovech et al.   JOURNAL OF VIROLOGY

Structure of importin-α bound to a non-classical nuclear localization signal of the influenza A virus nucleoprotein

(2015) Ryohei Nakada et al.   Scientific Reports

High-resolution genetic profile of viral genomes: why it matters

(2015) Hangfei Qi et al.   Current Opinion in Virology

The Nucleoprotein of Newly Emerged H7N9 Influenza A Virus Harbors a Unique Motif Conferring Resistance to Antiviral Human MxA

(2014) David Riegger et al.   JOURNAL OF VIROLOGY

High-Throughput Identification of Loss-of-Function Mutations for Anti-Interferon Activity in the Influenza A Virus NS Segment

(2014) N. C. Wu et al.   JOURNAL OF VIROLOGY

An Experimentally Determined Evolutionary Model Dramatically Improves Phylogenetic Fit

(2014) Jesse D. Bloom   MOLECULAR BIOLOGY AND EVOLUTION

Historical contingency and its biophysical basis in glucocorticoid receptor evolution

(2014) Michael J. Harms et al.   NATURE

Deep mutational scanning: a new style of protein science

(2014) Douglas M Fowler et al.   NATURE METHODS

The Large GTPase Mx1 Is Involved in Apical Transport in MDCK Cells

(2014) Florian Hoff et al.   TRAFFIC

Integrating influenza antigenic dynamics with molecular evolution

(2014) Trevor Bedford et al.   eLife

The inherent mutational tolerance and antigenic evolvability of influenza hemagglutinin

(2014) Bargavi Thyagarajan et al.   eLife

Monomeric Nucleoprotein of Influenza A Virus

(2013) Sylvie Chenavas et al.   PLoS Pathogens

Pandemic Influenza A Viruses Escape from Restriction by Human MxA through Adaptive Mutations in the Nucleoprotein

(2013) Benjamin Mänz et al.   PLoS Pathogens

Evolution-Guided Identification of Antiviral Specificity Determinants in the Broadly Acting Interferon-Induced Innate Immunity Factor MxA

(2012) Patrick S. Mitchell et al.   Cell Host & Microbe

Myxovirus Resistance Gene A (MxA) Expression Suppresses Influenza A Virus Replication in Alpha Interferon-Treated Primate Cells

(2012) S. R. Matzinger et al.   JOURNAL OF VIROLOGY

Interferon-Inducible Protein Mx1 Inhibits Influenza Virus by Interfering with Functional Viral Ribonucleoprotein Complex Assembly

(2012) J. Verhelst et al.   JOURNAL OF VIROLOGY

Systematic identification of type I and type II interferon-induced antiviral factors

(2012) S.-Y. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Structure of Native Influenza Virion Ribonucleoproteins

(2012) R. Arranz et al.   SCIENCE

Organization of the Influenza Virus Replication Machinery

(2012) A. Moeller et al.   SCIENCE

Interferon-induced Antiviral Protein MxA Interacts with the Cellular RNA Helicases UAP56 and URH49

(2011) Christian Wisskirchen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Viral Nucleoprotein Determines Mx Sensitivity of Influenza A Viruses

(2011) P. Zimmermann et al.   JOURNAL OF VIROLOGY

Mx Is Dispensable for Interferon-Mediated Resistance of Chicken Cells against Influenza A Virus

(2011) B. Schusser et al.   JOURNAL OF VIROLOGY

A diverse range of gene products are effectors of the type I interferon antiviral response

(2011) John W. Schoggins et al.   NATURE

Influenza Virus Evolution, Host Adaptation, and Pandemic Formation

(2010) Jeffery K. Taubenberger et al.   Cell Host & Microbe

High yields of influenza A virus in Madin-Darby canine kidney cells are promoted by an insufficient interferon-induced antiviral state

(2010) C. Seitz et al.   JOURNAL OF GENERAL VIROLOGY

Introduction of Virulence Markers in PB2 of Pandemic Swine-Origin Influenza Virus Does Not Result in Enhanced Virulence or Transmission

(2010) S. Herfst et al.   JOURNAL OF VIROLOGY

Permissive Secondary Mutations Enable the Evolution of Influenza Oseltamivir Resistance

(2010) J. D. Bloom et al.   SCIENCE

Interferon-inducedSus scrofaMx1 blocks endocytic traffic of incoming influenza A virus particles

(2010) Mélanie Palm et al.   VETERINARY RESEARCH

Heterocellular induction of interferon by negative-sense RNA viruses

(2010) S. Chen et al.   VIROLOGY

Innate immune evasion strategies of influenza viruses

(2009) Benjamin G Hale et al.   Future Microbiology

Using Non-Homogeneous Models of Nucleotide Substitution to Identify Host Shift Events: Application to the Origin of the 1918 ‘Spanish’ Influenza Pandemic Virus

(2009) Mario dos Reis et al.   JOURNAL OF MOLECULAR EVOLUTION

Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic

(2009) Gavin J. D. Smith et al.   NATURE

The Persistent Legacy of the 1918 Influenza Virus

(2009) David M. Morens et al.   NEW ENGLAND JOURNAL OF MEDICINE

Stochasticity in evolution

(2009) Thomas Lenormand et al.   TRENDS IN ECOLOGY & EVOLUTION

Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization, and vaccine design

(2008) Andy Ka-Leung Ng et al.   FASEB JOURNAL

Influenza A Virus Strains Differ in Sensitivity to the Antiviral Action of Mx-GTPase

(2008) J. Dittmann et al.   JOURNAL OF VIROLOGY

Historical contingency and the evolution of a key innovation in an experimental population of Escherichia coli

(2008) Z. D. Blount et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA