Detours to Replication: Functions of Specialized DNA Polymerases during Oncogene-induced Replication Stress

DNA polymerase η mutational signatures are found in a variety of different types of cancer

(2018) Igor B. Rogozin et al.   CELL CYCLE

Potential roles for G-quadruplexes in mitochondria

(2018) Micol Falabella et al.   CURRENT MEDICINAL CHEMISTRY

Advances in therapeutic targeting of the DNA damage response in cancer

(2018) Amar Desai et al.   DNA REPAIR

Polη, a Y-family translesion synthesis polymerase, promotes cellular tolerance of Myc-induced replication stress

(2018) Kiminori Kurashima et al.   JOURNAL OF CELL SCIENCE

Role of specialized DNA polymerases in the limitation of replicative stress and DNA damage transmission

(2018) Elodie Bournique et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Hallmarks of Cellular Senescence

(2018) Alejandra Hernandez-Segura et al.   TRENDS IN CELL BIOLOGY

Cis - and Trans -Modifiers of Repeat Expansions: Blending Model Systems with Human Genetics

(2018) Ryan J. McGinty et al.   TRENDS IN GENETICS

Mechanisms of Oncogene-Induced Replication Stress: Jigsaw Falling into Place

(2018) Panagiotis Kotsantis et al.   Cancer Discovery

Distinct Mechanisms of Nuclease-Directed DNA-Structure-Induced Genetic Instability in Cancer Genomes

(2018) Junhua Zhao et al.   Cell Reports

Dual Roles of Poly(dA:dT) Tracts in Replication Initiation and Fork Collapse

(2018) Anthony Tubbs et al.   CELL

Intragenic origins due to short G1 phases underlie oncogene-induced DNA replication stress

(2018) Morgane Macheret et al.   NATURE

DNA Polymerase Eta Prevents Tumor Cell-Cycle Arrest and Cell Death during Recovery from Replication Stress

(2018) Ryan P. Barnes et al.   CANCER RESEARCH

DNA repair factor RAD18 and DNA polymerase Polκ confer tolerance of oncogenic DNA replication stress

(2017) Yang Yang et al.   JOURNAL OF CELL BIOLOGY

Coupling of Homologous Recombination and the Checkpoint by ATR

(2017) Rémi Buisson et al.   MOLECULAR CELL

The impact of replication stress on replication dynamics and DNA damage in vertebrate cells

(2017) Hervé Técher et al.   NATURE REVIEWS GENETICS

Alternative DNA structure formation in the mutagenic human c-MYC promoter

(2017) Imee Marie A. del Mundo et al.   NUCLEIC ACIDS RESEARCH

Alterations in cellular metabolism triggered byURA7orGLN3inactivation cause imbalanced dNTP pools and increased mutagenesis

(2017) Tobias T. Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pre-RC Protein MCM7 depletion promotes mitotic exit by Inhibiting CDK1 activity

(2017) Dianpeng Zheng et al.   Scientific Reports

Mcm10 promotes rapid isomerization of CMG-DNA for replisome bypass of lagging strand DNA blocks

(2017) Lance D Langston et al.   eLife

Maintenance of Genome Integrity: How Mammalian Cells Orchestrate Genome Duplication by Coordinating Replicative and Specialized DNA Polymerases

(2017) Ryan Barnes et al.   Genes

Human Translesion Polymerase κ Exhibits Enhanced Activity and Reduced Fidelity Two Nucleotides from G-Quadruplex DNA

(2016) Sarah Eddy et al.   BIOCHEMISTRY

Conflict Resolution in the Genome: How Transcription and Replication Make It Work

(2016) Stephan Hamperl et al.   CELL

Is Senescence Reversible?

(2016) Shweta Chakradeo et al.   CURRENT DRUG TARGETS

FANCD2 Facilitates Replication through Common Fragile Sites

(2016) Advaitha Madireddy et al.   MOLECULAR CELL

Break-induced telomere synthesis underlies alternative telomere maintenance

(2016) Robert L. Dilley et al.   NATURE

G-quadruplex recognition and remodeling by the FANCJ helicase

(2016) Colin G. Wu et al.   NUCLEIC ACIDS RESEARCH

Translocation and deletion breakpoints in cancer genomes are associated with potential non-B DNA-forming sequences

(2016) Albino Bacolla et al.   NUCLEIC ACIDS RESEARCH

Rad18-dependent SUMOylation of human specialized DNA polymerase eta is required to prevent under-replicated DNA

(2016) Emmanuelle Despras et al.   Nature Communications

Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities

(2016) Kumar Sanjiv et al.   Cell Reports

Proteomic Profiling Reveals a Specific Role for Translesion DNA Polymerase η in the Alternative Lengthening of Telomeres

(2016) Laura Garcia-Exposito et al.   Cell Reports

Cyclin Kinase-independent role of p21CDKN1A in the promotion of nascent DNA elongation in unstressed cells

(2016) Sabrina F Mansilla et al.   eLife

Characterization of human translesion DNA synthesis across a UV-induced DNA lesion

(2016) Mark Hedglin et al.   eLife

Cdk2: a key regulator of the senescence control function of Myc

(2016) Per Hydbring et al.   Aging-US

DNA Replication Stress as a Hallmark of Cancer

(2015) Morgane Macheret et al.   Annual Review of Pathology-Mechanisms of Disease

REV1 is important for the ATR-Chk1 DNA damage response pathway in Xenopus egg extracts

(2015) Darla DeStephanis et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Evidence for the Kinetic Partitioning of Polymerase Activity on G-Quadruplex DNA

(2015) Sarah Eddy et al.   BIOCHEMISTRY

Repetitive DNA in eukaryotic genomes

(2015) Maria Assunta Biscotti et al.   CHROMOSOME RESEARCH

Molecular Pathways: Targeting ATR in Cancer Therapy

(2015) L. M. Karnitz et al.   CLINICAL CANCER RESEARCH

Metabolic Dependencies in RAS-Driven Cancers

(2015) A. C. Kimmelman   CLINICAL CANCER RESEARCH

DNA Secondary Structure at Chromosomal Fragile Sites in Human Disease

(2015) Ryan G. Thys et al.   CURRENT GENOMICS

Contributions of the specialised DNA polymerases to replication of structured DNA

(2015) Caroline M. Wickramasinghe et al.   DNA REPAIR

DNA replication origin activation in space and time

(2015) Michalis Fragkos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity

(2015) Tony M. Mertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

dNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants

(2015) Lindsey N. Williams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncogenes create a unique landscape of fragile sites

(2015) Karin Miron et al.   Nature Communications

Short Inverted Repeats Are Hotspots for Genetic Instability: Relevance to Cancer Genomes

(2015) Steve Lu et al.   Cell Reports

ATM Couples Replication Stress and Metabolic Reprogramming during Cellular Senescence

(2015) Katherine M. Aird et al.   Cell Reports

RECQL1 and WRN DNA repair helicases: potential therapeutic targets and proliferative markers against cancers

(2015) Kazunobu Futami et al.   Frontiers in Genetics

Association of G-quadruplex forming sequences with human mtDNA deletion breakpoints

(2014) Dawei W Dong et al.   BMC GENOMICS

Updating the mechanisms of common fragile site instability: how to reconcile the different views?

(2014) Benoît Le Tallec et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

DNA Replication and Oncogene-Induced Replicative Stress

(2014) Stephanie A. Hills et al.   CURRENT BIOLOGY

DNA Sequences Proximal to Human Mitochondrial DNA Deletion Breakpoints Prevalent in Human Disease Form G-quadruplexes, a Class of DNA Structures Inefficiently Unwound by the Mitochondrial Replicative Twinkle Helicase

(2014) Sanjay Kumar Bharti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myc and Ras oncogenes engage different energy metabolism programs and evoke distinct patterns of oxidative and DNA replication stress

(2014) Apolinar Maya-Mendoza et al.   Molecular Oncology

CMG helicase and DNA polymerase   form a functional 15-subunit holoenzyme for eukaryotic leading-strand DNA replication

(2014) L. D. Langston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Pol   purified with accessory subunits is active in translesion DNA synthesis and complements Pol   in cisplatin bypass

(2014) Y.-S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CHK2 kinase in the DNA damage response and beyond

(2014) L. Zannini et al.   Journal of Molecular Cell Biology

Breast Cancer Proteins PALB2 and BRCA2 Stimulate Polymerase η in Recombination-Associated DNA Synthesis at Blocked Replication Forks

(2014) Rémi Buisson et al.   Cell Reports

An Overview of MYC and Its Interactome

(2014) M. Conacci-Sorrell et al.   Cold Spring Harbor Perspectives in Medicine

Identification of Early Replicating Fragile Sites that Contribute to Genome Instability

(2013) Jacqueline H. Barlow et al.   CELL

Mouse DNA polymerase kappa has a functional role in the repair of DNA strand breaks

(2013) Xiuli Zhang et al.   DNA REPAIR

DNA polymerase κ-dependent DNA synthesis at stalled replication forks is important for CHK1 activation

(2013) Rémy Bétous et al.   EMBO JOURNAL

DNA synthesis by Pol η promotes fragile site stability by preventing under-replicated DNA in mitosis

(2013) Valérie Bergoglio et al.   JOURNAL OF CELL BIOLOGY

Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates

(2013) Kai J. Neelsen et al.   JOURNAL OF CELL BIOLOGY

The Human Specialized DNA Polymerases and Non-B DNA: Vital Relationships to Preserve Genome Integrity

(2013) Anne-Sophie Boyer et al.   JOURNAL OF MOLECULAR BIOLOGY

Replication stress links structural and numerical cancer chromosomal instability

(2013) Rebecca A. Burrell et al.   NATURE

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

Friedreich's ataxia–associated GAA repeats induce replication-fork reversal and unusual molecular junctions

(2013) Cindy Follonier et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human Rev1 polymerase disrupts G-quadruplex DNA

(2013) S. Eddy et al.   NUCLEIC ACIDS RESEARCH

DNA polymerase δ stalls on telomeric lagging strand templates independently from G-quadruplex formation

(2013) Justin D. Lormand et al.   NUCLEIC ACIDS RESEARCH

A novel interplay between the Fanconi anemia core complex and ATR-ATRIP kinase during DNA cross-link repair

(2013) J. Tomida et al.   NUCLEIC ACIDS RESEARCH

Rev3, the catalytic subunit of Polζ, is required for maintaining fragile site stability in human cells

(2013) Audesh Bhat et al.   NUCLEIC ACIDS RESEARCH

DNA polymerases ζ and Rev1 mediate error-prone bypass of non-B DNA structures

(2013) Matthew R. Northam et al.   NUCLEIC ACIDS RESEARCH

Expression of DNA Translesion Synthesis Polymerase η in Head and Neck Squamous Cell Cancer Predicts Resistance to Gemcitabine and Cisplatin-Based Chemotherapy

(2013) Wendi Zhou et al.   PLoS One

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Translesion DNA Synthesis and Mutagenesis in Eukaryotes

(2013) J. E. Sale   Cold Spring Harbor Perspectives in Biology

Transcriptional control of DNA replication licensing by Myc

(2013) Taras Valovka et al.   Scientific Reports

Suppression of Nucleotide Metabolism Underlies the Establishment and Maintenance of Oncogene-Induced Senescence

(2013) Katherine M. Aird et al.   Cell Reports

Roles for MYC in the Establishment and Maintenance of Pluripotency

(2013) J. Chappell et al.   Cold Spring Harbor Perspectives in Medicine

Depletion of Deoxyribonucleotide Pools Is an Endogenous Source of DNA Damage in Cells Undergoing Oncogene-Induced Senescence

(2012) Sudha Mannava et al.   AMERICAN JOURNAL OF PATHOLOGY

MYC Regulation of CHK1 and CHK2 Promotes Radioresistance in a Stem Cell-like Population of Nasopharyngeal Carcinoma Cells

(2012) W.-J. Wang et al.   CANCER RESEARCH

DNA polymerase kappa microsatellite synthesis: Two distinct mechanisms of slippage-mediated errors

(2012) Beverly A. Baptiste et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

A genome-wide analysis of common fragile sites: What features determine chromosomal instability in the human genome?

(2012) Arkarachai Fungtammasan et al.   GENOME RESEARCH

Mechanism of Replicative DNA Polymerase Delta Pausing and a Potential Role for DNA Polymerase Kappa in Common Fragile Site Replication

(2012) Erin Walsh et al.   JOURNAL OF MOLECULAR BIOLOGY

MYC-Driven Tumorigenesis Is Inhibited by WRN Syndrome Gene Deficiency

(2012) R. Moser et al.   MOLECULAR CANCER RESEARCH

Noncanonical Mismatch Repair as a Source of Genomic Instability in Human Cells

(2012) Javier Peña-Diaz et al.   MOLECULAR CELL

DNA secondary structures: stability and function of G-quadruplex structures

(2012) Matthew L. Bochman et al.   NATURE REVIEWS GENETICS

Effects of Friedreich's ataxia GAA repeats on DNA replication in mammalian cells

(2012) Gurangad S. Chandok et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial DNA deletions are associated with non-B DNA conformations

(2012) Joana Damas et al.   NUCLEIC ACIDS RESEARCH

A four-subunit DNA polymerase ζ complex containing Pol δ accessory subunits is essential for PCNA-mediated mutagenesis

(2012) Alena V. Makarova et al.   NUCLEIC ACIDS RESEARCH

Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress

(2012) R M Jones et al.   ONCOGENE

Dormant Origins, the Licensing Checkpoint, and the Response to Replicative Stresses

(2012) D. McIntosh et al.   Cold Spring Harbor Perspectives in Biology

Oncogenes in Cell Survival and Cell Death

(2012) J. Shortt et al.   Cold Spring Harbor Perspectives in Biology

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development

(2011) Assaf C. Bester et al.   CELL

Impact of cyclin E overexpression on Smad3 activity in breast cancer cell lines 

(2011) Anne Cooley et al.   CELL CYCLE

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

(2011) J. Y. Guo et al.   GENES & DEVELOPMENT

Insights Into Mutagenesis UsingEscherichia coliChromosomallacZStrains That Enable Detection of a Wide Spectrum of Mutational Events

(2011) Tracey Seier et al.   GENETICS

ATR-mediated phosphorylation of DNA polymerase η is needed for efficient recovery from UV damage

(2011) Thomas Göhler et al.   JOURNAL OF CELL BIOLOGY

Collisions between Replication and Transcription Complexes Cause Common Fragile Site Instability at the Longest Human Genes

(2011) Anne Helmrich et al.   MOLECULAR CELL

Failure of Origin Activation in Response to Fork Stalling Leads to Chromosomal Instability at Fragile Sites

(2011) Efrat Ozeri-Galai et al.   MOLECULAR CELL

Studies of genomic copy number changes in human cancers reveal signatures of DNA replication stress

(2011) Aygül Dereli-Öz et al.   Molecular Oncology

Copy number variation and selection during reprogramming to pluripotency

(2011) Samer M. Hussein et al.   NATURE

Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site

(2011) Anne Letessier et al.   NATURE

DNA secondary structures and epigenetic determinants of cancer genome evolution

(2011) Subhajyoti De et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors

(2011) Matilde Murga et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA

(2011) Peter Sarkies et al.   NUCLEIC ACIDS RESEARCH

Beyond translesion synthesis: polymerase κ fidelity as a potential determinant of microsatellite stability

(2011) Suzanne E. Hile et al.   NUCLEIC ACIDS RESEARCH

The consequences of structural genomic alterations in humans: Genomic Disorders, genomic instability and cancer

(2011) Rita Colnaghi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Repetitive Elements May Comprise Over Two-Thirds of the Human Genome

(2011) A. P. Jason de Koning et al.   PLoS Genetics

Variable Tandem Repeats Accelerate Evolution of Coding and Regulatory Sequences

(2010) Rita Gemayel et al.   Annual Review of Genetics

DNA Instability at Chromosomal Fragile Sites in Cancer

(2010) Laura W. Dillon et al.   CURRENT GENOMICS

Structure, location and interactions of G-quadruplexes

(2010) Julian L. Huppert   FEBS Journal

Epigenetic Instability due to Defective Replication of Structured DNA

(2010) Peter Sarkies et al.   MOLECULAR CELL

Signatures of mutation and selection in the cancer genome

(2010) Graham R. Bignell et al.   NATURE

Structure and mechanism of human DNA polymerase η

(2010) Christian Biertümpfel et al.   NATURE

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Secondary structure formation and DNA instability at fragile site FRA16B

(2010) Allison A. Burrow et al.   NUCLEIC ACIDS RESEARCH

Suppression of Rev3, the catalytic subunit of Pol , sensitizes drug-resistant lung tumors to chemotherapy

(2010) J. Doles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Over half of breakpoints in gene pairs involved in cancer-specific recurrent translocations are mapped to human chromosomal fragile sites

(2009) Allison A Burrow et al.   BMC GENOMICS

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

(2009) Agnel Sfeir et al.   CELL

Non-B DNA structure-induced genetic instability and evolution

(2009) Junhua Zhao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Polymerase   mRNA Expression Predicts Survival of Non-Small Cell Lung Cancer Patients Treated with Platinum-Based Chemotherapy

(2009) P. Ceppi et al.   CLINICAL CANCER RESEARCH

Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals

(2009) Sigal Shachar et al.   EMBO JOURNAL

Participation of DNA Polymerase   in Replication of Undamaged DNA in Saccharomyces cerevisiae

(2009) M. R. Northam et al.   GENETICS

Chromosome Aberrations Resulting From Double-Strand DNA Breaks at a Naturally Occurring Yeast Fragile Site Composed of Inverted Ty Elements Are Independent of Mre11p and Sae2p

(2009) A. M. Casper et al.   GENETICS

Impaired replication dynamics at the FRA3B common fragile site

(2009) Aparna Palakodeti et al.   HUMAN MOLECULAR GENETICS

TopBP1 and DNA polymerase-α directly recruit the 9-1-1 complex to stalled DNA replication forks

(2009) Shan Yan et al.   JOURNAL OF CELL BIOLOGY

Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance

(2009) L. S. Waters et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Human DNA Polymerase   Is Required for Common Fragile Site Stability during Unperturbed DNA Replication

(2009) L. Rey et al.   MOLECULAR AND CELLULAR BIOLOGY

Role of TLS DNA polymerases eta and kappa in processing naturally occurring structured DNA in human cells

(2009) Rémy Bétous et al.   MOLECULAR CARCINOGENESIS

Replisome stalling and stabilization at CGG repeats, which are responsible for chromosomal fragility

(2009) Irina Voineagu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D

(2009) Sandeep N. Shah et al.   NUCLEIC ACIDS RESEARCH

A ‘DNA replication’ signature of progression and negative outcome in colorectal cancer

(2009) M-J Pillaire et al.   ONCOGENE

Characterization of Naturally Occurring HPV16 Integration Sites Isolated from Cervical Keratinocytes under Noncompetitive Conditions

(2008) K. L. Dall et al.   CANCER RESEARCH

Chromosomal instability mediated by non-B DNA: Cruciform conformation and not DNA sequence is responsible for recurrent translocation in humans

(2008) H. Inagaki et al.   GENOME RESEARCH

Cdt1 and Cdc6 Are Destabilized by Rereplication-induced DNA Damage

(2008) Jonathan R. Hall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA Structure-induced Genomic Instability In Vivo

(2008) Guliang Wang et al.   JNCI-Journal of the National Cancer Institute

Oncogenes and Cancer

(2008) Carlo M. Croce   NEW ENGLAND JOURNAL OF MEDICINE

Global Regulation of Nucleotide Biosynthetic Genes by c-Myc

(2008) Yen-Chun Liu et al.   PLoS One

Replication stalling at unstable inverted repeats: Interplay between DNA hairpins and fork stabilizing proteins

(2008) I. Voineagu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human DNA polymerase   activity and translocation is regulated by phosphorylation

(2008) Y.-w. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE

Human chromosome fragility

(2007) T. Lukusa et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms