DNA polymerase η mutational signatures are found in a variety of different types of cancer

Exploring background mutational processes to decipher cancer genetic heterogeneity

(2017) Alexander Goncearenco et al.   NUCLEIC ACIDS RESEARCH

Human Cancers Express a Mutator Phenotype: Hypothesis, Origin, and Consequences

(2016) Lawrence A. Loeb   CANCER RESEARCH

Understanding mutagenesis through delineation of mutational signatures in human cancer

(2016) Mia Petljak et al.   CARCINOGENESIS

Antibody diversification caused by disrupted mismatch repair and promiscuous DNA polymerases

(2016) Kimberly J. Zanotti et al.   DNA REPAIR

DNA polymerase ι functions in the generation of tandem mutations during somatic hypermutation of antibody genes

(2016) Robert W. Maul et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The landscape of somatic mutations in protein coding genes in apparently benign human tissues carries signatures of relaxed purifying selection

(2016) Vinod Kumar Yadav et al.   NUCLEIC ACIDS RESEARCH

Predominant role of DNA polymerase eta and p53-dependent translesion synthesis in the survival of ultraviolet-irradiated human cells

(2016) Leticia K. Lerner et al.   NUCLEIC ACIDS RESEARCH

Activation induced deaminase mutational signature overlaps with CpG methylation sites in follicular lymphoma and other cancers

(2016) Igor B. Rogozin et al.   Scientific Reports

The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts

(2016) Natalie Saini et al.   PLoS Genetics

How the environment shapes cancer genomes

(2015) Gerd P. Pfeifer   CURRENT OPINION IN ONCOLOGY

The somatic autosomal mutation matrix in cancer genomes

(2015) Nuri A. Temiz et al.   HUMAN GENETICS

Whole genomes redefine the mutational landscape of pancreatic cancer

(2015) Nicola Waddell et al.   NATURE

An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers

(2015) Kin Chan et al.   NATURE GENETICS

Mutations in early follicular lymphoma progenitors are associated with suppressed antigen presentation

(2015) Michael R. Green et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High burden and pervasive positive selection of somatic mutations in normal human skin

(2015) I. Martincorena et al.   SCIENCE

Disruption of Transcriptional Coactivator Sub1 Leads to Genome-Wide Re-distribution of Clustered Mutations Induced by APOBEC in Active Yeast Genes

(2015) Artem G. Lada et al.   PLoS Genetics

AID-induced remodeling of immunoglobulin genes and B cell fate

(2015) Brice Laffleur et al.   Oncotarget

B Cell Super-Enhancers and Regulatory Clusters Recruit AID Tumorigenic Activity

(2014) Jason Qian et al.   CELL

Replicative DNA polymerase mutations in cancer

(2014) Ellen Heitzer et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Mutational signatures: the patterns of somatic mutations hidden in cancer genomes

(2014) Ludmil B Alexandrov et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin

(2014) Omer Ziv et al.   Nature Communications

Active RNAP pre-initiation sites are highly mutated by cytidine deaminases in yeast, with AID targeting small RNA genes

(2014) Benjamin JM Taylor et al.   eLife

APOBEC3B is an enzymatic source of mutation in breast cancer

(2013) Michael B. Burns et al.   NATURE

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers

(2013) Steven A Roberts et al.   NATURE GENETICS

Emerging patterns of somatic mutations in cancer

(2013) Ian R. Watson et al.   NATURE REVIEWS GENETICS

DNA polymerase ζ generates tandem mutations in immunoglobulin variable regions

(2012) Huseyin Saribasak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

Translesion DNA Polymerases and Cancer

(2012) Nick M. Makridakis et al.   Frontiers in Genetics

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

Rate, molecular spectrum, and consequences of human mutation

(2010) M. Lynch   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA polymerase   and   proofreading suppress discrete mutator and cancer phenotypes in mice

(2009) T. M. Albertson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA