Rad18-dependent SUMOylation of human specialized DNA polymerase eta is required to prevent under-replicated DNA

Aberrant C-terminal domain of polymerase η targets the functional enzyme to the proteosomal degradation pathway

(2015) Sana Ahmed-Seghir et al.   DNA REPAIR

Ubiquitin-SUMO Circuitry Controls Activated Fanconi Anemia ID Complex Dosage in Response to DNA Damage

(2015) Ian Gibbs-Seymour et al.   MOLECULAR CELL

The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability

(2015) Huzefa Dungrawala et al.   MOLECULAR CELL

HLTF’s Ancient HIRAN Domain Binds 3′ DNA Ends to Drive Replication Fork Reversal

(2015) Andrew C. Kile et al.   MOLECULAR CELL

DNA–protein crosslink repair: proteases as DNA repair enzymes

(2015) Julian Stingele et al.   TRENDS IN BIOCHEMICAL SCIENCES

Wss1 metalloprotease partners with Cdc48/Doa1 in processing genotoxic SUMO conjugates

(2015) Maxim Y Balakirev et al.   eLife

Uncovering global SUMOylation signaling networks in a site-specific manner

(2014) Ivo A Hendriks et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PIP degron proteins, substrates of CRL4Cdt2, and not PIP boxes, interfere with DNA polymerase η and κ focus formation on UV damage

(2014) Nikolay Tsanov et al.   NUCLEIC ACIDS RESEARCH

DNA synthesis by Pol η promotes fragile site stability by preventing under-replicated DNA in mitosis

(2013) Valérie Bergoglio et al.   JOURNAL OF CELL BIOLOGY

The Human Specialized DNA Polymerases and Non-B DNA: Vital Relationships to Preserve Genome Integrity

(2013) Anne-Sophie Boyer et al.   JOURNAL OF MOLECULAR BIOLOGY

FANCD2 Binds MCM Proteins and Controls Replisome Function upon Activation of S Phase Checkpoint Signaling

(2013) Gérald Lossaint et al.   MOLECULAR CELL

Role of Cdc48/p97 as a SUMO-targeted segregase curbing Rad51–Rad52 interaction

(2013) Steven Bergink et al.   NATURE CELL BIOLOGY

ERCC1 and MUS81–EME1 promote sister chromatid separation by processing late replication intermediates at common fragile sites during mitosis

(2013) Valeria Naim et al.   NATURE CELL BIOLOGY

MUS81 promotes common fragile site expression

(2013) Songmin Ying et al.   NATURE CELL BIOLOGY

The helicase FBH1 is tightly regulated by PCNA via CRL4(Cdt2)-mediated proteolysis in human cells

(2013) Agathe Bacquin et al.   NUCLEIC ACIDS RESEARCH

A Proteomic Characterization of Factors Enriched at Nascent DNA Molecules

(2013) Andres J. Lopez-Contreras et al.   Cell Reports

TrxG and PcG Proteins but Not Methylated Histones Remain Associated with DNA through Replication

(2012) Svetlana Petruk et al.   CELL

Regulation of the specialized DNA polymerase eta: Revisiting the biological relevance of its PCNA- and ubiquitin-binding motifs

(2012) Emmanuelle Despras et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Dual Recruitment of Cdc48 (p97)-Ufd1-Npl4 Ubiquitin-selective Segregase by Small Ubiquitin-like Modifier Protein (SUMO) and Ubiquitin in SUMO-targeted Ubiquitin Ligase-mediated Genome Stability Functions

(2012) Minghua Nie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Y-family DNA polymerases and their role in tolerance of cellular DNA damage

(2012) Julian E. Sale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage

(2012) Emily J Davis et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DVC1 (C1orf124) is a DNA damage–targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks

(2012) Anna Mosbech et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Predicting protein sumoylation sites from sequence features

(2011) Shaolei Teng et al.   AMINO ACIDS

PCNA ubiquitination-independent activation of polymerase η during somatic hypermutation and DNA damage tolerance

(2011) Peter H.L. Krijger et al.   DNA REPAIR

Analysis of protein dynamics at active, stalled, and collapsed replication forks

(2011) B. M. Sirbu et al.   GENES & DEVELOPMENT

ATR-mediated phosphorylation of DNA polymerase η is needed for efficient recovery from UV damage

(2011) Thomas Göhler et al.   JOURNAL OF CELL BIOLOGY

Replication stress induces 53BP1-containing OPT domains in G1 cells

(2011) Jeanine A. Harrigan et al.   JOURNAL OF CELL BIOLOGY

The hMsh2-hMsh6 Complex Acts in Concert with Monoubiquitinated PCNA and Pol η in Response to Oxidative DNA Damage in Human Cells

(2011) Anastasia Zlatanou et al.   MOLECULAR CELL

53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

(2011) Claudia Lukas et al.   NATURE CELL BIOLOGY

Human RAD18 Interacts with Ubiquitylated Chromatin Components and Facilitates RAD9 Recruitment to DNA Double Strand Breaks

(2011) Akiko Inagaki et al.   PLoS One

PCNA Ubiquitination Is Important, But Not Essential for Translesion DNA Synthesis in Mammalian Cells

(2011) Ayal Hendel et al.   PLoS Genetics

PCNA is ubiquitinated by RNF8

(2010) Sufang Zhang et al.   CELL CYCLE

ATR/Chk1 pathway is essential for resumption of DNA synthesis and cell survival in UV-irradiated XP variant cells

(2010) Emmanuelle Despras et al.   HUMAN MOLECULAR GENETICS

Phosphorylated Rad18 directs DNA Polymerase η to sites of stalled replication

(2010) Tovah A. Day et al.   JOURNAL OF CELL BIOLOGY

Regulation of Translesion Synthesis DNA Polymerase η by Monoubiquitination

(2010) Marzena Bienko et al.   MOLECULAR CELL

CRL4Cdt2 E3 Ubiquitin Ligase Monoubiquitinates PCNA to Promote Translesion DNA Synthesis

(2010) Kenta Terai et al.   MOLECULAR CELL

Structure and mechanism of human DNA polymerase η

(2010) Christian Biertümpfel et al.   NATURE

Human DNA Polymerase   Is Required for Common Fragile Site Stability during Unperturbed DNA Replication

(2009) L. Rey et al.   MOLECULAR AND CELLULAR BIOLOGY

Pirh2 E3 Ubiquitin Ligase Targets DNA Polymerase Eta for 20S Proteasomal Degradation

(2009) Y.-S. Jung et al.   MOLECULAR AND CELLULAR BIOLOGY

The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress

(2009) Joanna R. Morris et al.   NATURE

Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

(2009) Yaron Galanty et al.   NATURE

RAD18 transmits DNA damage signalling to elicit homologous recombination repair

(2009) Jun Huang et al.   NATURE CELL BIOLOGY

Replication stress induces sister-chromatid bridging at fragile site loci in mitosis

(2009) Kok Lung Chan et al.   NATURE CELL BIOLOGY

The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities

(2009) Valeria Naim et al.   NATURE CELL BIOLOGY

RAD18 promotes DNA double-strand break repair during G1 phase through chromatin retention of 53BP1

(2009) Kenji Watanabe et al.   NUCLEIC ACIDS RESEARCH

Highly error-free role of DNA polymerase   in the replicative bypass of UV-induced pyrimidine dimers in mouse and human cells

(2009) J.-H. Yoon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic localization of human RAD18 during the cell cycle and a functional connection with DNA double-strand break repair

(2008) Akiko Inagaki et al.   DNA REPAIR

Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks

(2008) Yuri Tsuji et al.   GENES TO CELLS

Regulated Proteolysis of DNA Polymerase η during the DNA-Damage Response in C. elegans

(2008) Seung-Hwan Kim et al.   MOLECULAR CELL

PCNA Ubiquitination and REV1 Define Temporally Distinct Mechanisms for Controlling Translesion Synthesis in the Avian Cell Line DT40

(2008) Charlotte E. Edmunds et al.   MOLECULAR CELL

Regulation of proliferating cell nuclear antigen ubiquitination in mammalian cells

(2008) A. Niimi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human DNA polymerase   activity and translocation is regulated by phosphorylation

(2008) Y.-w. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA