Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity

A Common Cancer-Associated DNA Polymerase   Mutation Causes an Exceptionally Strong Mutator Phenotype, Indicating Fidelity Defects Distinct from Loss of Proofreading

(2014) D. P. Kane et al.   CANCER RESEARCH

Replicative DNA polymerase mutations in cancer

(2014) Ellen Heitzer et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Polymerase Proofreading-Associated Polyposis

(2014) James M. Church   DISEASES OF THE COLON & RECTUM

DNA Replication Error-Induced Extinction of Diploid Yeast

(2014) A. J. Herr et al.   GENETICS

Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication

(2014) Eve Shinbrot et al.   GENOME RESEARCH

New insights into POLE and POLD1 germline mutations in familial colorectal cancer and polyposis

(2014) Laura Valle et al.   HUMAN MOLECULAR GENETICS

Proper functioning of the GINS complex is important for the fidelity of DNA replication in yeast

(2014) Ewa Grabowska et al.   MOLECULAR MICROBIOLOGY

The Exomes of the NCI-60 Panel: A Genomic Resource for Cancer Biology and Systems Pharmacology

(2013) O. D. Abaan et al.   CANCER RESEARCH

Human Pol ɛ-dependent replication errors and the influence of mismatch repair on their correction

(2013) Anderson Ayuk Agbor et al.   DNA REPAIR

Telomere Length Homeostasis Responds to Changes in Intracellular dNTP Pools

(2013) A. Gupta et al.   GENETICS

Emergence of DNA Polymerase   Antimutators That Escape Error-Induced Extinction in Yeast

(2013) L. N. Williams et al.   GENETICS

DNA polymerase ɛ and δ exonuclease domain mutations in endometrial cancer

(2013) David N. Church et al.   HUMAN MOLECULAR GENETICS

A Substitution in the Fingers Domain of DNA Polymerase δ Reduces Fidelity by Altering Nucleotide Discrimination in the Catalytic Site

(2013) Marc J. Prindle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Germline and somatic polymerase ϵ and δ mutations define a new class of hypermutated colorectal and endometrial cancers

(2013) Sarah Briggs et al.   JOURNAL OF PATHOLOGY

Use of Quantitative Mass Spectrometric Analysis to Elucidate the Mechanisms of Phospho-priming and Auto-activation of the Checkpoint Kinase Rad53in Vivo

(2013) Eric S.-W. Chen et al.   MOLECULAR & CELLULAR PROTEOMICS

Effect of dNTP pool alterations on fidelity of leading and lagging strand DNA replication in E. coli

(2013) Damian Gawel et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Integrated genomic characterization of endometrial carcinoma

(2013) Gad Getz et al.   NATURE

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

The burden of faulty proofreading in colon cancer

(2013) Somasekar Seshagiri   NATURE GENETICS

Suppression of Nucleotide Metabolism Underlies the Establishment and Maintenance of Oncogene-Induced Senescence

(2013) Katherine M. Aird et al.   Cell Reports

Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype

(2012) Marta B Davidson et al.   EMBO JOURNAL

Recurrent R-spondin fusions in colon cancer

(2012) Somasekar Seshagiri et al.   NATURE

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas

(2012) Claire Palles et al.   NATURE GENETICS

Lesion bypass by S. cerevisiae Pol ζ alone

(2011) Jana E. Stone et al.   DNA REPAIR

AMPK directly inhibits NDPK through a phosphoserine switch to maintain cellular homeostasis

(2011) Rob U. Onyenwoke et al.   MOLECULAR BIOLOGY OF THE CELL

Increase in dNTP pool size during the DNA damage response plays a key role in spontaneous and induced-mutagenesis in Escherichia coli

(2011) S. Gon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutator Suppression and Escape from Replication Error–Induced Extinction in Yeast

(2011) Alan J. Herr et al.   PLoS Genetics

Ixr1 Is Required for the Expression of the Ribonucleotide Reductase Rnr1 and Maintenance of dNTP Pools

(2011) Olga Tsaponina et al.   PLoS Genetics

Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase

(2010) H. Niida et al.   GENES & DEVELOPMENT

Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpoint

(2010) Dinesh Kumar et al.   NUCLEIC ACIDS RESEARCH

Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools

(2010) D. Kumar et al.   NUCLEIC ACIDS RESEARCH

The ribonucleotide reductase inhibitor, Sml1, is sequentially phosphorylated, ubiquitylated and degraded in response to DNA damage

(2010) Bethany L. Andreson et al.   NUCLEIC ACIDS RESEARCH

Abundant ribonucleotide incorporation into DNA by yeast replicative polymerases

(2010) S. A. Nick McElhinny et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Participation of DNA Polymerase   in Replication of Undamaged DNA in Saccharomyces cerevisiae

(2009) M. R. Northam et al.   GENETICS

Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase δ

(2009) Michael K Swan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A cancer-associated DNA polymerase   variant modeled in yeast causes a catastrophic increase in genomic instability

(2009) D. L. Daee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA polymerase   and   proofreading suppress discrete mutator and cancer phenotypes in mice

(2009) T. M. Albertson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of pathways controlling DNA damage induced mutation in Saccharomyces cerevisiae

(2008) Ewa T. Lis et al.   DNA REPAIR

Dif1 Controls Subcellular Localization of Ribonucleotide Reductase by Mediating Nuclear Import of the R2 Subunit

(2008) X. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

Differential Regulation of the Cellular Response to DNA Double-Strand Breaks in G1

(2008) Jacqueline H. Barlow et al.   MOLECULAR CELL

Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage

(2008) Nasim Sabouri et al.   NUCLEIC ACIDS RESEARCH