Intragenic origins due to short G1 phases underlie oncogene-induced DNA replication stress

Detecting DNA double-stranded breaks in mammalian genomes by linear amplification–mediated high-throughput genome-wide translocation sequencing

(2016) Jiazhi Hu et al.   Nature Protocols

Increased global transcription activity as a mechanism of replication stress in cancer

(2016) Panagiotis Kotsantis et al.   Nature Communications

Replication landscape of the human genome

(2016) Nataliya Petryk et al.   Nature Communications

Dynamic loading and redistribution of the Mcm2-7 helicase complex through the cell cycle

(2015) S. K. Powell et al.   EMBO JOURNAL

Large transcription units unify copy number variants and common fragile sites arising under replication stress

(2014) Thomas E. Wilson et al.   GENOME RESEARCH

Myc and Ras oncogenes engage different energy metabolism programs and evoke distinct patterns of oxidative and DNA replication stress

(2014) Apolinar Maya-Mendoza et al.   Molecular Oncology

Identification of Early Replicating Fragile Sites that Contribute to Genome Instability

(2013) Jacqueline H. Barlow et al.   CELL

ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

(2013) Luis Ignacio Toledo et al.   CELL

Pan-cancer patterns of somatic copy number alteration

(2013) Travis I Zack et al.   NATURE GENETICS

Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells

(2013) Lorenzo Costantino et al.   SCIENCE

Suppression of Nucleotide Metabolism Underlies the Establishment and Maintenance of Oncogene-Induced Senescence

(2013) Katherine M. Aird et al.   Cell Reports

Cyclin-Dependent Kinase Suppression by WEE1 Kinase Protects the Genome through Control of Replication Initiation and Nucleotide Consumption

(2012) H. Beck et al.   MOLECULAR AND CELLULAR BIOLOGY

Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress

(2012) R M Jones et al.   ONCOGENE

Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development

(2011) Assaf C. Bester et al.   CELL

The effect of the intra-S-phase checkpoint on origins of replication in human cells

(2011) Neerja Karnani et al.   GENES & DEVELOPMENT

Genome-wide depletion of replication initiation events in highly transcribed regions

(2011) M. M. Martin et al.   GENOME RESEARCH

Collisions between Replication and Transcription Complexes Cause Common Fragile Site Instability at the Longest Human Genes

(2011) Anne Helmrich et al.   MOLECULAR CELL

Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site

(2011) Anne Letessier et al.   NATURE

Signatures of mutation and selection in the cancer genome

(2010) Graham R. Bignell et al.   NATURE

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

Sequencing newly replicated DNA reveals widespread plasticity in human replication timing

(2009) R. S. Hansen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE